Progressive Muscle Weakness and Atrophy: Causes & Reasons

Possible Causes for Progressive Muscle Weakness and Atrophy

Without adequate nerve function, patients with SMA experience progressive muscle weakness and atrophy, impacting the ability to crawl, sit, or stand and eventually to breathe [rdmag.com]

The loss of functioning motor neurons leads to progressive muscle weakness and atrophy (the gradual decrease in the mass and strength of muscles), as muscles stop receiving [togetherinsma.com]

Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord. [patient.info]

X-linked Distal Spinal Muscular Atrophy Type 3

Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord. [patient.info]

Clinical findings Non-progressive thigh muscle atrophy, weak thigh adductors and knee and foot extensors, minimal jaw muscle and neck flexor weakness, flexion contractures [medical-dictionary.thefreedictionary.com]

Patients typically present during infancy or early childhood with progressive weakness, hypotonia, muscle atrophy, hyporeflexia /areflexia, and varying degrees of bulbar weakness [amboss.com]

Spinal and Bulbar Muscular Atrophy

Abstract Spinal and bulbar muscular atrophy (SBMA) is an adult-onset neurodegenerative disease characterized by slowly progressive muscle weakness and atrophy. [ncbi.nlm.nih.gov]

Abstract Spinal and bulbar muscular atrophy (SBMA) is the first member identified among polyglutamine diseases characterized by slowly progressive muscle weakness and atrophy [ncbi.nlm.nih.gov]

The main symptoms are slowly progressive muscle weakness and atrophy of bulbar, facial and limb muscles. [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 4

Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord. [patient.info]

Patients typically present during infancy or early childhood with progressive weakness, hypotonia, muscle atrophy, hyporeflexia/areflexia, and varying degrees of bulbar weakness [amboss.com]

(SMA) is an autosomal recessive neuromuscular disorder involving degeneration of anterior horn cells of spinal cord, resulting in progressive muscle weakness and atrophy. [annalsofian.org]

Distal Spinal Muscular Atrophy Type 3

Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord. [patient.info]

Patients typically present during infancy or early childhood with progressive weakness, hypotonia, muscle atrophy, hyporeflexia /areflexia, and varying degrees of bulbar weakness [amboss.com]

Charcot-Marie-Tooth Disease Type 2S

[…] in progressive muscle weakness and atrophy [13]. [ijcasereportsandimages.com]

[…] distal muscle weakness and atrophy. [uniprot.org]

[…] in progressive muscle weakness and atrophy [14],[15]. [ijcasereportsandimages.com]

Emery-Dreifuss Muscular Dystrophy Type 1

muscle weakness and atrophy (initially with a humero-peroneal distribution but later becoming more diffuse); joint contractures of the Achilles, elbow, and neck tendons, [link.springer.com]

Chapter First Online: 27 June 2014 Abstract Emery-Dreifuss muscular dystrophy (EDMD) is a progressive myopathy characterized by a clinical triad including slowly progressive [link.springer.com]

Chapter First Online: 06 October 2017 Abstract Emery-Dreifuss muscular dystrophy (EDMD) is a progressive myopathy characterized by a clinical triad including slowly progressive [link.springer.com]

Distal Spinal Muscular Atrophy Type 5

autosomal recessive, 5 (DSMA5) [MIM:614881]: An autosomal recessive neurologic disorder characterized by young adult onset of slowly progressive distal muscle weakness and [genecards.org]

Definition A neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of [uniprot.org]

Get Update Overview HMSNO is an autosomal dominant neurodegenerative disorder characterized by young adult onset of proximal or distal muscle weakness and atrophy, muscle [diseaseinfosearch.org]

Hypergonadotropic Hypogonadism - Partial Alopecia

[…] distal muscle weakness and atrophy. [ab-y-ss.com]

weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. [antibodyplus.com]

[…] entry.Charcot-Marie-Tooth disease 2B1 (CMT2B1) [MIM:605588]: A recessive axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive [innatedb.com]

Distal Spinal Muscular Atrophy Type 1

Overview Spinal muscular atrophy with respiratory distress 1: An inherited neuromuscular disease that causes progressive weakness in the arm and chest muscles leading to severe [checkorphan.org]

Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord. [patient.info]

symmetrical, distal-to-proximal muscle weakness and atrophy (in lower limbs especially). [orpha.net]

Emery-Dreifuss Muscular Dystrophy Type 2

muscle weakness and atrophy (initially with a humero-peroneal distribution but later becoming more diffuse); joint contractures of the Achilles, elbow, and neck tendons, [link.springer.com]

RESULTS: The proband had typical clinical manifestation of EDMD: joint contracture, progressive muscle weakness and atrophy and cardiac conduction dysfunction. [pesquisa.bvsalud.org]

