Prominent Nucleoli: Causes & Reasons

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Possible Causes for Prominent Nucleoli

nucleoli and large, vesicular nuclei that vary substantially in size and shape. [mendelian.co]

[…] pedunculated, well-circumscribed papules with an average size of 5 mm, histologically predominantly composed of epithelioid melanocytes with abundant amphophilic cytoplasm, prominent [mendelian.co]

Lipid Cell Tumor of the Ovary

uniform nuclei, prominent nucleoli Abundant pale (lipid-rich) cytoplasm Abundant lipid (oil red-O stain) Two atypical mitotic figures Images hosted on other servers: H&E [pathologyoutlines.com]

Cytoplasm is vacuolated to eosinophilic and granular with vesicular nuclei along with presence of prominent nucleoli. [ijpmonline.org]

The nuclei were large vesicular nuclei with prominent nucleoli and showed a moderate degree of nuclear pleomorphism. [jmedicalcasereports.biomedcentral.com]

Plasmablastic Lymphoma

The histological examination of the specimen showed a diffuse proliferation of round- to oval-shaped large cells with scant cytoplasm, and prominent nucleoli. [ncbi.nlm.nih.gov]

The tumor consisted of a monotonous proliferation of undifferentiated large cells with relatively abundant cytoplasm, eccentrically located round nuclei with prominent nucleoli [ncbi.nlm.nih.gov]

They have large vesicular nuclei, multiple prominent nucleoli, and moderate amount of eosinophilic cytoplasm. Mitotic activity is brisk. [webpathology.com]

Hereditary Leiomyomatosis and Renal Cell Cancer

The morphologic features of renal tumors that arise in the setting of HLRCC are well described, the hallmark feature being the presence of prominent eosinophilic nucleoli [doi.org]

[…] eosinophilic nucleoli with a clear perinucleolar halo May have prominent nucleoli Both can show tubulocystic architecture and have similar cytologic features including prominent [surgpathcriteria.stanford.edu]

The renal cell carcinomas have prominent eosinophilic nucleoli surrounded by a clear halo. [en.wikipedia.org]

Malignant Angioendotheliomatosis

The cells are large, with 1 or more prominent nucleoli, scant cytoplasm, and frequent mitotic figures, and are commonly positive for cluster of differentiation markers 79a [ncbi.nlm.nih.gov]

Leydig Cell Tumor of the Testis

Occasionally, pleomorphic cells with hyperchromatic nuclei and prominent nucleoli were seen. Immunocytochemistry was positive against vimentin, inhibin, and calretinin. [ncbi.nlm.nih.gov]

Round or ovoid nuclei, prominent nucleoli, rarely binucleated or multinucleated. [auanet.org]

The high-power view shows the typical large, irregularly shaped, overlapping nuclei with multiple prominent nucleoli. [slideshare.net]

Epithelioid Cell Sarcoma

The proximal variant (with larger cells, prominent nucleoli, and rhabdoid changes) is clinically more aggressive. [ncbi.nlm.nih.gov]

The cells had vesicular nuclei with prominent nucleoli. Binucleated and multinucleated forms were noted [ [Figure 1] a]. [jcytol.org]

Individual cells had moderate eosinophilic cytoplasm, and round to oval enlarged vesicular nuclei with prominent nucleoli [Figure 4]. [e-ijd.org]

Primary Effusion Lymphoma

Figure 2: Marked pleomorphic lymphocytes, loose chromatin, several prominent nucleoli and deep cytoplasmatic basophilia with vacuoles in occasional cells. [aclr.com.es]

The effusions show a dispersed population of large pleomorphic cells with eccentrically located nuclei, 1 or more prominent nucleoli, a perinuclear pallor, and moderately [mdanderson.influuent.utsystem.edu]

Cytological analysis of the pleural effusion revealed a high-grade lymphoma with round nuclei, prominent nucleoli and abundant cytoplasm with immunophenotypes positive for [ncbi.nlm.nih.gov]

