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43 Possible Causes for Proximal Muscle Weakness - Less Severe

  • Duchenne Muscular Dystrophy

    Epidemiology: Clinical Findings: Physical Examination Affected children will show progressive weakness in the proximal muscles of the shoulder and hip girdle.[posna.org] severe phenotype and more protracted progression of the disease.[posna.org] ’s muscular dystrophy is caused by less significant mutations in the same dystrophin gene with higher levels of functioning dystrophin found in myocytes; this leads to a less[posna.org]

  • Paraneoplastic Syndrome

    Mild distal weakness 2 axonal neuropathy: Less prominent than sensory change Proximal weakness 2 type II muscle fiber atrophy Progression Slow Occurs later in course of disease[neuromuscular.wustl.edu] : Rare at neoplasm onset Severity: Neuropathy not disabling Associated disorder: Proximal weakness 2 Type II muscle fiber atrophy Lab Nerve conduction: Axonal loss CSF: Normal[neuromuscular.wustl.edu] […] change: 30% to 40% Clinical Distribution: Distal; Legs Arms; Symmetric Sensory: Panmodal sensory loss; Paresthesias Weakness: Distal & Proximal with sparing of intermediate muscles[neuromuscular.wustl.edu]

  • Myositis

    Anti-SRP antibodies identify a syndrome of severe and rapidly progressive proximal muscle weakness, markedly elevated levels of serum CK, an association with cardiac involvement[rheumatologyadvisor.com] Antibodies directed against the signal recognition particle complex are present in less than 3 % of patients.[rheumatologyadvisor.com] Antibodies directed against the signal recognition particle complex are present in less than 3% of patients.[rheumatologyadvisor.com]

  • Arthrogryposis due to Muscular Dystrophy

    The classical form of the disease manifests as more or less severe hypotonia and generalized weakness with predominance in axial and proximal limb muscles.[scilit.net]

  • Arthrogryposis Multiplex Congenita

    . – 162370 NR Neuropathy congenital with AMC Severe foot deformities and weakness atrophy distal. Proximal muscles with less weakness. Autosomal dominant inheritance.[scielo.br]

  • X-linked Distal Spinal Muscular Atrophy Type 3

    All the mentioned forms of 5q-SMA commonly share proximal muscle weakness with slow progression in case of type II-IV SMA.[frontiersin.org] The 5q-SMA type IV, also called “adult SMA,” is considered the mildest and less severe form with a late onset of around 30 years of age ( Zerres et al., 1995 ).[frontiersin.org]

  • Porphyria

    Motor neuropathy usually manifests initially as proximal upper-extremity muscle weakness and can be difficult to detect.[web.archive.org] Acute attacks may be severe and are potentially fatal, but on average are less frequent and less severe than those observed in AIP [ Hift & Meissner 2005 ].[web.archive.org]

  • Cerebellar Neoplasm

    Mild distal weakness 2 axonal neuropathy: Less prominent than sensory change Proximal weakness 2 type II muscle fiber atrophy Progression Slow Occurs later in course of disease[neuromuscular.wustl.edu] : Rare at neoplasm onset Severity: Neuropathy not disabling Associated disorder: Proximal weakness 2 Type II muscle fiber atrophy Lab Nerve conduction: Axonal loss CSF: Normal[neuromuscular.wustl.edu] […] change: 30% to 40% Clinical Distribution: Distal; Legs Arms; Symmetric Sensory: Panmodal sensory loss; Paresthesias Weakness: Distal & Proximal with sparing of intermediate muscles[neuromuscular.wustl.edu]

  • Cardiodysrhythmic Potassium-Sensitive Periodic Paralysis

    Seasonal More common in May-October (Summer) Less common in December-March Duration of episodes: Hours to Days; Usual 2 to 6 hours Weakness: Distribution Legs Arms; Proximal[neuromuscular.wustl.edu] Distal May selectively involve recently exercised muscles Severe attacks may involve: Respiration; Bulbar function Occasionally asymmetric Sphincters not involved Tendon[neuromuscular.wustl.edu]

  • Enterovirus Infection

    […] affected more commonly than upper extremities (poliovirus, enterovirus 71, and coxsackievirus A7); other non-polio enteroviruses usually have less severe symptoms (for example[medicinenet.com] Paralysis (infrequent in both polio and non-polio intro viral infections): flaccid paralysis that is often asymmetric with proximal extremity muscles affected; lower extremities[medicinenet.com] , muscle weakness and oculomotor palsy) if paralysis develops As noted above, some strains of enteroviruses produce different symptoms, some of which are much more severe[medicinenet.com]

Further symptoms