It presents slowly progressive muscle weakness and atrophy (initially and generally with a humeroperoneal distribution but later becoming more diffuse). [orpha.net]

Erb Muscular Dystrophy

[…] attacked, and rate of progression These disorders include, but are not limited to A group of genetic degenerative myopathies characterized by weakness and muscle atrophy [seslisozluk.net]

[…] established. [9] Walton and Nattrass described the disease as a progressive muscle weakness with atrophy involving predominantly proximal muscles (eg, pelvis, shoulder). [emedicine.medscape.com]

The major symptoms of LGMD are progressive wasting (atrophy) and weakness of the proximal muscles of the hip and shoulder areas. [rarediseases.org]

Lower Motor Neuron Syndrome with Late-Adult Onset

Symptoms include pharyngeal muscle weakness (muscles that are involved in swallowing), weak facial muscles, progressive loss of speech, and tongue muscle atrophy. [advancedpsy.com]

Autosomal recessive -slowly progressive, fasciculations, proximal weakness, resembles myopathy Anterior Horn Cell Disease -atrophy of pectoralis & thigh muscles Adult Onset [brainscape.com]

Symptoms vary in severity and may include muscle weakness and atrophy, fasciculations, emotional lability, and respiratory muscle weakness. [msdmanuals.com]

Upper Motor Neuron Disease

Symptoms include pharyngeal muscle weakness (muscles that are involved in swallowing), weak facial muscles, progressive loss of speech, and tongue muscle atrophy. [advancedpsy.com]

Progressive muscular atrophy A rare subtype of MND is which you get atrophy, fasiculation and muscle weakness in the arms only A rare subtype of MND is which you get atrophy [brainscape.com]

Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy. [ninds.nih.gov]

Amyotrophic Lateral Sclerosis Type 11

Progressive muscle weakness and atrophy eventually leads to respiratory paralysis and death. [symptoma.com]

DO ID DOID:332 Description A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing [yeastgenome.org]

Muscle weakness is followed by atrophy, and fasciculations are very common, too. [symptoma.com]

Inclusion Body Myositis

It is characterized by slowly progressive muscle weakness and atrophy, with typical pathological changes of inflammation, degeneration and mitochondrial abnormality in affected [ncbi.nlm.nih.gov]

progressive muscle weakness and atrophy typically of the limbs and especially the quadriceps and flexors of the wrist and fingers and histologically by abnormal inclusions [merriam-webster.com]

A 69-year-old man, who was a human T lymphotropic virus type 1 carrier, exhibited slowly progressive muscle weakness and atrophy, predominantly affecting the scapular, quadriceps [ncbi.nlm.nih.gov]

Amyotrophic Lateral Sclerosis Type 3

ALS is a degenerative disorder characterized by the death of motor neurons in the cortex, brainstem, and spinal cord, resulting in progressive muscle weakness and atrophy [ncbi.nlm.nih.gov]

Progressive muscle weakness and atrophy leads to respiratory paralysis and death within five years of symptom onset. [symptoma.com]

Weakness of the respiratory muscles requires ventilatory assistance. Finally, ALS patients should be offered psychological support. [symptoma.com]

Singleton Merten Syndrome

Other physical findings may include generalized muscle weakness; progressive muscle atrophy ; growth delay; delays in motor development; skin conditions; and/or malformation [globalgenes.org]

Other physical findings may include generalized muscle weakness; progressive muscle atrophy; growth delay; delays in motor development; skin conditions; and/or malformation [diseaseinfosearch.org]

Generalised muscle weakness with progressive muscle atrophy, and poor development are usually associated. Occasionally psoriatic skin manifestation. Aetiology unknown. [whonamedit.com]

Adult Spinal Muscular Atrophy

Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord. [patient.info]

Spinal muscular atrophy is a group of inherited disorders that cause progressive muscle degeneration and weakness. What is spinal muscular atrophy? [genome.gov]

Patients typically present during infancy or early childhood with progressive weakness, hypotonia, muscle atrophy, hyporeflexia /areflexia, and varying degrees of bulbar weakness [amboss.com]

Scapuloperoneal Spinal Muscular Atrophy

Scapuloperoneal spinal muscular atrophy (SPSMA) is a very rare genetic disorder that causes muscle weakness and a decrease of muscle tissue (atrophy) that gets worse with [diseaseinfosearch.org]

progressive girdle atrophy and progressive distal weakness and amyotrophy. [medical-dictionary.thefreedictionary.com]

[…] scapuloperoneal atrophy and progressive distal weakness and amyotrophy. [uniprot.org]