Alveolar Soft-Tissue Sarcoma

Prominent nucleoli No crystals Crystals in up to 80% of cases Uniformly desmin, actin positive Occasionally desmin, actin positive Frequently MyoD1 positive MyoD1 rare or [surgpathcriteria.stanford.edu]

nucleoli Vascular invasion common; also characteristic rod-shaped crystalloids No / rare mitotic figures, minimal pleomorphism Microscopic (histologic) images Images hosted [pathologyoutlines.com]

- The tumour cells are large, round to oval shaped, with eosinophilic granular cytoplasm, eccentric rounded nuclei and prominent nucleoli. - The cellular aggregates show [histopathology-india.net]

Atypical Teratoid Rhabdoid Tumor

The CSF cytomorphologic findings of the AT/RT cells are most notably large cells, eccentrically placed pleomorphic nuclei, prominent nucleoli and, commonly, cytoplasmic inclusions [ncbi.nlm.nih.gov]

The most consistent cytologic features of AT/RT are the large size of the tumor cells, eccentricity of the nuclei, and prominent nucleoli. [ncbi.nlm.nih.gov]

The surgically resected mass was marked by sheets of cells with large nuclei and prominent nucleoli. [ncbi.nlm.nih.gov]

Hilar Cell Tumor of the Ovary

The cells forming these aggregates were large with oval to round eosinophilic cytoplasm and vesicular nuclei containing prominent nucleoli (Figure 1B). [turkjpath.org]

Cytoplasm is vacuolated to eosinophilic and granular with vesicular nuclei along with presence of prominent nucleoli. [ijpmonline.org]

Nucleoli are occasionally moderately prominent, particularly in luteinized tumors which often lack nuclear grooves. [basicmedicalkey.com]

Gemistocytic Astrocytoma

nucleoli Background is coarse fibrillary; perivascular lymphocyte cuffing is common Microscopic (histologic) images Images hosted on other servers : Astrocytes with abundant [pathologyoutlines.com]

The nucleus of the cell showed even granular chromatin and occasional prominent nucleoli. [jlponline.org]

(Images 03, 04 and 05 ) The large cells have pleomorphic nuclei with dispersed chromatin and prominent nucleoli, with occasional eosinophilic intranuclear inclusions (Images [path.upmc.edu]

Primary Malignant Melanoma of the Cervix

nucleoli (Figs. 1 and 2). [scielo.br]

The cells showed hyperchromatic nuclei, prominent nucleoli, intranuclear inclusions, and abundant eosinophilic cytoplasm [Figure 1]a. [cancerjournal.net]

The histopathological examination showed clusters of atypical spindle cells with prominent nucleoli and eosinophilic cytoplasm [Figure 3], with evident intra- and extracellular [jcmtjournal.com]

Ductal Carcinoma in Situ

The prominent nucleoli are the best discriminator between the two. [docksci.com]

Histologically, the mass is composed of large cells with vesicular nuclei and prominent nucleoli. [usmleforum.com]

Atypical stromal cells with enlarged nuclei and prominent nucleoli are admixed with a prominent inflammatory infiltrate (B). [abdominalkey.com]

Microglandular Adenosis

[…] layer but thick basement membrane Atypical microglandular adenosis: Pleomorphic glands and microacini Budding glandular units and luminal bridging, mild cytologic atypia, prominent [pathologyoutlines.com]

nucleoli, apoptosis Increased Ki67 and p53 staining (5-10% of cells) Carcinomas retain the immunophenotype of microglandular adenosis Richard L Kempson MD Robert V Rouse [surgpathcriteria.stanford.edu]

It often shows budding glandular units and luminal bridging, with occasional mitotic figures and some cytologic atypia, including vesicular nuclei and prominent nucleoli [archivesofpathology.org]

