Progressive Proximal Muscle Weakness: Causes & Reasons

Possible Causes for Progressive Proximal Muscle Weakness

MFM3 is characterized by progressive skeletal muscle weakness greater distally than proximally, tight heel cords, hyporeflexia, cardiomyopathy and peripheral neuropathy in [genecards.org]

In general, the signs and symptoms of type 6 myofibrillar myopathy appear in the first decade of life and include generalized weakness and muscle proximal rapidly progressive [ivami.com]

muscle weakness •5% weakness predominantly distal non-progressive or only slowly Progressive •Respiratory muscles •Non progressive minimal facial muscle involvement •Minimal [slideshare.net]

X-Linked Scapuloperoneal Myopathy

muscle fibers Peroneal muscle weakness Progressive proximal muscle weakness Nemaline bodies Neck muscle weakness Muscle stiffness Clumsiness Bradykinesia Ranula Slow progression [mendelian.co]

proximal muscle weakness (not muscle pain/minimal muscle tenderness) 3: Skin involvement (dermatomyositis) 4: Serum muscle enzymes ( CPK and aldolase) elevated (Heliotrope [quizlet.com]

A progressive disorder involving pelvic and scapular girdle muscles marked by weakness of proximal muscles of hip and shoulder areas with variable psychiatric disorders and [icd10data.com]

X-Linked Reducing-Body Myopathy 1A

Onset during childhood or adulthood is characterised by mainly proximal muscle weakness, a rigid spine syndrome and a slowly progressive disease course. [orpha.net]

Predominantly proximal muscle weakness, generalized muscle hypotrophy. [academic.oup.com]

muscle weakness leading to death due to respiratory insufficiency within the first five years of life. [orpha.net]

Late-Onset Pompe Disease

PATIENT 1 A 58-year-old woman began to have symptoms at age 44 of slowly progressive proximal muscle weakness predominantly affecting the lower limbs. [ncbi.nlm.nih.gov]

elevated CK Becker muscular dystrophy (BMD) Progressive proximal muscle weakness, prominent quadriceps weakness, calf hypertrophy, elevated CK, cardiomyopathy Selenoprotein [ncbi.nlm.nih.gov]

muscle weakness affecting proximal more than distal muscles.24,34 In a recent observational study, weakness of the proximal extremities was the presenting symptom in 93% [ncbi.nlm.nih.gov]

Limb-Girdle Muscular Dystrophy Type 1H

Five subjects presented with a slowly progressive proximal muscle weakness, in both upper and lower limbs, with onset during the fourth-fifth decade of life, which fulfilled [moh-it.pure.elsevier.com]

OMIM : 58 Limb-girdle muscular dystrophy type 1H (LGMD1H) is an autosomal dominant disorder characterized by adult onset of progressive proximal muscle weakness affecting [malacards.org]

Five subjects presented with a slowly progressive proximal muscle weakness, in both… CONTINUE READING From This Paper Figures, tables, and topics from this paper. [semanticscholar.org]

Muscular Dystrophy-Dystroglycanopathy Type C14

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

weakness of proximal muscles. [journals.lww.com]

Limb-Girdle Muscular Dystrophy Type 1G

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

proximal muscle weakness affecting the upper and lower limbs. [mendelian.co]

The disease is characterized by progressing wasting and weakness of the proximal muscles of arms and legs around the HIPS and SHOULDERS (the pelvic and shoulder girdles). [connects.catalyst.harvard.edu]

Infantile-Onset Pompe Disease

proximal muscle weakness Absence of reflexes Difficulties in feeding Elevated levels of CK Congenital muscular dystrophy Severe hypotonia Severe weakness in muscles Hypothyroidism [ncbi.nlm.nih.gov]

[…] diagnoses of IOPD Shared symptoms between IOPD and other disorders Disorder Shared symptoms with IOPD Spinal muscular atrophy | (acute Werdnig–Hoffman disease) Hypotonia Progressive [ncbi.nlm.nih.gov]

Limb-Girdle Muscular Dystrophy Type 2G

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

proximal upper and lower limb muscle weakness and atrophy. [malacards.org]

