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84 Possible Causes for Protoporphyrin Increased

  • Porphyria

    The only condition in which free protoporphyrin (not complexed with Zn) is increased is EPP.[web.archive.org] In addition, urine coproporphyrin and erythrocyte protoporphyrin are increased.[web.archive.org] […] protoporphyria Not increased Not increased Protoporphyrin increased or decreased Protoporphyrin Acknowledgments We thank Dr N Dani (general practitioner), Dr Z Yahya, and[ncbi.nlm.nih.gov]

  • Acute Hepatic Porphyria

    In addition, urine coproporphyrin and erythrocyte protoporphyrin are increased.[web.archive.org] Porphyrin and porphyrin precursor determination in urine showed an increase in porphobilinogen, as well as delta-aminolevulinic acid, coproporphyrin, and protoporphyrins in[revespcardiol.org] People with EPP are also at increased risk to develop gallstones.[house.wikia.com]

  • Erythropoietic Protoporphyria

    RCE decreased RBC protoporphyrin levels from 2,879 to 1,225 μg/dL but plasma protoporphyrin increased from 180.4 to 1,044.1 μg/dL, and liver function failed to improve.[ncbi.nlm.nih.gov] , red-purple urine, and increased protoporphyrin IX in red blood cells, plasma, and feces; characterized by acute solar urticaria or more chronic solar eczema develops quickly[medical-dictionary.thefreedictionary.com] However, cholestyramine and cholestyramine combined with bile acids caused a threefold increase in fecal protoporphyrin excretion, whereas bile acids alone had no effect in[ncbi.nlm.nih.gov]

  • Iron Deficiency

    With reduction of the amount of iron available for heme synthesis, the erythrocyte zinc protoporphyrin level progressively increases.[cancertherapyadvisor.com] The concentration of erythrocyte protoporphyrin in blood increases when insufficient iron is available for Hb production.[cdc.gov] Synthesis of transferrin increases with iron deficiency but decreases with any type of chronic disease.[merckmanuals.com]

  • Anemia

    increased serum transferrin receptor (sTfR).[doi.org] Intra-erythrocytic ferritin and erythrocyte zinc-protoporphyrin also help to differentiate IDA from ACD.[dx.doi.org] The serum markers of iron deficiency include low ferritin, low transferrin saturation, low iron, raised total iron-binding capacity, raised red cell zinc protoporphyrin, and[doi.org]

  • Actinic Keratosis

    Insufficient accumulation of protoporphyrin IX (PpIX) may cause these inferior efficacy rates.[ncbi.nlm.nih.gov] Wulf, Increased protoporphyrin IX accumulation does not improve the effect of photodynamic therapy for actinic keratosis: a randomized controlled trial, British Journal of[doi.org] However, it is possible to increase PpIX accumulation by extending the MAL application time and/or pretreating the skin with curettage.[ncbi.nlm.nih.gov]

  • Diabetic Nephropathy

    Nrf2 small interfering RNA (siRNA) and the HO-1 inhibitor zinc protoporphyrin (ZnPPIX) significantly increased the nuclear translocation of NF-ĸB and the production of pro-inflammatory[ncbi.nlm.nih.gov]

  • Microcytic Anemia

    Hematocrit increase of 3 to 19 vol% was associated with correction of microcytosis, significant reduction in abnormal levels of free erythrocyte protoporphyrins, and amelioration[ncbi.nlm.nih.gov] 1. ferrochelatase: binds Fe to protoporphyrin in the mito2.[brainscape.com] […] the Hb concentration by decreasing the volume Hb Haem Globin (Fe protoporphyrin) (globin) So Too low Fe leads to too little haem, Hb and thus small cells e.g. sucked into[alancam.com]

  • Pediatric Crohn's Disease

    increased serum transferrin receptor (sTfR).[doi.org] The serum markers of iron deficiency include low ferritin, low transferrin saturation, low iron, raised total iron-binding capacity, raised red cell zinc protoporphyrin, and[doi.org]

  • Anemia of Infection

    Mean cell volume, iron-binding capacity, protoporphyrin, and haptoglobin did not show changes. Reticulocyte index and erythropoietin increased significantly at 30 days.[pediatrics.aappublications.org] Serum iron and percentage saturation of transferrin decreased, whereas serum ferritin increased significantly.[pediatrics.aappublications.org]

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