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217 Possible Causes for Progressive Pyramidal and Cerebellar Signs

  • Pelizaeus-Merzbacher Disease

    Early nystagmus and developmental delay, progressive pyramidal, cerebellar and dystonic signs as well as white matter changes in brain MRI are typical for PMD.[ncbi.nlm.nih.gov]

  • Superficial Siderosis of the Central Nervous System

    Progressive sensorineural deafness, cerebellar ataxia, and pyramidal signs comprise the typical clinical presentation.[ncbi.nlm.nih.gov] All patients developed progressive deafness and cerebellar ataxia associated with pyramidal tract signs or mental deterioration.[readbyqxmd.com] […] with signs of pyramidal liberation associated with cerebellar ataxia and bilateral hypoacusia.[ncbi.nlm.nih.gov]

  • 2-Hydroxyglutaric Aciduria

    The disorder was characterized by a progressive neurological syndrome with cerebellar and pyramidal signs, mental deterioration, epilepsy and subcortical leukoencephalopathy[ncbi.nlm.nih.gov] Occurring mostly in childhood, it is characterized by slowly progressive neurological dysfunction with cerebellar ataxia, pyramidal signs, intellectual decline, seizure, and[ncbi.nlm.nih.gov] Cerebellar and pyramidal signs with progressive neurological syndromes, mental deterioration, tremors, seizures, epilepsy and rarely macrocephaly are clinical findings of[ncbi.nlm.nih.gov]

  • Progressive Myoclonic Epilepsy Type 3

    Lafora disease is clinically characterised by generalised tonic-clonic seizures, myoclonias, progressive mental decline, and pyramidal, extrapyramidal, and cerebellar signs[elsevier.es]

  • X-linked Parkinsonism-Spasticity Syndrome

    DIAGNOSTIC CLINICAL APPROACH Motor signs  Parkinsonism poorly responsive to levodopa  Cerebellar ataxia  Pyramidal signs  Early instability and falls Within 3 years of[slideshare.net] This is a dysmyelinating disease affecting the CNS, which consists of early onset cerebellar and pyramidal signs, with rapid progression resulting in death usually in infancy[jnnp.bmj.com] It is useful to remember that a non-demented patient who is impotent and incontinent with poorly responsive parkinsonism, pyramidal and cerebellar signs does not have another[annalsofian.org]

  • Progressive Myoclonic Epilepsy Type 7

    Lafora disease is clinically characterised by generalised tonic-clonic seizures, myoclonias, progressive mental decline, and pyramidal, extrapyramidal, and cerebellar signs[elsevier.es]

  • Pallidopyramidal Syndrome

    signs; Dementia; Generalized cerebral, cerebellar, and brainstem atrophy, progressive; Atrophy of pyramids; [Behavioral/psychiatric manifestations]; Hallucinations; Psychotic[genome.jp] DIAGNOSTIC CLINICAL APPROACH Motor signs  Parkinsonism poorly responsive to levodopa  Cerebellar ataxia  Pyramidal signs  Early instability and falls Within 3 years of[slideshare.net] Mask-like facies; Rigidity; Anarthria; Festinate gait; Facial-faucial-finger mini-myoclonus (FFF); Spasticity; Mild paraparesis; Hyperreflexia; Extensor plantar responses; Pyramidal[genome.jp]

  • Progressive Myoclonic Epilepsy Type 8

    Lafora disease is clinically characterised by generalised tonic-clonic seizures, myoclonias, progressive mental decline, and pyramidal, extrapyramidal, and cerebellar signs[elsevier.es]

  • Proliferating Angioendotheliomatosis

    […] neurological dysfunction Pyramidal tract signs, cerebellar ataxia, cognitive impairment, peripheral neuropathy Osteoporosis with ?[orthopaedicsone.com] […] hyperintense to involved tendon Cerebrotendinous xanthomatosis Autosomal recessive lipid-storage disease Bilateral Achilles tendon xanthoma Bilateral cataract formation Progressive[orthopaedicsone.com]

  • Machado-Joseph Disease

    The patient presented all the characteristic features of the disease which consist of progressive cerebellar ataxia, pyramidal signs, progressive external ophthalmoplegia[ncbi.nlm.nih.gov] MJD Type 1 patients generally present with cerebellar signs and external progressive ophthalmoplegia with variable degrees of pyramidal manifestations (spasticity, hyperreflexia[orpha.net] Clinical description Onset is generally early (mean of 24 years) and symptoms progress rapidly.[orpha.net]

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