Testicular Seminoma

Tumour cells have abundant pale cytoplasm, large vesicular nuclei and prominent nucleoli. [radiopaedia.org]

Fig 67b – Germinoma –Large single cells with unique central vesicular nuclei and with prominent nucleoli. Lymphocytes are abundant (H&E). [eurocytology.eu]

The tumor cells have abundant eosinophilic cytoplasm, pleomorphic hyperchromatic nuclei, one or more prominent nucleoli, and show brisk mitotic activity. [webpathology.com]

Bronchial Adenocarcinoma

Discohesive malignant cells with lack of gland formation, vesicular chromatin, and prominent nucleoli. [eurocytology.eu]

Non-Small Cell Lung Cancers (NSCLCs) In general, NSCLCs are distinguished from SCLCs by their much more abundant cytoplasm, prominent nucleoli, and their tendency to grow [pathwaymedicine.org]

Figure 4 Morphology of combined adenocarcinoma. ( a ) Adenocarcinoma shows vesicular nuclei with prominent nucleoli. [nature.com]

Tonsillar Lymphoepithelioma

Tumour cells contained large central nuclei with prominent nucleoli and surrounding abundant eosinophilic cytoplasm (fig 2). [jcp.bmj.com]

Syncytial growth with oval or round vesicular nuclei and prominent nucleoli CK5 / 6+ EBER+ p63+ Contributed by Andrey Bychkov, M.D., Ph.D. [pathologyoutlines.com]

The nuclei were round with slightly irregular contours and exhibit one or two prominent nucleoli. [papsociety.org]

Anorectal Malignant Melanoma

Biopsy from polypoidal growth in rectum revealed tumor cells in lobules and nests with vesicular nuclei, prominent nucleoli and scant cytoplasm, with few cells containing [amhsjournal.org]

nucleoli. [jmsh.ac.in]

The tumor cells had eosinophilic cytoplasm and high nucleus to cytoplasm ratio and prominent nucleoli. Frequent mitoses and focal tumor necrosis were found. [tro.amegroups.com]

Hairy Cell Leukemia Variant

nucleoli and blastic / convoluted nuclei; negative staining for CD25, Annexin A1 and TRAP on tumor cells; patients are resistant to conventional chemotherapeutic regimen [pathologyoutlines.com]

Prominent nucleoli were observed in most HCL-v but rarely in HCL. A third of HCL and HCL-v marrows were hypocellular or aplastic-appearing. [ncbi.nlm.nih.gov]

Fig. 1 a PB smear showing large cells with villous projections and prominent nucleoli. [link.springer.com]

Diffuse Lymphoma

Aggressive histology means that many of the lymphoma cells are highly atypical: large and irregular, with vesicular nuclei and prominent nucleoli. [pleiad.umdnj.edu]

May have prominent nucleoli Uniform cells Heterogeneous cells Generally only a problem in suboptimally processed specimens Diffuse Mixed Lymphoma DLBCL 50-75% of cells are [surgpathcriteria.stanford.edu]

The most characteristic cell, called a "centroblast", has a large, open nucleus with several moderately prominent nucleoli that apply themselves to the nuclear membrane. [pleiad.umdnj.edu]

Benign Interstitial Cell Tumor of the Testis

Round or ovoid nuclei, prominent nucleoli, rarely binucleated or multinucleated. [auanet.org]

The high-power view shows the typical large, irregularly shaped, overlapping nuclei with multiple prominent nucleoli. [slideshare.net]

Comment: The tumour consists of polygonal cells with abundant eosinophilic cytoplasm, round nuclei with prominent nucleoli. Features suggestive of malignancy are absent. [librepathology.org]

Pleomorphic Rhabdomyosarcoma

Tumor cells had granular hyperchromatic nucleiwith prominent nucleoli. Cross-striations in their cytoplasm were not observed. [jstage.jst.go.jp]

Most tumor cells had large prominent nucleoli. Background rhabdomyoblasts varied from spindled to polygonal. [ncbi.nlm.nih.gov]

