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304 Possible Causes for Proximal Muscle Weakness of the Lower Extremity, Supraclavicular Fat Pads

  • Cushing's Disease

    Weight gain in face ( moon face ) Weight gain above the collar bone (supraclavicular fat pad) Weight gain on the back of neck ( buffalo hump ) Skin changes with easy bruising[aans.org] Individuals with Cushing syndrome can develop moon facies, facial plethora, supraclavicular fat pads, buffalo hump, truncal obesity, and purple striae, as shown in the image[emedicine.medscape.com]

  • Iatrogenic Cushing's Disease

    Weight gain in face ( moon face ) Weight gain above the collar bone (supraclavicular fat pad) Weight gain on the back of neck ( buffalo hump ) Skin changes with easy bruising[aans.org] Common: centripetal obesity with dorsocervical and supraclavicular fat pads, facial plethora and "moon face," fatigue, hyperglycemia, hypertension, mood lability, easy bruisability[hopkinsguides.com] Individuals with Cushing syndrome can develop moon facies, facial plethora, supraclavicular fat pads, buffalo hump, truncal obesity, and purple striae, as shown in the image[emedicine.medscape.com]

  • ACTH-Secreting Pituitary Adenoma

    fat pad, sometimes known as a 'buffalo hump' purple skin striae easy skin bruising acanthosis nigricans proximal myopathy depression and other mood disorders osteoporosis[radiopaedia.org] Weight gain (with centripetal distribution, buffalo-hump, supraclavicular fat pad), arterial hypertension, ecchymoses and purple striae on flanks and lower abdomen are all[primarycare.imedpub.com] Typically, patients have the following clinical features 6 : rounded face, sometimes described as 'moon-shaped' progressive centripetal obesity and weight gain prominent supraclavicular[radiopaedia.org]

  • Adrenal Cortex Hormone

    The Swiss-Polish chemist and botanist Tadeus Reichstein was a truly remarkable researcher. Not only was he involved in the discovery and characterization of the hormones of the adrenal cortex, which earned him a share of the 1950 Nobel Prize in Physiology or Medicine, he also established the so-called Reichstein[…][mediatheque.lindau-nobel.org]

  • Bronchogenic Carcinoma

    – between scapula and neck Supraclavicular fat pads I mmunosuppression (Opportunistic infection) – decreases lymphocyte and monocyte function and production; decreased complement[epomedicine.com] ): omental fat are able to convert inactive cortisone to cortisol via enzyme (11B-HSD1) Moon facies (bitemporal fat deposition) Buffalo hump (cervicodorsal fat deposition)[epomedicine.com] […] in muscle (negative nitrogen balance) and hypokalemia O besity – Insulin resistance and hyperphagia Central obesity (intra-abdominal visceral fat rather than subcutaneous fat[epomedicine.com]

  • Adrenocortical Carcinoma

    Minimally invasive surgery for adrenocortical carcinoma (ACC) is controversial. We sought to evaluate the perioperative and long-term outcomes following minimally invasive (MIS) and open resection (OA) of ACC in patients treated with curative intent surgery. Retrospective data from patients who underwent[…][ncbi.nlm.nih.gov]

  • Botulism

    By history, the most common symptoms were dysphagia (66%), proximal muscle weakness of upper and lower extremity (60%), neck flexor muscle weakness (33%), ophthalmoplegia[ncbi.nlm.nih.gov] During the examination, the most common features noted were: proximal muscle weakness of upper and lower extremities (73%), ophthalmoplegia (53%), ptosis (46%).[ncbi.nlm.nih.gov]

    Missing: Supraclavicular Fat Pads
  • Dermatomyositis

    Proximal muscle weakness (upper or lower extremity and trunk) 3. Elevated serum creatine kinase or aldolase level 4. Muscle pain on grasping or spontaneous pain 5.[aafp.org] […] erythema on the upper palpebra Gottron's sign: red-purple keratotic, atrophic erythema or macules on the extensor surface of finger joints Erythema on the extensor surface of extremity[aafp.org]

    Missing: Supraclavicular Fat Pads
  • Inclusion Body Myositis

    Inclusion body myositis features a slowly progressive inflammatory myopathy characterized by progressive proximal muscle weakness in the lower extremities, followed by proximal[ncbi.nlm.nih.gov] We present a case of a 76-year-old woman with systemic lupus erythematosus (SLE) who developed proximal muscle weakness of lower extremities and mild elevation of serum creatine[ncbi.nlm.nih.gov] It manifests as progressive muscle atrophy and weakness, typically affecting proximal lower extremity muscles initially but insidiously progressing to affect other muscles[ncbi.nlm.nih.gov]

    Missing: Supraclavicular Fat Pads
  • Childhood Dermatomyositis

    Proximal muscle weakness (upper or lower extremity and trunk) 3. Elevated serum creatine kinase or aldolase level 4. Muscle pain on grasping or spontaneous pain 5.[aafp.org] […] erythema on the upper palpebra Gottron's sign: red-purple keratotic, atrophic erythema or macules on the extensor surface of finger joints Erythema on the extensor surface of extremity[aafp.org]

    Missing: Supraclavicular Fat Pads

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