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255 Possible Causes for Progressive Pyramidal and Cerebellar Signs

  • Pelizaeus-Merzbacher Disease

    Early nystagmus and developmental delay, progressive pyramidal, cerebellar and dystonic signs as well as white matter changes in brain MRI are typical for PMD.[ncbi.nlm.nih.gov]

  • Alexander Disease

    Unlike the much more common infantile form, the juvenile form is slowly progressive with bulbar, pyramidal and cerebellar signs.[ncbi.nlm.nih.gov]

  • Canavan Disease

    Clinically, she presented progressive psychomotor retardation, cerebellar signs, pyramidal signs and relative megalencephaly.[ncbi.nlm.nih.gov]

  • Olivopontocerebellar Atrophy

    Some years after the visual symptoms, gradually progressing cerebellar dysfunction and pyramidal signs developed.[ncbi.nlm.nih.gov] Recessive Congenital Cerebellar Ataxia; Autosomal Recessive Cerebellar Ataxia-pyramidal Signs-nystagmus-oculomotor Apraxia Syndrome; Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual[diseaseinfosearch.org] The first symptom was insidious, progressive visual loss caused by macular degeneration. Another early sign was slow saccades.[ncbi.nlm.nih.gov]

  • Neuroferritinopathy

    We report a family in which neuroferritinopathy begins with chronic headaches, later developing progressive orolingual and arm dystonia, dysarthria, cerebellar ataxia, pyramidal[ncbi.nlm.nih.gov] […] tract signs, and psychiatric symptoms.[ncbi.nlm.nih.gov]

  • Cerebellar Ataxia

    cerebellar syndrome, mild cognitive impairment, pyramidal signs, and rapid eye movement sleep behavior disorder with imaging abnormalities on the DaTSCAN single-photon emission[ncbi.nlm.nih.gov] […] a long history of psychiatric disorders such as mixed anxiety-depressive disorder associated with somatization disorder and histrionic personality who developed a slowly progressive[ncbi.nlm.nih.gov]

  • Motor Neuron Disease

    signs with a slow progression.[ncbi.nlm.nih.gov] MMND variant has the additional features of optic atrophy and cerebellar signs.[ncbi.nlm.nih.gov] ) are onset in the young in the first two decades, sporadic occurrence, facial and bulbar paralysis, sensorineural hearing impairment, asymmetrical weakness of limbs and pyramidal[ncbi.nlm.nih.gov]

  • Machado-Joseph Disease

    The patient presented all the characteristic features of the disease which consist of progressive cerebellar ataxia, pyramidal signs, progressive external ophthalmoplegia[ncbi.nlm.nih.gov] MJD Type 1 patients generally present with cerebellar signs and external progressive ophthalmoplegia with variable degrees of pyramidal manifestations (spasticity, hyperreflexia[orpha.net] Clinical description Onset is generally early (mean of 24 years) and symptoms progress rapidly.[orpha.net]

  • 2-Hydroxyglutaric Aciduria

    The disorder was characterized by a progressive neurological syndrome with cerebellar and pyramidal signs, mental deterioration, epilepsy and subcortical leukoencephalopathy[ncbi.nlm.nih.gov] Occurring mostly in childhood, it is characterized by slowly progressive neurological dysfunction with cerebellar ataxia, pyramidal signs, intellectual decline, seizure, and[ncbi.nlm.nih.gov] Cerebellar and pyramidal signs with progressive neurological syndromes, mental deterioration, tremors, seizures, epilepsy and rarely macrocephaly are clinical findings of[ncbi.nlm.nih.gov]

  • Superficial Siderosis of the Central Nervous System

    Progressive sensorineural deafness, cerebellar ataxia, and pyramidal signs comprise the typical clinical presentation.[ncbi.nlm.nih.gov] […] with signs of pyramidal liberation associated with cerebellar ataxia and bilateral hypoacusia.[ncbi.nlm.nih.gov] All patients developed progressive deafness and cerebellar ataxia associated with pyramidal tract signs or mental deterioration.[readbyqxmd.com]

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