Protruding Lips: Causes & Reasons

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Possible Causes for Protruding Lips

3q13.31 Microdeletion Syndrome

OMIM : 57 The chromosome 3q13.31 deletion syndrome is characterized by marked developmental delay, characteristic facies with a short philtrum and protruding lips, and abnormal [malacards.org]

lips. [ncbi.nlm.nih.gov]

[…] major characteristics including significant developmental delay, muscular hypotonia, a high arched palate, and recognisable facial features including a short philtrum and protruding [ncbi.nlm.nih.gov]

Acrocallosal Syndrome

lips, high-arched palate, bifid uvula, broad trunk, apparently widely spaced nipples, diastasis recti, small umbilical hernia, tapering fingers, fifth-finger clinodactyly [ncbi.nlm.nih.gov]

[…] year-old girl with macrocephaly, bulging forehead, ocular hypertelorism, antimongoloid palpebral slant, convergent strabismus, atrophy of optic papillae, short philtrum, protruding [ncbi.nlm.nih.gov]

Stromal Corneal Dystrophy

lips, skin laxity, "hound dog" ) cranial and peripheral neuropathy -cardiac and renal failure -lattice may look like prominent corneal nerves (nerves won't show up in retroillumination [studyblue.com]

lips and pendulous ears (due to amyloid deposition and secondary muscular dysfunction) Pathology Sub-Bowman layer deposits of amyloid lattice lines and intra-lamellar amyloid [eyewiki.aao.org]

[…] decreased vision -tx keratoplasty Lattice 2 Dystrophy / Meretoia Syndrome - systemic familial amyloidosis -in addition to lattice like stromal deposits: bilateral facial palsy ( protruding [studyblue.com]

Tricho-Rhino-Phalangeal Syndrome

protruding ears, prominent forehead, small jaw, and short hands and feet. [ncbi.nlm.nih.gov]

[…] deformity, protruding ears, mandibular hypoplasia, and cone-shaped epiphyses of the phalanges. [ncbi.nlm.nih.gov]

and protruding ears. [ncbi.nlm.nih.gov]

Hypomandibular Faciocranial Dysostosis

Protruding lips Anteverted nostrils Short head Cleft palate Low set ears Chronic inflammatory lung disease Excess amniotic fluid Small nose Mental retardation Cardiac septal [checkorphan.org]

Ludman et al. (1993) reported a third case, with photographs showing the pursed and protruding lips. [omim.org]

The lips were tightly pursed and protruded. There appeared to be a persistent buccal- pharyngeal membrane, and what remained of the man- dible was fused to the maxilla. [dokumen.tips]

Gingival Fibromatosis 5

lips, came to our Department of Stomatology. [nature.com]

[…] scarce blood vessels and increased fibroblasts in most cases.1,2,4,11 Case report A 21-year-old man, with complaint of gingival overgrowth in the past 15 years resulting in protruding [nature.com]

Partial Monosomy 9p

(philtrum); and/or a small jaw (micrognathia) and small mouth with protruding lips. [rarediseases.org]

[…] midfacial hypoplasia), including a short nose, flattened nasal bridge, and upturned nostrils (anteverted nares); an abnormally long vertical groove in the center of the upper lip [rarediseases.org]

Orofacial Granulomatosis

causing them to protrude. [en.wikipedia.org]

If recurrent, the interval during which the lips are enlarged may be weeks or months. [en.wikipedia.org]

[…] disagreement as to how it relates to Crohn's disease and sarcoidosis.[1] Signs and symptoms[edit] Signs and symptoms may include: Persistent or recurrent enlargement of the lips [en.wikipedia.org]

Kleefstra Syndrome 2

a protruding tongue and prognathism. [cags.org.ae]

[…] and open mouth in infancy with protruding tongue), various developmental delays and other physical abnormalities. [kidsiqproject.org]

[…] jaw single eyebrow widely spaced eyes rolled out lips large tongue nostrils that open out high birth weight and childhood obesity In some cases, symptoms may include severe [childrenshospital.org]

Kleefstra Syndrome 1

[…] jaw (prognathism), rolled out (everted) lips, and a large tongue (macroglossia). [encyclopedia.pub]

[…] and open mouth in infancy with protruding tongue), various developmental delays and other physical abnormalities. [kidsiqproject.org]

Fibular Dimelia-Diplopodia Syndrome

[…] and philtrum (continued) Protruding lips Short philtrum Tented upper lip Thick lips Thin/retracted lips Anomalies of tongue, gingiva and oral mucosa Abnormal pigmentation [readbag.com]

