Protein S Deficiency: Causes & Reasons

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Possible Causes for Protein S Deficiency

Stroke

C deficiency, protein S deficiency, pregnancy) Sickle cell disease Fibromuscular dysplasia Arterial dissections Vasoconstriction associated with substance abuse (eg, cocaine [emedicine.com]

Testing for protein C, protein S, and antithrombin deficiency is generally indicated 2 to 4 weeks after completion of anticoagulation. [doi.org]

[…] other patients, especially younger patients, other causes should be considered, including the following: [7, 42] Hypercoagulable states (eg, antiphospholipid antibodies, protein [emedicine.com]

Mesenteric Vein Thrombosis

An underlying hypercoagulable state is often present, but protein S deficiency has rarely been implicated. [ncbi.nlm.nih.gov]

A protein S deficiency was found by means of an extensive workup for hypercoagulable state. [ncbi.nlm.nih.gov]

A family study demonstrated protein S deficiency in his father and in a sister. [ncbi.nlm.nih.gov]

Cerebral Thrombosis

A 52-year-old Chinese female with recurrent cerebral thrombosis associated with hereditary protein S deficiency is described. [ncbi.nlm.nih.gov]

| Article | PubMed Januario G, Ramroop S, Shingadia DV and Novelli V. Postinfectious purpura fulminans secondary to varicella-induced protein S deficiency. [hoajonline.com]

C, or protein S deficiency; homozygous factor V Leiden or prothrombin G20210A mutation; antiphospholipid antibodies; or combined prothrombotic conditions). [acepnow.com]

Superior Mesenteric Vein Thrombosis

Laboratory test showed low protein S activity and protein S antigen, leading to a diagnosis of superior mesenteric vein thrombosis caused by protein S deficiency. [jstage.jst.go.jp]

We report a case of a young adult man with SMVT due to a hypercoagulable state (protein S deficiency), in whom an early diagnosis and appropriate anticoagulant treatment prevented [ncbi.nlm.nih.gov]

Both patients completed a hypercoagulable workup; the female patient tested positive for protein S deficiency, while the male patient did not have a hypercoagulable predisposition [sages.org]

Intracranial Sinus Thrombosis

C or protein S deficiency, homozygous factor V Leiden or prothrombin G20210A mutation, antiphospholipid antibodies and combined abnormalities (good practice point). [ean.org]

| Article | PubMed Januario G, Ramroop S, Shingadia DV and Novelli V. Postinfectious purpura fulminans secondary to varicella-induced protein S deficiency. [hoajonline.com]

Protein C, protein S or antithrombin deficiency are known causes of thrombosis. [nature.com]

Thrombomodulin-Related Bleeding Disorder

Protein S Deficiency Thrombomodulin Heparin Cofactor II Tissue Factor Pathway Inhibitor Tissue Plasminogen Activator Plasminogen Activator Inhibitor 1 Thrombin-activatable [ihtc.org]

Type II deficiency is characterized by normal protein S levels but reduction in functional activity of protein S. [clotbase.bicnirrh.res.in]

antithrombin deficiency, protein C and protein S deficiency, TPA deficiency, and PAI-1 defects played no role in RMS. [46] However, in a similar study assessing hereditary [emedicine.medscape.com]

Recurrent Thrombophlebitis due to Hereditary Disorders

The most common inherited disorder of coagulation inhibitors is protein S deficiency. [rnceus.com]

Protein S Deficiency… Protein S deficiency is an uncommon clotting disorder: approximately 1 per 500 to 1 per 3,000 people has inherited protein S deficiency. [stoptheclot.org]

Protein S Deficiency Thrombomodulin Heparin Cofactor II Tissue Factor Pathway Inhibitor Tissue Plasminogen Activator Plasminogen Activator Inhibitor 1 Thrombin-activatable [ihtc.org]

Protein S Deficiency

Protein S deficiency at Curlie [en.wikipedia.org]

Patients with type II protein S deficiency, or functional deficiency, will have normal protein S levels but decreased activity of protein S. [symptoma.com]

