Progressive Disease: Causes & Reasons

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Possible Causes for Progressive Disease

Geographic Atrophy

AMD is a progressive eye disease. Each eye may be in a different stage. Advanced AMD is the last stage of this progressive retinal disease. [webrn-maculardegeneration.com]

We are now enrolling two Phase II clinical trials that will help us understand if these positive effects translate into slowing disease progression. [gyroscopetx.com]

[…] in one year (right) The prognosis is poor, as there are no available treatment, and the disease is chronic and progressive. [eyewiki.aao.org]

Chronic Kidney Insufficiency

The majority of patients with chronic kidney disease rarely progress beyond Stage 2. [medicalnewstoday.com]

Treatment is aimed at stopping or slowing down the progression of the disease - this is usually done by controlling its underlying cause. [medicalnewstoday.com]

There are no well-recognised factors for progression of the disease, which hampers the implementation of preventive measures. [revistanefrologia.com]

Diabetic Nephropathy

Diabetic nephropathy (DN) is a progressive disease that affects about one third of diabetic patients and is among the most frequent causes of the end stage renal disease [ncbi.nlm.nih.gov]

Disease progression depends on many factors. [healthline.com]

Diabetic nephropathy progresses slowly. With early treatment, you can slow or even stop the progression of the disease. [healthline.com]

Primary Progressive Multiple Sclerosis

[…] the onset of a progressive disease course in MS. [mayoclinic.pure.elsevier.com]

The majority of patients starts with relapsing remitting (RR) disease; approximately 50-60% of these patients progress to secondary progressive (SP) disease. [ncbi.nlm.nih.gov]

Author information 1 Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55902, USA. kantarci.orhun@mayo.edu Abstract Primary progressive multiple [ncbi.nlm.nih.gov]

Progressive Myoclonic Epilepsy Type 3

Homepage Rare diseases Search Search for a rare disease Progressive myoclonic epilepsy type 3 Disease definition A rare, genetic, neuronal ceroid lipofuscinosis disorder characterized [orpha.net]

J Kor Neurol Ass 17(3):420 ~ 426, 1999 Key Words : Gaucher’s disease, progressive myoclonus epilepsy, ß-glucosidase [jkna.org]

[…] myoclonic epilepsies are a group of disorders characterised by a relentlessly progressive disease course until death; treatment-resistant epilepsy is just a part of the phenotype [pn.bmj.com]

Lafora Disease

[…] myoclonic epilepsy type 2 Lafora Disease Epilepsy progressive myoclonic 2 Lafora body disorder Lafora Body Disease edit English Lafora disease Lafora disease (LD) is a rare [wikidata.org]

[…] occipital seizures), and progressive neurological decline Lafora Progressive Myoclonic Epilepsy Lafora disease (disorder) Lafora's disease MYOCLONIC EPILEPSY OF LAFORA Melf [wikidata.org]

progression. [ncbi.nlm.nih.gov]

Unverricht-Lundborg Syndrome

Lundborg disease, epilepsy, progressive myoclonic, 1A, Baltic myoclonic epilepsy [monarchinitiative.org]

For early Unverricht-Lundborg disease patients, the disease would begin to progress early and lack of effective treatment meant a quick progression. [diki.pl]

Myoclonic Type 1 Epilepsy, Mediterranean Myoclonic Unverricht Lundborg Disease Unverricht-Lundborg Disease Lundborg Unverricht Syndrome Progressive Myoclonus Epilepsy 1 Epilepsy [finto.fi]

Progressive Myoclonic Epilepsy Type 7

Homepage Rare diseases Search Search for a rare disease Progressive myoclonic epilepsy type 7 Disease definition A rare, genetic, neurological disorder characterized by childhood [orpha.net]

J Kor Neurol Ass 17(3):420 ~ 426, 1999 Key Words : Gaucher’s disease, progressive myoclonus epilepsy, ß-glucosidase [jkna.org]

Laforin (EPM2A) ELISA kit; RP1-28C20.2; EPM2; MELF; epilepsy; progressive myoclonus type 2; Lafora disease (laforin) ; laforin; epilepsy; progressive myoclonus type 2A; Lafora [mybiosource.com]

Chronic Kidney Disease

Kidney disease is a chronic, progressive disease. As a result, there are specific symptoms associated with its progression. [nationalkidneycenter.org]

Understanding the molecular mechanisms participating in the progression of renal diseases and uncovering the pathways implicated will permit the identification of novel and [ncbi.nlm.nih.gov]

Results of interventional studies suggest that alkali therapy in CKD patients slows progression of kidney disease. [ncbi.nlm.nih.gov]

