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958 Possible Causes for Progressive Polyneuropathy

  • Vitamin B12 Deficiency

    peripheral neuropathy, and spinal degeneration.[ncbi.nlm.nih.gov] […] normal One-Carbon metabolism leading to the observed clinical neurological manifestations such as nerve damage and, demyelination, degeneration of PNS leading to paralysis, progressive[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…][ncbi.nlm.nih.gov]

  • Diabetes Mellitus

    Also called: Diabetes mellitus, DM Summary Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose comes from the foods you eat. Insulin is a hormone that helps the glucose get into your cells to give them energy. With type 1 diabetes, your body does not make insulin. With type 2[…][nlm.nih.gov]

  • Vasculitis

    Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[neuromuscular.wustl.edu] CIDP Peripheral Nerve Specific Vasculitis 2 Epidemiology: Females & Males Onset Age: Mean 59 years; Range 22 to 70 years Pain & Sensory loss Progression: 3 months to 5 years[neuromuscular.wustl.edu] 50 years Vasculitis: Male Female 2:1 Prognosis: Worse with Increased age Several anatomical patterns of neuropathy Mononeuritis Multiplex Onset Abrupt : Most common Slow progression[neuromuscular.wustl.edu]

  • Paraneoplastic Syndrome

    We report a fatal case of severe chronic progressive axonal polyradiculoneuropathy in association with this antibody.[doi.org] It is usually a distal sensorimotor polyneuropathy that causes mild motor weakness, sensory loss, and absent distal reflexes.[merckmanuals.com] Electromyography and nerve conduction studies demonstrate findings compatible with multifocal neuropathy or diffuse axonal polyneuropathy with asymmetric involvement. 97 Combined[bloodjournal.org]

  • Diabetic Polyneuropathy

    Ms Q is a 52-year-old woman who has had progressive polyneuropathy in the setting of diabetes for the past 8 years.[ncbi.nlm.nih.gov] […] extremities and by flaccid paralysis. progressive hypertrophic polyneuropathy Déjérine-Sottas disease.[medical-dictionary.thefreedictionary.com] Our observations are consistent with a progressive centripetal degeneration of axons in predominantly sensory diabetic polyneuropathy.[ncbi.nlm.nih.gov]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[ncbi.nlm.nih.gov] We report a 58-year-old woman with DADS that progressed to a severe case of classic CIDP.[ncbi.nlm.nih.gov] We report a case of Waldenström's macroglobulinemia in an adult male presenting with cranial nerve palsy and rapidly progressive asymmetric polyneuropathy.[ncbi.nlm.nih.gov]

  • Multiple Myeloma

    […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] Trial-ineligibility was determined by presence of at least one of the common exclusion criteria: heart/renal failure, liver/renal diseases, polyneuropathy, HIV positivity.[ncbi.nlm.nih.gov] […] in months; LFU, last follow-up; DADS, distal acquired demyelinating symmetric neuropathy; CIDP, chronic inflammatory demyelinating polyneuropathy; SMM, smoldering multiple[doi.org]

  • Occult Malignancy

    Thromb Res. 2017 Nov;159:48-51. doi: 10.1016/j.thromres.2017.08.021. Epub 2017 Sep 28. Robin P 1 , Le Roux PY 2 , Tromeur C 3 , Planquette B 4 , Prévot-Bitot N 5 , Lavigne C 6 , Pastre J 4 , Merah A 7 , Couturaud F 3 , Le Gal G 8 , Salaun PY 9 . Author information 1 Service de MédecineNucléaire, EA 3878 (GETBO) IFR 148,[…][ncbi.nlm.nih.gov]

  • Familial Amyloid Polyneuropathy

    Finnish-type familial amyloidosis (FAP-IV) is an autosomal, dominantly inherited disorder characterized by progressive polyneuropathy and lattice corneal dystrophy type II[ncbi.nlm.nih.gov] Araki S and Ando Y (2010) Transthyretin‐related familial amyloidotic polyneuropathyProgress in Kumamoto, Japan (1967–2010).[els.net] Familial amyloid polyneuropathy (FAP) aka TTR amyloid neuropathy is characterized by slowly progressive, peripheral sensorimotor polyneuropathy and autonomic dysfunction.[genedx.com]

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