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474 Possible Causes for Progressive Proximal Muscle Weakness

  • Myofibrillar Myopathy Type 4

    MFM3 is characterized by progressive skeletal muscle weakness greater distally than proximally, tight heel cords, hyporeflexia, cardiomyopathy and peripheral neuropathy in[genecards.org] In general, the signs and symptoms of type 6 myofibrillar myopathy appear in the first decade of life and include generalized weakness and muscle proximal rapidly progressive[ivami.com] Get Update Overview Myofibrillar myopathies (MFM) are a group of neuromuscular disorders characterized by slowly progressive weakness that can involve both proximal muscles[diseaseinfosearch.org]

  • Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1H

    OMIM : 58 Limb-girdle muscular dystrophy type 1H (LGMD1H) is an autosomal dominant disorder characterized by adult onset of progressive proximal muscle weakness affecting[malacards.org] Five subjects presented with a slowly progressive proximal muscle weakness, in both upper and lower limbs, with onset during the fourth-fifth decade of life, which fulfilled[moh-it.pure.elsevier.com] Five subjects presented with a slowly progressive proximal muscle weakness, in both… CONTINUE READING From This Paper Figures, tables, and topics from this paper.[semanticscholar.org]

  • Limb-Girdle Muscular Dystrophy

    Progressive proximal muscle weakness began again at age 8 years. Serum CK was 14,910 IU/L. She was wheelchair-bound by age 12.[ncbi.nlm.nih.gov] This is a 39-year-old man who had slowly progressive proximal muscle weakness and cardiac arrhythmia since adolescent and a family history of similar manifestation.[ncbi.nlm.nih.gov] The father had slowly progressive proximal muscle weakness, whereas three sons and their mother, all currently asymptomatic, had normal physical examinations.[ncbi.nlm.nih.gov]

  • Adult-Onset Nemaline Myopathy

    His symptoms consisted of a 2-year history of progressive proximal muscle weakness; his family history was unremarkable.[ncbi.nlm.nih.gov] […] and Swelling in the Neck 522 Case 83 A Woman with Muscle Pains and Dark Urine 526 Case 84 A Woman with Progressive Proximal Muscle Weakness 533 Case 85 A Sedentary Man with[books.google.com] Most patients present with proximal muscle weakness, which is typically slowly progressive and often unresponsive to steroid therapy.[the-medical-dictionary.com]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy

    proximal muscle weakness and wasting of the pelvic and shoulder girdles with onset that usually occurs during the second or third decade of life.[orpha.net] Abstract BACKGROUND: Autosomal recessive limb girdle muscular dystrophy (LGMD2) is a heterogeneous group of myopathies characterised by progressive muscle weakness involving[ncbi.nlm.nih.gov] Affected individuals have severe progressive proximal muscle weakness.[rarediseases.org]

  • Neuropathy

    It usually presents with weakness and muscle wasting beginning in the feet, and over time progressing more proximally to the legs, then the thighs, hands and forearms.[precisionhealth.com.au] Over time, the numbness may extend proximally, and mild distal muscle weakness and atrophy may occur.[aafp.org] As well as muscle weakness and wasting, the feet usually develop high arches and hammer toes.[precisionhealth.com.au]

  • Peripheral Neuropathy

    Over time, the numbness may extend proximally, and mild distal muscle weakness and atrophy may occur.[aafp.org] In the early stages of peripheral neuropathy, patients typically present with progressive symptoms, including sensory loss, numbness, and pain or burning sensations in distal[aafp.org]

  • Polyneuropathy

    proximal and distal muscles with impaired sensation and absent/diminished tendon reflexes.[orpha.net] Signs & Symptoms The chief symptoms of CIDP are slowly progressive (over at least 2 months) symmetric weakness of both muscles around the hip and shoulder as well as of the[rarediseases.org] Variants Typical CIDP is a symmetrical motor and sensory progressive neuropathy affecting proximal and distal muscles with loss of deep tendon reflexes.[gbs-cidp.org]

  • Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1B

    proximal muscle weakness associated with cardiac complications such as atrioventricular conduction blocks (AVB), dilated cardiomyopathy, and sudden death caused by arrhythmias[exeterlaboratory.com] Remember they will also have progressive proximal muscle weakness, as in polymyositis.[lecturio.com] Case presentation This is a 39-year-old man who had slowly progressive proximal muscle weakness and cardiac arrhythmia since adolescent and a family history of similar manifestation[bmcresnotes.biomedcentral.com]

  • Inclusion Body Myopathy

    The disease is associated with progressive proximal muscle weakness, inclusions and vacuoles in muscle fibers, malfunction in the bone remodeling process resulting in Paget's[ncbi.nlm.nih.gov] Clinically it is is characterized by congenital joint contractures and slowly progressive, proximal muscle weakness and ophthalmoplegia.[ncbi.nlm.nih.gov] Abstract Hereditary inclusion body myopathy (HIBM) is a unique group of neuromuscular disorders characterized by adult-onset, slowly progressive distal and proximal muscle[ncbi.nlm.nih.gov]

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