Possible Causes for prominent nucleoli Plasmablastic Lymphoma The histological examination of the specimen showed a diffuse proliferation of round- to oval-shaped large cells with scant cytoplasm, and prominent nucleoli. [ncbi.nlm.nih.gov] The tumor consisted of a monotonous proliferation of undifferentiated large cells with relatively abundant cytoplasm, eccentrically located round nuclei with prominent nucleoli [ncbi.nlm.nih.gov] some neoplastic cells with prominent nucleoli, apoptosis and necrosis were often presented. [ncbi.nlm.nih.gov] Lipid Cell Tumor of the Ovary uniform nuclei, prominent nucleoli Abundant pale (lipid-rich) cytoplasm Abundant lipid (oil red-O stain) Two atypical mitotic figures Images hosted on other servers: H&E [pathologyoutlines.com] Cytoplasm is vacuolated to eosinophilic and granular with vesicular nuclei along with presence of prominent nucleoli. [ijpmonline.org] The nuclei were large vesicular nuclei with prominent nucleoli and showed a moderate degree of nuclear pleomorphism. [jmedicalcasereports.biomedcentral.com] Hereditary Leiomyomatosis and Renal Cell Cancer The morphologic features of renal tumors that arise in the setting of HLRCC are well described, the hallmark feature being the presence of prominent eosinophilic nucleoli [doi.org] […] eosinophilic nucleoli with a clear perinucleolar halo May have prominent nucleoli Both can show tubulocystic architecture and have similar cytologic features including prominent [surgpathcriteria.stanford.edu] The renal cell carcinomas have prominent eosinophilic nucleoli surrounded by a clear halo. [en.wikipedia.org] Epithelioid Cell Sarcoma The proximal variant (with larger cells, prominent nucleoli, and rhabdoid changes) is clinically more aggressive. [ncbi.nlm.nih.gov] The cells had vesicular nuclei with prominent nucleoli. Binucleated and multinucleated forms were noted [ [Figure 1] a]. [jcytol.org] Micro Large epithelioid cells with marked atypia and prominent nucleoli, varying amounts of rhabdoid features. epithelioid sarcoma A low-grade sarcoma of the upper extremity [medical-dictionary.thefreedictionary.com] Primary Effusion Lymphoma Cytological analysis of the pleural effusion revealed a high-grade lymphoma with round nuclei, prominent nucleoli and abundant cytoplasm with immunophenotypes positive for [ncbi.nlm.nih.gov] Figure 2: Marked pleomorphic lymphocytes, loose chromatin, several prominent nucleoli and deep cytoplasmatic basophilia with vacuoles in occasional cells. [aclr.com.es] A biopsy of the pelvic mass and bone marrow showed large atypical cells with irregular multi-lobulated nuclei, prominent nucleoli, and abundant amphophilic cytoplasm. [ncbi.nlm.nih.gov] Leydig Cell Tumor of the Testis Occasionally, pleomorphic cells with hyperchromatic nuclei and prominent nucleoli were seen. Immunocytochemistry was positive against vimentin, inhibin, and calretinin. [ncbi.nlm.nih.gov] The tumor was 2.5 x 2.5 cm encapsulated, composed of small clusters of round to polygonal cells with central nuclei and prominent nucleoli with eosinophilic cytoplasm [Figure [indianjurol.com] Round or ovoid nuclei, prominent nucleoli, rarely binucleated or multinucleated. [auanet.org] Alveolar Soft-Tissue Sarcoma Prominent nucleoli No crystals Crystals in up to 80% of cases Uniformly desmin, actin positive Occasionally desmin, actin positive Frequently MyoD1 positive MyoD1 rare or [surgpathcriteria.stanford.edu] nucleoli Vascular invasion common; also characteristic rod-shaped crystalloids No / rare mitotic figures, minimal pleomorphism Microscopic (histologic) images Images hosted [pathologyoutlines.com] - The tumour cells are large, round to oval shaped, with eosinophilic granular cytoplasm, eccentric