Progeroid Appearance: Causes & Reasons

Possible Causes for Progeroid Appearance

Other Reports Palestine Megarbane and Loiselet (1997) reported a Palestinian girl in Lebanon with a progeroid appearance, with prominent occiput, blepharophimosis, cataract [cags.org.ae]

The syndrome is characterized by progeroid appearance, decreased subcutaneous fat, hypotrichosis, macrocephaly, and in some natal teeth. [wwww.unboundmedicine.com]

During 15 years of observation progeroid appearance of face remained almost unchanged. [stary.lf2.cuni.cz]

De Barsey-Moens-Dierckx Syndrome

appearance, large and late-closing fontanel, cutis laxa (CL), joint hyperlaxity, athetoid movements and hyperreflexia, pre- and postnatal growth retardation, intellectual [findexpertmd.com]

appearance with distinctive facial features and cutis laxa. [clinicaterapeutica.it]

Definition A syndrome characterized by facial dysmorphism with a progeroid appearance, large and late-closing fontanel, cutis laxa, joint hyperlaxity, athetoid movements and [uniprot.org]

Mandibular Hypoplasia - Deafness - Progeroid Syndrome

Affected individuals may have “progeroid” features that give them a prematurely aged appearance. [rarediseases.org]

[…] facial appearance 0005328 Prominent scalp veins 0001043 Reduced subcutaneous adipose tissue Reduced fat tissue below the skin 0003758 Relative macrocephaly Relatively large [rarediseases.info.nih.gov]

[…] loss of subcutaneous fat, metabolic abnormalities including insulin resistance and diabetes mellitus, sclerodermatous skin, and a facial appearance characterized by mandibular [malacards.org]

Lenz-Majewski Syndrome

Abstract Here we report a 10 year-old mentally retarded, deaf boy with a unique pattern of anomalies: progeroid appearance, characteristic facial and limb anomalies, multiple [ncbi.nlm.nih.gov]

appearance. [accesspediatrics.mhmedical.com]

Loose and wrinkled atrophic skin with prominent veins is also apparent, giving the patient a progeroid appearance. [malacards.org]

Hypergonadotropic Hypogonadism - Partial Alopecia

appearance, partial alopecia, soft tissue calcinosis, joint contractures, and partial lipodystrophy with loss of subcutaneous fat from the extremities. [ab-y-ss.com]

[…] dysplasia with type A lipodystrophy (MADA) [MIM:248370]: A disorder characterized by mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture, progeroid [antibodyplus.com]

A disorder characterized by mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture, progeroide appearance, partial alopecia, soft tissue [genscript.com]

Autosomal Recessive Cutis Laxa Type 1A

Definition A syndrome characterized by facial dysmorphism with a progeroid appearance, large and late-closing fontanel, cutis laxa, joint hyperlaxity, athetoid movements and [uniprot.org]

Patient-1 The elder sibling, 18-year-old female (35 kg, 161 cm), whose parents were first cousins, had a progeroid appearance, downward slanting palpebral fissures, broad [ijpd.in]

Figure 1: Autosomal recessive cutis laxa in two siblings showing progeroid appearance, downward slanting palpebral fissures, broad flat nose, sparse eyebrows, a vertically [ijpd.in]

Cutis Laxa

The patients presented with typical features of de Barsy syndrome and an overall progeroid appearance. [ncbi.nlm.nih.gov]

Abstract The autosomal dominant progeroid form of cutis laxa is a recently identified multiple congenital anomaly disorder characterized by thin, wrinkled skin, a progeroid [ncbi.nlm.nih.gov]

Patients display facial dysmorphism, with triangular facies and progeroid appearance. [visualdx.com]

Ehlers-Danlos Syndrome Spondylodysplastic Type 1

Although "progeroid" means "appearance similar to old age," affected people do not actually have premature aging and are not expected to have a shortened life span. [rarediseases.info.nih.gov]

[…] facial appearance Premature aged appearance 0005328 Pulmonic stenosis Narrowing of pulmonic valve 0001642 Short stature Decreased body height Small stature [ more ] 0004322 [rarediseases.info.nih.gov]

[…] sparse eyebrows and eyelashes Joint contractures and hypermobility Loose, elastic skin on the face The former name for spondylodysplastic Ehlers-Danlos syndrome was "EDS, progeroid [rarediseases.info.nih.gov]

Progeroid Facial Appearance with Hand Anomalies

Abstract Here we report a 10 year-old mentally retarded, deaf boy with a unique pattern of anomalies: progeroid appearance, characteristic facial and limb anomalies, multiple [wwww.unboundmedicine.com]

[…] aged appearance at birth (neonatal progeroid appearance); growth delays before and after birth (prenatal and postnatal growth retardation); and deficiency or absence of the [checkorphan.org]

Facial Appearance With Hand Anomalies Progeroid Syndrome, Neonatal Skin Creases, Congenital Symmetric Circumferential, 1 Spondyloocular Syndrome Stickler Syndrome, Type II [familydiagnosis.com]

