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37 Possible Causes for Proximal Muscle Weakness (Late Symptom), Tongue Weakness, Vacuolization

Did you mean: Proximal Muscle Weakness (Late Symptom, Tongue Weakness, Vacuolization

  • Distal Myopathy Type 3

    Tubulofilamentous inclusion, myeloid bodies, and autophagic vacuoles in the area corresponding to rimmed vacuoles ( d ; bar 1 μm).[karger.com] There is a slowly progressive weakness and the proximal muscles may be involved lately 3,6,7. The CK is usually high 1,3-6.[scielo.br] (ie, tongue and pharyngeal weakness) is manifested by symptoms of dysarthria and dysphagia.[sites.google.com]

  • Limb-Girdle Muscular Dystrophy

    […] pathology Vacuoles/ultrastructure Substances Chromatin LMNA protein, human Lamin Type A MyoD Protein MyoD1 myogenic differentiation protein PAX7 Transcription Factor PAX7[ncbi.nlm.nih.gov] The disease is characterized by slowly progressive wasting and weakness of the proximal muscles of arms and legs around the pelvic or shoulder girdles, elevated creatine kinase[uniprot.org] Involvement of the heart, respiratory muscles or tongue. (Facial weakness is not usual.)[patient.info]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy

    Histopathology of skeletal muscles biopsies showed typical dystrophic changes with many rimmed vacuoles.[ncbi.nlm.nih.gov] weakness that begins from the proximal limb muscles.[genome.jp] Involvement of the heart, respiratory muscles or tongue. (Facial weakness is not usual.)[patient.info]

  • Hereditary Proximal Myopathy with Early Respiratory Failure

    TDP43 immunoreactivity was observed adjacent to rimmed vacuoles and in areas around cytoplasmic bodies.[bmcneurol.biomedcentral.com] History Common symptoms: Malaise, fatigue. Symmetrical proximal muscle weakness with absence of sensory symptoms (paraesthesia).[patient.info] Other regions: Some patients Cranial nerves: Face; Tongue Posterior neck : Head ptosis Back: Camptocormia Asymmetric : Often Progression Slow: Over 1 to 2 decades To severe[neuromuscular.wustl.edu]

  • Glycogen Storage Disease Type 2

    At juvenile onset, a more moderate vacuolization without significant differences in overall morphology is notable.[ncbi.nlm.nih.gov] Late-onset Pompe disease The first symptoms are related or caused by muscle weakness, predominant in proximal lower limbs and paraspinal trunk muscles.[ncbi.nlm.nih.gov] Jones, Expanding the phenotype of late‐onset pompe disease: Tongue weakness: A new clinical observation, Muscle & Nerve, 44, 6, (897-901), (2011).[dx.doi.org]

  • Limb-Girdle Muscular Dystrophy Type 1E

    Pathologic findings in one of the patients showed rimmed vacuoles.[ncbi.nlm.nih.gov] Onset Early Symptoms Late Symptoms *Sarcoglycanopathy (complete deficiency) 3–15 years (8.5 average) Proximal weakness Contractures Difficulty walk/run Curvature in the spine[encyclopedia.com] Additional symptoms may occur including overgrowth (hypertrophy) of the muscles of the legs, an abnormally enlarged tongue (macroglossia), weakness and wasting (atrophy) of[rarediseases.org]

  • Secondary Myopathy

    Sensorimotor neuropathy Hypothyroid (amiodarone) Elevated serum CK EMG: fibs, PSWs, myotonia (choroquine), myopathic MUAPs NCS: axonal sensorimotor neuropathy Autophagic vacuoles[neurology.mhmedical.com] . • Muscle tone normal or reduced. 6. history • Common symptoms a. Symmetrical proximal muscle weakness. b. Malaise. c. Fatigue. d.[slideshare.net] (ie, tongue and pharyngeal weakness) is manifested by symptoms of dysarthria and dysphagia.[sites.google.com]

  • Limb-Girdle Muscular Dystrophy Type 2J

    License: CC BY-SA 3.0 On histological investigation, ringed vacuoles and intranuclear inclusion are seen. There is no known therapy.[lecturio.com] symptoms of weakness are usually first noted in late childhood, adolescence or adult life (thus differing from the Duchenne type). 6.[mdsa.co.za] Involvement of the heart, respiratory muscles or tongue. (Facial weakness is not usual.)[patient.info]

  • Limb-Girdle Muscular Dystrophy Type 1F

    Muscle biopsy shows dystrophic changes with abnormal nuclei, rimmed vacuoles, and filamentous inclusions (summary by Melia et al., 2013).[ncbi.nlm.nih.gov] Onset Early Symptoms Late Symptoms *Sarcoglycanopathy (complete deficiency) 3–15 years (8.5 average) Proximal weakness Contractures Difficulty walk/run Curvature in the spine[encyclopedia.com] Involvement of the heart, respiratory muscles or tongue. (Facial weakness is not usual.)[patient.info]

  • Myopathy

    Both patients demonstrated myogenic abnormalities on electromyography, multiple glycogen-containing vacuoles and undetectable muscle myophosphorylase activity on muscle biopsy[ncbi.nlm.nih.gov] History Common symptoms: Malaise, fatigue. Symmetrical proximal muscle weakness with absence of sensory symptoms (paraesthesia).[patient.info] General Asymmetry Distal Proximal Hereditary Face & Periocular With EOM Weakness No EOM Weakness Limb-Girdle Syndromes Focal Congenital Cranial Bulbar EOM Ptosis Tongue Trunk[neuromuscular.wustl.edu]

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