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497 Possible Causes for Progressive Dysphagia, Proximal Muscle Weakness

  • Oculopharyngeal Muscular Dystrophy

    We report a 64 year old Chinese-Malaysian woman who presented with progressive dysphagia and bilateral ptosis for about 6 years.[] Oculopharyngeal muscular dystrophy (OPMD) is typically inherited in an autosomal dominant fashion and is characterized by late onset proximal muscle weakness, ptosis and difficulty[] weakness.[]

  • Limb-Girdle Muscular Dystrophy

    At age 38, progressive dysphagia for solids, and subsequently liquids, ensued.[] Progressive proximal muscle weakness began again at age 8 years. Serum CK was 14,910 IU/L. She was wheelchair-bound by age 12.[] Moreover, polymyositis (PM) is manifested as symmetrical proximal muscle weakness of the four limbs, accompanied by an increased level of serum CK.[]

  • Myasthenia Gravis

    A 37-year-old man with anti-muscle-specific tyrosine kinase (MuSK) antibody-positive myasthenia gravis (MG) presented with subacute progressive dysphagia and muscle weakness[] This report presents a case-vignette of a 72-year-old woman with progressive proximal muscle weakness and myalgias, diagnosed with thymoma-associated myasthenia and bioptically[] Conclusion MG is a diagnosis that should be suspected in the cases of progressive dysphagia.[]

  • Diffuse Scleroderma

    […] and acid reflux Associated conditions other autoimmune diseases Prognosis systemic scleroderma is rapidly progressive involvement of pulmonary, renal, or cardiac systems[] As scleroderma progresses, esophageal involvement from abnormalities in decreased motility may worsen due to progressive fibrosis (scarring).[] Skin and nail manifestations Swelling of the skin is usually symmetric and progresses to induration.[]

  • Thyroid Lymphoma

    Abstract Tumors originating in the neck are well-known causes of progressive dysphagia and dyspnea (including stridor), and thyroid lymphoma is an uncommon example.[] There was symmetric proximal muscle weakness, and 2/5 strength in upper and lower extremities.[] A 55-year-old woman presented with a 3-week history of weakness. On examination, she had a heliotrope rash, V-neck and shawl signs.[]

  • Cyclophosphamide

    The refractoriness of this disease was characterised by an increase of the already severe muscle wasting that led to respiratory failure and progressive dysphagia, regardless[] A 49-year-old woman was hospitalized with progressively worsening left-sided weakness, dysphagia, diplopia, and vertigo.[] A 50-year-old man presented with dysphagia and proximal muscle weakness.[]

  • Scleredema Adultorum

    A 55-yr-old white female with biopsy proven scleredema adultorum was evaluated for progressive dysphagia.[] No clinical evidence of proximal muscle weakness. With this clinical presentation, a provisional diagnosis of scleredema was made.[] Am J Gastroenterol 1982 Jan;77(1):9-11 Abstract quote A 55-yr-old white female with biopsy proven scleredema adultorum was evaluated for progressive dysphagia.[]

  • Lichen Myxoedematosus

    Gastrointestinal involvement presents as progressive dysphagia due to esophageal induration. Cardiovascular, renal and ocular manifestations may also occur.[] muscle weakness occasionally associated with slight elevation of muscle enzymes have been reported. [4] Occasionally systemic involvement have been reported in other internal[] MUSCULAR Slight to severe proximal muscle weakness is found in 27% of patients and is occasionally associated with slight elevation of muscle enzymes and inflammatory electromyographic[]

  • Food-Borne Botulism

    An 83-year-old man with rapidly progressive diplopia, dysphagia, and tetraplegia was hospitalized; he required intensive care, including artificial ventilatory support.[] Common clinical features included ptosis, ophthalmoplegia, proximal muscle weakness, pupillary abnormality, and respiratory failure.[]

  • Botulism

    Botulism is a rare disease caused by intoxication leading to muscle weakness and rapidly progressive dysphagia.[] By history, the most common symptoms were dysphagia (66%), proximal muscle weakness of upper and lower extremity (60%), neck flexor muscle weakness (33%), ophthalmoplegia[] On January 28, 2011, an Ohio resident, aged 29 years, was hospitalized after 5 days of progressive dizziness, blurred vision, dysphagia, and difficulty breathing.[]

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