[…] cheilitis Philtrum deeply grooved Philtrum flat/large/featureless/absent cupidon bows www.orphanet.net/ 6 of 39 Thesaurus of Clinical Signs and Symptoms Anomalies of mouth, lip [readbag.com]

Monosomy 9p

(philtrum); and/or a small jaw (micrognathia) and small mouth with protruding lips. [rarediseases.org]

Zlotogora-Ogur Syndrome

[…] and malformed ears, micrognathia, bilateral cleft lip and palate), cutaneous syndactyly (fingers and toes) and transverse crease on the palms. [findzebra.com]

Features: Head And Neck Brachycephaly Trigonodolichomicrocephaly Maxillary Micrognathia Frontal Bossing Ears Malformed Protruding Ears And Intertragic Notch Eyes Blepharoptosis [neo-genetics.com]

[…] sparse eyebrows, hypohidrosis, dry skin, palmoplantar keratoderma, abnormal teeth (delayed eruption, microdontia/hypodontia, and anodontia in adults), facial dysmophism (protruding [findzebra.com]

Tricho-Rhino-Phalangeal Syndrome Type 3

[…] as well as a long, protruding upper lip; underdeveloped cheek bones (malar hypoplasia); and/or an abnormally prominent upper jaw bone (maxilla). [rarediseases.org]

[…] ears, a bulbous nose, an elongated upper lip and sparse scalp hair), winged scapulae, multiple cartilaginous exostoses, redundant skin and mental retardation. [medical-dictionary.thefreedictionary.com]

[…] may include a pear-shaped or rounded (bulbous) nose with small, underdeveloped nostrils (hypoplastic alae nasi); an abnormally long broad groove (philtrum) on the upper lip [rarediseases.org]

Sigmoid Diverticulitis

Value of "protruding lips" sign in malignant bowel obstructions. [ncbi.nlm.nih.gov]

Axenfeld-Rieger Syndrome Type 3

Craniofacial abnormalities include a protruding lower lip, a broad, flat bridge of the nose, and/or underdeveloped bones of the upper jaw (hypoplasia) causing the face to [hourlybook.com]

[…] lower lip. [rarediseases.org]

Symptoms affecting the facial bones may include an underdeveloped jaw, a protruding lower lip, and widely-spaced eyes. [rarediseases.info.nih.gov]

Familial Amyloid Polyneuropathy Type 4

Meretoja syndrome (mer-ĕ-tō'yă), a familial form of systemic amyloidosis with lattice, corneal dystrophy, cranial and peripheral nerve palsies, protruding lips, masklike facies [medical-dictionary.thefreedictionary.com]

A "mask-like" facies with a protruding lower lip, dry itchy skin, peripheral and cranial neuropathy, and renal failure are clinical features but often have their onset late [disorders.eyes.arizona.edu]

lips and pendulous ears (due to amyloid deposition and secondary muscular dysfunction) Pathology Sub-Bowman layer deposits of amyloid lattice lines and intra-lamellar amyloid [eyewiki.aao.org]

Distal Monosomy 9p

(philtrum); and/or a small jaw (micrognathia) and small mouth with protruding lips. [rarediseases.org]

Branchio-Oculo-Facial Syndrome

lips - Retinoschisis / retinal / chorioretinal coloboma - Skin hypoplasia / aplasia / atrophy Frequent - Abnormal cry / voice / phonation disorder / nasal speech - Anodontia [csbg.cnb.csic.es]

[…] upper lip with an unusually broad and prominent philtrum, and full mouth. [orpha.net]

[…] deafness / hearing loss - Dermoid sinus / dimple / pit (excluding sacral) - External ear anomalies - Low set ears / posteriorly rotated ears - Philtrum deeply grooved - Protruding [csbg.cnb.csic.es]

Axenfeld-Rieger Syndrome

Examination revealed maxillary hypoplasia, thin upper lip, protruding lower lip and flattening of the mid face [Figure 1] and [Figure 2]. [aeronline.org]

Craniofacial abnormalities include a protruding lower lip, a broad, flat bridge of the nose, and/or underdeveloped bones of the upper jaw (hypoplasia) causing the face to [hourlybook.com]

Progeria

They develop a characteristic facial appearance including: prominent eyes, a thin nose with a beaked tip, thin lips, a small chin, and protruding ears. [rxlist.com]