[…] dystrophy R7 Disease definition A mild subtype of autosomal recessive limb-girdle muscular dystrophy characterized by a variable onset (ranging from infancy to adolescence) of progressive [orpha.net]

Muscular Dystrophy-Dystroglycanopathy Type C9

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

weakness of proximal muscles. [journals.lww.com]

Limb-Girdle Muscular Dystrophy Type 2B

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

She began to experience proximal muscle weakness of both lower limbs without obvious inducement, which markedly increased when she climbed the stairs or stood up after squatting [ncbi.nlm.nih.gov]

Limb-Girdle Muscular Dystrophy Type 2Q

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

weakness of proximal muscles. [journals.lww.com]

Erb Muscular Dystrophy

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

A progressive disorder involving pelvic and scapular girdle muscles marked by weakness of proximal muscles of hip and shoulder areas with variable psychiatric disorders and [icd10data.com]

Physical Exam Symptoms progressive weakness affecting proximal muscles first (begins with gluteal muscle weakness) gait abnormalities delayed walking toe walking clumsy, waddling [orthobullets.com]

Limb-Girdle Muscular Dystrophy

Progressive proximal muscle weakness began again at age 8 years. Serum CK was 14,910 IU/L. She was wheelchair-bound by age 12. [ncbi.nlm.nih.gov]

This is a 39-year-old man who had slowly progressive proximal muscle weakness and cardiac arrhythmia since adolescent and a family history of similar manifestation. [ncbi.nlm.nih.gov]

The father had slowly progressive proximal muscle weakness, whereas three sons and their mother, all currently asymptomatic, had normal physical examinations. [ncbi.nlm.nih.gov]

Autosomal Recessive Limb-Girdle Muscular Dystrophy

proximal muscle weakness and wasting of the pelvic and shoulder girdles with onset that usually occurs during the second or third decade of life. [orpha.net]

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Abstract BACKGROUND: Autosomal recessive limb girdle muscular dystrophy (LGMD2) is a heterogeneous group of myopathies characterised by progressive muscle weakness involving [ncbi.nlm.nih.gov]

Muscular Dystrophy-Dystroglycanopathy Type C3

LGMDs are a heterogeneous group of disorders with progressive proximal muscle weakness in an autosomal inheritance pattern. [omicsonline.org]

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Proximal Myopathy with Extrapyramidal Signs

[…] by early childhood onset of proximal muscle weakness, with development of progressive extrapyramidal motor signs in most patients, and learning disabilities that has material [malacards.org]

muscle weakness and learning disabilities. [malacards.org]

[…] fiber diameter 0003557 Orofacial dyskinesia 0002310 Progressive extrapyramidal movement disorder 0007153 Progressive extrapyramidal muscular rigidity 0007158 Proximal muscle [rarediseases.info.nih.gov]

Limb-Girdle Muscular Dystrophy Type 2C

LGMDs are a heterogeneous group of disorders with progressive proximal muscle weakness in an autosomal inheritance pattern. [omicsonline.org]

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Limb-Girdle Muscular Dystrophy Type 2J

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

weakness of proximal muscles. [journals.lww.com]

Limb-Girdle Muscular Dystrophy Type 2E

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

A progressive disorder involving pelvic and scapular girdle muscles marked by weakness of proximal muscles of hip and shoulder areas with variable psychiatric disorders and [icd10data.com]

Limb-Girdle Muscular Dystrophy Type 2F

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

weakness of proximal muscles. [journals.lww.com]

Granulomatous Myositis

This report presents a case-vignette of a 72-year-old woman with progressive proximal muscle weakness and myalgias, diagnosed with thymoma-associated myasthenia and bioptically [ncbi.nlm.nih.gov]

Patients with granulomatous myositis usually present with slowly progressive muscle pain and weakness affecting mainly proximal muscles. [ncbi.nlm.nih.gov]

The clinical features of metabolic myopathies may be indistinguishable from idiopathic inflammatory myopathy (progressive, persistent, proximal muscle weakness) but will often [rheumatologyadvisor.com]