Mandibuloacral Dysplasia with Type B Lipodystrophy

The lipodystrophy is more generalized.The patient had severe MAD associated with progeroid appearance and generalized lipodystrophy. [fdna.health]

[…] facial appearance Premature aged appearance 0005328 Proptosis Bulging eye Eyeballs bulging out Prominent eyes Prominent globes Protruding eyes [ more ] 0000520 Short nose [rarediseases.info.nih.gov]

0003077 Hyperpigmentation of the skin Patchy darkened skin 0000953 Insulin resistance Body fails to respond to insulin 0000855 Nail dystrophy Poor nail formation 0008404 Progeroid [rarediseases.info.nih.gov]

Ventruto Digirolamo Festa Syndrome

appearence Van Bogaert-Hozay syndrome Van Buchem disease - See Hyperostosis corticalis generalisata Van Buchem disease type 2 Van De Berghe Dequeker syndrome - See Ulnar [herenciageneticayenfermedad.blogspot.com]

[…] syndrome Van Bervliet syndrome - See Arthrogryposis IUGR thoracic dystrophy Van Biervliet Hendrickx Van Ertbruggen syndrome - See Craniofacial dysostosis arthrogryposis progeroid [herenciageneticayenfermedad.blogspot.com]

Autosomal Recessive Cutis Laxa Type 2

Patient-1 The elder sibling, 18-year-old female (35 kg, 161 cm), whose parents were first cousins, had a progeroid appearance, downward slanting palpebral fissures, broad [ijpd.in]

ARCL Type III (De Barsy syndrome) has progeroid appearance with presence of athetoid movements and corneal clouding. [journals.lww.com]

Figure 1: Autosomal recessive cutis laxa in two siblings showing progeroid appearance, downward slanting palpebral fissures, broad flat nose, sparse eyebrows, a vertically [ijpd.in]

Progeroid Syndrome Type Petty

Abstract We report on a Palestinian family with three affected individuals exhibiting progeroid syndrome characterized by intrauterine growth retardation, a progeroid appearance [onlinelibrary.wiley.com]

In males or females, hair loss and premature graying may contribute to a progeroid appearance. [obgynkey.com]

Progeroid facial appearance at birth can occur in Hallermann–Streiff, Berardinelli–Seip, Bamatter and DeBarsy syndromes. [plasticsurgerykey.com]

Autosomal Recessive Cutis Laxa Type 2A

PATIENT-1 The elder sibling, 18-year-old female (35 kg, 161 cm), whose parents were first cousins, had a progeroid appearance, downward slanting palpebral fissures, broad [journals.lww.com]

Patient-1 The elder sibling, 18-year-old female (35 kg, 161 cm), whose parents were first cousins, had a progeroid appearance, downward slanting palpebral fissures, broad [ijpd.in]

ARCL Type III (De Barsy syndrome) has progeroid appearance with presence of athetoid movements and corneal clouding. [ncbi.nlm.nih.gov]

Autosomal Recessive Cutis Laxa Type 2B

PATIENT-1 The elder sibling, 18-year-old female (35 kg, 161 cm), whose parents were first cousins, had a progeroid appearance, downward slanting palpebral fissures, broad [journals.lww.com]

The infant was noted to have microcephaly, progeroid facial appearance, cutis laxa, hypermobile joints, wide open anterior fontanelle and congenital vertical talus. [link.springer.com]

Although both groups show a late closure of the anterior fontanel, the facial features are quite different, demonstrating a somewhat older, almost progeroid appearance in [nature.com]

Tollner-Horst-Manzke Syndrome

Facial Appearance with Hand Anomalies Pseudotrisomy 13 Syndrome Radio-Ulnar Synostosis Type 1 Radio-Ulnar Synostosis Type 2 Rhizomelic Dysplasia Patterson Lowry Type Richieri [rgd.mcw.edu]

Facial Appearance with Hand Anomalies Pseudotrisomy 13 Syndrome Radial Defect Robin Sequence Radio-Ulnar Synostosis Type 1 Radio-Ulnar Synostosis Type 2 Ray Peterson Scott [rgd.mcw.edu]

Metatarsal IV Patent Ductus Arteriosus and Bicuspid Aortic Valve with Hand Anomalies Pfeiffer Tietze Welte Syndrome Postaxial Polydactyly, with Dental and Vertebral Anomalies Progeroid [rgd.mcw.edu]

Acroosteolysis-Keloid-Like Lesions-Premature Aging Syndrome

Symptoms - Progeroid syndrome- Penttinen type * Prematurely aged appearance * Delayed bone maturation * Delayed dental development * Bone degeneration in extremities * Short [checkorphan.org]

Progeroid syndrome with characteristic facial appearance and hand anomalies in father and son. American Journal of Medical Genetics, 73, 227–229. [doi.org]

Progeroid syndrome with characteristic facial Appearance and hand anomalies in father and son. Am J Med Genet 73:227–229, 1997. CrossRef PubMed Google Scholar 22. [link.springer.com]

Saul-Wilson Syndrome

Ferreira et al. compared and followed-up characteristics of their patients which revealed short stature and progeroid appearance in all patients. [mdpi.com]

