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27 Possible Causes for Prominent Perivascular Spaces

  • Mucopolysaccharidosis 1H

    The estimated incidence is 1:100,000. macrocephaly prominent perivascular spaces pachymeningiopathy J-shaped sella concave articular surface of mandibular condyle cord compression[radiopaedia.org] , cortical atrophy, and enlargement of the perivascular spaces.[surgicalneurologyint.com] perivascular spaces hepatosplenomegaly History and etymology It is named after Gertrud Hurler (1889-1965), a German pediatrician 1 .[radiopaedia.org]

  • Macrocephaly-Developmental Delay Syndrome

    Brain MRI typically shows prominent Virchow-Robin/perivascular spaces with a posterior predominance (Figure 1).[consultqd.clevelandclinic.org] Review of his brain MRI, reported as normal, showed slightly prominent perivascular spaces on T2-weighted imaging with a posterior predominance.[consultqd.clevelandclinic.org] Sagittal (left) and axial (right) T2-weighted images with prominent perivascular spaces showing a posterior predominance in a young child with germline PTEN gene mutation.[consultqd.clevelandclinic.org]

  • Pseudo-Hurler Polydystrophy

    The estimated incidence is 1:100,000. macrocephaly prominent perivascular spaces pachymeningiopathy J-shaped sella concave articular surface of mandibular condyle cord compression[radiopaedia.org] perivascular spaces hepatosplenomegaly History and etymology It is named after Gertrud Hurler (1889-1965), a German pediatrician 1 .[radiopaedia.org] […] involvement cardiac valve disease: early onset severe regurgitation and stenosis coronary artery disease cardiomegaly: initially hypertrophic then dilated Other features include prominent[radiopaedia.org]

  • Mucopolysaccharidosis 1 H-S

    The estimated incidence is 1:100,000. macrocephaly prominent perivascular spaces pachymeningiopathy J-shaped sella concave articular surface of mandibular condyle cord compression[radiopaedia.org] perivascular spaces hepatosplenomegaly History and etymology It is named after Gertrud Hurler (1889-1965), a German pediatrician 1 .[radiopaedia.org] […] involvement cardiac valve disease: early onset severe regurgitation and stenosis coronary artery disease cardiomegaly: initially hypertrophic then dilated Other features include prominent[radiopaedia.org]

  • PTEN Hamartoma Tumor Syndrome

    Brain MRI typically shows prominent Virchow-Robin/perivascular spaces with a posterior predominance (Figure 1).[consultqd.clevelandclinic.org] Review of his brain MRI, reported as normal, showed slightly prominent perivascular spaces on T2-weighted imaging with a posterior predominance.[consultqd.clevelandclinic.org] Sagittal (left) and axial (right) T2-weighted images with prominent perivascular spaces showing a posterior predominance in a young child with germline PTEN gene mutation.[consultqd.clevelandclinic.org]

  • Lissencephaly

    RESULTS: Most patients with LIS1 mutations demonstrated posterior agyria (grade 3a, 55.3%) with thin corpus callosum (50%) and prominent perivascular spaces (67.4%).[ncbi.nlm.nih.gov]

  • Boucher-Neuhauser Syndrome

    Prominent perivascular spaces (15.3%) and restricted diffusion in the splenium of the corpus callosum (7.6%) were less frequent findings.[ajnr.org]

  • Thymoma

    […] septa Perivascular spaces usually prominent Sharp borders Contain scattered lymphocytes Central vessel usually visible Scant reticulin between epithelial cells Infrequently[surgpathcriteria.stanford.edu] Thymomas with epithelial predominance contain prominent perivascular spaces with lymphocytes, proteinaceous fluid, red blood cells, and foamy macrophages.[atlasgeneticsoncology.org] Perivascular spaces are common and on occasion very prominent. A perivascular arrangement of tumor cells that results in a palisading effect may be seen.[itmig.org]

  • Rocky Mountain Spotted Fever

    Four of these were abnormal: 1 patient had “prominent perivascular spaces,” 1 had focal arterial infarctions, 1 had diffuse edema, and 1 had meningeal enhancement.[neurology.org]

  • Osteogenesis Imperfecta Typ 4

    Chronic subcortical ischemic changes in the left parietal lobe and prominent perivascular spaces in the bilateral centra semiovale were also noted.[ajnr.org]

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