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3,081 Possible Causes for Progressive or Intermittent Jaundice, Reticulocytes Increased, Splenomegaly

  • Hereditary Spherocytosis

    Reticulocyte count: Increased Treatment: Splenectomy is indicated for moderate to severe cases, but not mild cases.[medical-labs.net] Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] MATERIALS AND METHODS: A retrospective review was conducted to evaluate all SILS for splenomegaly performed by a single surgeon.[ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice
  • Leukoerythroblastic Anemia

    An increased absolute number of reticulocytes indicates increased marrow erythropoiesis. u. Rouleaux: red cells in stacks, as coins.[kerrybrandis.com] Symptoms and Signs Myeloid metaplasia may result in splenomegaly, particularly in patients with storage diseases.[merckmanuals.com] […] erythropoiesis -- increased percentage of reticulocytes in peripherial blood - Low reticulocyte count: production of red blood cells affected, such as bone marrow disorder[quizlet.com]

    Missing: Progressive or Intermittent Jaundice
  • Primary Myelofibrosis

    The percentage of reticulocytes is mildly increased but may vary widely in a given case.[patient-help.com] Significant thrombopenia ( KEYWORDS: Myelofibrosis; Palliation; Splenic irradiation; Splenomegaly[ncbi.nlm.nih.gov] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice
  • Autoimmune Hemolytic Anemia

    Over the course of the next 5 days, the Hb and Hct decreased to 4.1 g/dL and 12%, respectively, direct bili increased to 12.3 mg/day, reticulocytes slightly increased to 0.9%[ncbi.nlm.nih.gov] Examination demonstrated scleral icterus, splenomegaly, and anemia. By peripheral blood smear, the patient was diagnosed with Plasmodium ovale.[ncbi.nlm.nih.gov] Laboratory data showed low hemoglobin levels and slightly increased reticulocyte counts, while direct and indirect antiglobulin tests were positive.[ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice
  • Polycythemia Vera

    […] hemoglobin or hematocrit Red blood cell morphology is unremarkable except in cases with concomitant iron deficiency Deeply basophilic reticulocytes or rare normoblasts may[pathologyoutlines.com] […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] […] efficacy and safety of ruxolitinib with the best available therapy (BAT) in hydroxyurea-resistant/hydroxyurea-intolerant polycythemia vera (PV) patients without palpable splenomegaly[ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice
  • Cooley's Anemia

    Children may develop dramatic, often life threatening drops in hematocrit with reticulocyte counts of nearly zero.[de.slideshare.net] Splenomegaly, episodes of jaundice and roentgenologic evidence of bone involvement were prominent features.[jamanetwork.com] However, hemoglobin (Hb) levels often decrease over time, splenomegaly appears, and progressive iron overload occurs from increased gastrointestinal iron absorption.[news.weill.cornell.edu]

    Missing: Progressive or Intermittent Jaundice
  • Hemoglobin SC Disease

    With each course, fetal reticulocytes increased within 48-72 h, peaked in 7-11 d, and fell by 18-21 d.[doi.org] We report here our experience with an adult patient with severe SC disease who developed symptomatic splenomegaly requiring splenectomy while being treated with hydroxyurea[ncbi.nlm.nih.gov] ASSC is the sudden confiscation of erythrocytes by the spleen leading to a rapid decline in hemoglobin concentration, increased reticulocyte count and splenomegaly.[eposters.net]

    Missing: Progressive or Intermittent Jaundice
  • Paroxysmal Cold Hemoglobinuria

    […] count – usually elevated Positive indicators of hemolysis – hyperbilirubinemia, increased lactate dehydrogenase Direct Coombs Establish presence of immunoglobins and complement[arupconsult.com] Signs Splenomegaly Hepatomegaly Transient Jaundice Pale fingers, toes, and tip of nose VI.[fpnotebook.com] Hepato splenomegaly can be due to an underlying lympho proliferative or other neoplastic process, and clinical examination to rule out lymphadenopathy and/or splenomegaly[omicsonline.org]

    Missing: Progressive or Intermittent Jaundice
  • Paroxysmal Nocturnal Hemoglobinuria

    Erythrocytes fractionated by centrifugation revealed increased glycolytic enzyme activities of hexokinase, G3PD, PGK, TPI, PK, LDH, G6PD, and 6PGD in the reticulocyte-rich[pediatrics.aappublications.org] PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[ncbi.nlm.nih.gov] We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice
  • Gaucher Disease

    CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[ncbi.nlm.nih.gov] [ncbi.nlm.nih.gov] Massive Splenomegaly CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[symptoma.com] In symptomatic patients, splenomegaly is progressive and can become massive.[emedicine.medscape.com]

    Missing: Progressive or Intermittent Jaundice

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