Second, most patients have a progeroid appearance during early infancy. [nature.com]

[…] facial appearance (Figure 1 and Figure 2). [mdpi.com]

Cutis Laxa - Osteoporosis

Clinically, developmental disorders with progeroid appearance, dwarfism, joint hyperlaxis, microcephaly, strabismus, bilateral cataracts, facial dysmorphy and severe mental [altmeyers.org]

He had a progeroid appearance due to lax and wrinkled skin and reduced subcutaneous fatty tissue. [nature.com]

[…] as well as additional findings suggesting a progeroid condition and proposed the term acrometageria. [scielo.br]

Ehlers-Danlos Syndrome Spondylodysplastic Type 2

“Progeroid” means “appearance similar to old age”, which is the symptom that this EDS type is best known for. [diseaseinfosearch.org]

Although "progeroid" means "appearance similar to old age," affected people do not actually have premature aging and are not expected to have a shortened life span. [rarediseases.info.nih.gov]

Ehlers-Danlos syndrome progeroid type (EDS-PF, EDSP1 and/or EDSP2) is a very rare form of EDS. [diseaseinfosearch.org]

Vagneur-Triolle-Ripert Syndrome

Autosomal Recessive Cutis Laxa Type 1

ARCL Type III (De Barsy syndrome) has progeroid appearance with presence of athetoid movements and corneal clouding. [idoj.in]

The infant was noted to have microcephaly, progeroid facial appearance, cutis laxa, hypermobile joints, wide open anterior fontanelle and congenital vertical talus. [link.springer.com]

Although both groups show a late closure of the anterior fontanel, the facial features are quite different, demonstrating a somewhat older, almost progeroid appearance in [nature.com]

Granddad Syndrome

Progeroid facial appearance MedGen UID: 341830 •Concept ID: C1857710 • Finding A degree of wrinkling of the facial skin that is more than expected for the age of the individual [ncbi.nlm.nih.gov]

[…] facial appearance 31 HP:0005328 10 reduced subcutaneous adipose tissue 31 HP:0003758 11 prominent nasal septum 31 HP:0005322 12 abnormal hair morphology 31 HP:0001595 Symptoms [malacards.org]

[…] facial appearance, Prominent forehead, Frontal bossing, Abnormal hair morphology, Autosomal dominant inheritance, Protruding ear, Thin vermilion border *This computer-generated [fdna.health]

Mandibuloacral Dysostosis

Definition A disorder characterized by mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture, progeroid appearance, partial alopecia, [uniprot.org]

appearance and generalized lipodystrophy. [citeseerx.ist.psu.edu]

The lipodystrophy is more generalized.The patient had severe MAD associated with progeroid appearance and generalized lipodystrophy. [fdna.health]

Nestor-Guillermo Progeria Syndrome

Homepage Rare diseases Search Search for a rare disease Nestor-Guillermo progeria syndrome Disease definition Nestor-Guillermo progeria syndrome is a rare, genetic, progeroid [orpha.net]

Homepage Rare diseases Search Search for a rare disease Disease definition Nestor-Guillermo progeria syndrome is a rare, genetic, progeroid syndrome characterized by a prematurely [orpha.net]

Autosomal Recessive Cutis Laxa Type 1B

Patient-1 The elder sibling, 18-year-old female (35 kg, 161 cm), whose parents were first cousins, had a progeroid appearance, downward slanting palpebral fissures, broad [ijpd.in]

The progeroid appearance originates due to hypoplasia of the dermis. [3], [4], [5] There is no racial variation, but male predominance has been noted. [2] History of the reported [e-ijd.org]

ARCL Type III (De Barsy syndrome) has progeroid appearance with presence of athetoid movements and corneal clouding. [idoj.in]

Chitty-Hall-Webb Syndrome

appearence Craniofacial dysostosis with diaphyseal hyperplasia Craniofacial dyssynostosis Craniofacial dystonia Craniofacial malformations asymmetric with polysyndactyly [personalizedcause.com]

Craniodigital syndrome mental retardation Cranioectodermal dysplasia Craniofacial and skeletal defects Craniofacial deafness hand syndrome Craniofacial dysostosis arthrogryposis progeroid [personalizedcause.com]

Massa-Casaer-Ceulemans Syndrome

Van Biervliet Hendrickx Van Ertbruggen Syndrome (Craniofacial Dysostosis Arthrogryposis Progeroid Appearance): Extremely rare disease with intrauterine growth retardation [accessanesthesiology.mhmedical.com]

Malouf Syndrome

Although these patients had a progeroid appearance, none had severe growth failure, alopecia or rapidly progressive atherosclerosis and McPherson et al(8) suggested that the [spandidos-publications.com]

Tarsal Kink Syndrome

appearance, macrocephaly, wrinkled skin, reduced subcutaneous fat, and neonatal teeth. [entokey.com]

Batur et al15 reported a case of bilateral tarsal kink in an infant with Wiedemann-Rautenstrauch syndrome, an extremely rare, autosomal recessive disorder characterized by progeroid [entokey.com]