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532 Possible Causes for Progression of Phenotype with Age

  • Atopy

    Although the complex interactions between environmental and genetic factors affect the development and progression of asthma, studies on asthma phenotypes considering environmental[ncbi.nlm.nih.gov] CONCLUSION: Identification of atopy phenotypes facilitates prediction of the development of asthma and bronchial hyperresponsiveness in school-age children.[ncbi.nlm.nih.gov] This study aimed to identify asthma phenotypes using latent class analysis including environmental factors in school-age children.[ncbi.nlm.nih.gov]

  • Scoliosis

    IS is marked by phenotypic complexity (variations in curve morphology and magnitude, age of onset, rate of progression), and a prognosis ranging from increase in curve magnitude[doi.org] The children, ranging from the sturdy phenotype to the dysmorphic with unnamed syndromes, portray, by the escalating speed and severity of progression of their scoliosis,[dx.doi.org] Mental retardation in children with progressive infantile scoliosis is not uncommon. 14 – 16 These four clinical subgroups can be recognised at an early age and often at the[dx.doi.org]

  • Asthma

    WHEEZING PHENOTYPES IN THE TUCSON STUDY Number ( % ) Lung Function Shortly after Birth Wheeze Age 3 Lung Function Age 6 Wheeze Age 6 Normal subjects 425 ( 51 ) Normal — Normal[doi.org] When novel therapeutic strategies do become available, we will certainly need biomarkers of which children are destined to progress to multiple-trigger wheeze for intervention[doi.org]

  • Acanthosis Nigricans

    The lesions typically begin during early childhood but may manifest at any age.[emedicine.medscape.com] Familial acanthosis nigricans often progresses until puberty, at which time it stabilizes or regresses.[emedicine.medscape.com] […] malignancy. [15] Familial acanthosis nigricans Familial acanthosis nigricans is a rare genodermatosis that seems to be transmitted in an autosomal dominant fashion with variable phenotypic[emedicine.medscape.com]

  • Lynch Syndrome

    It is not until 2 years of age or later that the typical syndrome phenotype becomes obvious, yet it is often apparent by 6 months of age.[medicalhomeportal.org] Children with AS appear normal at birth, then show progressive developmental delays.[medicalhomeportal.org]

  • Congenital Deafness

    The classic phenotype is renal failure and progressive sensorineural deafness. The hearing loss is bilateral and correlated with age (Moon et al, 2009).[dizziness-and-balance.com]

  • Neurogenic Bladder

    LUTS were not influenced by age, phenotype, disability, cognitive or behavioural impairment, or disease progression, but female sex appeared to be a protective factor (OR[ncbi.nlm.nih.gov]

  • Panic Disorder

    Abstract The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes.[ncbi.nlm.nih.gov] We therefore performed a genome-wide association study with a dimensional, PD/AG-related anxiety phenotype based on the Agoraphobia Cognition Questionnaire (ACQ) in a sample[ncbi.nlm.nih.gov]

  • X-linked Parkinsonism-Spasticity Syndrome

    The significant variations in patients' ages at symptom onset and the degree of progression in these kindreds indicate that the complete phenotype is influenced by different[emedicine.medscape.com] Kindreds with autosomal dominant HSP linked to 2p have exhibited (1) the prototypical adolescent- or adult-onset, progressive form and (2) the less common childhood-onset,[emedicine.medscape.com]

  • Parkinson's Disease

    Age at onset in carriers of parkin mutations varied as did the rate of progression of the disease: the younger the age at onset the slower the evolution.[ncbi.nlm.nih.gov] Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.[ncbi.nlm.nih.gov] Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype.[ncbi.nlm.nih.gov]

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