They will seek it out, or engage in the behaivor even though it is causing harm (physical problems, poor work or study performance, problems with friends, family, fellow workers
[indiana.edu]
disability, and failure to meet major responsibilities at work, school, or home.
[en.wikipedia.org]
Statistical Manual of Mental Disorders (DSM-5) referring to recurrent use of alcohol or other drugs that causes clinically and functionally significant impairment, such as health problems
[en.wikipedia.org]