Proximal Muscle Weakness: Causes & Reasons

Possible Causes for Proximal Muscle Weakness

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

In 4 of the 5 patients having a severe phenotype, symptoms appeared during infancy (2 to 3.5 years), with proximal muscle weakness predominating in the lower limbs and early [pediatricneurologybriefs.com]

weakness of lower limbs Proximal muscle weakness and early involvements of foot and hand Muscle weakness Upper limb, proximal No Yes Upper limb, distal Yes Yes Lower limb [ojrd.biomedcentral.com]

Late-Onset Pompe Disease

PATIENT 1 A 58-year-old woman began to have symptoms at age 44 of slowly progressive proximal muscle weakness predominantly affecting the lower limbs. [ncbi.nlm.nih.gov]

weakness affecting proximal more than distal muscles.24,34 In a recent observational study, weakness of the proximal extremities was the presenting symptom in 93% of patients [ncbi.nlm.nih.gov]

elevated CK Becker muscular dystrophy (BMD) Progressive proximal muscle weakness, prominent quadriceps weakness, calf hypertrophy, elevated CK, cardiomyopathy Selenoprotein [ncbi.nlm.nih.gov]

Muscular Dystrophy-Dystroglycanopathy Type C14

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

LGMD 2A (calpain 3) Childhood (8-15) There is mainly proximal muscle weakness. There is slow progression. [patient.info]

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

Polymyositis

This report highlights the case of a 30-year-old male who had severe myalgia and proximal muscle weakness. [ncbi.nlm.nih.gov]

From Wikidata Jump to navigation Jump to search rare idiopathic inflammatory myopathy characterized by symmetric proximal muscle weakness and elevated muscle enzymes edit [wikidata.org]

Polymyositis-like syndrome in hypothyroidism is a rare condition characterised by proximal muscle weakness and elevated muscle enzymes. [ncbi.nlm.nih.gov]

Limb-Girdle Muscular Dystrophy Type 2Q

Autosomal recessive limb-girdle muscular dystrophy-17 is characterized by early childhood onset of proximal muscle weakness and atrophy without skin involvement. [ncbi.nlm.nih.gov]

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

LGMD 2A (calpain 3) Childhood (8-15) There is mainly proximal muscle weakness. There is slow progression. [patient.info]

Limb-Girdle Muscular Dystrophy Type 2B

Moreover, polymyositis (PM) is manifested as symmetrical proximal muscle weakness of the four limbs, accompanied by an increased level of serum CK. [ncbi.nlm.nih.gov]

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

In 1884, Erb characterized a juvenile form of proximal muscle weakness. [checkorphan.org]

Limb-Girdle Muscular Dystrophy Type 2J

LGMD 2A (calpain 3) Childhood (8-15) There is mainly proximal muscle weakness. There is slow progression. [patient.info]

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

Remember they will also have progressive proximal muscle weakness, as in polymyositis. [lecturio.com]

Muscular Dystrophy-Dystroglycanopathy Type C3

LGMD 2A (calpain 3) Childhood (8-15) There is mainly proximal muscle weakness. There is slow progression. [patient.info]

proximal muscle weakness with autosomal patterns of inheritance. [omicsonline.org]

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

Limb-Girdle Muscular Dystrophy Type 2L

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

LGMD 2A (calpain 3) Childhood (8-15) There is mainly proximal muscle weakness. There is slow progression. [patient.info]

Approx. 5 years Mild to moderate proximal weakness Muscle cramping Enlargement of the calf muscles Some have no symptoms Bethlem myopathy Floppy muscles in infancy 2/3 of [encyclopedia.com]

Limb-Girdle Muscular Dystrophy

Progressive proximal muscle weakness began again at age 8 years. Serum CK was 14,910 IU/L. She was wheelchair-bound by age 12. [ncbi.nlm.nih.gov]

Moreover, polymyositis (PM) is manifested as symmetrical proximal muscle weakness of the four limbs, accompanied by an increased level of serum CK. [ncbi.nlm.nih.gov]

Abstract The limb girdle muscular dystrophies are a heterogeneous group of conditions characterized by proximal muscle weakness and disease onset ranging from infancy to adulthood [ncbi.nlm.nih.gov]

Muscular Dystrophy-Dystroglycanopathy Type C5

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

Clinical features include proximal muscle weakness, waddling gait, calf hypertrophy, cardiomyopathy and respiratory insufficiency. [uniprot.org]

826C>A 4 M 14 21 35 Stress induced rhabdomyolysis, mild proximal leg weakness 4/5 proximal arm muscles, 4/5 proximal leg muscles 900 Vastus lateralis + n.d. [jmg.bmj.com]

Oculopharyngeal Muscular Dystrophy

We describe a 70-year-old Italian woman with an adult-onset ptosis, mild dysphagia and proximal muscle weakness belonging to a family segregating OPMD according to an autosomal [ncbi.nlm.nih.gov]

