Progressive Disease: Causes & Reasons

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Possible Causes for Progressive Disease

Primary Progressive Multiple Sclerosis

The majority of patients starts with relapsing remitting (RR) disease; approximately 50-60% of these patients progress to secondary progressive (SP) disease. [ncbi.nlm.nih.gov]

METHODS: A systematic literature research was performed to identify predictors for disease progression in PPMS. [ncbi.nlm.nih.gov]

Only about 15% of the patients develop a progressive disease course from onset, termed primary progressive multiple sclerosis (PPMS); the underlying pathogenic mechanisms [ncbi.nlm.nih.gov]

Progressive Myoclonic Epilepsy Type 3

[…] gene sharing: Search GEO for disease gene expression data for Epilepsy Progressive Myoclonic Type 3. [malacards.org]

[…] gene expression data for Epilepsy Progressive Myoclonic Type 3. [malacards.org]

J Kor Neurol Ass 17(3):420 426, 1999 Key Words : Gaucher’s disease, progressive myoclonus epilepsy, ß-glucosidase [jkna.org]

Lafora Disease

Daily living activities and social interaction were preserved in all cases and, overall, the progression of the disease was slow. [ncbi.nlm.nih.gov]

Lafora disease (LD), also known as progressive myoclonic epilepsy-2 (EPM2), is a rare, fatal autosomal recessive disorder typically starting during adolescence in otherwise [ncbi.nlm.nih.gov]

In this work, we characterize the mutations present in the EPM2A gene in a patient displaying a slow progression form of the disease. [ncbi.nlm.nih.gov]

Unverricht-Lundborg Syndrome

This disease is classified as a type of progressive myoclonus epilepsy. [ivami.com]

Category Nervous system disease Brite Human diseases [BR: br08402 ] Nervous system diseases Epilepsy H00810 Progressive myoclonic epilepsy Human diseases in ICD-11 classification [genome.jp]

Progressive myoclonus epilepsy Unverricht-Lundborg of (Unverricht-Lundborg disease, myoclonus epilepsy rogressive P) - CSTB gene. [ivami.com]

Chronic Kidney Insufficiency

[…] the risk factors for disease progression and cardiovascular complications. [karger.com]

Navaneethan SD, Yehnert H: Bariatric surgery and progression of chronic kidney disease. [bmcnephrol.biomedcentral.com]

The majority of patients with chronic kidney disease rarely progress beyond Stage 2. [medicalnewstoday.com]

Primary Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is a chronic, progressive disease characterized by inflammatory and fibrosing strictures of the biliary tree. [ncbi.nlm.nih.gov]

[…] of the disease. [ncbi.nlm.nih.gov]

CONCLUSION: We present a large international PSC cohort, and report genetic loci associated with PSC disease progression. [ncbi.nlm.nih.gov]

Recurrent Small-Cell Carcinoma of the Lung

Twenty (40%) patients had stable disease (SD) and 13 (26%) had progressive disease (PD). [ncbi.nlm.nih.gov]

A Markov model including three health states: progression-free state, progressive disease (PD), and death, was developed to simulate the process of sensitive relapsed small-cell [ncbi.nlm.nih.gov]

Stable disease rate was 39.3%, and 45.4% of patients had progressive disease. [ncbi.nlm.nih.gov]

Progressive Bulbar Paralysis

[…] bulbar palsy. ( 8270924 ) Chancellor A.M....Swingler R.J. 1993 8 Progressive bulbar palsy: a case report of a type of motor neuron disease presenting with oral symptoms. [malacards.org]

A case is presented of a patient with progressive bulbar palsy, a form of motor neuron disease, which is a progressive degenerative disorder of the motor nuclei in the medulla [ncbi.nlm.nih.gov]

PATIENT C September 30 2004 ( Patient C is diagnosed with Motor Neurone Disease and another muscle-wasting disease Progressive Bulbar Palsy. [acronymfinder.com]

Progressive Muscular Atrophy

[…] muscular atrophy have a relentlessly progressive disease course. [ncbi.nlm.nih.gov]

Klinefelter's syndrome associated with progressive muscular atrophy simulating Kennedy's disease. [annalsofian.org]

Patients Thirty-seven consecutive patients newly diagnosed (onset of weakness MAIN OUTCOME MEASURES: Disease progression was measured at 0, 3, 6, 9, 12, 15, and 18 months [ncbi.nlm.nih.gov]

Classic Progressive Supranuclear Palsy Syndrome

Not Applicable tideglusib;tideglusib;placebo 44 Deep TMS for the Treatment of Patients With Parkinson's Disease and Progressive Supranuclear Palsy Completed NCT02734485 Not [malacards.org]

The progression of the disease is slow between 5 to 10 years. The age of onset is typically over 50 years old. The duration of the disease is 7 years. [alzheimer-europe.org]

