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621 Possible Causes for Prominent Nucleoli

  • Influenza

    These atypical cells were unusually large and had large nuclei, coarse chromatin, and prominent nucleoli.[]

  • Infectious Mononucleosis

    There is a mixture of cell types, including plasmacytoid cells, and individual cells with prominent nucleoli. Immunohistochemical studies are non-specific.[] However, soon after, there is an immunoblastic proliferation, which may be quite striking. 18 , 19 , 20 These cells typically have prominent nucleoli and abundant cytoplasm[] The earliest manifestation of acute infectious mononucleosis may be a prominent monocytoid B-cell proliferation, along with reactive follicular hyperplasia.[]

  • BAP1-Related Tumor Predisposition Syndrome

    This tumor predisposition syndrome is inherited in an autosomal dominant pattern. Individuals carrying heterozygous BAP1 mutations are at high-risk for the development of a variety of tumors, including benign melanocytic tumors as well as several malignant tumors, including uveal melanoma ({155720}), cutaneous[…][]

  • Primary Effusion Lymphoma

    Figure 2: Marked pleomorphic lymphocytes, loose chromatin, several prominent nucleoli and deep cytoplasmatic basophilia with vacuoles in occasional cells.[] The effusions show a dispersed population of large pleomorphic cells with eccentrically located nuclei, 1 or more prominent nucleoli, a perinuclear pallor, and moderately[] Cytological analysis of the pleural effusion revealed a high-grade lymphoma with round nuclei, prominent nucleoli and abundant cytoplasm with immunophenotypes positive for[]

  • B-Cell Prolymphocytic Leukemia

    The morphology of these cells was compatible with prolymphocytes with prominent nucleoli and condensed nuclear chromatin. A diagnosis of B-PLL was made.[] nucleoli.[] […] and biopsy revealed diffuse infiltration of medium to large prolymphocytes having moderate amount of basophilic cytoplasm, round to oval nuclei with coarse chromatin, and prominent[]

  • Collecting Duct Carcinoma

    Cytologic examination of voided urine showed glandlike clusters of large cells with granular cytoplasm and prominent nucleoli, along with normal transitional cells.[] The cells consisted of highly atypical cells having large nuclei with coarse or vesicular chromatin, prominent nucleoli and lacy or granular cytoplasm.[] Neoplastic cells had moderate to abundant eosinophilic cytoplasm and large hyperchromatic nuclei with prominent nucleoli as Fuhrman nuclear grade 3 or 4.[]

  • Hairy Cell Leukemia Variant

    Prominent nucleoli were observed in most HCL-v but rarely in HCL. A third of HCL and HCL-v marrows were hypocellular or aplastic-appearing.[] nucleoli and blastic / convoluted nuclei; negative staining for CD25, Annexin A1 and TRAP on tumor cells; patients are resistant to conventional chemotherapeutic regimen[] Fig. 1 a PB smear showing large cells with villous projections and prominent nucleoli.[]

  • Langerhans Cell Sarcoma

    nucleoli.[] nucleoli, and abundant cytoplasm Difficult diagnosis to establish without immunohistochemistry ANCILLARY TESTS Immunohistochemistry CD1a( ), S100 protein( ), or langerin[] Histology ( Fig. 16-35 ) shows large cells with malignant features including hyperchromatic nuclei and prominent nucleoli.[]

  • Plasmablastic Lymphoma

    The histological examination of the specimen showed a diffuse proliferation of round- to oval-shaped large cells with scant cytoplasm, and prominent nucleoli.[] The tumor consisted of a monotonous proliferation of undifferentiated large cells with relatively abundant cytoplasm, eccentrically located round nuclei with prominent nucleoli[] , some neoplastic cells with prominent nucleoli, apoptosis and necrosis were often presented.[]

  • Clear Cell Sarcoma

    Biopsy of a 2.5 cm mass showed nests of large round to oval neoplastic cells with abundant amphophilic to clear cytoplasm, prominent nucleoli and high mitotic activity.[] Prominent nucleoli - basophilic - key feature . /-Binucleation. DDx: Malignant melanoma . PEComa . Carcinoma. Images Clear cell sarcoma - intermed. mag.[] […] not prominent Prominent large nucleoli Lacks necrosis Frequent necrosis Epithelioid Leiomyosarcoma Clear Cell Sarcoma No irregular nests Usually irregular nests HMB45 negative[]

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