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297 Possible Causes for Proopiomelanocortin Deficiency

  • Obesity

    Diabetes 55 : 2549 – 2553 26 2005 Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids.[doi.org] Annu Rev Genet 37 : 67 – 90 28 2003 Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4–10.[doi.org] Complete POMC Deficiency In 1998, Krude et al . provided the first description of humans congenitally lacking proopiomelanocortin ( POMC ) gene products ( 24 ).[doi.org]

  • Familial Hypercholesterolemia

    Deficiency 2 Propionic Acidemia 6 Proprotein Convertase 1/3 Deficiency 7 Prostate Cancer 9 Prothrombin Deficiency, Congenital 3 Protoporphyria, Erythropoietic, X-Linked 3[preventiongenetics.com] Epilepsy With Ataxia 1 Progressive Osseous Heteroplasia 2 Progressive Sclerosing Poliodystrophy 7 Prolactinoma, Familial 1 Prolonged Electroretinal Response Suppression 2 Proopiomelanocortin[preventiongenetics.com]

  • Dilated Cardiomyopathy Type 2B

    Deficiency 2 Propionic Acidemia 6 Proprotein Convertase 1/3 Deficiency 7 Prostate Cancer 9 Prothrombin Deficiency, Congenital 3 Protoporphyria, Erythropoietic, X-Linked 3[preventiongenetics.com] Epilepsy With Ataxia 1 Progressive Osseous Heteroplasia 2 Progressive Sclerosing Poliodystrophy 7 Prolactinoma, Familial 1 Prolonged Electroretinal Response Suppression 2 Proopiomelanocortin[preventiongenetics.com]

  • Eating Disorder

    Meal pattern analysis in neural-specific proopiomelanocortin-deficient mice. Eur J Pharmacol 2011; 660 : 131–138. 32.[doi.org]

  • Luteinizing Hormone Deficiency

    deficiency syndrome Psychosocial growth hormone deficiency RHYNS syndrome Secondary hypopituitarism Secondary pituitary - hypothalamic infertility Sheehan's syndrome Stenosis[icdlist.com] Prepuberal panhypopituitarism Primary hypergonadotropic hypogonadism and partial alopecia syndrome Primary pituitary - hypothalamic infertility Primary testicular failure Proopiomelanocortin[icdlist.com]

  • Adrenal Infarction

    (CPHD) Congenital Isolated ACTH Deficiency Pituitary Apoplexy/Hemorrhage Sheehan’s Syndrome (Post-Partum Pituitary Necrosis) Pituitary Irradiation Proopiomelanocortin Deficiency[mdnxs.com] ACTH consists of the precursor of proopiomelanocortin, which branches off into the melanocyte-stimulating hormone (MSH) and endorphins.[lecturio.com] Granulomatosis (see Wegener’s Granulomatosis, [[Wegeners Granulomatosis]]) Tuberculosis (see Tuberculosis, [[Tuberculosis]]) Other Autoimmune Hypophysitis Combined Pituitary Hormone Deficiency[mdnxs.com]

  • Kostmann Syndrome

    Prolidase Deficiency Carlos Ferreira and Heng Wang. Initial Posting: June 25, 2015. Proopiomelanocortin Deficiency Ben G Challis and George WM Millington.[ncbi.nlm.nih.gov]

  • Ventricular Arrhythmia

    Prolidase Deficiency Carlos Ferreira and Heng Wang. Initial Posting: June 25, 2015. Proopiomelanocortin Deficiency Ben G Challis and George WM Millington.[ncbi.nlm.nih.gov]

  • Long QT Syndrome

    Prolidase Deficiency Carlos Ferreira and Heng Wang. Initial Posting: June 25, 2015. Proopiomelanocortin Deficiency Ben G Challis and George WM Millington.[ncbi.nlm.nih.gov]

  • Congenital Isolated ACTH Deficiency

    POMC gene defects have been shown to result in a phenotype of ACTH deficiency combined with red hair and obesity.[endocrine-abstracts.org] We demonstrated that human and mouse mutations of the TPIT gene cause a neonatal-onset form of congenital isolated ACTH deficiency (IAD).[lirias.kuleuven.be] Candidate genes include proopiomelanocortin (POMC), prohormone convertase 1 (PC1), corticotropin releasing hormone (CRH) and its receptor (CRH-R1).[endocrine-abstracts.org]

Further symptoms