Possible Causes for protruding lips Acrocallosal Syndrome lips, high-arched palate, bifid uvula, broad trunk, apparently widely spaced nipples, diastasis recti, small umbilical hernia, tapering fingers, fifth-finger clinodactyly [ncbi.nlm.nih.gov] […] year-old girl with macrocephaly, bulging forehead, ocular hypertelorism, antimongoloid palpebral slant, convergent strabismus, atrophy of optic papillae, short philtrum, protruding [ncbi.nlm.nih.gov] Stromal Corneal Dystrophy lips, skin laxity, "hound dog" ) cranial and peripheral neuropathy -cardiac and renal failure -lattice may look like prominent corneal nerves (nerves won't show up in retroillumination [studyblue.com] lips and pendulous ears (due to amyloid deposition and secondary muscular dysfunction) Pathology Sub-Bowman layer deposits of amyloid lattice lines and intra-lamellar amyloid [eyewiki.aao.org] […] decreased vision -tx keratoplasty Lattice 2 Dystrophy / Meretoia Syndrome - systemic familial amyloidosis -in addition to lattice like stromal deposits: bilateral facial palsy ( protruding [studyblue.com] Familial Hypercholanemia lips - Ptosis - Short hand / brachydactyly - Short stature / dwarfism / nanism - Strabismus / squint Occasional - Cleft palate without cleft lip / submucosal cleft palate [csbg.cnb.csic.es] / learning disability - Intrauterine growth retardation - Large fontanelle / delayed fontanelle closure - Low hair line (back) - Macrostomia / big mouth - Microcephaly - Protruding [csbg.cnb.csic.es] Actinic Keratosis Lower lip with protruding sore, white patches and cracks with dried blood, a possible mix of actinic cheilitis and skin cancer. Crusted red spots on the cheek and ear. [skincancer.org] Hypogonadism The school-age boy with hypogonadism from Klinefelter syndrome probably has characteristic knock-knees (genu valgum), high arches (pes cavus), protruding lips, a projecting [testocreams.com] Geographic Tongue Brenner S, Lipitz R, Ilie B, Krakowski A: Psoriasis of the lips: the unusual Köbner phenomenon caused by protruding upper teeth. Dermatologica 1982;164:413-416. [karger.com] Brenner et al. [ 24 ] reported on the induction of lip psoriasis by koebnerization in a patient whose psoriatic condition was triggered by chronic trauma from protruding maxillary [karger.com] Despite chronicity, the overlapping signs and symptoms, as well as the atypical site of involvement, may cause lip psoriasis to be mistaken for solar cheilosis, chronic eczema [karger.com] Growth Failure mild protruding ears, short neck, small hands with brachydactyly and clinodactyly of II left digit and V digit bilaterally, feet with broad big toes, brachydactyly, and [cyberleninka.org] […] round face, short forehead, medial eyebrow flare, wide nasal bridge, hypertelorism, epicanthal folds, broad nasal tip with prominent columella, long philtrum, thin upper lip [cyberleninka.org] Branchio-Oculo-Facial Syndrome lips - Retinoschisis / retinal / chorioretinal coloboma - Skin hypoplasia / aplasia / atrophy Frequent - Abnormal cry / voice / phonation disorder / nasal speech - Anodontia [csbg.cnb.csic.es] […] upper lip with an unusually broad and prominent philtrum, and full mouth. [orpha.net] […] deafness / hearing loss - Dermoid sinus / dimple / pit (excluding sacral) - External ear anomalies - Low set ears / posteriorly rotated ears - Philtrum deeply grooved - Protruding [csbg.cnb.csic.es] Psoriasis Brenner S, Lipitz R, Ilie B, Krakowski A (1982) Psoriasis of the lips: the unusual Koebner phenomenon caused by protruding upper teeth. [doi.org] Hypomandibular Faciocranial Dysostosis Protruding lips Anteverted nostrils Short head Cleft palate Low set ears Chronic inflammatory lung disease Excess amniotic fluid Small nose Mental retardation Cardiac septal [checkorphan.org] Ludman et al. (1993) reported a third case, with photographs showing the pursed and protruding lips. [omim.org] The lips