rounded nuclei and prominent nucleoli. - The cellular aggregates show [histopathology-india.net] Seminoma Fig 67b – Germinoma –Large single cells with unique central vesicular nuclei and with prominent nucleoli. Lymphocytes are abundant (H&E). [eurocytology.eu] The tumor cells have abundant eosinophilic cytoplasm, pleomorphic hyperchromatic nuclei, one or more prominent nucleoli, and show brisk mitotic activity. [webpathology.com] Tumour cells have abundant pale cytoplasm, large vesicular nuclei and prominent nucleoli. [radiopaedia.org] Diffuse Lymphoma Aggressive histology means that many of the lymphoma cells are highly atypical: large and irregular, with vesicular nuclei and prominent nucleoli. [pleiad.umdnj.edu] May have prominent nucleoli Uniform cells Heterogeneous cells Generally only a problem in suboptimally processed specimens Diffuse Mixed Lymphoma DLBCL 50-75% of cells are [surgpathcriteria.stanford.edu] The lymphocytes are large centroblast-like and immunoblast-like cells with non-cleaved nuclei and prominent nucleoli (figure 6, 7). [dermnetnz.org] Adenocarcinoma of the Prostate nucleoli. [ncbi.nlm.nih.gov] PIN-like ductal adenocarcinoma differs from HGPIN by the presence of cystically dilated glands, a greater predominance of flat architecture, and less frequently prominent [ncbi.nlm.nih.gov] Large nuclei with prominent nucleoli that can be multiple. Cytoplasmic tincture different to adjacent benign glands. [auanet.org] Atypical Teratoid Rhabdoid Tumor The CSF cytomorphologic findings of the AT/RT cells are most notably large cells, eccentrically placed pleomorphic nuclei, prominent nucleoli and, commonly, cytoplasmic inclusions [ncbi.nlm.nih.gov] The most consistent cytologic features of AT/RT are the large size of the tumor cells, eccentricity of the nuclei, and prominent nucleoli. [ncbi.nlm.nih.gov] The surgically resected mass was marked by sheets of cells with large nuclei and prominent nucleoli. [ncbi.nlm.nih.gov] Malignant Angioendotheliomatosis The cells are large, with 1 or more prominent nucleoli, scant cytoplasm, and frequent mitotic figures, and are commonly positive for cluster of differentiation markers 79a [ncbi.nlm.nih.gov] Microglandular Adenosis […] layer but thick basement membrane Atypical microglandular adenosis: Pleomorphic glands and microacini Budding glandular units and luminal bridging, mild cytologic atypia, prominent [pathologyoutlines.com] nucleoli, apoptosis Increased Ki67 and p53 staining (5-10% of cells) Carcinomas retain the immunophenotype of microglandular adenosis Richard L Kempson MD Robert V Rouse [surgpathcriteria.stanford.edu] It often shows budding glandular units and luminal bridging, with occasional mitotic figures and some cytologic atypia, including vesicular nuclei and prominent nucleoli [archivesofpathology.org] Hairy Cell Leukemia Variant Prominent nucleoli were observed in most HCL-v but rarely in HCL. A third of HCL and HCL-v marrows were hypocellular or aplastic-appearing. [ncbi.nlm.nih.gov] nucleoli and blastic / convoluted nuclei; negative staining for CD25, Annexin A1 and TRAP on tumor cells; patients are resistant to conventional chemotherapeutic regimen [pathologyoutlines.com] Fig. 1 a PB smear showing large cells with villous projections and prominent nucleoli. [link.springer.com] Pleomorphic Rhabdomyosarcoma Most tumor cells had large prominent nucleoli. Background rhabdomyoblasts varied from spindled to polygonal. [ncbi.nlm.nih.gov] Tumor cells had granular hyperchromatic nucleiwith prominent nucleoli. Cross-striations in their cytoplasm were not observed. [jstage.jst.go.jp] The individual cells were showing high N: C ratio, variable amount of the fibrillary cytoplasm, many bizarre