Hereditary protein S deficiency is an autosomal dominant disorder caused by a PROS1 mutation. [ncbi.nlm.nih.gov]

Cerebral Venous Sinus Disorder

| Article | PubMed Januario G, Ramroop S, Shingadia DV and Novelli V. Postinfectious purpura fulminans secondary to varicella-induced protein S deficiency. [hoajonline.com]

Risk factors hormonal oral contraceptive pill, pregnancy, puerperium, steroids, hyperthyroidism prothrombotic hematological conditions protein S deficiency, polycythemia local [radiopaedia.org]

Protein S deficiency in men with long-term human immunodeficiency virus infection. Blood. 1993;81(7):1801-7. [panafrican-med-journal.com]

Sagittal Sinus Thrombosis

Of four cortical AVFs in two patients, thrombosis of cortical veins caused by protein S deficiency might play an important role in their formation. [ncbi.nlm.nih.gov]

Cerebral sinus thrombosis associated with acquired free protein S deficiency is very rare. [ncbi.nlm.nih.gov]

Congenital protein S deficiency is associated with an increased risk of venous thrombosis. [ncbi.nlm.nih.gov]

Calciphylaxis

Protein malnutrition increases the likelihood of calciphylaxis, as does warfarin use and hypercoagulable states, such as protein C and/or protein S deficiency. [ncbi.nlm.nih.gov]

Free protein S deficiency in hemodialysis patients due to vascular calcifications?. Nephron. 1996. 74(2):356-60. [Medline]. Rostaing L, el Feki S, Delisle MB, et al. [emedicine.com]

Hypercoagulable conditions, including protein C and protein S deficiencies, and the presence of a circulating anticoagulant have been described in a number of patients. [28 [emedicine.com]

Venous Thrombosis

It may occur in neonates with congenital severe protein C or protein S deficiencies, older children and adults with infections, or patients with protein C or protein S deficiency [patient.info]

To determine whether protein S deficiency is associated with recurrent thrombosis, we developed a functional assay for the plasma protein. [oadoi.org]

In particular, protein S levels are reduced by pregnancy and protein S deficiency cannot be diagnosed in pregnancy. [patient.info]

Protein C Deficiency

Protein S, Deficiency, Protein S, Protein S Deficiencies, Protein S Deficiency, DEFIC PROTEIN S, PROTEIN S DEFIC, protein S deficiency, protein S deficiency (diagnosis), [fpnotebook.com]

Pathophysiology Protein C neutralizes factors V and VIII Deficiency inherited Autosomal Dominant Venous thrombosis occurs if functional levels <50% Protein S is Cofactor for [fpnotebook.com]

Protein S Deficiency [Disease/Finding], deficiency protein s, s protein deficiency, protein s deficiencies, protein s deficiency, Hereditary Thrombophilia Due To Protein [fpnotebook.com]

Hereditary Protein C Deficiency

Protein S deficiency is caused by mutations in the PROS1 gene. [ghr.nlm.nih.gov]

Etiology Protein S deficiency is caused by mutations in the PROS1 gene (3q11-q11.2). [orpha.net]

[…] disease Protein C deficiency disorder Protein C resistance Protein S deficiency disease Protein S deficiency disorder Prothrombin G20210A mutation Prothrombin gene mutation [icd9data.com]

Hereditary Antithrombin Deficiency

These causes include polycythemia, thrombocytosis, antithrombin III deficiency, and protein C or protein S deficiency. [medical-dictionary.thefreedictionary.com]

Protein S deficiency. Genetics Home Reference.Available online at http://ghr.nlm.nih.gov/condition/protein-s-deficiency through http://ghr.nlm.nih.gov. [labtestsonline.it]

Non-Genetic Protein C and Protein S Deficiency Children with liver disease or vitamin K deficiency can also become deficient in protein C or protein S. [chla.org]