Progressive Myoclonic Epilepsy Type 8

Homepage Rare diseases Search Search for a rare disease Progressive myoclonic epilepsy type 8 Disease definition A rare, genetic, neurological disorder characterized by childhood [orpha.net]

Defects in EPM2A are a cause of progressive myoclonic epilepsy type 2(EPM2), also known as Lafora disease. [antibodies-online.com]

Disease onset was between 6 and 16 years of age. The diagnosis of Unverricht-Lundborg disease and all other known causes of progressive ... [allmedx.com]

Idiopathic Pulmonary Fibrosis

disease progression, and indication for lung transplantation. [ncbi.nlm.nih.gov]

IPF is a progressive disease marked by scarring of the lung tissue. [my.clevelandclinic.org]

Novel antifibrotic therapies have been recently demonstrated to slow disease progression and improve survival. [ncbi.nlm.nih.gov]

Primary Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is a chronic, progressive disease characterized by inflammatory and fibrosing strictures of the biliary tree. [ncbi.nlm.nih.gov]

As the disease progresses, the liver may become nodular in appearance. [symptoma.com]

Because PSC is a progressive disease, symptoms may come and go over several months and years after the diagnosis is made. [rxlist.com]

Parkinson Disease

A prerequisite for effective interventions that would modify disease progression in Parkinson's disease is the identification of the earliest preclinical stages of illness [ncbi.nlm.nih.gov]

For an in-depth guide to navigating Parkinson’s disease and living well as the disease progresses, check out our Parkinson’s 360 toolkit. What Is Parkinson's Disease? [michaeljfox.org]

A prerequisite for effective interventions that would modify disease progression in Parkinson’s disease is the identification of the earliest preclinical stages of illness [dx.doi.org]

Recurrent Small-Cell Carcinoma of the Lung

Twenty (40%) patients had stable disease (SD) and 13 (26%) had progressive disease (PD). [ncbi.nlm.nih.gov]

Among all patients, ORR was 8% (95% confidence interval [CI], 2%-21%), 24% had stable disease, and disease in 47% progressed. [ncbi.nlm.nih.gov]

A Markov model including three health states: progression-free state, progressive disease (PD), and death, was developed to simulate the process of sensitive relapsed small-cell [ncbi.nlm.nih.gov]

Pulmonary Fibrosis

IPF is a progressive disease marked by scarring of the lung tissue. [my.clevelandclinic.org]

Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, debilitating disease of unknown etiology with a median survival from diagnosis of 3-5 years. [frontiersin.org]

Idiopathic pulmonary fibrosis (IPF) is a progressive disease (gets worse over time) isolated to the lung. [my.clevelandclinic.org]

Duchenne Muscular Dystrophy

The progressive disease is caused by a mutation in the x-linked DMD gene that encodes the protein dystrophin. [upi.com]

Abstract Duchenne muscular dystrophy (DMD) is a severe, progressive disease that affects 1 in 3600–6000 live male births. [citeseerx.ist.psu.edu]

Being a progressive disease, patients are rarely candidates for cardiac transplantation and death from dilated cardiomyopathy (DCM) is common. [ncbi.nlm.nih.gov]

Progressive Muscular Atrophy

[…] muscular atrophy have a relentlessly progressive disease course. [ncbi.nlm.nih.gov]

What Is Progressive Muscular Atrophy? Progressive muscular atrophy is an inherited form of motor neuron disease. [healthcare.utah.edu]

Klinefelter's syndrome associated with progressive muscular atrophy simulating Kennedy's disease. [annalsofian.org]

Keratoconus

Corneal Collagen Cross-Linking (CXL) is the only treatment that can actually halt the progression of the disease. [keratoconuscanada.org]

Keratoconus is a progressive eye disease, in which the normally round cornea thins and begins to bulge into a cone-like shape. [optilase.com]

Keratoconus is a non-inflammatory, progressive disease affecting the cornea. It causes progressive thinning of the cornea and bulging into a cone-like shape. [touchophthalmology.com]

Alzheimer Disease

Alzheimer’s is a progressive disease. This means that gradually, over time, more parts of the brain are damaged. [alzheimers.org.uk]

However, none of them are able to slow down or stop the progression of the disease. [asceneuron.com]

There are some drug treatments for Alzheimer’s disease that can help boost the levels of some chemical messengers in the brain. This can help with some of the symptoms. [alzheimers.org.uk]

Progressive Bulbar Paralysis

Bulbar, Progressive Bulbar Palsies, Progressive Bulbar Palsy, Bulbar Palsy, Progressive [Disease/Finding], bulbar palsies, bulbar palsy progressive, bulbar palsy, bulbar [fpnotebook.com]

