Proliferation of Spindle Cells: Causes & Reasons

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Possible Causes for Proliferation of Spindle Cells

Spindle Cell Hemangioma

Spindle cell hemangioma is a rare benign tumor characterized by cavernous blood vessels and spindle cell proliferation. [ncbi.nlm.nih.gov]

The tumor was a well-circumscribed vascular proliferation of spindled to epithelioid endothelial cells. [ncbi.nlm.nih.gov]

Spindle Cell Hemangioma Spindle cell hemangioma is an uncommon benign vascular tumor of the oral cavity (39). [ijp.iranpath.org]

Spindle Cell Carcinoma of the Larynx

Spindle cell carcinoma (SPCC) is a rare, malignant variant of squamous cell carcinoma (SCC), which shows biphasic proliferation of the conventional SCC component and malignant [experts.umich.edu]

cells in loose stroma mimicking granulation tissue (H&E stain, x100) Click here to view Figure 5: Photomicrograph shows proliferating sheets of spindle cells below a normal [jomfp.in]

Biopsy of the nasal mass showed a proliferation of spindle and epithelioid cells. [pagepress.org]

Spindle Cell Sarcoma of the Duodenum

Cellular proliferation of bland spindle cells with pale to eosinophilic fibrillar cytoplasm Cells in whorls or short intersecting fascicles, with frequent and prominent [pathologyoutlines.com]

A resection of the skin lesion, which was sent to Brigham and Women’s Hospital for consultation, revealed a multinodular proliferation of spindle cells. [pagepress.org]

Mucosal Schwann cell hamartomas Mucosal Schwann cell hamartoma is characterized by a diffuse, ill-defined proliferation of spindle cells within the lamina propria, which surrounds [nature.com]

Perineurioma

Histopathologically, the tumor is composed of a well circumscribed nodular proliferation of spindle cells arranged in a storiform growth pattern, in some areas subtly arranged [ncbi.nlm.nih.gov]

Histologically, the tumor consisted of a proliferation of spindle cells interwoven by a lattice of basal lamina. [ncbi.nlm.nih.gov]

The cellular area was mainly composed of proliferation of plump spindle, oval or epithelioid cells. [ncbi.nlm.nih.gov]

Dermatofibroma

Dermatofibromas are slow-growing solitary nodules, composed mostly of a dermal proliferation of spindle cells and epithelioid cells. [ncbi.nlm.nih.gov]

In the dermis, there was a proliferation of spindle cells in storiform arrangement with central retraction of the dermis ( Figure 2 ). [ncbi.nlm.nih.gov]

The excision specimen showed a large, dermal-based, well-circumscribed, nonencapsulated heterogenous spindle cell proliferation. [ncbi.nlm.nih.gov]

Kaposi Sarcoma

The skin biopsy specimens showed KS infiltration (proliferation of spindle-shaped cells). Immunosuppressive therapy was discontinued. [ncbi.nlm.nih.gov]

[…] no spindle cell proliferation HHV8 negative Spindle cell hemangioma Spindled endothelial cells with slit-like channels but also has epithelioid cells Biphasic: solid spindled [pathologyoutlines.com]

The lesions that characterize Kaposi's sarcoma are not a result of neoplastic transformation of cells but arise from an excessive proliferation of spindle cells mixed with [ncbi.nlm.nih.gov]

Endemic Kaposi Sarcoma

The proliferation of spindle cells has been related to the expression of viral interferon regulatory factor 1, viral G-protein-coupled receptor, and the ORF-K1 gene. [symptoma.com]

Microscopic view showing prominent slit like vascular spaces H&E stain × 40 (a). proliferation of spindle cells, prominent slit like vascular spaces, and extravasated red [article.sapub.org]

Follicular Dendritic Cell Sarcoma

In cases involving the liver and spleen, the tumor cells often do not demonstrate a cohesive proliferation of spindled cells, and have a greater degree of inflammatory infiltrate [path.upmc.edu]

BACKGROUND: Follicular dendritic cell (FDC) sarcoma is a neoplastic proliferation of spindled to ovoid cells showing morphologic and phenotypic features of follicular dendritic [ncbi.nlm.nih.gov]

Histologically, five cases showed low grade cytology with proliferation of spindled cells, growth patterns included whorled, storiform, fasicular and nodular. [bloodjournal.org]

Dermatofibrosarcoma Protuberans

A) proliferation of spindle cells, with storiform pattern and “cartwheel” aspect in the dermis. [ncbi.nlm.nih.gov]

Histopathological analysis revealed a proliferation of spindle-shaped mesenchymal cells arranged in interlacing fascicles amidst fibrous stroma. [ncbi.nlm.nih.gov]

Biopsy of the nodule and atrophic plaque revealed dense proliferation of spindle-shaped tumor cells from the dermis to the subcutaneous adipose tissue, and positive immunostaining [ncbi.nlm.nih.gov]

