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256 Possible Causes for Proximal Muscle Weakness of the Lower Extremity

  • Botulism

    By history, the most common symptoms were dysphagia (66%), proximal muscle weakness of upper and lower extremity (60%), neck flexor muscle weakness (33%), ophthalmoplegia[ncbi.nlm.nih.gov] During the examination, the most common features noted were: proximal muscle weakness of upper and lower extremities (73%), ophthalmoplegia (53%), ptosis (46%).[ncbi.nlm.nih.gov]

  • Dermatomyositis

    Proximal muscle weakness (upper or lower extremity and trunk) 3. Elevated serum creatine kinase or aldolase level 4. Muscle pain on grasping or spontaneous pain 5.[aafp.org] […] erythema on the upper palpebra Gottron's sign: red-purple keratotic, atrophic erythema or macules on the extensor surface of finger joints Erythema on the extensor surface of extremity[aafp.org]

  • Inclusion Body Myositis

    Inclusion body myositis features a slowly progressive inflammatory myopathy characterized by progressive proximal muscle weakness in the lower extremities, followed by proximal[ncbi.nlm.nih.gov] We present a case of a 76-year-old woman with systemic lupus erythematosus (SLE) who developed proximal muscle weakness of lower extremities and mild elevation of serum creatine[ncbi.nlm.nih.gov] It manifests as progressive muscle atrophy and weakness, typically affecting proximal lower extremity muscles initially but insidiously progressing to affect other muscles[ncbi.nlm.nih.gov]

  • Childhood Dermatomyositis

    Proximal muscle weakness (upper or lower extremity and trunk) 3. Elevated serum creatine kinase or aldolase level 4. Muscle pain on grasping or spontaneous pain 5.[aafp.org] […] erythema on the upper palpebra Gottron's sign: red-purple keratotic, atrophic erythema or macules on the extensor surface of finger joints Erythema on the extensor surface of extremity[aafp.org]

  • Oculopharyngeal Muscular Dystrophy

    The proband first noticed bilateral ptosis, dysphagia, and proximal dominant muscle weakness in the lower extremities at age 53.[ncbi.nlm.nih.gov] Other signs that occur as the disease progresses include tongue weakness and atrophy, proximal upper and lower extremity weakness, dysphonia, dysarthria, facial muscle weakness[orpha.net] Electromyographs revealed myogenic/neurogenic changes, and computed tomography disclosed selective muscle wasting with fatty replacement, predominantly in the lower extremities[ncbi.nlm.nih.gov]

  • Polymyositis

    Three months later he experienced severe proximal muscle weakness, more pronounced in the lower extremities.[nature.com] The most common presenting symptoms are moderate to severe proximal muscle weakness and myalgias. 11 Lower extremities seem to be more commonly involved. 15 , 26 , 27 Other[nature.com]

  • Diabetic Amyotrophy

    Diabetic amyotrophy is a syndrome consisting of bilateral, but often asymmetrical, proximal muscle weakness and atrophy primarily affecting the lower extremities accompanied[e-arm.org] , hip, and anterior thigh heralds onset Within days to weeks, weakness of proximal and, to a lesser extent, distal lower-extremity muscles (iliopsoas, gluteus, thigh adductor[slideshare.net] The common form of diabetic neuropathy is a distal polyneuropathy whereas diabetic amyotrophy is caused by proximal lesions.[e-arm.org]

  • Limb-Girdle Muscular Dystrophy

    The proband displayed major weakness in lower extremities that progressed and affected the upper proximal shoulder and girdle muscles.[humgenomics.biomedcentral.com] Muscular weakness was stable until the age of 21, afterward, progressive weakening of the muscles of the proximal regions of the lower extremities began.[frontiersin.org] The girl had a global proximal weakness affecting, lower more than the upper, extremities.[humgenomics.biomedcentral.com]

  • Lambert Eaton Myasthenic Syndrome

    In fact, almost all LEMS patients with oculobulbar or proximal upper extremity weakness also have proximal lower extremity weakness.[emedicine.medscape.com] muscle weakness, most commonly in the lower extremities.[clinicaladvisor.com] Definición: An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder[hon.ch]

  • Secondary Hyperparathyroidism

    Physical examination on admission revealed a blood pressure of 155/89 mmHg, pulse rate of 81/min, and severe flaccid weakness of the proximal muscles of all four limbs, with[edmcasereports.com] […] relative sparing of the distal groups and tenderness in the lower extremities.[edmcasereports.com]

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