Oculopharyngeal muscular dystrophy (OPMD) is typically inherited in an autosomal dominant fashion and is characterized by late onset proximal muscle weakness, ptosis and difficulty [ncbi.nlm.nih.gov]

weakness. [ncbi.nlm.nih.gov]

Muscular Dystrophy-Dystroglycanopathy Type C4

LGMD 2A (calpain 3) Childhood (8-15) There is mainly proximal muscle weakness. There is slow progression. [patient.info]

Patients generally present with slowly progressive weakness and wasting restricted to the proximal muscles. [chs-journal.com]

Defects in FKTN are the cause of cardiomyopathy dilated type 1X (CMD1X); also called dilated cardiomyopathy with mild or no proximal muscle weakness. [mybiosource.com]

Oculo-Pharyngo-Distal Myopathy

[…] and Swelling in the Neck 522 Case 83 A Woman with Muscle Pains and Dark Urine 526 Case 84 A Woman with Progressive Proximal Muscle Weakness 533 Case 85 A Sedentary Man with [books.google.com]

Weak onset proximal muscle weakness + falls + lung and cardio involvement How are dermatomyositis and polymyositis diagnosed? [brainscape.com]

[…] and a Positive Family History of Similar Problems 436 Case 70 A Woman with Muscle Weakness and Areflexia 444 Case 71 An Elderly Woman with Proximal Weakness 448 Case 72 A [books.google.com]

Dermatomyositis

The proximal muscle weakness, dysphagia and presence of Gottron's papules as well poikiloderma like skin changes led to the clinical diagnosis of dermatomyositis. [ncbi.nlm.nih.gov]

Later she developed progressive, symmetrical proximal muscle weakness. [ncbi.nlm.nih.gov]

This patient was diagnosed with dermatomyositis due to the presence of proximal muscle weakness with abnormal electromyography and magnetic resonance imaging findings; skin [ncbi.nlm.nih.gov]

Childhood Dermatomyositis

Typical MRI and muscle biopsy changes were rated by all to be the most useful clinically relevant diagnostic criteria after proximal muscle weakness, characteristic skin rash [doi.org]

A 62-year-old woman presented to the emergency department with malaise, lethargy and proximal muscle weakness. She had a similar presentation in childhood. [ncbi.nlm.nih.gov]

All responders routinely used proximal muscle weakness and characteristic skin rash in the diagnosis of JDM, while 86.8% used elevated muscle enzymes. [doi.org]

Vitamin D Deficiency

We report a four-year-old African boy referred for proximal muscle weakness, fatigability and episodic limb pain. [ncbi.nlm.nih.gov]

A young woman with severe vitamin D deficiency presented with proximal muscle weakness, fragility fracture and pseudoarthrosis. [ncbi.nlm.nih.gov]

All had generalized bone pain and tenderness, muscle weakness, stooping posture, difficulty walking, and waddling gait due to severe proximal muscle weakness for a period [ncbi.nlm.nih.gov]

Jankovic Rivera Syndrome

muscle weakness and generalized muscular atrophy due to degeneration of spinal motor neurons, followed by the onset of myoclonic seizures. [diseaseinfosearch.org]

Comments: Reference: HP:0003391 Genes and Diseases: Child Nodes: Sister Nodes: ..Late-onset proximal muscle weakness (HP:0003694) ..Progressive proximal muscle weakness (HP [mseqdr.org]

Proximal muscle weakness and generalized muscular atrophy are due to degeneration of spinal motor neurons. [malacards.org]

Autosomal Recessive Centronuclear Myopathy

[…] fibrillation 0010546 Polyhydramnios High levels of amniotic fluid 0001561 Proximal muscle weakness in lower limbs 0008994 Proximal muscle weakness in upper limbs 0008997 [rarediseases.info.nih.gov]

Early onset of symptoms with hypotonia, motor developmental delay, proximal muscle weakness, and a stable course were common clinical features in the cohort. [institut-myologie.org]

There is usually weakness of the muscles closest to the trunk of the body, known as the proximal muscles. [contact.org.uk]

Muscular Dystrophy-Dystroglycanopathy Type B5

Clinical features include proximal muscle weakness, waddling gait, calf hypertrophy, cardiomyopathy and respiratory insufficiency. [abcam.com]

LGMD 2A (calpain 3) Childhood (8-15) There is mainly proximal muscle weakness. There is slow progression. [patient.info]

In addition to proximal muscle weakness, there may or may not be: Distal muscle weakness. Muscle hypertrophy. Contractures. [patient.info]

Lambert-Eaton Syndrome

Proximal muscle weakness, absent reflexes, normal serum creatine kinase, and autonomic dysfunction should prompt electrodiagnostic testing for LEMS. [pediatricneurologybriefs.com]

