Progressive Muscle Weakness: Causes & Reasons

Possible Causes for Progressive Muscle Weakness

PATIENT 1 A 58-year-old woman began to have symptoms at age 44 of slowly progressive proximal muscle weakness predominantly affecting the lower limbs. [ncbi.nlm.nih.gov]

As muscle weakness is progressive, facial muscles, muscles supporting the spine, and those involved in breathing and eating can also be affected. [pompediseasenews.com]

Its clinical presentation includes: progressive muscle weakness, especially in the trunk and lower limbs; respiratory symptoms; and progression to respiratory insufficiency [ncbi.nlm.nih.gov]

Congenital Muscular Dystrophy

Abstract A 6-year-old boy born by a third-degree consanguineous marriage presented with progressive muscle weakness and delayed motor milestones noticed in early infancy with [ncbi.nlm.nih.gov]

These siblings, aged 37 and 40, are cognitively normal with mild non-progressive muscle weakness and a susceptibility to rhabdomyolysis. [ncbi.nlm.nih.gov]

Abstract Congenital muscular dystrophies (CMD) cause progressive muscle weakness resulting in severe motor disabilities. [ncbi.nlm.nih.gov]

Pompe Disease

It is characterized by delayed motor skills (such as rolling over and sitting) and progressive muscle weakness. [ghr.nlm.nih.gov]

The glycogen accumulation leads to myopathy / progressive muscle weakness, notably limb-girdle muscle weakness. [youtube.com]

Most individuals with late-onset Pompe disease experience progressive muscle weakness, especially in the legs and the trunk, including the muscles that control breathing. [ghr.nlm.nih.gov]

Spinal Muscular Atrophy

She presented with progressive muscle weakness, tremor, seizure, and cognitive impairment. [ncbi.nlm.nih.gov]

Spinal muscular atrophy (SMA) is a genetic neuromuscular disease characterized by progressive muscle weakness and atrophy. [ncbi.nlm.nih.gov]

Patients with milder forms of SMA exhibit slowly progressive muscle weakness over many years. [ncbi.nlm.nih.gov]

Spinal Muscular Atrophy Type 1

AIM: This study described end-of-life care for children affected by spinal muscular atrophy type 1 (SMA1), which is characterised by progressive muscle weakness and develops [ncbi.nlm.nih.gov]

Key facts Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterised by progressive muscle weakness owing to the degeneration and loss of the anterior [genomicseducation.hee.nhs.uk]

Patients with DSMA1 present between 6 weeks and 6 months of age with progressive muscle weakness and respiratory failure due to diaphragmatic palsy. [ncbi.nlm.nih.gov]

Nemaline Myopathy Type 5

and tremors, and then progressive muscle weakness, a severely deformed chest, muscle wasting, and life-threatening respiratory insufficiency How is nemaline myopathy diagnosed [patientworthy.com]

Presenting neonatal signs were axial hypotonia, hip and shoulder stiffness, and tremors, followed by progressive muscle weakness, atrophy and contractures. [clinicforspecialchildren.org]

[…] in neonatal onset 0001319 Pectus carinatum Pigeon chest 0000768 Progressive muscle weakness 0003323 Proximal amyotrophy 0007126 Shoulder flexion contracture 0003044 Tremor [rarediseases.info.nih.gov]

Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth disease comprises a group of disorders characterized by progressive muscle weakness and wasting. [ncbi.nlm.nih.gov]

The patients developed adult-onset slowly progressive muscle weakness that was predominant in the calf muscles and sensory disturbance. [ncbi.nlm.nih.gov]

The major clinical features of CMT are progressive muscle weakness of distal extremities and sensory loss. [ncbi.nlm.nih.gov]

Lethal Ataxia with Deafness and Optic Atrophy

[…] myoclonic epilepsy • action induced polymyoclonus • ataxia Late Symptoms • progressive muscle weakness and atrophy • hypertrophic cardiomyopathy • dementia • deafness • multiple [emilytam.com]

muscle weakness 0003323 Respiratory insufficiency Respiratory impairment 0002093 5%-29% of people have these symptoms Hyperreflexia Increased reflexes 0001347 Pancreatic [rarediseases.info.nih.gov]

During infection, the slowly progressive muscle weakness is punctuated by acute deterioration in muscle strength, which may result in respiratory failure requiring mechanical [ncbi.nlm.nih.gov]

Infantile-Onset Pompe Disease

[…] proximal muscle weakness Absence of reflexes Difficulties in feeding Elevated levels of CK Congenital muscular dystrophy Severe hypotonia Severe weakness in muscles Hypothyroidism [ncbi.nlm.nih.gov]

[…] diagnoses of IOPD Shared symptoms between IOPD and other disorders Disorder Shared symptoms with IOPD Spinal muscular atrophy | (acute Werdnig–Hoffman disease) Hypotonia Progressive [ncbi.nlm.nih.gov]

