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224 Possible Causes for Progressive Polyneuropathy, Pruritus, Thrombocytopenia

  • Multiple Myeloma

    KEYWORDS: Multiple myeloma; autoimmun hemolytic anemia; evan s syndrome; thrombocytopenia[] […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[] Her pruritus resolved, but the lesions persisted. Footnotes Competing interests: None declared. This article has been peer reviewed.[]

  • Waldenstrom Macroglobulinemia

    , leads to an improvement of concurrent thrombocytopenia.[] Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[] His severe thrombocytopenia and attendant bleeding manifestations were attributed to an immune thrombocytopenia.[]

  • Paraneoplastic Syndrome

    Nasopharyngeal cancer (NPC) presenting with thrombocytopenia is rare. This report details 2 cases of NPC with grade III thrombocytopenia as a paraneoplastic syndrome.[] We report a fatal case of severe chronic progressive axonal polyradiculoneuropathy in association with this antibody.[] This 59-year-old man developed ophthalmoplegia, dysarthria, dysphagia, pruritus, ataxia, corticobulbar and corticospinal signs in association with prostate cancer.[]

  • Chronic Alcoholism

    Leukopenia and Thrombocytopenia due to direct bone marrow effect, but also from cirrhosis/splenomegaly.[] Generalised pruritus Generalised skin itching ( pruritus ) may occur due to the build up of poorly metabolised substances that stimulate nerve endings in the skin.[] In chronic alcoholism, macrocytosis, thrombocytopenia, prolonged PT, elevated GGT, hyperuricaemia or hypertriglyceridaemia may be found.[]

  • Diabetes Mellitus

    Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus.[] […] outweighed by the benefits of reducing cardiovascular risk. [ 8 ] Presentation Patients with all types of diabetes may present with polyuria, polydipsia, lethargy, boils, pruritus[] Evaluation and management of thrombocytopenia and suspected heparin-induced thrombocytopenia in hospitalized patients: the Complications After Thrombocytopenia Caused by Heparin[]

  • Systemic Scleroderma

    SBP of 30mmHg or a rise in DBP of 20mmHg as well as one of five additional criteria (increased serum creatinine by 50% over baseline, dipstick proteinuria of 2 or greater, thrombocytopenia[] […] due to systemic sclerosis Progressive systemic sclerosis Scleredema Scleredema buschkes Scleroderma Scleroderma induced by chemical, including drugs Scleroderma of lung Scleroderma[] Anaemia and thrombocytopenia are classical, with peripheral blood smear analysis, showing fragments.[]

  • Vitamin B12 Deficiency

    thrombocytopenia were improved by vitamin B12 supplementation alone, with a single session of plasma exchange.[] peripheral neuropathy, and spinal degeneration.[] […] lactate dehydrogenase, vasoconstriction, increased platelet aggregation, and abnormal activation of the coagulation followed by microangiopathy as well as neutropenia and thrombocytopenia[]

  • African Trypanosomiasis

    Symptoms persisted 4 days later, at which time there was evidence of severe thrombocytopenia (12,000 platelets per cubic millimeter).[] After a second regimen, she developed a severe toxic polyneuropathy, progressing to coma and eventually death.[] T.b gambiense does not have a specific presentation but weight loss, lymphadenopathy, pruritus, facial edema, myalgia, malaise, headache and fever may be recorded.[]

  • Vasculitis

    ‘Other side effects include hepatitis, vasculitis, and thrombocytopenia.’[] Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[] The lesions may be asymptomatic or associated with burning, pruritus, or pain.[]

  • Castleman Disease

    There was no anemia or thrombocytopenia. Kidney biopsy was consistent with glomerular thrombotic microangiopathy (TMA).[] Progressive motor polyneuropathy suggesting coexistent POEMS does not respond well to rituximab or to IL-6–targeted therapy, and these patients require autologous stem cell[] The most frequent adverse reactions (greater than 10 percent compared to placebo) during treatment with SYLVANT in the MCD clinical trial were rash (28 percent), pruritus[]

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