Proliferating Trichilemmal Cyst

Y. 1991 32 Proliferating trichilemmal cyst with spindle cell carcinoma. ( 1700885 ) Mori O....Sasai Y. 1990 33 Unusual proliferating trichilemmal cyst. ( 3688371 ) Jaworski [malacards.org]

Warner T (1979) Proliferating pilar cyst with spindle cell component. J Cutan Pathol 6: 310–316 PubMed Google Scholar 22. [link.springer.com]

We report a 58-year-old woman with proliferating trichilemmal cyst (PTC), from which a spindle cell carcinoma arose. [ncbi.nlm.nih.gov]

Pulmonary Plasma Cell Granuloma

histiocytes, mast cells and lymphocytes. - Fibrohistiocytic variant: Characterized by proliferation of spindle cells arranged in whorled or storiform pattern. [histopathology-india.net]

[…] of bland spindle cells with admixed lymphocytes, plasma cells and histiocytes. plasma cell granuloma/lymphoplasmacytic type: fascicles of benign spindle cells associated [e-immunohistochemistry.info]

IMT is characterized histologically by spindle cell proliferation. [cardiothoracicsurgery.biomedcentral.com]

Kaposi Sarcoma of the Lung

Rather, it is the result of polyclonal proliferation of virus infected spindle cells. [immunopaedia.org.za]

[…] of spindle cells and mixed inflammatory cell infiltrates (lymphocytes and plasma cells). [info.gov.hk]

Calcified Aponeurotic Fibroma

Chondroid tissue and calcification within the areas of proliferated spindle cells are the characteristic features of this lesion and differentiate it from the other forms [unboundmedicine.com]

[…] fibroblastic cells arranged in nodules, palisading or intertwining tangles of eosinophilic spindle-shaped cells. [jamanetwork.com]

Numerous cells with large nuclei and spindle cells. Some very atypical cells referred to as ‘Monster cells’. Respects subQ fat TX: Reassurance. [slideplayer.com]

Proliferating Angioendotheliomatosis

The spindled cells were highlighted with a CD31 IHC staining (Figure 3), and a Factor XIIIa staining also highlighted many cells within the spindle cell proliferation, confirming [f1000research.com]

The spindled cells were highlighted with a CD31 IHC staining ( Figure 3 ), and a Factor XIIIa staining also highlighted many cells within the spindle cell proliferation, confirming [f1000research.com]

Microscopic features: The lesion is characterized by the proliferation of epithelioid and spindle-shaped cells in superficial and mid-dermis lining vascular channels, arranged [histopathology-india.net]

Blue Nevus

Histopathology shows a proliferation of bland spindle cells within the dermis with associated sclerosis and without associated pigment. [jaadcasereports.org]

A neurofibroma is characterized by an intradermal proliferation of spindled cells with minimal overlying epidermal changes. [dermatologyadvisor.com]

[…] of spindle cells, dendritic melanocytes, and melanophages into a sclerotic dermis or subcutis. [statpearls.com]

Angiofibroma

The lesion is characterized by a proliferation of stellate and spindled cells around blood vessels (figure 2). [dermnetnz.org]

Histologic analysis demonstrated a proliferation of spindle cells in a fibrous stroma. Multinucleated giant cells were found as were multiple pseudovascular spaces. [ajnr.org]

Several histological subtypes have been described: Hypercellular angiofibroma is characterised by an increased number of stellate and spindled cells (figure 3). [dermnetnz.org]

Familial Ossifying Fibroma

A, Cellular proliferation of spindle cells with osteoid and woven bone formation. B, Osteoid, woven bone, spindle cells, and giant cells. [pocketdentistry.com]

[…] associated fibro-osseous proliferation Well differentiated osteosarcoma Infiltrative, relatively hypocellular and consists of monomorphic, minimally atypical spindle cells [pathologyoutlines.com]

The histological pattern of spindle cell proliferation in a storiform, tangled or radiating cartwheel pattern characteristic of benign fibrous histiocytomas were noticed in [njcponline.com]

Benign Ovarian Neoplasm

Ovarian myxoma has recently been a new distinct pathological entity that show moderate cellular proliferation of spindle cell increased with areas of fibrosis and haemorrhage [orion-group.net]

The histologic sections reveal a neoplastic proliferation composed of spindled to rounded cells, with ill-defined cellular borders and pale cytoplasm. [cap.org]

The pelvic mass or luteinized thecoma comprises a proliferation of ovarian spindle cells, which enlarge under the influence of progesterone. [ogscience.org]

Fibrosarcoma

[…] fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern fibroblastic sarcoma Fibrocytic tumor fibrosarcoma of soft tissue fibrous tissue neoplasm [wikidata.org]

From Wikidata Jump to navigation Jump to search connective tissue cancer that has material basis in fibrous connective tissue and characterized by the presence of immature proliferating [wikidata.org]

Description Also known as English fibrosarcoma connective tissue cancer that has material basis in fibrous connective tissue and characterized by the presence of immature proliferating [wikidata.org]