It is clinically presented with proximal muscle weakness and autonomic dysfunction. [nature.com]

The first symptom noted by patients is usually proximal leg muscle weakness (80%), followed by weakness of the arms. [ime.acponline.org]

Myopathy and Diabetes mellitus

[…] fibers 33 HP:0003200 38 mitochondrial myopathy 33 HP:0003737 39 motor delay 33 HP:0001270 40 hyporeflexia 33 HP:0001265 41 proximal muscle weakness 33 HP:0003701 42 generalized [malacards.org]

Most myopathies manifest with weakness involving the proximal muscles. [clevelandclinicmeded.com]

muscle cramps and occasional dysphagia 198 TK2, which encodes thymidine kinase 2 Ptosis, scapular winging, facial and proximal muscle weakness and wasting, dysphagia and [nature.com]

Multicore Myopathy with External Ophthalmoplegia

Multicore myopathy, classified with the benign congenital myopathies, is manifest clinically as proximal muscle weakness, hypotonia, and delayed motor development. [ncbi.nlm.nih.gov]

It is marked by hypotonia and proximal muscle weakness. [kmle.co.kr]

muscle weakness ; Ptosis ; Pulmonary hypoplasia ; Recurrent respiratory infections ; Respiratory insufficiency ; Scoliosis ; Skeletal muscle atrophy ; Type 1 and type 2 muscle [mousephenotype.org]

Osteomalacia

Proximal muscle weakness, spinal tenderness to percussion, pseudofractures, and skeletal deformities are found commonly. [bestpractice.bmj.com]

All had generalized bone pain and tenderness, muscle weakness, stooping posture, difficulty walking, and waddling gait due to severe proximal muscle weakness for a period [ncbi.nlm.nih.gov]

Spinal Muscular Atrophy Type 3

Abstract: Three young boys in an extended family were first seen in their first decade for proximal muscle weakness without sensory loss. [scholarbank.nus.sg]

Neurodegenerative condition affecting motor neurons in the anterior horn cells of the spinal cord, leading to progressive proximal muscle weakness. [genetics4medics.com]

muscle weakness and hypotonia caused by the degeneration of the lower motor neurons in the spinal cord and the brainstem nuclei. [link.springer.com]

Inclusion Body Myositis

Inclusion body myositis features a slowly progressive inflammatory myopathy characterized by progressive proximal muscle weakness in the lower extremities, followed by proximal [ncbi.nlm.nih.gov]

We report a 17-year-old girl with an unusual neuromuscular disorder characterised by slowly progressive proximal muscle weakness whose muscle biopsy showed multiple ring fibres [ncbi.nlm.nih.gov]

We present a case of a 76-year-old woman with systemic lupus erythematosus (SLE) who developed proximal muscle weakness of lower extremities and mild elevation of serum creatine [ncbi.nlm.nih.gov]

Pompe Disease

Progressive proximal muscle weakness including major impairment of respiratory function dominates the picture. [ommbid.mhmedical.com]

[…] infections Late-onset disease often manifests itself with proximal muscle weakness, which may be interpreted as clumsiness 2. [radiopaedia.org]

We present a case of adult-onset Pompe’s disease with progressive proximal muscles weakness over 5 years and respiratory failure on admission, requiring prolonged mechanical [hindawi.com]

Hypokalemic Periodic Paralysis

She developed significant proximal muscle weakness within 16 hours after the initial dose. Her serum potassium was 1.6 mEq/L. [ncbi.nlm.nih.gov]

Thyrotoxichypokalaemic periodic paralysis (PPHT) is an emergency that can occur predominantly from proximal muscle weakness until complete paralysis, with the risk of death [go.gale.com]

Congenital Generalized Lipodystrophy Type 4

[…] umbilicus Prominent belly button Prominent navel [ more ] 0001544 Proximal muscle weakness Weakness in muscles of upper arms and upper legs 0003701 Pyloric stenosis 0002021 [rarediseases.info.nih.gov]

[…] stiffness 0003552 Muscular dystrophy 0003560 Myalgia Muscle ache Muscle pain [ more ] 0003326 Osteopenia 0000938 Osteoporosis 0000939 Prolonged QT interval 0001657 Prominent [rarediseases.info.nih.gov]

[ more ] 0003593 Insulin resistance Body fails to respond to insulin 0000855 Lipodystrophy Inability to make and keep healthy fat tissue 0009125 Muscle mounding 0003719 Muscle [rarediseases.info.nih.gov]

Spinal Muscular Atrophy

Some years later, his two older teenage brothers presented with proximal muscle weakness. [ncbi.nlm.nih.gov]

We described a 25-year-old woman presented with proximal muscle weakness with calf muscle hypertrophy. [ncbi.nlm.nih.gov]

The clinical symptoms of SMA are progressive proximal muscle weakness and paralysis. [ncbi.nlm.nih.gov]