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21 Possible Causes for Progressive Distal and Proximal Symmetric Limb Weakness

  • Spinal Muscular Atrophy with Respiratory Distress Type 1

    , symmetrical, distal-to-proximal muscle weakness and atrophy (in lower limbs especially).[orpha.net] […] a rare genetic motor neuron disease characterized by severe respiratory distress/respiratory failure in association with diaphragmatic eventration and palsy, as well as progressive[orpha.net]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    , predominantly LMN pattern of weakness in the upper limbs, typically beginning in proximal muscle groups with progression to distal involvement.[jnnp.bmj.com] Symmetrical weakness confined to the upper limbs may indicate the flail arm variant of MND, but here the weakness typically begins in proximal muscle groups and extends distally[jnnp.bmj.com] An insidious onset of slowly progressive relatively symmetrical weakness over many years is suggestive of dHMN when the pattern of weakness is distal or SMA if weakness is[jnnp.bmj.com]

  • Upper Motor Neuron Disease

    , predominantly LMN pattern of weakness in the upper limbs, typically beginning in proximal muscle groups with progression to distal involvement.[jnnp.bmj.com] Symmetrical weakness confined to the upper limbs may indicate the flail arm variant of MND, but here the weakness typically begins in proximal muscle groups and extends distally[jnnp.bmj.com] An insidious onset of slowly progressive relatively symmetrical weakness over many years is suggestive of dHMN when the pattern of weakness is distal or SMA if weakness is[jnnp.bmj.com]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Main clinical manifestations include progressive symmetrical weakness in both proximal and distal muscles of lower and/or upper limbs with partial or complete recovery between[orpha.net]

  • CANOMAD Syndrome

    […] peripheral nerves with symmetrical proximal and distal weakness of the four limbs, sensory involvement and areflexia.[bmcneurol.biomedcentral.com] IgG/A MGUS with associated neuropathy resembling chronic inflammatory demyelinating polyneuropathy (CIDP) is a relapsing or progressive sensori-motor disorder involving the[bmcneurol.biomedcentral.com]

  • Transverse Myelitis

    The weakness was symmetric, involving distal and proximal muscles and had not progressed since its onset.[casereports.in] A few hours after onset of limb weakness, he noticed urinary retention as well. He also developed constipation a day later.[casereports.in] Case Report A 24 year old male smoker presented with sudden onset of weakness and loss of sensation over both upper limbs for 2 days.[casereports.in]

  • Emery-Dreifuss Muscular Dystrophy

    Muscle weakness and atrophy usually have a symmetrical bilateral distribution and progress slowly.[elsevier.pt] The proximal upper and distal lower limb muscles are most commonly affected in the initial stages, while the pectoral and pelvic girdles are generally affected later.[elsevier.pt]

  • Emery-Dreifuss Muscular Dystrophy Type 1

    Muscle weakness and atrophy usually have a symmetrical bilateral distribution and progress slowly.[revportcardiol.org] The proximal upper and distal lower limb muscles are most commonly affected in the initial stages, while the pectoral and pelvic girdles are generally affected later.[revportcardiol.org]

  • Emery-Dreifuss Muscular Dystrophy Type 2

    Muscle weakness and atrophy usually have a symmetrical bilateral distribution and progress slowly.[revportcardiol.org] The proximal upper and distal lower limb muscles are most commonly affected in the initial stages, while the pectoral and pelvic girdles are generally affected later.[revportcardiol.org]

  • Limb-Girdle Muscular Dystrophy

    : Difficulty climbing stairs & running Neonatal onset: Hypotonia; Rapid progression Weakness Common: Limb-Girdle; Mild Proximal Symmetric Legs Arms Distal: Ankles Eyes: Up[neuromuscular.wustl.edu] Limb-Girdle: Proximal Distal Respiratory: Vital capacity reduced in some (67%) Trunk: Scapular winging ; Abdominal Symmetric Course: Progressive to wheelchair by 13 to 36[neuromuscular.wustl.edu] Symmetric Severity: 4/5 Face: Mild; Eyes Mouth Voice: Nasal Neck: Flexors (100%) Limbs Proximal arms: Most common (75%) Distal arms (50%) Proximal legs (30%) Distal legs:[neuromuscular.wustl.edu]

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