Marinesco-Sjögren Syndrome

muscle weakness due to myopathy, and delayed psychomotor development. [cags.org.ae]

The presence of hypotonia with progressive muscle weakness (myotonia) is believed to be from neurogenic origin. [accessanesthesiology.mhmedical.com]

Hypotonia with progressive muscle weakness of neurogenic origin. Short stature with kyphoscoliosis and contractures. [accessanesthesiology.mhmedical.com]

Myopathy with Lactic Acidosis and Sideroblastic Anemia Type 2

muscle weakness. [miami.pure.elsevier.com]

Affected individuals manifest progressive muscle weakness, exercise intolerance, lactic acidosis, sideroblastic anemia and delayed growth. [uniprot.org]

[…] association via MalaCards Myopathy with lactic acidosis and sideroblastic anemia 1 (MLASA1) [MIM:600462]: A rare oxidative phosphorylation disorder specific to skeletal muscle [genecards.org]

Autosomal Dominant Progressive External Ophthalmoplegia Type 1

weakness ; Multiple mitochondrial DNA deletions ; Myalgia ; Progressive ; Progressive external ophthalmoplegia ; Progressive muscle weakness ; Ptosis ; Seizures ; Variable [mousephenotype.org]

UniProtKB/Swiss-Prot : 76 Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5: A disorder characterized by progressive weakness of [malacards.org]

Definition A disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. [uniprot.org]

Autosomal Dominant Progressive External Ophthalmoplegia Type 3

Patients with C10ORF2-linked Autosomal dominant Progressive external ophthalmoplegiamay have other Clinical features including proximal Muscle weakness, ataxia, peripheral [medicbind.com]

Progressive external ophthalmoplegia is a condition characterized by weakness of the eye muscles. [ghr.nlm.nih.gov]

Symptoms: Myoclonus, epilepsy, progressive ataxia, muscle weakness and degeneration, deafness, and dementia. [umdf.org]

Delta Aminolevulinate Dehydrase Deficiency

She suffered from intermittent difficulty breathing, elevated blood pressure, bleeding, progressive muscle weakness and hallucinations. [house.fandom.com]

The weakness can progress to virtually all the muscles, including those involved in breathing. Tremors and seizures may develop. [merckmanuals.com]

Nerves that control muscles can be affected, leading to weakness, usually beginning in the shoulders and arms. [merckmanuals.com]

Muscular Dystrophy

From Wikidata Jump to navigation Jump to search myopathy characterized by progressive skeletal muscle weakness degeneration edit English muscular dystrophy myopathy characterized [wikidata.org]

[…] by progressive skeletal muscle weakness degeneration MD Muscular dystrophy, MD Statements Identifiers Sitelinks Wikipedia (33 entries) edit Wikibooks (0 entries) edit Wikiquote [wikidata.org]

Duchenne Muscular Dystrophy

English Duchenne muscular dystrophy Duchenne muscular dystrophy (DMD) is a neuromuscular disease characterized by rapidly progressive muscle weakness and wasting due to degeneration [wikidata.org]

DMD leads to progressive muscle weakness, degeneration, and wasting; finally, follows with the premature demise in affected individuals due to respiratory and/or cardiac failure [ncbi.nlm.nih.gov]

Progressive, Duchenne Type DMD Duchenne Muscular Dystrophy MUSCULAR DYSTROPHY, DUCHENNE TYPE [wikidata.org]

Progressive Muscular Atrophy

This results in progressive muscle weakness, fasciculations (rippling effect under the skin), and shrinkage in muscle bulk and weight loss. [umcutrecht.nl]

Symptoms The main sign of muscular dystrophy is progressive muscle weakness. [mayoclinic.org]

Individuals may experience progressive muscle weakness in the muscles closest to the center of the body, such as the shoulders, thighs, and pelvis. [togetherinsma.com]

Distal Spinal Muscular Atrophy Type 4

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Myofibrillar Myopathy: Myofibrillar myopathies are characterized by slowly progressive weakness involving the proximal and distal muscles. [mayomedicallaboratories.com]

Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord. [patient.info]

X-linked Distal Spinal Muscular Atrophy Type 3

muscle weakness. [encyclopedia.com]

[…] book series (CUHI, volume 9) Abstract The spinal muscular atrophies are a group of inherited disorders characterized by degeneration of anterior horn cells (Figure 5.1) and progressive [link.springer.com]

Clinical findings Non-progressive thigh muscle atrophy, weak thigh adductors and knee and foot extensors, minimal jaw muscle and neck flexor weakness, flexion contractures [medical-dictionary.thefreedictionary.com]

Distal Spinal Muscular Atrophy Type 3

Typical Presentation: Progressive muscle weakness, poor weight gain, sleep difficulties, pneumonia, scoliosis, joint contractures. [athenadiagnostics.com]