Alpha-B Crystallinopathy

weakness affecting both the proximal and distal muscles and associated with respiratory insufficiency, cardiomyopathy, and cataracts. [checkorphan.org]

In general, the signs and symptoms of type 6 myofibrillar myopathy appear in the first decade of life and include generalized weakness and muscle proximal rapidly progressive [ivami.com]

Get Update Overview Alpha-B crystallin-related myofibrillar myopathy is an autosomal dominant muscular disorder characterized by adult onset of progressive muscle weakness [diseaseinfosearch.org]

Limb-Girdle Muscular Dystrophy Type 1E

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

Case presentation This is a 39-year-old man who had slowly progressive proximal muscle weakness and cardiac arrhythmia since adolescent and a family history of similar manifestation [bmcresnotes.biomedcentral.com]

A progressive disorder involving pelvic and scapular girdle muscles marked by weakness of proximal muscles of hip and shoulder areas with variable psychiatric disorders and [icd10data.com]

Hereditary Proximal Myopathy with Early Respiratory Failure

Background: Hereditary myopathy with early respiratory failure is a rare dominantly inherited muscle disease characterized by slowly progressive proximal weakness and respiratory [neurology.org]

Hands > Legs in most Muscles involved: Long finger extensors; Intrinsic hand; Thumb & index-finger Progression to legs: Toe & ankle extensors Only rarely proximal weakness [neuromuscular.wustl.edu]

Weakness eventually generalizes and affects both proximal and distal muscles. Weakness of respiratory muscles also progresses with time. [ncbi.nlm.nih.gov]

Steroid Myopathy

In chronic SM, there is an insidious onset of progressive proximal muscle weakness in the arms and legs. [symptoma.com]

Typical symptoms of steroid myopathy are slowly progressive, proximal muscle weakness of shoulder muscles and of hip and thigh muscles with a symmetric distribution. [ard.bmj.com]

Progressive proximal muscle weakness of the upper and lower limbs is reported. [emedicine.medscape.com]

Oculo-Pharyngo-Distal Myopathy

[…] and Swelling in the Neck 522 Case 83 A Woman with Muscle Pains and Dark Urine 526 Case 84 A Woman with Progressive Proximal Muscle Weakness 533 Case 85 A Sedentary Man with [books.google.com]

weakness Ophthalmoparesis Elevated serum creatine phosphokinase Dysarthria Rare Symptoms - Less than 30% cases Increased serum lactate Slow progression Proximal muscle weakness [mendelian.co]

Later Contractures 503 Case 80 A Woman with Longstanding Weakness and Foot Deformities 510 Case 81 A Woman with Droopy Eyelids and Ophthalmoplegia 515 Case 82 A Man with Weakness [books.google.com]

Limb-Girdle Muscular Dystrophy Type 2A

Affected individuals have severe progressive proximal muscle weakness. [rarediseases.org]

Limb-Girdle Muscular Dystrophy type 2A (LGMD2A) is an autosomal recessive disorder characterized by progressive weakness of proximal muscles. [ncbi.nlm.nih.gov]

weakness of proximal muscles. [journals.lww.com]

Idiopathic Camptocormia

Case report An Asian male 67 years of age who was residing in São Paulo presented with an insidious and chronic history of progressive proximal muscle weakness that affected [scielo.br]

Case report An Asian male 67 years of age who was residing in Sao Paulo presented with an insidious and chronic history of progressive proximal muscle weakness that affected [cyberleninka.org]

Inclusion Body Myopathy

The disease is associated with progressive proximal muscle weakness, inclusions and vacuoles in muscle fibers, malfunction in the bone remodeling process resulting in Paget's [ncbi.nlm.nih.gov]

Clinically it is is characterized by congenital joint contractures and slowly progressive, proximal muscle weakness and ophthalmoplegia. [ncbi.nlm.nih.gov]

Abstract Hereditary inclusion body myopathy (HIBM) is a unique group of neuromuscular disorders characterized by adult-onset, slowly progressive distal and proximal muscle [ncbi.nlm.nih.gov]