were tightly pursed and protruded. There appeared to be a persistent buccal- pharyngeal membrane, and what remained of the man- dible was fused to the maxilla. [dokumen.tips] Tricho-rhino-phalangeal Syndrome protruding ears, prominent forehead, small jaw, and short hands and feet. [ncbi.nlm.nih.gov] […] deformity, protruding ears, mandibular hypoplasia, and cone-shaped epiphyses of the phalanges. [ncbi.nlm.nih.gov] and protruding ears. [ncbi.nlm.nih.gov] Labile Hypertension Vascular EDS is characterized by thin, transparent looking skin, fragile blood vessels, thin nose and lips, sunken cheeks and small chin, protruding eyes, collapsed lungs [healthrising.org] Endometriosis During the examination, she repeatedly smacks her lips and slightly protrudes her tongue. [pejoweb.com] Ondine Syndrome Protruding tongue High-arched palate Microretrognathia Malocclusion Low-set ears Ear minor malformation Short neck Premature hair graying Hypertonia Heart defect/disease [docksci.com] 3/6 Protruding tongue 2/6 High-arched palate 6/6 Microretrognathia 6/6 Malocclusion 6/6 Low-set ears 2/6 Ear minor malformation 5/6 Short neck 2/6 Premature hair graying [hindawi.com] Hypertelorism Epicanthal folds Strabismus divergent/convergent Lateral downward-slanting palpebral fissures Downturned corners of the mouth Slightly open mouth Full lower lip [docksci.com] Micturition Syncope […] of trisomy 13, the presence of prominent occipit, micrognathia, clenched fist together with protruding heel make the appearance of trisomy 18 unmistakable [13]. [wikigenes.org] Biological context of Microphthalmos While the combination of microcephaly, cleft lip and/or palate, microphthalmos, capillary haemangioma and polydactyly form the hallmark [wikigenes.org] Alcohol Dementia Tongue thrust In this case there is a display of too much tension of the muscles of tongue, cheeks, lips, palate and throat. The tongue is protruded. [coordinatie-stemtherapie.nl] Epulis A, Coronal 2‐dimensional sonogram of the mass (arrow) seen protruding from the fetal upper lip. [onlinelibrary.wiley.com] […] interfere with respiration or feeding or lip closure. [jioh.org] The examination revealed a large tumor protruding outside the oral cavity and filling almost the entire space between the lips, with discrete sideto- side mobility (Figure [scielo.org.co] Uterine Prolapse A 55-year-old, para 7, Tanzanian woman, 7 months postmenopausal, presented with history of a protruding vaginal mass for 3 months. [ncbi.nlm.nih.gov] She also had a third-degree uterine prolapse with the cervix beyond the hymen and a huge, ulcerated, round mass on the anterior lip of the cervix. [ncbi.nlm.nih.gov] Rieger Syndrome Examination revealed maxillary hypoplasia, thin upper lip, protruding lower lip and flattening of the mid face [Figure 1] and [Figure 2]. [aeronline.org] Craniofacial abnormalities include a protruding lower lip, a broad, flat bridge of the nose, and/or underdeveloped bones of the upper jaw (hypoplasia) causing the face to [hourlybook.com] Hereditary Corneal Dystrophy Lattice dystrophy type II (Familial amyloidosis with lattice dystrophy, Meretoja syndrome) Mask-like facies Mask-like faciesl Blepharochalasis, Floppy ears Protruding lips [slideshare.net] lips and pendulous ears (due to amyloid deposition and secondary muscular dysfunction) Pathology Sub-Bowman layer deposits of amyloid lattice lines and intra-lamellar amyloid [eyewiki.aao.org] A characteristic "mask-like" facial expression, protruding lips with impaired movement, pendulous ears and blepharochalasis are also features. [ojrd.com] Dehydration […] ear Thick eyebrow Very frequently present symptoms in 80-99% of the cases: Depressed nasal ridge Downslanted palpebral fissures Everted lower lip vermilion Hypertelorism [dovemed.com] Syndrome may include: Broad forehead Broad nasal tip Distal/middle symphalangism of 5th finger Highly arched