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207 Possible Causes for Protein Electrophoresis Abnormal

  • Multiple Myeloma

    Serum protein electrophoresis demonstrated an immunoglobulin G kappa monoclonal gammopathy, and bone marrow aspiration revealed 30% involvement by abnormally appearing plasma[ncbi.nlm.nih.gov] […] of having an M-protein (detected by electrophoresis, immunofixation, or both) and an abnormal kappa-lambda FLC-ratio separately ( Table 2 ) among subjects subsequently diagnosed[doi.org] Using assays for monoclonal (M)–proteins (electrophoresis/immunofixation) and kappa-lambda free light chains (FLCs), we determined longitudinally the prevalence of MGUS and[doi.org]

  • Idiopathic Cryoglobulinemia

    It would appear that these abnormal serum proteins even with the same physico-chemical properties by electrophoresis and ultracentrifugation can be differentiated and classified[jstage.jst.go.jp]

  • Alpha-1 Antitrypsin Deficiency

    […] folding, blocking its movement along the remainder of the secretory pathway Diagnosis Serum protein electrophoresis; liver biopsy to determine extent of histologic damage[pathologyoutlines.com] […] serum AAT but no disease AAT deficiency variants: secretory protein does not move from endoplasmic reticulum to Golgi; for PiZ, is due to single AA substitution, causing abnormal[pathologyoutlines.com]

  • Gamma-Heavy Chain Disease

    No serum abnormality was noted on serum protein electrophoresis (SPEP).[ncbi.nlm.nih.gov] The abnormal gamma-chain protein had a alpha2-globulin mobility and was immunochemically related to the Fc fragment.[ncbi.nlm.nih.gov] Serum and urine protein electrophoresis demonstrated a monoclonal protein migrating in the beta region.[ncbi.nlm.nih.gov]

  • Monoclonal Gammapathy

    When this immunoglobulin is produced from genetically identical (clonal) plasma cells, it is able to be identified on a blood test (serum protein electrophoresis).[melbournehaematology.com.au] Detection of an M-protein is accomplished by electrophoresis on agarose or cellulose acetate followed by immunoelectrophoresis or immunofixation.[link.springer.com] This abnormal protein is called a paraprotein (monoclonal gamma globulin, hence "monoclonal gammopathy"). MGUS commonly affects older people (more than 70 years old).[melbournehaematology.com.au]

  • Heavy Chain Disease

    No serum abnormality was noted on serum protein electrophoresis (SPEP).[ncbi.nlm.nih.gov] The abnormal protein concentration in the serum was unusually high, 38 g/l measured in our patient is the highest reported value in the literature so far.[ncbi.nlm.nih.gov] Capillary zone electrophoresis in the evaluation of serum protein abnormalities. Am J Clin Pathol 1998 ; 110 : 248 -252. Bossuyt X , Marien G.[clinchem.aaccjnls.org]

  • IgE Myeloma

    Serum protein electrophoresis showed a monoclonal protein in the gammaglobulin fraction. Immunofixation confirmed the presence of an IgE kappa monoclonal protein.[ncbi.nlm.nih.gov] This test is often done when the results of a blood protein electrophoresis or total blood protein test are abnormal.[northshore.org] Serum protein electrophoresis showed a monoclonal protein in the beta-globulin fraction. Immunofixation confirmed the presence of an IgE kappa monoclonal protein.[ncbi.nlm.nih.gov]

  • Kappa Chain Deficiency

    . 6 View/Print Figure Figure 2 Abnormal serum protein electrophoresis pattern in a patient with multiple myeloma.[aafp.org] Initially, the test is ordered along with a serum protein electrophoresis test to detect abnormal monoclonal protein (M-protein) production and to calculate a kappa/lambda[labtestsonline.org.au] Initially, serum free light chain testing is ordered along with a serum protein electrophoresis test to detect abnormal monoclonal protein (M-protein) production and to calculate[labtestsonline.org]

  • Systemic Amyloidosis

    Urine protein electrophoresis was abnormal, with a 24-hour total urine protein level of 1.229 g/vol (reference range, 0.05 0.10 g/vol) and an M-protein spike (λ light chain[cutis.com] Initially, serum free light chain testing is ordered along with a serum protein electrophoresis test to detect abnormal monoclonal protein (M-protein) production and to calculate[labtestsonline.org] If the protein electrophoresis test is abnormal, then an immunofixation electrophoresis test is performed to determine which immunoglobulin is present in excess.[labtestsonline.org]

  • Cryoglobulinemia

    Protein electrophoresis - blood -- may show an abnormal antibody protein. Urinalysis -- may show blood in the urine if the kidneys are affected.[medlineplus.gov]

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