Prothrombin Time Prolonged: Causes & Reasons

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Possible Causes for Prothrombin Time Prolonged

Factor V Deficiency

[…] bleeding time Diagnosis factor V assay (showing decreased activity) activated partial thromboplastin time (aPTT) test (prolonged) prothrombin time (PT) test (prolonged) thrombin [rnpedia.com]

The positive laboratory findings consisted of a prolonged prothrombin time and a slightly prolonged clotting time. Ac globulin deficiency was confirmed both by Dr. [pediatrics.aappublications.org]

[…] menstrual bleeding (menorrhagia) Umbilical stump bleeding Excessive bleeding following injury Excessive bleeding following surgery Excessive bleeding after giving birth Prolonged [rnpedia.com]

Factor X Deficiency

Congenital factor X deficiency is a rare inherited coagulation disorder, characterized by prolonged prothrombin time and partial thromboplastin time. [ncbi.nlm.nih.gov]

Factor X deficiency was diagnosed on the basis of prolonged prothrombin time and prolonged partial thromboplastin time with kaolin, which were corrected by addition of aged [ncbi.nlm.nih.gov]

The proposita showed a markedly prolonged activated partial thromboplastin time and a mild prolongation of prothrombin time. [ncbi.nlm.nih.gov]

Factor VII Deficiency

His baseline prothrombin time was prolonged and further investigation showed the patient to have a mild factor VII deficiency. [ncbi.nlm.nih.gov]

However, obstetricians should consider this diagnosis whenever the prothrombin time is prolonged while the activated partial thromboplastin time is normal. [ncbi.nlm.nih.gov]

Here, we present the report of a young woman who presented with pyelonephritis, anaemia, prolonged prothrombin time and normal activated partial prothrombin time (aPTT). [ncbi.nlm.nih.gov]

Factor II Deficiency

Uneventful convalescence was interrupted by signs of sudden major blood loss, accompanied by prolonged prothrombin time. [ncbi.nlm.nih.gov]

Both partial thromboplastin time (APTT) and prothrombin time (PT) are prolonged in hypoprothrombinemia, while the functional activity of factor II through assay testing is [symptoma.com]

Disseminated Intravascular Coagulation

prothrombin time (PT) prolonged international normalized ratio (INR) prolonged activated partial thromboplastin time (aPTT) schistocytes on blood smear due to microangiopathic [radiopaedia.org]

Routine coagulation tests showed a low platelet count (98×109/L), prolonged prothrombin time (PT; 17 seconds), prolonged activated partial thromboplastin time (aPTT; 43 seconds [ashclinicalnews.org]

Laboratory findings suggestive of DIC consist of a low platelet count, elevation of the D-dimer and fibrinogen concentrations, and prolongation of prothrombin time (PT) and [arupconsult.com]

Hereditary Factor X Deficiency

The propositus had a markedly prolonged prothrombin time, a mild prolongation of activated partial thromboplastin time and a clotting time activated by Russell's viper venom [ncbi.nlm.nih.gov]

prolonged prothrombin time (PT) and prolonged partial thromboplastin time(PTT).[1] FX antigen and its coagulant activity can be used to classify the severity of the condition [en.wikipedia.org]

However, a high index of suspicion should follow an abnormal clotting profile with prolonged PT (prothrombin time) and APTT (activated partial thromboplastin time). [symptoma.com]

Vitamin K Deficiency

At the time of detection of prolongation of the prothrombin time, cefazolin was being administered in four cases, cefmetazole and latamoxef (moxalactam) in three cases each [academic.oup.com]

All the infants had prolonged prothrombin time (PT) and seven had prolonged activated partial thromboplastin time (APTT), both of which were corrected by the administration [ncbi.nlm.nih.gov]

Her blood examination showed metabolic alkalosis, prolonged prothrombin time, and extremely high level of plasma des-gamma-carboxyprothrombin (protein induced by vitamin K [ncbi.nlm.nih.gov]

Reye Syndrome

Prothrombin time: prolonged. A CT scan of the brain is obtained which shows cerebral edema. His neurologic symptoms rapidly worsen and he becomes unresponsive. [web.archive.org]

Prothrombin time: prolonged. A CT scan of the brain is obtained which shows diffuse cerebral edema. His neurologic symptoms rapidly worsen, and he becomes unresponsive. [hawaii.edu]

These enzymatic changes were associated with prolongation of prothrombin time. A rise in blood ammonia concentrations began on the fourth day of coma. [ncbi.nlm.nih.gov]

Alcoholic Hepatitis

Alcoholic hepatitis can vary from mild with only liver enzyme elevation to severe liver inflammation with development of jaundice, prolonged prothrombin time, and even liver [en.wikipedia.org]