Non-classic variant of infantile-onset disease may present with slowly progressive muscle weakness, motor development delay,and they may died due to respiratory failure in [explainmedicine.com]

muscle weakness. [encyclopedia.com]

Distal Spinal Muscular Atrophy Type 1

Most patients presented at the age of 1 to 6 months with respiratory distress due to diaphragmatic paralysis and progressive muscle weakness with predominantly distal lower [ncbi.nlm.nih.gov]

Typical Presentation: Progressive muscle weakness, poor weight gain, sleep difficulties, pneumonia, scoliosis, joint contractures. [athenadiagnostics.com]

Non-classic variant of infantile-onset disease may present with slowly progressive muscle weakness, motor development delay,and they may died due to respiratory failure in [explainmedicine.com]

Progressive Bulbar Paralysis

Symptoms include pharyngeal muscle weakness (muscles that are involved in swallowing), weak facial muscles, progressive loss of speech, and tongue muscle atrophy. [advancedpsy.com]

Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. [icd9data.com]

[…] http://www.ebi.ac.uk/efo/EFO_0003783 A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. [ebi.ac.uk]

Juvenile Primary Lateral Sclerosis

Symptoms The symptoms of PLS usually take years to progress and the hallmark of PLS is progressive weakness and spasticity of voluntary muscles. [humanitas.net]

Primary Lateral Sclerosis (PLS) is a rare neuromuscular disease characterized by progressive muscle weakness in the voluntary muscles. [spineandsports.com]

Primary lateral sclerosis (PLS) is a rare neuromuscular disease characterized by progressive muscle weakness in the voluntary muscles. [en.wikipedia.org]

Becker Muscular Dystrophy

From Wikidata Jump to navigation Jump to search X-linked recessive inherited disorder characterized by slowly progressive muscle weakness of the legs and pelvis Benign pseudohypertrophic [wikidata.org]

Becker muscular dystrophy (BMD), a genetic disorder of X-linked recessive inheritance, typically presents with gradually progressive muscle weakness. [ncbi.nlm.nih.gov]

Becker muscular dystrophy is an X-linked recessive inherited disorder characterized by slowly progressing muscle weakness of the legs and pelvis. [en.wikipedia.org]

Primary Lateral Sclerosis

Primary lateral sclerosis (PLS) is a rare neuromuscular disease characterized by progressive muscle weakness in the voluntary muscles. [patientslikeme.com]

Approximately six and a half years ago John received the diagnosis of primary lateral sclerosis PLS, a rare neuromuscular disease characterized by progressive muscle weakness [stemcellofamerica.com]

Spinal and Bulbar Muscular Atrophy

Abstract Spinal and bulbar muscular atrophy (SBMA) is an adult-onset neurodegenerative disease characterized by slowly progressive muscle weakness and atrophy. [ncbi.nlm.nih.gov]

Abstract Spinal and bulbar muscular atrophy (SBMA) is the first member identified among polyglutamine diseases characterized by slowly progressive muscle weakness and atrophy [ncbi.nlm.nih.gov]

The main symptoms are slowly progressive muscle weakness and atrophy of bulbar, facial and limb muscles. [ncbi.nlm.nih.gov]

Muscular Dystrophy-Dystroglycanopathy Type C14

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Case Discussion Limb girdle muscular dystrophy (LGMD) is a group of progressive muscle weakness genetically determined diseases in which the muscles of the pelvic or shoulder [radiopaedia.org]

An x-linked inherited disorder characterized by slowly progressing weakness in the muscles of the legs and pelvis. [icd10data.com]

Emery-Dreifuss Muscular Dystrophy

Most affected individuals also experience slowly progressive muscle weakness and wasting, beginning in muscles of the upper arms and lower legs and progressing to muscles [mda.org.nz]

We report two patients with emerin deficient X-linked EDMD and two probable patients with EDMD with typical early contractures, progressive muscle weakness and cardiac involvement [ncbi.nlm.nih.gov]

Abstract Emery-Dreifuss muscular dystrophy (EDMD) is a neuromuscular disorder resulting in progressive muscle weakness, contractures, and cardiomyopathy. [ncbi.nlm.nih.gov]

Upper Motor Neuron Disease

Progressive muscle weakness in vouluntary muscles A rare neuromuscular disorder that causes progressive weakening and wasting of the muscles in the arms and legs in particular [brainscape.com]

Symptoms include pharyngeal muscle weakness (muscles that are involved in swallowing), weak facial muscles, progressive loss of speech, and tongue muscle atrophy. [advancedpsy.com]

muscle weakness. [neuropathology-web.org]

Erb Muscular Dystrophy

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

[…] of diseases that are, for the most part, genetically determined and cause gradual wasting of muscle with accompanying weakness and deformity Progressive muscle weakness and [seslisozluk.net]

Resumo: Muscular dystrophies comprise a group of heterogeneous genetic diseases characterized by progressive muscle weakness. [repositorio.insa.pt]