Hereditary Antithrombin Deficiency Type 2

이러한 역할을 하는 S 단백의 결핍은 결국 혈전증의 원인이 됩니다. 3. 증상 C 단백 결핍 (protein C deficiency) 또는 항트롬빈 결핍 (antithrombin deficiency) 와 비슷하게 정맥 혈전증이 특징적입니다. [health.cdc.go.kr]

Regulation of coagulation by protein S. Curr Opin Hematol 2008;15:529-36. 16. ten Kate MK, van der Meer J. Protein S deficiency: a clinical perspective. [e-ceth.org]

단백 결핍(Protein S deficiency) PROS1 유전자 돌연변이에 의해 발생, 상염색체 우성 유전 S 단백 결핍의 분자유전학적 진단: 직접염기서열분석검사를 통한 PROS1 유전자 돌연변이 검출률은 약 50%에 불과한 것으로 알려져 있다. [hema-research.or.kr]

Factor II Mutation

Family Member Testing for Thrombophilia February 2nd, 2011 | Clotting disorder - thrombophilia, Factor V Leiden, Inherited (genetic), Protein C deficiency, Protein S deficiency [patientblog.clotconnect.org]

Protein S Deficiency Thrombomodulin Heparin Cofactor II Tissue Factor Pathway Inhibitor Tissue Plasminogen Activator Plasminogen Activator Inhibitor 1 Thrombin-activatable [ihtc.org]

S deficiency. [karger.com]

Hereditary Factor I Deficiency

In these respects protein S deficiency is similar to protein C deficiency. FULL TEXT [annals.org]

[…] the protein S gene causing protein S deficiency. [medtextfree.wordpress.com]

C, or protein S deficiency [ 26 ]. [thrombosisjournal.biomedcentral.com]

Thrombophilia due to Activated-Protein C Resistance

C deficiency disease, protein C deficiency disorder, protein C resistance, protein S deficiency disease, protein S deficiency disorder, prothrombin G20210A mutation, prothrombin [healthresearchfunding.org]

protein C deficiency Heterozygous protein S deficiency Heterozygous prothrombin G20210A mutation Homozygous Factor V Leiden mutation Homozygous protein C deficiency Homozygous [icd9data.com]

Antithrombin Deficiency

Antithrombin deficiency is considered the least common of the three main anticoagulant deficiencies (the other two being protein C deficiency and protein S deficiency ). [radiopaedia.org]

Applicable To Antithrombin III deficiency Hypercoagulable state NOS Primary hypercoagulable state NEC Primary thrombophilia NEC Protein C deficiency Protein S deficiency Thrombophilia [icd10data.com]

ATIII deficiency is found in between 4 and 6 percent of young patients with venous thrombosis, similar to but slightly lower than the prevalence of protein C and protein S [ncbi.nlm.nih.gov]

Neonatal Purpura Fulminans

Abstract Homozygous protein C deficiency or homozygous protein S deficiency are rare genetic diseases with catastrophic and fatal purpura fulminans-like or thrombotic complications [ncbi.nlm.nih.gov]

Therefore, protein C or S deficiency predisposes to a decreased capacity to reduce thrombin generation and hypercoagulable state Protein C deficiency, 2008 Protein S defiency [flipper.diff.org]

Neonatal purpura fulminans is associated with a severe protein C or S deficiency. [unboundmedicine.com]

Purpura Fulminans

S deficiency. [ncbi.nlm.nih.gov]

Acquired protein S deficiency is a rare complication of varicella zoster infection often resulting in purpura fulminans, which is a potentially life-threatening syndrome of [ncbi.nlm.nih.gov]

Cerebral Vein Thrombosis

| Article | PubMed Januario G, Ramroop S, Shingadia DV and Novelli V. Postinfectious purpura fulminans secondary to varicella-induced protein S deficiency. [hoajonline.com]

[…] anemia is associated with CVT Hemoglobinopathies (ex, Sickle Cell Disease ) Pro-thrombotic Disorders (noted in 12-50%) Anticardiolipin antibody Protein C and Protein S deficiencies [pedemmorsels.com]