Well-Differentiated Liposarcoma

Spindle cell liposarcoma is the rarest variant and is composed neural-like spindle cell proliferation set in a fibrous and/or myxoid background and associated with an atypical [ncbi.nlm.nih.gov]

The remaining 7 tumors showed moderate cellular spindle-cell proliferation with mild nuclear atypia and scant mitotic figures (low-grade DDL [LDDL]). [ncbi.nlm.nih.gov]

WD liposarcoma is further subdivided in the adipocytic (lipoma-like), sclerosing, inflammatory, and spindle cell subtypes, of which the first two are by far the commoner. [ncbi.nlm.nih.gov]

Ganglioneuroma

Microscopically, there is proliferation of benign spindle cells with Schwannian features in association with small clusters of ganglion cells in the lamina propria that grossly [acupath.com]

Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. [codes.iarc.fr]

cell proliferation and fibrillary cytoplasm seen in neoplasms of neural origin, and the paucity of ganglion cells. [academic.oup.com]

Dedifferentiated Liposarcoma

Histopathologically, tumor had a heterogeneous cell population, composed of spindle cells with fibrous collagen proliferation. [ncbi.nlm.nih.gov]

Neoplastic spindle cell proliferation was found from submucosa to subserosa. [surgicalcasereports.springeropen.com]

The remaining 7 tumors showed moderate cellular spindle-cell proliferation with mild nuclear atypia and scant mitotic figures (low-grade DDL [LDDL]). [ncbi.nlm.nih.gov]

Acquired Hemangioma

Microscopically, the localized tufts with extensive proliferation of non-endothelial spindle and polygonal cells surrounding vascular channels is distinctly different from [cda-adc.ca]

[…] and polygonal cell population, is unlike the lobular, capillary proliferation of a mature hemangioma. [cda-adc.ca]

The nature of the spindle and polygonal cells associated with the acquired tufted angioma is unclear. [cda-adc.ca]

Myofibroblastoma of the Breast

Microscopically, the tumor consisted of a proliferation of uniform spindle cells arranged in short fascicles and separated by proeminent hyalinised collagen bundles. [latunisiemedicale.com]

Iatrogenic Kaposi Sarcoma

Kaposi sarcoma is caused by an excessive proliferation of spindle cells that are thought to have an endothelial cell origin. [emedicine.medscape.com]

The histopathology of Kaposi sarcoma shows red cells in slit-like spaces formed by atypical spindle cell proliferation of endothelial cells and associated with inflammatory [dermnetnz.org]

The spindle cells proliferate in a background of reticular fibers, collagen, and mononuclear cells including macrophages, lymphocytes and plasma cells. [emedicine.medscape.com]

Myopericytoma

In those nodules, there were numerous, small, concentric proliferations of myoid-appearing spindle cells around small vascular lumina. [ncbi.nlm.nih.gov]

[…] of spindle cells (7 cases). [ncbi.nlm.nih.gov]

It was adopted in 1998 by McMenamin and Fletcher to describe a spectrum of tumours with striking concentric perivascular proliferation of spindle cells (perivascular myoid [e-immunohistochemistry.info]

Inflammatory Myofibroblastic Tumor

The histological findings on hematoxylin and eosin staining showed proliferation of spindle cells with infiltration of lymphocytes and plasma cells. [ncbi.nlm.nih.gov]

INTRODUCTION: Inflammatory myofibroblastic tumors (IMT) are rare neoplasms characterized by a proliferation of spindle-shaped cells with a stroma infiltrated by macrophages [ncbi.nlm.nih.gov]

IMTs are characterized by proliferating spindle cells with variable inflammatory component. [ncbi.nlm.nih.gov]

Fibrous Hamartoma of Infancy

Definition / general Tumor-like condition in newborns to 2 year olds Poorly circumscribed proliferation of immature spindle cells in organoid pattern with fat and dense fibrocollagenous [pathologyoutlines.com]

The histological study showed a fusocelullar proliferation in dermis and hypodermis of biphasic distribution, with an infiltrative, swirling pattern and bundles of spindle [repositorio.uchile.cl]

[…] fibroblast-like and myofibroblast-like cells, associated in depth with a mature adipose tissue component. [repositorio.uchile.cl]

Intraneural Perineurioma

Histologically, the tumour comprised a tortuous proliferation of spindle cells arranged like an onion bulb. [ncbi.nlm.nih.gov]

Histologic analysis showed a plexiform dermal lesion composed of enlarged nerve fascicles due to proliferation of spindle perineurial cells, arranged in onion-bulb-like structures [ncbi.nlm.nih.gov]

The proliferating cells showed positive membranous staining for epithelial membrane antigen and were negative for S100 protein, which highlighted residual Schwann cells. [ncbi.nlm.nih.gov]

Large Cell Carcinoma

Metastasis to the hilum and to mediastinal lymph nodes is common. spindle cell carcinoma squamous cell carcinoma marked by development of rapidly proliferating spindle cells [medical-dictionary.thefreedictionary.com]

[…] in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells [medical-dictionary.thefreedictionary.com]