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486 Possible Causes for Prothrombin Time Increased

  • Chronic Alcoholism

    time Hypoalbuminemia Liver enzyme levels Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels elevated, usually 300 U/L; AST/ALT ratio 2:1 Hematologic[clevelandclinicmeded.com] Anemia Leukocytosis or leukopenia Thrombocytopenia Increased serum globulin levels Metabolic Elevated blood ammonia level Hyperglycemia Respiratory alkalosis Hypomagnesemia[clevelandclinicmeded.com] Splenomegaly Ascites Hepatic tenderness Neurologic Asterixis Confusion, stupor Laboratory Findings Liver synthetic function Hyperbilirubinemia (usually conjugated) Prolonged prothrombin[clevelandclinicmeded.com]

  • Liver Cirrhosis

    Albumin – levels fall as the synthetic function of the liver declines with worsening cirrhosis, since albumin is exclusively synthesized in the liver Prothrombin timeincreases[en.wikipedia.org] […] of endoscopy), and prothrombin time were found to be associated with an increased risk of rebleeding.[dx.doi.org] Multivariate analysis identified previous long term endoscopic treatment (p 0.04), and prothrombin time (p 0.004) as independent variables predicting rebleeding (table 5 )[dx.doi.org]

  • Portal Cirrhosis

    .  Prothrombin time - increases since the liver synthesizes clotting factors.  Globulins - increased due to shunting of bacterial antigens away from the liver to lymphoid[slideshare.net] As the liver synthesizes clotting factors, this will be impaired in disease; prothrombin time will increase. And coagulation studies will be deranged as well.[kenhub.com]

  • Disseminated Intravascular Coagulation

    Moderate increase Strong increase Fibrinogen (g/L) 1 Prothrombin time (increase in seconds) 3-6 6 FEU fibrinogen equivalent units Toh, ISTH, 2007 Laboratory Testing D-dimer[arupconsult.com] A reduced platelet count, increased prothrombin time (PT) ratio, and lower antithrombin activity were correlated with 28-day mortality, while fibrinogen and fibrin degradation[ncbi.nlm.nih.gov] Diagnosis is based on presence of 1 known underlying conditions causing DIC plus abnormal global coagulation tests: decreased platelet count, increased prothrombin time, elevated[bestpractice.bmj.com]

  • Acute Liver Failure

    prothrombin time ( 3 seconds prolonged) or international normalized ratio (INR 1.5) Symptoms or signs of hepatic encephalopathy.[livertox.nih.gov] Bilirubin increases to more than 171 mmol/L, prothrombin time (PT) decreases to less than 40%, progressive shrinkage of liver, significant deterioration of liver function,[doi.org] […] course of illness Mild to moderate elevations in serum alkaline phosphatase levels (early in the injury) Latency of a few days to 6 months after starting the medication Increased[livertox.nih.gov]

  • Malabsorption Syndrome

    Prothrombin time- Vitamin K level decreased 3. Serum albumin- Decreased (protein loss) 4.[histopathology-india.net] Prothrombin time - Vit K decreased E. Bile salt reabsorption: Bile acid breath test: Labelled glycine is used. Bile acid glycocholate is formed.[histopathology-india.net] There is increased protein leakage in the intestine. 4. Serum albumin is decreased. D. Vitamin absorption: 1. Vitamin B12- Schilling test 2.[histopathology-india.net]

  • Leukemia

    Article Navigation Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston Search for other works by this author on: Jose R. Valbuena, MD Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston Search for other works by this author on:[…][doi.org]

  • Embolic Mesenteric Infarction

    Jeffrey Norton, Philip S. Barie, Ralph R. Bollinger, Alfred E. Chang, Stephen Lowry, Sean J. Mulvihill, Harvey I. Pass, Robert W. Thompson Springer Science & Business Media, ١٧‏/٠٨‏/٢٠٠٠ - 2170 من الصفحات An up-to-the-minute, clinically oriented, and encyclopedic textbook of general surgery for all surgical residents,[…][books.google.com]

  • Massive Hepatic Necrosis

    An increase in prothrombin time between day three and day four after overdose.[patient.info] A combination of a prothrombin time of more than 100 seconds (INR 6.5), plasma creatinine 300 μmol/L and grade 3 or 4 hepatic encephalopathy (only a 17% survival rate).[patient.info]

  • Liver Disease

    Therapy with vitamin K may be a useful option in patients with increased prothrombin time due to vitamin K deficiency; in patients with malnutrition; in patients using antibiotics[ncbi.nlm.nih.gov]

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