Amyotrophic Lateral Sclerosis (ALS), commonly known as Lou Gehrig's disease, is a progressive neuromuscular disease. [hopkinsmedicine.org]

PATIENT C September 30 2004 ( Patient C is diagnosed with Motor Neurone Disease and another muscle-wasting disease Progressive Bulbar Palsy. [acronymfinder.com]

Amyotrophic Lateral Sclerosis Type 1

Amyotrophic Lateral Sclerosis (ALS), commonly known as Lou Gehrig's disease, is a progressive neuromuscular disease. [hopkinsmedicine.org]

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. [alsa.org]

ALS is a progressive disease, which means it gets worse over time. It affects nerves in your brain and spinal cord that control your muscles. [webmd.com]

Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS), commonly known as Lou Gehrig's disease, is a progressive neuromuscular disease. [hopkinsmedicine.org]

Motor neuron disease, also known as amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease, is a progressive disease that attacks motor neurons, components of the nervous [curlie.org]

Progressive Muscular Atrophy (PMA) - a progressive neurological disease in which the lower motor neurons (nerve cells) deteriorate. [hopkinsmedicine.org]

Kienbock Disease

Abstract Kienbock's disease, or avascular necrosis of the lunate, is a progressive disease ultimately resulting in end-stage arthrosis of the wrist. [ncbi.nlm.nih.gov]

Kienböck’s disease follows a specific progressive pattern through four stages. [concannonplasticsurgery.com]

Kienböck’s disease progresses through four stages. [londonhand.com]

Primary Lateral Sclerosis

Primary lateral sclerosis (PLS) is a progressive, degenerative disease of upper motor neurons characterized by progressive spasticity (ie, stiffness). [emedicine.com]

Patients with primary lateral sclerosis (PLS) have a slower progression of disease and different clinical spectrum. [ncbi.nlm.nih.gov]

Classification and terminology of motor neuron diseases Motor neuron diseases (MNDs) are progressive degenerative diseases in which death of the cell bodies of motor neurons [emedicine.com]

Glomerulonephritis

[…] and progression of disease D) Spontaneous remission is unlikely, and steroid treatment alone is not effective in reducing proteinuria and progression of disease E) Steroid [highered.mheducation.com]

Prognosis Typically progresses to end-stage kidney disease over the course of several years in up to 50% of patients Corticosteroids can halt progression in some cases Membranous [geekymedics.com]

Therefore, treatments focus on slowing the progression of the disease preventing complications. [chop.edu]

Motor Neuron Disease

According to the NHS, MND is a progressive disease. Over time, the patient will lose the use of their muscles and be unable to walk, stand or sit without assistance. [alsnewstoday.com]

Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. [ncbi.nlm.nih.gov]

However MND usually begins by affecting a single limb or aspect of motor function, becoming more generalised as the disease progresses. [mndnsw.asn.au]

Upper Motor Neuron Disease

However MND usually begins by affecting a single limb or aspect of motor function, becoming more generalised as the disease progresses. [mndnsw.asn.au]

In progressive bulbar palsy a disease of upper motor neurones, lower motor neurones or both? [brainscape.com]

A cervical collar worn in the early stages of disease has been shown to halt progress of the disease in some cases, as it prevents neck flexion. [orpha.net]

Interstitial Lung Disease

Worsening hypoxia and respiratory failure may develop with disease progression. [ncbi.nlm.nih.gov]

Although many people with CTD-ILD do not develop progressive lung disease, a significant proportion do progress, leading to reduced physical function, decreased quality of [ncbi.nlm.nih.gov]

Because it is a progressive disease, it can worsen over time. [lunginstitute.com]

Lymphangioleiomyomatosis

Clinical symptoms of this progressive disease include dyspnoea, cough, recurrent pneumothorax, hemoptysis and chylothorax. [ncbi.nlm.nih.gov]

Treatment includes supportive care, bronchodilators, and for those with progressive disease, mammalian target of rapamycin (mTOR) inhibitors. [ncbi.nlm.nih.gov]

Lymphangioleiomyomatosis is an uncommon progressive disease characterized by hamartomatous smooth muscle proliferation of the airways within the lungs as well as the lymph [ncbi.nlm.nih.gov]

Spinal and Bulbar Muscular Atrophy

In addition, patients with early symptom onset had slower rate of disease progression. [ncbi.nlm.nih.gov]

SBMA is a slowly progressive disease by nature. [ncbi.nlm.nih.gov]

To date, several agents have been shown to prevent or slow disease progression in animal models of this disease. [ncbi.nlm.nih.gov]