Most tumor cells showed severe cytologic atypia manifested in prominent nucleoli and pleomorphic nuclei. Tumor cells were focally positive for desmin. [diagnosticpathology.biomedcentral.com]

Peripheral Neuroblastoma

Minireview 84 Downloads 16 Citations Abstract The presence of large cells having simultaneously increased cytoplasmic and nuclear volume accompanied by prominent nucleoli; [link.springer.com]

[…] eosinophilic cytoplasm Indistinct cell borders Ganglion cells Large round nuclei with prominent nucleoli Abundant eosinophilic cytoplasm Nissl substance in cytoplasm Basophilic [surgpathcriteria.stanford.edu]

It is differentiated into large ganglion like cells with the prominent nucleoli. [omicsonline.org]

Granulocytic Sarcoma

nucleoli (blast cells) Few large monocytoid cells with prominent nucleoli Cytology images Images hosted on other servers: FNA breast (fig 2C-2E) Back to top [pathologyoutlines.com]

Nucleoli are frequently prominent and the number of mitotic figures is variable. [bjo.bmj.com]

Cytomorphology is accurate and efficient to confirm the diagnosis. [3], [4] Figure 2: Cytological smear showing myeloblast with prominent nucleoli and band forms Click here [indianjcancer.com]

Sertoli Cell Tumor of the Testis

The high-power view shows the typical large, irregularly shaped, overlapping nuclei with multiple prominent nucleoli. [slideshare.net]

Leydig cell tumor Leydig cells vary in size but usually have round nuclei, single prominent nucleoli, and abundant eosinophilic cytoplasm or abundant clear cytoplasm (see [emedicine.medscape.com]

nucleoli, no nuclear grooves, no inclusions Rarely mild nuclear atypia and pleomorphism Intervening stroma is fibrous; variably cellular, hyalinized, edematous, containing [pathologyoutlines.com]

Subependymal Giant Cell Astrocytoma

nucleoli NSE Negative stains HMB45 (unlike other tuberous sclerosis related lesions) Back to top [pathologyoutlines.com]

Histologically, the tumors were composed of large polygonal cells with vesicular nuclei, prominent nucleoli and glassy eosinophilic cytoplasm, intermingled with spindle and [ncbi.nlm.nih.gov]

The nucleus of the cell showed even granular chromatin and occasional prominent nucleoli. [jlponline.org]

B-Cell Prolymphocytic Leukemia

The morphology of these cells was compatible with prolymphocytes with prominent nucleoli and condensed nuclear chromatin. A diagnosis of B-PLL was made. [ncbi.nlm.nih.gov]

nucleoli. [jpatholtm.org]

[…] and biopsy revealed diffuse infiltration of medium to large prolymphocytes having moderate amount of basophilic cytoplasm, round to oval nuclei with coarse chromatin, and prominent [jpatholtm.org]

Blue Nevus

Malignant blue nevi arise within cellular blue nevi and contain atypical mitoses, necrosis, nuclear pleomorphism and prominent nucleoli. [ncbi.nlm.nih.gov]

In all cases, malignancy was evidenced by increased mitotic rate, necrosis, nuclear atypia, pleomorphism, hyperchromasia, and prominent nucleoli. [doi.org]

Celiac Disease with Diffuse Intestinal Ulceration

[…] crypt epithelium; villous atrophy due to celiac disease may be present Most commonly: relatively monotonous medium to large cells with round / angulated vesicular nuclei, prominent [pathologyoutlines.com]

These lymphocytes exhibited marked nuclear pleomorphism, vesicular nuclei, prominent nucleoli, and abundant cytoplasm. [journals.plos.org]

nucleoli and moderate / abundant pale cytoplasm Less commonly: marked pleomorphism with multinucleated cells similar to anaplastic large cell lymphoma Infiltration by inflammatory [pathologyoutlines.com]