White blood cell counts and serum creatinine levels were higher, red blood cell counts were lower and prothrombin time were prolonged in the patients who had died than in [ci.nii.ac.jp]

correlates with severity Prolonged prothrombin time; correlates with severity Decreased serum albumin level Increased serum IgA and IgG levels Decreased serum cholesterol [euroliver.org]

Purpura Fulminans

Disseminated intravascular coagulation was evidenced by low platelet count (46,000), prolonged prothrombin time (19 seconds) and partial thromboplastin time (78 seconds, INR [jamanetwork.com]

Laboratory test results showed new-onset thrombocytopenia, prolonged prothrombin time/international normalized ratio and partial thromboplastin time, and low fibrinogen levels [mdedge.com]

Bleeding time was normal but prothrombin time and activated partial thromboplastin time reports were prolonged. D-dimer levels were elevated. [ijpd.in]

Hereditary Factor I Deficiency

Coagulation time, prothrombin time and reptilase time were prolonged. [link.springer.com]

[…] bleeding time (in some people) • prolonged partial thromboplastin time • prolonged prothrombin time Treatments There are no commercially available concentrates of factor [slideshare.net]

Screening coagulogram was performed, which showed marked prolongation of prothrombin time (93'/13'), activated partial thromboplastin time (145'/30'), and thrombin time (45 [ehj.eg.net]

Wilson Disease

time prolongation (seconds) < 4 4-8 9-12 13-20 >30 Prognosis after liver transplantation is relatively good. [emedicine.com]

[…] bilirubin (reference range, 3-20 mmol/L) < 100 100-150 151-200 201-300 >300 Serum aspartate transaminase (reference range, 7-40 IU/L) < 100 100-150 151-200 201-300 >300 Prothrombin [emedicine.com]

Acute Liver Failure

The former produces a prolongation in prothrombin time which is widely used to monitor the severity of hepatic injury. [en.wikipedia.org]

prothrombin time, which the amount of time it takes for blood plasma to clot. [verywell.com]

She was mildly encephalopathic and the prothrombin time was prolonged. She was transferred to a liver transplant center. [livertox.nih.gov]

Liver Cirrhosis

If the prothrombin time is is 4-6 seconds prolonged then, a transfusion of fresh frozen plasma may bring the prothrombin time into the desired range (see sections 6.4 and [web.archive.org]

If the prothrombin time is 6 seconds prolonged then other biopsy methods should be tried. Recommendation grade B. [gut.bmj.com]

If the prothrombin time is >6 seconds prolonged then other biopsy methods should be tried. Recommendation grade B. [web.archive.org]

Portal Cirrhosis

prothrombin time (PT) Prolonged international normalized ratio (INR) Prolonged activated partial thromboplastin time (aPTT) This condition does not respond to Vitamin K because [amboss.com]

time (seconds prolonged) < 4 4 to 6 > 6 or INR < 1.7 1.7 to 2.3 > 2.3 Albumin (g per dL) > 3.5 2.8 to 3.5 < 2.8 Bilirubin (mg per dL) < 2 2 to 3 > 3 CONTRAINDICATIONS Absolute [aafp.org]

Decreased serum albumin and a prolonged prothrombin time (PT) directly reflect impaired hepatic synthesis—usually an end-stage event. [merckmanuals.com]

Primary Biliary Cirrhosis

prothrombin time (≥12.9 s). [ncbi.nlm.nih.gov]

Diarrhea may occur, and secondary malabsorption of fat-soluble vitamins A, D, E, and K may lead to night blindness, osteomalacia, dermatitis, and prolonged prothrombin time [consultant360.com]

Based on adequate performance and its simplicity, we propose that male sex, low albumin, elevated bilirubin, and/or prolonged prothrombin time be used as a model to noninvasively [ncbi.nlm.nih.gov]

Anticardiolipin Antibody Syndrome

[…] normal or slightly prolonged prothrombin time normal bleeding time normal platelet count false positives due to antibodies + VDRL/RPR due to anticardiolipin antibodies prolonged [medbullets.com]

Seven years later, Loeliger ( 7 ) described the presence of a factor in some plasmas that prolonged the clotting time, even when the plasma was diluted with normal pooled [clinchem.aaccjnls.org]

[…] dilute Russell viper venom time (DRVVT) test prolonged partial thromboplastin time (PTT) anti-β 2 glycoprotein (IgG and IgM) anticardiolipin (IgG and IgM) coagulation studies [medbullets.com]

Acute Promyelocytic Leukemia

In addition to her elevated D-dimer at presentation, she developed further evidence of a coagulopathy, with a prolonged prothrombin time (17.0 seconds, NR 12.0 to 15.5 seconds [circ.ahajournals.org]