[…] childhood and characterized by growth reduction, failure to thrive, a typical facial appearance (prominent forehead, protuberant eyes, thin nose with a beaked tip, thin lips [orpha.net]

[…] eyes thin lips stiff joints Progeria is caused by a genetic mutation. [healthline.com]

Multiple Endocrine Neoplasia Type 2B

Our patient presented with multiple keloids, thickened protruding lips, and multiple neuromas of her tongue. [ispub.com]

[…] and tongue Distinctive facial features, including an elongated face and protruding lips A tall and slender body type Medullated corneal nerve fibers (abnormal nerves in the [stjude.org]

Affected individuals tend to be tall and lanky, with an elongated face and protruding, blubbery lips. [en.wikipedia.org]

Ehlers-Danlos Syndrome Hypermobility Type

Lips that are thin Small earlobes In people with fair skin the blood vessels that are under the skin are very visible through their skin. [healthool.com]

[…] eyes thin lips sunken cheeks small chin collapsed lung heart valve problems Doctors may use a series of tests to diagnose EDS (except for hEDS), or rule out other similar [healthline.com]

There is also a characteristic facial appearance: Protruding eyes, Thin nose and lips, Sunken cheeks, and Small chin. [hypermobility.org]

PEHO Syndrome

protruding ear lobes and a short nose with anteverted nostrils). [rarediseases.info.nih.gov]

[…] fingers and facial dysmorphism (including a 'Pear-shaped' face with a narrow forehead and full cheeks, receding chin, epicanthic folds, an open mouth with a curved upper lip [rarediseases.info.nih.gov]

Diamond-Blackfan Anemia Type 4

Facial anomalies may include a snub nose, widely separated eyes, and/or a protruding upper lip. [rarediseases.org]

Hereditary Corneal Dystrophy

Lattice dystrophy type II (Familial amyloidosis with lattice dystrophy, Meretoja syndrome) Mask-like facies Mask-like faciesl Blepharochalasis, Floppy ears Protruding lips [slideshare.net]

lips and pendulous ears (due to amyloid deposition and secondary muscular dysfunction) Pathology Sub-Bowman layer deposits of amyloid lattice lines and intra-lamellar amyloid [eyewiki.aao.org]

[…] nephrotic syndromes) Cardiac conduction abnormalities, orthostatic hypotension, perspiration dysfunction Severe mask-like facial paresis with gradual onset of facial drooping, protruding [eyewiki.aao.org]

Spondyloepiphyseal Dysplasia Type MacDermot

[…] lower lip, and prognathia (Fig. la). [documents.tips]

[…] lower lip), along with oligodon- tia, coarse hair, and finger 2-3 syndactyly, but she was not retarded, had lip/palate clefting, microcephaly, and ACKNOWLEDGMENTS The authors [documents.tips]

[…] hairline, large S-like palpebral fissures with lower lid pseudoectropion, midface hypoplasia, broad nasal bridge, wide nostrils, short philtrum, constantly open mouth with protruding [documents.tips]

Clark-Baraitser Syndrome

Clinical manifestations Clinical criteria are: Mental disability Macrocephaly Facial abnormalities with a rectangular forehead, protruding bulge above the eye, broad tip of [de.zxc.wiki]

[…] bulge above the eye, wide tip of the nose, prominent lower lip, large auricles Obesity Macroorchidie Differential diagnosis The Atkin-Flaitz syndrome with short stature and [second.wiki]

[…] the nose, prominent lower lip, large auricles Obesity Macro orchid Differential diagnosis To be delimited is u. a. the Atkin-Flaitz syndrome with short stature and hypertelorism [de.zxc.wiki]

Familial Hypercholanemia

lips - Ptosis - Short hand / brachydactyly - Short stature / dwarfism / nanism - Strabismus / squint Occasional - Cleft palate without cleft lip / submucosal cleft palate [csbg.cnb.csic.es]

/ learning disability - Intrauterine growth retardation - Large fontanelle / delayed fontanelle closure - Low hair line (back) - Macrostomia / big mouth - Microcephaly - Protruding [csbg.cnb.csic.es]

Reis-Bucklers Corneal Dystrophy

lips and pendulous ears (due to amyloid deposition and secondary muscular dysfunction) Pathology Sub-Bowman layer deposits of amyloid lattice lines and intra-lamellar amyloid [eyewiki.aao.org]

It presents in early adulthood with peripheral neuropathies, cranial neuropathies, hound-like facies, dry skin, blepharochalasis, protruding lips, and corneal lattice lines [webeye.ophth.uiowa.edu]