The disorder's long name indicates that the disease begins slowly and continues to get worse ( progressive ), and causes weakness ( palsy ) by damaging certain parts of the [my.clevelandclinic.org]

Idiopathic Pulmonary Fibrosis

However, accelerated disease progression after nintedanib discontinuation has never been reported. [ncbi.nlm.nih.gov]

disease progression, and indication for lung transplantation. [ncbi.nlm.nih.gov]

diseases. [ncbi.nlm.nih.gov]

Pulmonary Fibrosis

However, accelerated disease progression after nintedanib discontinuation has never been reported. [ncbi.nlm.nih.gov]

IPF is a progressive disease marked by scarring of the lung tissue. [my.clevelandclinic.org]

Accelerated disease progression after the discontinuation of nintedanib therapy for IPF. One patient received steroid therapy. [ncbi.nlm.nih.gov]

Progressive Supranuclear Palsy

The current gold standard for measuring clinical disease progression in PSP is the PSP Rating Scale score. [ncbi.nlm.nih.gov]

The ability to assess the distribution and extent of tau pathology in Alzheimer's disease and progressive supranuclear palsy in vivo would help to develop biomarkers for these [ncbi.nlm.nih.gov]

PSP-RS, Progressive Supranuclear Palsy-Richardson's Syndrome; Parkinson's disease; Progressive Supranuclear Palsy; ROC, receiver operating characteristics; SCP, superior [ncbi.nlm.nih.gov]

Interstitial Lung Disease

Often a period of observation is appropriate to assess whether the disease resolves spontaneously or progresses. [doi.org]

Interstitial lung disease involves all areas of medicine as it often occurs in patients with comorbidities or as a consequence of systemic diseases and their treatment. [ncbi.nlm.nih.gov]

Worsening hypoxia and respiratory failure may develop with disease progression. [ncbi.nlm.nih.gov]

Gingivitis

Gum disease may progress painlessly, producing few obvious signs, even in the late stages of the disease. [webmd.com]

As the disease progresses, the pockets deepen and more gum tissue and bone are destroyed. [webmd.com]

progression. [webmd.com]

Primary Lateral Sclerosis

Primary lateral sclerosis (PLS) is a progressive, degenerative disease of upper motor neurons characterized by progressive spasticity (ie, stiffness). [emedicine.com]

Classification and terminology of motor neuron diseases Motor neuron diseases (MNDs) are progressive degenerative diseases in which death of the cell bodies of motor neurons [emedicine.com]

Patients with early PLS may not be limited in these respects, but they should be reassessed as the disease progresses. [emedicine.com]

Amyotrophic Lateral Sclerosis

This review examined current research related to moderate exercise for maintaining independence without accelerating disease progression in persons with ALS. [ncbi.nlm.nih.gov]

PMID: 19556916 Issn Print: 1557-0576 Publication Date: 2009/06/01 Checking for direct PDF access through Ovid Abstract Amyotrophic lateral sclerosis (ALS) is an idiopathic disease [doi.org]

Motor neuron disease, also known as amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease, is a progressive disease that attacks motor neurons, components of the nervous [curlie.org]

Diabetic Nephropathy

Diabetic nephropathy (DN) is a progressive disease that affects about one third of diabetic patients and is among the most frequent causes of the end stage renal disease [ncbi.nlm.nih.gov]

[…] expansion and glomerular basement membrane thickening characteristic of diabetic nephropathy recur in diabetic recipients of renal allografts from non-diabetic donors but progression [ncbi.nlm.nih.gov]

Disease progression depends on many factors. [healthline.com]

Periodontitis

Gingivitis is a milder form of gum disease that causes irritated, bleeding gums. If left untreated, it can progress to periodontitis. [everydayhealth.com]

See also periodontal disease. periodontitis Gum disease, pyorrhea gum disease Dentistry A condition caused by progression of gingivitis, with inflammation and infection of [medical-dictionary.thefreedictionary.com]

A transseptal band of reconstituted periodontal fibers (interdental) walls off the gingival inflammation from the underlying bone. n 2. a chronic, progressive disease of the [medical-dictionary.thefreedictionary.com]

Progressive Myoclonic Epilepsy Type 7

Myoclonus Epilepsy 7 Expression for Progressive Myoclonus Epilepsy 7 Search GEO for disease gene expression data for Progressive Myoclonus Epilepsy 7. [malacards.org]

Disease Ontology Browser progressive myoclonus epilepsy 6 (DOID:0111449) Alliance: disease page Synonyms: EPM6; GOSR2-related progressive myoclonus ataxia; North Sea progressive [informatics.jax.org]

Search GEO for disease gene expression data for Epilepsy Progressive Myoclonic Type 3. [malacards.org]