The pancytopenia also causes abnormal results in other tests, such as a prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT), high levels of fibrin [symptoma.com]

Massive Hepatic Necrosis

The former produces a prolongation in prothrombin time which is widely used to monitor the severity of hepatic injury. [en.wikipedia.org]

time INR of 1.0-1.4; 10% inc. after vit K in 24 hrs No response to parenteral vit. [slideshare.net]

Ex- cept for terminal prothrombin times, liver- function studies were not obtained in either of these patients; the prothrombin time in each case was prolonged. [nap.edu]

Salicylate Poisoning

Prolonged prothrombin time: Vitamin K, IM, 5 mg (one dose). [angelfire.com]

The patient presented elevated liver transaminases and prolonged prothrombin time (PT), with gradual improvement in subsequent days after supportive measures and use of sodium [oatext.com]

[…] of the prothrombin and bleeding times and decreased platelet adhesiveness. [emedicine.medscape.com]

Childhood Celiac Disease

prothrombin time (PT) and activated partial thromboplastin time (APTT). [ncbi.nlm.nih.gov]

[…] included 22 children with CD in whom the disease remained undiagnosed until they had presented with hematological abnormalities, such as anemia, thrombocytopenia, leukopenia or prolonged [ncbi.nlm.nih.gov]

Chronic Alcoholism

prothrombin time Hypoalbuminemia Liver enzyme levels Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels elevated, usually < 300 U/L; AST/ALT ratio [clevelandclinicmeded.com]

Laboratory tests include: Full blood count, Blood film, Prothrombin time, Gamma glutamyltransferase, Urate, Triglycerides, as appropriate. [rcpa.edu.au]

[…] liver Splenomegaly Ascites Hepatic tenderness Neurologic Asterixis Confusion, stupor Laboratory Findings Liver synthetic function Hyperbilirubinemia (usually conjugated) Prolonged [clevelandclinicmeded.com]

Hepatopathy

Recombinant activated factor VIIa administration is suggested for patients with significantly prolonged prothrombin time and contraindications to fresh frozen plasma therapy [ncbi.nlm.nih.gov]

All patients with clinical or laboratory evidence of moderate or severe acute hepatitis should have immediate measurement of prothrombin time (PT) and careful evaluation of [emedicine.medscape.com]

Trial with desmopressin may be considered before invasive procedures in patients with liver disease and with refractory and prolonged bleeding time. [ncbi.nlm.nih.gov]

Acute Iron Poisoning

Coagulopathies, characterized by prolonged prothrombin time (PT) and partial thromboplastin time (PTT)1 may occur early ( 24 hours).19 The early form of coagulopathy appears [healio.com]

prothrombin and bleeding times Vitamin K Cardiac medication Calcium channel blockers, beta blockers, digoxin Bradycardia, arrhythmias, hypotension, dizziness, heart block [aafp.org]

[…] drugs Tachycardia, hyperthermia, mydriasis, warm and dry skin, urinary retention, ileus, delirium — Anticoagulant Warfarin (Coumadin), rodenticides Ecchymoses, bleeding, prolonged [aafp.org]

Celiac Disease

Malabsorption of vitamin K may cause abnormal clotting test results such as a prolonged prothrombin time. [emedicinehealth.com]

prothrombin time (PT), international normalized ratio (INR) Stool examination - Fat malabsorption Oral tolerance tests - Lactose intolerance Serology - Immunoglobulin A [emedicine.com]

[…] laboratory tests include the following: Electrolytes and chemistries - Electrolyte imbalances; evidence of malnutrition Hematologic tests - Anemia, low serum iron level, prolonged [emedicine.com]

Malabsorption Syndrome

Prolonged prothrombin time can be caused by vitamin K deficiency. Serological studies. Specific tests are carried out to determine the underlying cause. [en.wikipedia.org]

Budd-Chiari Syndrome

Prothrombin time - this may be prolonged, which may be confusing if the condition is associated with a hypercoagulability state. [patient.info]

Embolic Mesenteric Infarction

Prothrombin time was 14 seconds. Activated partial thromboplastin Time was 50 seconds. The Dilute Russell Viper Venom Time (DRVVT) was prolonged at 67 seconds. [omicsonline.org]

Isoniazid Hepatitis

She was mildly encephalopathic and the prothrombin time was prolonged. She was transferred to a liver transplant center. [livertox.nih.gov]

This patient delayed stopping isoniazid and the subsequent liver injury was severe with ultrasound evidence of ascites and prolongation of the prothrombin time. [livertox.nih.gov]

Gaucher Disease

Prolongation of both the prothrombin time (PT) and the activated partial thromboplastin time (APTT) in GD patients has prompted the testing of individual coagulation factor [onlinelibrary.wiley.com]