C and S deficiency which was precipitated by malposition of subclavian central catheter into internal jugular vein. [ncbi.nlm.nih.gov]

Thrombophlebitis

S deficiency, protein C deficiency, or factor V Leiden are also at increased risk of thrombophlebitis. [en.wikipedia.org]

C and Protein S deficiencies. [eliankermd.com]

protein C deficiency protein S deficiency Your doctor will examine the affected area and the skin. [healthline.com]

Prata-Libéral-Gonçalves Syndrome

[…] with prostatic abscess Prostatitis Protein C deficiency Protein R deficiency Protein S acquired deficiency Protein S deficiency Proteus like syndrome mental retardation eye [bioreference.net]

Prostatitis Protein C deficiency[?] Protein R deficiency[?] Protein S acquired deficiency[?] Protein S deficiency[?] [encyclopedia.kids.net.au]

Progressive supranuclear palsy atypical Progressive supranuclear palsy Progressive systemic sclerosis Prol-Prou Prolactinoma, familial Prolerating trichilemmal cyst Prolidase deficiency [academickids.com]

Hereditary Thrombophilia due to Congenital Protein S Deficiency

Mild protein S deficiency will thus present with selective deficiency of free protein S, whereas more pronounced protein S deficiency will also decrease the complexed protein [mendelian.co]

Protein S deficiency, Thrombophilia due to protein S deficiency, autosomal dominant (THPH5) [MIM:612336] 93,898,524(-) T/C coding_sequence_variant, missense_variant rs121918474 [genecards.org]

Protein S deficiency is caused by mutations in the PROS1 gene. [ghr.nlm.nih.gov]

Pfeiffer-Palm-Teller Syndrome

Prostatitis Protein C deficiency[?] Protein R deficiency[?] Protein S acquired deficiency[?] Protein S deficiency[?] [encyclopedia.kids.net.au]

[…] associated with prostatic abscess * Prostatitis * Protein C deficiency * Protein-energy malnutrition * Protein R deficiency * Protein S acquired deficiency * Protein S deficiency [en.academic.ru]

Hereditary Coagulopathy

protein S Normal total and free protein S, functionally abnormal protein S For full discussion, see Protein S Deficiency. [emedicine.medscape.com]

Protein S Deficiency Thrombomodulin Heparin Cofactor II Tissue Factor Pathway Inhibitor Tissue Plasminogen Activator Plasminogen Activator Inhibitor 1 Thrombin-activatable [ihtc.org]

Protein C or protein S deficiency. Protein C and protein S help to regulate the bleeding and clotting system. [rileychildrens.org]

Hepatoportal Sclerosis

C Deficiency/congenital/diagnosis/therapy ; Protein S Deficiency/congenital/diagnosis/therapy ; Sclerotherapy ; Thrombocytopenia/congenital/diagnosis/therapy Abstract : [ [orbi.uliege.be]

S deficiency leads to obliterative portal venopathy and to compensatory nodular regenerative hyperplasia in HIV-infected patients. ( 19512859 ) 2009 32 Response to Schiano [malacards.org]

S deficiency leads to obliterative portal venopathy and to compensatory nodular regenerative hyperplasia in HIV-infected patients. ( 19512859 ) Mallet V.O....Pol S. 2009 [malacards.org]

Hepatic Vein Occlusion

C or Protein S deficiency, Leiden mutation...) or other factors like: polycythemia vera; use of oral contraceptives; trauma (cause of a new abnormality of hepatic vein); [wikilectures.eu]

ETIOLOGY Hypercoagulable states: • Myeloproliferative disease: Polycythemia vera Essential thrombocytosis • Protein C deficiency • Antithrombin III deficiency • Protein S [encyclopedia.lubopitko-bg.com]

Examples of genetic tendencies include protein C deficiency, protein S deficiency, the Factor V Leiden mutation, hereditary anti-thrombin deficiency and prothrombin mutation [ipfs.io]