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146 Possible Causes for Progressive Pyramidal and Cerebellar Signs

  • Pelizaeus-Merzbacher Disease

    Early nystagmus and developmental delay, progressive pyramidal, cerebellar and dystonic signs as well as white matter changes in brain MRI are typical for PMD.[ncbi.nlm.nih.gov]

  • Superficial Siderosis of the Central Nervous System

    Progressive sensorineural deafness, cerebellar ataxia, and pyramidal signs comprise the typical clinical presentation.[ncbi.nlm.nih.gov] All patients developed progressive deafness and cerebellar ataxia associated with pyramidal tract signs or mental deterioration.[readbyqxmd.com] signs, and progressive mental deterioration.[ncbi.nlm.nih.gov]

  • 2-Hydroxyglutaric Aciduria

    The disorder was characterized by a progressive neurological syndrome with cerebellar and pyramidal signs, mental deterioration, epilepsy and subcortical leukoencephalopathy[ncbi.nlm.nih.gov] Occurring mostly in childhood, it is characterized by slowly progressive neurological dysfunction with cerebellar ataxia, pyramidal signs, intellectual decline, seizure, and[ncbi.nlm.nih.gov] Cerebellar and pyramidal signs with progressive neurological syndromes, mental deterioration, tremors, seizures, epilepsy and rarely macrocephaly are clinical findings of[ncbi.nlm.nih.gov]

  • Early-Onset Cerebellar Ataxia

    Abstract Twenty patients are described with a distinctive clinical syndrome characterised by progressive cerebellar ataxia developing within the first two decades.[ncbi.nlm.nih.gov] This is associated with dysarthria, pyramidal signs in the limbs, normal or increased knee jerks and upper limb reflexes and in some instances sensory loss.[ncbi.nlm.nih.gov]

  • Machado-Joseph Disease

    The patient presented all the characteristic features of the disease which consist of progressive cerebellar ataxia, pyramidal signs, progressive external ophthalmoplegia[ncbi.nlm.nih.gov] MJD Type 1 patients generally present with cerebellar signs and external progressive ophthalmoplegia with variable degrees of pyramidal manifestations (spasticity, hyperreflexia[orpha.net] Clinical description Onset is generally early (mean of 24 years) and symptoms progress rapidly.[orpha.net]

  • Autosomal Recessive Spastic Ataxia Type Charlevoix-Saguenay

    cerebellar ataxia, lower limb pyramidal signs, and peripheral neuropathy.[ncbi.nlm.nih.gov] Other early signs of cerebellar ataxia include dysarthria and nystagmus. The spasticity is progressive and eventually dominates the clinical picture.[orpha.net] Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a hereditary neurological disorder mostly manifested with a classical triad: progressive early-onset[ncbi.nlm.nih.gov]

  • Cerebrotendinous Xanthomatosis

    […] disturbances, pyramidal and/or cerebellar signs and seizures).[ncbi.nlm.nih.gov] Neurological findings were progressive walking deficit, limb ataxia and pyramidal signs. Both patients had bilateral Achilles tendon xanthomata.[ncbi.nlm.nih.gov] Adult-onset progressive neurologic dysfunction includes dementia, psychiatric disturbances, pyramidal and/or cerebellar signs, seizures, and neuropathy.[orpha.net]

  • Labrune Syndrome

    CT shows progressive calcifications in the basal and cerebellar gray nuclei and the central white matter.[childnervoussystem.blogspot.com] Discussion The clinical presentations of LCC include progressive extrapyramidal, cerebellar and pyramidal signs, slowed cognitive performances, and/or seizures.[link.springer.com] signs.[childnervoussystem.blogspot.com]

  • Polyendocrine - Polyneuropathy Syndrome

    […] demyelinating sensorimotor polyneuropathy, and cerebellar and pyramidal signs.[uniprot.org] PEPNS is characterized by central hypothyroidism, hypogonadotropic hypogonadism, incomplete puberty, progressive non-autoimmune insulin-dependent diabetes mellitus, peripheral[uniprot.org]

  • Olivopontocerebellar Atrophy

    Some years after the visual symptoms, gradually progressing cerebellar dysfunction and pyramidal signs developed.[ncbi.nlm.nih.gov] The first symptom was insidious, progressive visual loss caused by macular degeneration. Another early sign was slow saccades.[ncbi.nlm.nih.gov]

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