Progressive Familial Intrahepatic Cholestasis

Category Digestive system disease Brite Human diseases [BR:br08402] Digestive system diseases Liver diseases H00624 Progressive familial intrahepatic cholestasis Human diseases [genome.jp]

Category Digestive system disease Brite Human diseases [BR: br08402 ] Digestive system diseases Liver diseases H00624 Progressive familial intrahepatic cholestasis Human diseases [genome.jp]

The differentiation between PFIC and BRIC is based on phenotypic presentation: PFIC is a progressive disease, with evolution to end-stage liver disease. [ncbi.nlm.nih.gov]

Amyotrophic Lateral Sclerosis Type 1

Amyotrophic Lateral Sclerosis (ALS), commonly known as Lou Gehrig's disease, is a progressive neuromuscular disease. [hopkinsmedicine.org]

G12.21 Amyotrophic lateral sclerosis G12.22 Progressive bulbar palsy G12.23 Primary lateral sclerosis G12.24 Familial motor neuron disease G12.25 Progressive spinal muscle [icd10data.com]

ALS is a progressive disease, which means it gets worse over time. It affects nerves in your brain and spinal cord that control your muscles. [webmd.com]

Alzheimer Disease

BACKGROUND AND OBJECTIVE: Semantic memory measures may be useful in tracking and predicting progression of Alzheimer disease. [ncbi.nlm.nih.gov]

Alzheimer’s is a progressive disease. This means that gradually, over time, more parts of the brain are damaged. [alzheimers.org.uk]

There are some drug treatments for Alzheimer’s disease that can help boost the levels of some chemical messengers in the brain. This can help with some of the symptoms. [alzheimers.org.uk]

Motor Neuron Disease

The aim of the study was to explore the prevalence of VGKC-complex Abs in slow-progression motor neuron disease (MND). [ncbi.nlm.nih.gov]

Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. [ncbi.nlm.nih.gov]

Abstract We have performed whole-exome sequencing in a family trio with a 16-year-old girl suffering of progressive motor neuron disease. [ncbi.nlm.nih.gov]

Chronic Kidney Disease

It is generally believed that significant renal ablation leads to hyperfiltration and eventually progressively worsening chronic kidney disease. [ncbi.nlm.nih.gov]

OBJECTIVES: To assess the cost effectiveness of renin-angiotensin aldosterone system (RAAS) blockade in the progression of chronic kidney disease using Thai clinical data [ncbi.nlm.nih.gov]

Kidney disease is a chronic, progressive disease. As a result, there are specific symptoms associated with its progression. [nationalkidneycenter.org]

Lipedema

Q: Is Lipedema a disease? A: Yes, lipedema is a chronic progressive disease. Q: What is Lipo-Lymphedema? [theroxburyinstitute.com]

Abstract Lipedema is a chronic progressive disease characterized by abnormal fat distribution resulting in disproportionate, painful limbs. [onlinelibrary.wiley.com]

Progressive means that the disease progresses and the clinical picture or the course of the disease worsens. Lipedema is a so-called fat distribution disorder. [lipocura.de]

Parkinson Disease

This study assessed the effect of levodopa on the rate of progression of Parkinson's disease. [ncbi.nlm.nih.gov]

Slower progression of Parkinson's disease with ropinirole versus levodopa: the REAL-PET study. [nejm.org]

[…] of Parkinson's disease or has a prolonged effect on the symptoms of the disease. [ncbi.nlm.nih.gov]

Progressive Myoclonic Epilepsy Type 8

Citation metadata Abstract : Lafora disease is a rare autosomal recessive progressive myoclonic epilepsy characterized by seizures, myoclonus and progressive cognitive decline [go.gale.com]

Disease Ontology Browser progressive myoclonus epilepsy 4 (DOID:0111444) Alliance: disease page Synonyms: action myoclonus-renal failure syndrome; AMRF; EPM4; Myoclonus-nephropathy [informatics.jax.org]

Kienbock Disease

Abstract Kienbock's disease, or avascular necrosis of the lunate, is a progressive disease ultimately resulting in end-stage arthrosis of the wrist. [ncbi.nlm.nih.gov]

A significant difference in ulnar variance was seen between early and late stages of the disease. [ncbi.nlm.nih.gov]

Radiological progression of the disease was not noted in either group, despite the stage. [ncbi.nlm.nih.gov]

Lymphangioleiomyomatosis

Lymphangioleiomyomatosis (LAM) is a rare and progressive disease of young women with no effective treatment. [ncbi.nlm.nih.gov]

We also looked at the effect of various factors such as cigarette smoking on disease progression. [doi.org]

Treatment includes supportive care, bronchodilators, and for those with progressive disease, mammalian target of rapamycin (mTOR) inhibitors. [ncbi.nlm.nih.gov]