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630 Possible Causes for Progressive Limb Ataxia

  • Spinocerebellar Ataxia Type 23

    We have identified missense mutations in prodynorphin (PDYN) that cause SCA23 in four Dutch families displaying progressive gait and limb ataxia.[ncbi.nlm.nih.gov] Recently the prodynorphin (PDYN) gene was identified as the cause of SCA23 in four Dutch families displaying progressive gait and limb ataxia.[ncbi.nlm.nih.gov] Abstract Spinocerebellar ataxias (SCA) are a genetically heterogeneous group of neurodegenerative diseases characterised by progressive cerebellar ataxia, dysarthria and oculomotor[discovery.ucl.ac.uk]

  • Neuropathy

    All patients have gait ataxia and the majority have lower limb ataxia.[doi.org] GA is usually of insidious onset; however, it can also be rapidly progressive mimicking paraneoplastic cerebellar degeneration. Gaze-evoked nystagmus is common.[doi.org]

  • Restless Legs Syndrome

    All patients have gait ataxia and the majority have lower limb ataxia.[dx.doi.org] GA is usually of insidious onset; however, it can also be rapidly progressive mimicking paraneoplastic cerebellar degeneration. Gaze-evoked nystagmus is common.[dx.doi.org]

  • Peripheral Neuropathy

    All patients have gait ataxia and the majority have lower limb ataxia.[doi.org] GA is usually of insidious onset; however, it can also be rapidly progressive mimicking paraneoplastic cerebellar degeneration. Gaze-evoked nystagmus is common.[doi.org]

  • Alzheimer Disease

    All patients have gait ataxia and the majority have lower limb ataxia.[doi.org] GA is usually of insidious onset; however, it can also be rapidly progressive mimicking paraneoplastic cerebellar degeneration. Gaze-evoked nystagmus is common.[doi.org]

  • Friedreich Ataxia

    The classic phenotype of Friedreich ataxia is characterized by dysarthria, progressive limb and trunk ataxia, loss of reflexes, and gait disturbance with the onset of disease[ncbi.nlm.nih.gov] Friedreich ataxia (FRDA) is an autosomal recessive, neurodegenerative disease, characterized by progressive gait and limb ataxia, dysarthria, lower-limb areflexia, Babinski[ncbi.nlm.nih.gov] Friedreich's ataxia (FRDA) is an autosomal recessive inherited disorder characterized by progressive gait and limb ataxia, dysarthria, areflexia, loss of vibratory and position[ncbi.nlm.nih.gov]

  • Squamous Cell Carcinoma of the Lung

    We report a male patient who presented with a progressive ataxia, affecting predominantly the lower limbs and a cerebellar dysarthria.[ncbi.nlm.nih.gov]

  • Cerebral Thrombosis

    Possible neurological signs include hemiparesis, weakness of the lower limbs, sometimes bilaterally, aphasia, ataxia, chorea and hemianopia.[patient.info] […] seizures at the onset or during the first days after thrombosis occurs. [ 5 ] Impaired level of consciousness is common but it may be normal, there may be confusion or it may progress[patient.info]

  • Migraine

    Other more severe symptoms of FHM may include coma, fever, and meningismus; progressive ataxia, nystagmus, gait unsteadiness, limb incoordination, and dysarthria.[emedicine.com] Some FHM attacks are associated with cerebellar ataxia.[emedicine.com]

  • Diarrhea

    All patients have gait ataxia, and the majority have limb ataxia.[doi.org] Rarely, the ataxia can be rapidly progressive. Gaze-evoked nystagmus and other ocular signs of cerebellar dysfunction are seen in up to 80% of cases.[doi.org]

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