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255 Possible Causes for Progressive Pyramidal and Cerebellar Signs

  • Pelizaeus-Merzbacher Disease

    Early nystagmus and developmental delay, progressive pyramidal, cerebellar and dystonic signs as well as white matter changes in brain MRI are typical for PMD.[]

  • Alexander Disease

    Unlike the much more common infantile form, the juvenile form is slowly progressive with bulbar, pyramidal and cerebellar signs.[]

  • Canavan Disease

    Clinically, she presented progressive psychomotor retardation, cerebellar signs, pyramidal signs and relative megalencephaly.[]

  • Olivopontocerebellar Atrophy

    Some years after the visual symptoms, gradually progressing cerebellar dysfunction and pyramidal signs developed.[] Recessive Congenital Cerebellar Ataxia; Autosomal Recessive Cerebellar Ataxia-pyramidal Signs-nystagmus-oculomotor Apraxia Syndrome; Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual[] The first symptom was insidious, progressive visual loss caused by macular degeneration. Another early sign was slow saccades.[]

  • Neuroferritinopathy

    We report a family in which neuroferritinopathy begins with chronic headaches, later developing progressive orolingual and arm dystonia, dysarthria, cerebellar ataxia, pyramidal[] […] tract signs, and psychiatric symptoms.[]

  • Cerebellar Ataxia

    cerebellar syndrome, mild cognitive impairment, pyramidal signs, and rapid eye movement sleep behavior disorder with imaging abnormalities on the DaTSCAN single-photon emission[] […] a long history of psychiatric disorders such as mixed anxiety-depressive disorder associated with somatization disorder and histrionic personality who developed a slowly progressive[]

  • Motor Neuron Disease

    signs with a slow progression.[] MMND variant has the additional features of optic atrophy and cerebellar signs.[] ) are onset in the young in the first two decades, sporadic occurrence, facial and bulbar paralysis, sensorineural hearing impairment, asymmetrical weakness of limbs and pyramidal[]

  • Machado-Joseph Disease

    The patient presented all the characteristic features of the disease which consist of progressive cerebellar ataxia, pyramidal signs, progressive external ophthalmoplegia[] MJD Type 1 patients generally present with cerebellar signs and external progressive ophthalmoplegia with variable degrees of pyramidal manifestations (spasticity, hyperreflexia[] Clinical description Onset is generally early (mean of 24 years) and symptoms progress rapidly.[]

  • 2-Hydroxyglutaric Aciduria

    The disorder was characterized by a progressive neurological syndrome with cerebellar and pyramidal signs, mental deterioration, epilepsy and subcortical leukoencephalopathy[] Occurring mostly in childhood, it is characterized by slowly progressive neurological dysfunction with cerebellar ataxia, pyramidal signs, intellectual decline, seizure, and[] Cerebellar and pyramidal signs with progressive neurological syndromes, mental deterioration, tremors, seizures, epilepsy and rarely macrocephaly are clinical findings of[]

  • Superficial Siderosis of the Central Nervous System

    Progressive sensorineural deafness, cerebellar ataxia, and pyramidal signs comprise the typical clinical presentation.[] […] with signs of pyramidal liberation associated with cerebellar ataxia and bilateral hypoacusia.[] All patients developed progressive deafness and cerebellar ataxia associated with pyramidal tract signs or mental deterioration.[]

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