polygonal rhabdomyoblasts with prominent nucleoli and abundant [ccij-online.org] Subependymal Giant Cell Astrocytoma Histologically, the tumors were composed of large polygonal cells with vesicular nuclei, prominent nucleoli and glassy eosinophilic cytoplasm, intermingled with spindle and [ncbi.nlm.nih.gov] nucleoli, and abundant eosinophilic glassy cytoplasm. [ncbi.nlm.nih.gov] nucleoli NSE Negative stains HMB45 (unlike other tuberous sclerosis related lesions) Back to top [pathologyoutlines.com] Blue Nevus Malignant blue nevi arise within cellular blue nevi and contain atypical mitoses, necrosis, nuclear pleomorphism and prominent nucleoli. [ncbi.nlm.nih.gov] In all cases, malignancy was evidenced by increased mitotic rate, necrosis, nuclear atypia, pleomorphism, hyperchromasia, and prominent nucleoli. [doi.org] B-Cell Prolymphocytic Leukemia The morphology of these cells was compatible with prolymphocytes with prominent nucleoli and condensed nuclear chromatin. A diagnosis of B-PLL was made. [ncbi.nlm.nih.gov] C, Lymph node from case 2 showing cells with prominent nucleoli. [ajcp.oxfordjournals.org] D, Infiltrating prolymphocytes have prominent central nucleoli, and mitotic figures are observed (H&E, 1,000). [ajcp.oxfordjournals.org] Gemistocytic Astrocytoma nucleoli Background is coarse fibrillary; perivascular lymphocyte cuffing is common Microscopic (histologic) images Images hosted on other servers : Astrocytes with abundant [pathologyoutlines.com] The nucleus of the cell showed even granular chromatin and occasional prominent nucleoli. [jlponline.org] (Images 03, 04 and 05 ) The large cells have pleomorphic nuclei with dispersed chromatin and prominent nucleoli, with occasional eosinophilic intranuclear inclusions (Images [path.upmc.edu] Paget Disease of the Breast A malignant neoplasm in which there is infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells [monarchinitiative.org] Hematoxylin and eosin staining of the biopsy from the lesion showed large round cells with ample pale-staining cytoplasm, pleomorphic nuclei, and occasional prominent nucleoli [e-ijd.org] Histologically, the tumour is characterized by large, atypical neoplastic cells (Paget cells) featuring large nuclei with prominent nucleoli and abundant pale cytoplasm. [codes.iarc.fr] Benign Interstitial Cell Tumor of the Testis Round or ovoid nuclei, prominent nucleoli, rarely binucleated or multinucleated. [auanet.org] The high-power view shows the typical large, irregularly shaped, overlapping nuclei with multiple prominent nucleoli. [slideshare.net] Comment: The tumour consists of polygonal cells with abundant eosinophilic cytoplasm, round nuclei with prominent nucleoli. Features suggestive of malignancy are absent. [librepathology.org] Clear Cell Sarcoma Biopsy of a 2.5 cm mass showed nests of large round to oval neoplastic cells with abundant amphophilic to clear cytoplasm, prominent nucleoli and high mitotic activity. [ncbi.nlm.nih.gov] Prominent nucleoli - basophilic - key feature. /-Binucleation. DDx: Malignant melanoma. PEComa. Carcinoma. Images Clear cell sarcoma - intermed. mag. [librepathology.org] […] not prominent Prominent large nucleoli Lacks necrosis Frequent necrosis Epithelioid Leiomyosarcoma Clear Cell Sarcoma No irregular nests Usually irregular nests HMB45 negative [surgpathcriteria.stanford.edu] Extramammary Paget Disease Histopathologic examination of 2 scouting biopsies revealed a proliferation of large cells with pleomorphic nuclei, prominent nucleoli, and abundant pale to clear cytoplasm [ncbi.nlm.nih.gov] Sometimes with true glandular formation • Round vesicular nuclei with prominent nucleoli • Abundant clear cytoplasm May contain intracytoplasmic melanin • Absence of intercellular [basicmedicalkey.com] nucleoli Abundant pale cytoplasm Scattered individually and in clusters May form small acini Lack features of squamous differentiation No visible intercellular bridges No [surgpathcriteria.stanford.edu] Carcinoma of the Prostate The distinction between these forms of BCH, including the variant with prominent nucleoli (formerly called atypical BCH), and basal cell carcinoma depends on morphological [ncbi.nlm.nih.gov] The nuclei are enlarged, opened, with prominent nucleoli. Luminal borders are undulated, and amorphous pink secretion is often seen. [ncbi.nlm.nih.gov] Figure 1: Right testicular mass showing infiltrating glands composed of cells with hyperchromatic, enlarged nuclei, prominent nucleoli and increased nuclear:cytoplasmic ratio [academic.oup.com] Granulocytic Sarcoma nucleoli (blast cells) Few large monocytoid cells with prominent nucleoli Cytology images Images hosted on other servers: FNA breast (fig 2C-2E) Back to top [pathologyoutlines.com] Cytomorphology is accurate and efficient to confirm the diagnosis. [3], [4] Figure 2: Cytological smear showing myeloblast with prominent nucleoli and band forms Click here [indianjcancer.com] Nucleoli are frequently prominent and the number of mitotic figures is variable. [bjo.bmj.com] Primary Malignant Melanoma of the Cervix nucleoli (Figs. 1 and 2). [scielo.br] The cells showed hyperchromatic nuclei, prominent nucleoli, intranuclear inclusions, and abundant eosinophilic cytoplasm [Figure 1]a. [cancerjournal.net] The histopathological examination showed clusters of atypical spindle cells with prominent nucleoli and eosinophilic cytoplasm [Figure 3], with evident intra- and extracellular [jcmtjournal.com] Peripheral Neuroblastoma Minireview 84 Downloads 16 Citations Abstract The presence of large cells having simultaneously increased cytoplasmic and nuclear volume accompanied by prominent nucleoli; [link.springer.com] […] eosinophilic cytoplasm Indistinct cell borders Ganglion cells Large round nuclei with prominent nucleoli Abundant eosinophilic cytoplasm Nissl substance in cytoplasm Basophilic [surgpathcriteria.stanford.edu] It is differentiated into large ganglion like cells with the prominent nucleoli. [omicsonline.org] Bronchial Adenocarcinoma Discohesive malignant cells with lack of gland formation, vesicular chromatin, and prominent nucleoli. [eurocytology.eu] Non-Small Cell Lung Cancers (NSCLCs) In general, NSCLCs are distinguished from SCLCs by their much more abundant cytoplasm, prominent nucleoli, and their tendency to grow [pathwaymedicine.org] Figure 4 Morphology of combined adenocarcinoma. ( a ) Adenocarcinoma shows vesicular nuclei with prominent nucleoli. [nature.com] Thyroid Lymphoma nucleoli Bizarre cells may be seen MALT lymphoma : Infiltration of thyroid epithelium creates lymphoepithelial lesions (lymphocytes "stuff" glandular lumina, Arch Pathol [pathologyoutlines.com] Figure 1: (a) Dyscohesive sheets of atypical cells having large vesicular nuclei and 1-3 prominent nucleoli. [ccij-online.org] FNAC from the right lobe showed monotonous population of intermediate to large lymphoid cells having prominent nucleoli, cleaved nuclei and moderate amount of cytoplasm in [cancerjournal.net] Hilar Cell Tumor of the Ovary The cells forming these aggregates were large with oval to round eosinophilic cytoplasm and vesicular nuclei containing prominent nucleoli (Figure 1B). [turkjpath.org] Cytoplasm is vacuolated to eosinophilic and granular with vesicular nuclei along with presence of prominent nucleoli. [ijpmonline.org] Nucleoli are occasionally moderately prominent, particularly in luteinized tumors which often lack nuclear grooves. [basicmedicalkey.com]