Limb-Girdle Muscular Dystrophy Type 2C

[…] shoulder and pelvic girdle muscle weakness and atrophy frequently associated with calf hypertrophy, diaphragmatic weakness, and/or variable cardiac abnormalities. [orpha.net]

Becker muscular dystrophy is clinically characterized by the following: Progressive symmetric muscle weakness and atrophy with calf hypertrophy In some cases quadriceps femoris [centogene.com]

Autosomal recessive limb-girdle muscular dystrophy type 2C (LGMD2C) is a subtype of autosomal recessive limb-girdle muscular dystrophy characterized by a childhood onset of progressive [orpha.net]

Distal Hereditary Motor Neuropathy Type 5A

The disorder was characterized primarily by diffuse muscle weakness with prominent distal atrophy. [ucdavis.pure.elsevier.com]

In general, distal hereditary motor neuropathies affect the axons of distal motor neurons and are characterized by progressive weakness and atrophy of muscles of the extremities [en.wikipedia.org]

The clinical phenotype is variable, but includes progressive weakness and atrophy of the distal muscles, foot deformities, and decreased reflexes. [mayomedicallaboratories.com]

Muscular Dystrophy-Dystroglycanopathy Type C14

It is characterized by early weakness and atrophy of the pelvic and shoulder girdle muscles in adolescence or young adulthood, with slow progression. [jewishgeneticdiseases.org]

Subtypes of LGMD2 LGMD2A is caused by mutations in the calpain 3 gene and is characterised by variable condition onset, progressive proximal weakness and muscle atrophy. [mdfgauteng.org]

Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a genetic neuromuscular disease characterized by progressive muscle weakness and atrophy. [ncbi.nlm.nih.gov]

Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord. [patient.info]

SMA leads to progressive muscle weakness and atrophy; especially in the muscles of the torso, upper legs and upper arms. [genpathdiagnostics.com]

Muscular Dystrophy-Dystroglycanopathy Type C3

[…] shoulder and pelvic girdle muscle weakness and atrophy frequently associated with calf hypertrophy, diaphragmatic weakness, and/or variable cardiac abnormalities. [orpha.net]

It is characterized by early weakness and atrophy of the pelvic and shoulder girdle muscles in adolescence or young adulthood, with slow progression. [jewishgeneticdiseases.org]

Amyotrophic Lateral Sclerosis Type 5

[…] distal muscle weakness and atrophy, foot deformities, distal sensory loss, as well as diminished tendon reflexes. [semanticscholar.org]

Charcot-Marie-Tooth disease is a group of hereditary peripheral neuropathies that share clinical characteristics of progressive distal muscle weakness and atrophy, foot deformities [ncbi.nlm.nih.gov]

[…] a journal of neurology 2016 DOI: 10.1093/brain/awv320 Charcot-Marie-Tooth disease is a group of hereditary peripheral neuropathies that share clinical characteristics of progressive [semanticscholar.org]

Muscular Dystrophy

As the disease progresses, muscle weakness and atrophy spread to affect the trunk and forearms and gradually progress to involve additional muscles of the body. [rarediseases.org]

It is unknown how abnormal activity of the DUX4 gene damages or destroys these cells, leading to progressive muscle weakness and atrophy. [web.archive.org]

As the disease progresses, muscle weakness and atrophy spread to affect the lower legs, forearms, neck and trunk. [rarediseases.org]

Spinal Muscular Atrophy Type 2

muscle weakness and atrophy. [dovepress.com]

[…] leading to progressive weakness and muscle atrophy. [tipdergisi.bozok.edu.tr]

Spinal muscular atrophy is a group of inherited disorders that cause progressive muscle degeneration and weakness. [genome.gov]

Amyotrophic Lateral Sclerosis Type 6

Progressive muscle weakness and atrophy leads to respiratory paralysis and death within three and a half years of symptom onset. [symptoma.com]

Overview Amyotrophic lateral sclerosis type 6 is an inherited disorder involving progressive degeneration of motor neurons which results in muscle weakness and atrophy. [checkorphan.org]

Regardless of the part of the body first affected with the disease, muscle weakness and atrophy spread to other parts of the body and eventually of the respiratory. [checkorphan.org]

Limb-Girdle Muscular Dystrophy Type 2G

[…] proximal upper and lower limb muscle weakness and atrophy. [malacards.org]

[…] dystrophy R7 Disease definition A mild subtype of autosomal recessive limb-girdle muscular dystrophy characterized by a variable onset (ranging from infancy to adolescence) of progressive [orpha.net]

34514 Disease definition A mild subtype of autosomal recessive limb-girdle muscular dystrophy characterized by a variable onset (ranging from infancy to adolescence) of progressive [rarediseases.info.nih.gov]