eyebrow Intellectual disability, mild Low-set ears Parasomnia Protruding [dovemed.com] Deviated Nasal Septum Tongue thrust In this case there is a display of too much tension of the muscles of tongue, cheeks, lips, palate and throat. The tongue is protruded. [coordinatie-stemtherapie.nl] Adenoma and ears, as well as a protruding brow and lower jaw, joint pain, sleep apnea, and excess perspiration. [study.com] […] acromegaly' literally means 'large extremities' and accurately describes some of the symptoms of this condition, which include enlargement of body parts like hands, feet, nose, lips [study.com] 3q13.31 Microdeletion Syndrome lips. [ncbi.nlm.nih.gov] OMIM : 57 The chromosome 3q13.31 deletion syndrome is characterized by marked developmental delay, characteristic facies with a short philtrum and protruding lips, and abnormal [malacards.org] […] major characteristics including significant developmental delay, muscular hypotonia, a high arched palate, and recognisable facial features including a short philtrum and protruding [ncbi.nlm.nih.gov] Epignathus The duplicated mandible and lower lip was fused at the midline. The alveolar ridge was protruding through a wide-cleft soft palate involving the uvula. [ncbi.nlm.nih.gov] Associations polyhydramnios : when there is associated swallowing impairment mid line facial dafects cleft lip and/or palate Markers raised maternal serum alpha feto protein [radiopaedia.org] (MSAFP) Antenatal ultrasound Usually seen as a complex mass protruding from the fetal oral cavity (often with mixed echogenecity 11 ). [radiopaedia.org] Cleft Lip Repair of complete bilateral cleft lip with protruding premaxilla is challenging, and postoperative dehiscence was common. [ncbi.nlm.nih.gov] Preoperative alignment of the protruded premaxilla with a Latham appliance was planned to facilitate primary lip repair. [ncbi.nlm.nih.gov] Latham's appliance for presurgical repositioning of the protruded premaxilla in bilateral cleft lip and palate. J Craniomaxillofac Surg. 1992 ; 20: 99 – 110. [doi.org] Scarlet Fever […] ear Thick eyebrow Very frequently present symptoms in 80-99% of the cases: Depressed nasal ridge Downslanted palpebral fissures Everted lower lip vermilion Hypertelorism [dovemed.com] Syndrome may include: Broad forehead Broad nasal tip Distal/middle symphalangism of 5th finger Highly arched eyebrow Intellectual disability, mild Low-set ears Parasomnia Protruding [dovemed.com] Epilepsy […] ears Facial gestalt suggestive of Angelman syndrome Prominent forehead Broad forehead Micrognathia High forehead Short nose, upturned tip Full lips Prominent columella Widely [dx.doi.org] […] hypotonia Tourette’s syndrome Gait ataxia Feeding difficulties Feeding difficulties Slight hypotonia Dysmorphic features Square-shaped face Triangular face Brachycephaly Protruding [dx.doi.org] Facial Nerve Paralysis of the Newborn The mentalis muscle raises and protrudes the lower lip and the platysma muscle blends in with the DAOM and assists in its function. [ncbi.nlm.nih.gov] Patients may be unable to protrude their tongue beyond their lips because of this weakness. [physio-pedia.com] The depressor labii inferioris muscle (DLIM) extends from the mandible to the lower lip and depresses it. [ncbi.nlm.nih.gov] Reis-Bucklers Corneal Dystrophy lips and pendulous ears (due to amyloid deposition and secondary muscular dysfunction) Pathology Sub-Bowman layer deposits of amyloid lattice lines and intra-lamellar amyloid [eyewiki.aao.org] It presents in early adulthood with peripheral neuropathies, cranial neuropathies, hound-like facies, dry skin, blepharochalasis, protruding lips, and corneal lattice lines [webeye.ophth.uiowa.edu] […] nephrotic syndromes) Cardiac conduction abnormalities, orthostatic hypotension, perspiration dysfunction Severe mask-like facial paresis with gradual onset of facial drooping, protruding [eyewiki.aao.org]
