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219 Possible Causes for Proximal Muscle Weakness of the Lower Extremity, Supraclavicular Fat Pads

  • Iatrogenic Cushing's Disease

    Individuals with Cushing syndrome can develop moon facies, facial plethora, supraclavicular fat pads, buffalo hump, truncal obesity, and purple striae, as shown in the image[emedicine.medscape.com] Common: centripetal obesity with dorsocervical and supraclavicular fat pads, facial plethora and "moon face," fatigue, hyperglycemia, hypertension, mood lability, easy bruisability[hopkinsguides.com]

  • Cushing's Disease

    Individuals with Cushing syndrome can develop moon facies, facial plethora, supraclavicular fat pads, buffalo hump, truncal obesity, and purple striae, as shown in the image[emedicine.medscape.com] fat pads (buffalo hump) Usually, very slender distal extremities and fingers Muscle wasting and weakness are present.[merckmanuals.com] At baseline and at months 6 and 12, a reviewer at each site assessed patients for signs of hypercortisolism (facial rubor and supraclavicular and dorsal fat pads) by scoring[nejm.org]

  • Adrenocortical Carcinoma

    pads.[symptoma.com] The majority of patients with functional tumors shows symptoms of Cushing syndrome including truncal obesity, striae, malar flushing, supraclavicular and dorsocervical fat[symptoma.com]

  • Adrenal Cortex Hormone

    Cortisol (glucocorticoid), aldosterone (mineralocorticoid), dehydroepiandrosterone (DHEA) and androstenedione (adrenal androgens) Steroid hormone secreted by adrenal cortex Glucocorticoid Stimulates gluconeogenesis; inhibits inflammatory response; suppresses immune response; enhances vascular responsiveness to[…][quizlet.com]

  • ACTH-Secreting Pituitary Adenoma

    fat pad, sometimes known as a 'buffalo hump' purple skin striae easy skin bruising acanthosis nigricans proximal myopathy depression and other mood disorders osteoporosis[radiopaedia.org] Weight gain (with centripetal distribution, buffalo-hump, supraclavicular fat pad), arterial hypertension, ecchymoses and purple striae on flanks and lower abdomen are all[primarycare.imedpub.com] Typically, patients have the following clinical features 6 : rounded face, sometimes described as 'moon-shaped' progressive centripetal obesity and weight gain prominent supraclavicular[radiopaedia.org]

  • Bronchogenic Carcinoma

    – between scapula and neck Supraclavicular fat pads I mmunosuppression (Opportunistic infection) – decreases lymphocyte and monocyte function and production; decreased complement[epomedicine.com] ): omental fat are able to convert inactive cortisone to cortisol via enzyme (11B-HSD1) Moon facies (bitemporal fat deposition) Buffalo hump (cervicodorsal fat deposition)[epomedicine.com] […] in muscle (negative nitrogen balance) and hypokalemia O besity – Insulin resistance and hyperphagia Central obesity (intra-abdominal visceral fat rather than subcutaneous fat[epomedicine.com]

  • ACTH-Independent Cushing Syndrome

    fat pad, sometimes known as a 'buffalo hump' purple skin striae easy skin bruising acanthosis nigricans proximal myopathy depression and other mood disorders osteoporosis[radiopaedia.org] : muscle weakness is more often proximal and is usually most prominent in the lower extremities (myopathy) BONE : significant osteopenia and osteoporosis fractures, typically[slidepptx.com] Presentation Truncal obesity, supraclavicular fat pads, buffalo hump, weight gain. Facial fullness, moon facies, facial plethora. Proximal muscle wasting and weakness.[patient.info]

  • Lambert Eaton Myasthenic Syndrome

    The most common initial complaint is proximal muscle weakness involving the lower extremities more than the upper extremities.[ncbi.nlm.nih.gov] In fact, almost all LEMS patients with oculobulbar or proximal upper extremity weakness also have proximal lower extremity weakness.[emedicine.medscape.com] Proximal muscles are more affected than distal muscles; lower extremity muscles are affected predominantly.[emedicine.medscape.com]

    Missing: Supraclavicular Fat Pads
  • Inclusion Body Myositis

    Abstract Inclusion body myositis features a slowly progressive inflammatory myopathy characterized by progressive proximal muscle weakness in the lower extremities, followed[ncbi.nlm.nih.gov] We present a case of a 76-year-old woman with systemic lupus erythematosus (SLE) who developed proximal muscle weakness of lower extremities and mild elevation of serum creatine[ncbi.nlm.nih.gov] It manifests as progressive muscle atrophy and weakness, typically affecting proximal lower extremity muscles initially but insidiously progressing to affect other muscles[ncbi.nlm.nih.gov]

    Missing: Supraclavicular Fat Pads
  • Oculopharyngeal Muscular Dystrophy

    The proband first noticed bilateral ptosis, dysphagia, and proximal dominant muscle weakness in the lower extremities at age 53.[ncbi.nlm.nih.gov] Other signs that occur as the disease progresses include tongue weakness and atrophy, proximal upper and lower extremity weakness, dysphonia, dysarthria, facial muscle weakness[orpha.net] Electromyographs revealed myogenic/neurogenic changes, and computed tomography disclosed selective muscle wasting with fatty replacement, predominantly in the lower extremities[ncbi.nlm.nih.gov]

    Missing: Supraclavicular Fat Pads

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