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1,171 Possible Causes for Progressive Disease, Slow Speech

  • Primary Progressive Multiple Sclerosis

    The majority of patients starts with relapsing remitting (RR) disease; approximately 50-60% of these patients progress to secondary progressive (SP) disease.[ncbi.nlm.nih.gov] METHODS: A systematic literature research was performed to identify predictors for disease progression in PPMS.[ncbi.nlm.nih.gov] Only about 15% of the patients develop a progressive disease course from onset, termed primary progressive multiple sclerosis (PPMS); the underlying pathogenic mechanisms[ncbi.nlm.nih.gov]

  • Progressive Supranuclear Palsy

    The patient's language was characterized by AOS, with slow speech rate, prolonged intervals between syllables and words, decreased articulatory accuracy, sound distortions[ncbi.nlm.nih.gov] The current gold standard for measuring clinical disease progression in PSP is the PSP Rating Scale score.[ncbi.nlm.nih.gov] […] or stiff movements Speech difficulties, such as low voice volume, not able to say words clearly, slow speech Stiffness and rigid movement in the neck, middle of the body,[nlm.nih.gov]

  • Amyotrophic Lateral Sclerosis

    Symptoms of ALS include progressive muscle weakness beginning in the limbs, muscle twitching and cramping, slowed speech becoming progressively harder to understand, difficulty[brainfoundation.org.au] This review examined current research related to moderate exercise for maintaining independence without accelerating disease progression in persons with ALS.[ncbi.nlm.nih.gov] In a physical exam, your neurologist will also look for the signs of ALS, including: Muscle weakness, often on only one side of the body Slurred or slowed speech and other[webmd.com]

  • Binswanger Disease

    Other prominent features of the disease include urinary incontinence, difficulty walking, clumsiness, slowness of conduct, lack of facial expression, and speech difficulty[prep4usmle.com] Language rus PubMed ID 4074151 TY - JOUR T1 - [Progressive subcortical arteriosclerotic encephalopathy (Binswanger's disease)].[unboundmedicine.com] Frequent pauses in your speech while searching for words Slow speech Difficulty repeating phrases or sentences Progressive Nonfluent-agrammatic Aphasia (PNFA) Difficulty[alzheimersweekly.com]

  • Alzheimer Disease

    BACKGROUND AND OBJECTIVE: Semantic memory measures may be useful in tracking and predicting progression of Alzheimer disease.[ncbi.nlm.nih.gov] Alzheimer’s is a progressive disease. This means that gradually, over time, more parts of the brain are damaged.[alzheimers.org.uk] There are some drug treatments for Alzheimer’s disease that can help boost the levels of some chemical messengers in the brain. This can help with some of the symptoms.[alzheimers.org.uk]

  • Classic Progressive Supranuclear Palsy Syndrome

    Ex: Goals, sentences etc PSP cognitive symptoms: Language -Processing and comprehension relatively spared -Slowed speech -dysarthria difficult or unclear articulation of speech[quizlet.com] Not Applicable tideglusib;tideglusib;placebo 44 Deep TMS for the Treatment of Patients With Parkinson's Disease and Progressive Supranuclear Palsy Completed NCT02734485 Not[malacards.org] (slow speech) and a supranuclear gaze palsy and difficulties in swallowing.[orpha.net]

  • Parkinson's Disease

    […] blinking Difficulty swallowing Drooling Slowed, quieter speech and monotone voice No expression in your face (like you are wearing a mask) Movement problems may include:[nlm.nih.gov] This study assessed the effect of levodopa on the rate of progression of Parkinson's disease.[ncbi.nlm.nih.gov] Slower progression of Parkinson's disease with ropinirole versus levodopa: the REAL-PET study.[nejm.org]

  • Parkinson's Disease Type 3

    Non-motor symptoms include: problems with smell anxiety depression vision problems fatigue cognitive changes, such as memory loss or slow thinking insomnia problems with speech[medicalnewstoday.com] However, symptoms vary and may worsen as the disease progresses.[healthline.com] Living With Parkinson's Disease As Parkinson's develops, a person who has it may slow down and won't be able to move or talk quickly.[kidshealth.org]

  • Huntington's Disease

    speech or difficulty swallowing Slowed thinking and reaction time, difficulty planning and organizing, inflexible thinking, poor decision making skills or problems with short-term[health.ucsd.edu] HD is a progressive disease; this means that it gets worse over time, and coordination of everyday activities become harder and harder.[my.clevelandclinic.org] ., slow, slurred speech; difficulty in finding words; disorganized speech and sentence construction) Behavioral/personality changes Change in personal hygiene and habits Unusually[labtestsonline.org]

  • Multiple Sclerosis

    Speech may become slow, slurred, and hesitant. People with multiple sclerosis may become unable to control emotional responses and may laugh or cry inappropriately.[merckmanuals.com] The disease course of progressive MS is characterised by the build-up of neurologic disability (the loss of some bodily or mental functions) with or without relapses.[msif.org] […] or difficult speech purple patches or pinpoint dots (rash) on the skin decreased urination or blood in the urine Interferon beta-1a may cause other side effects.[nlm.nih.gov]

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