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11 Possible Causes for Proximal Muscle Weakness of the Lower Extremity, Supraclavicular Fat Pads

  • Iatrogenic Cushing's Disease

    Individuals with Cushing syndrome can develop moon facies, facial plethora, supraclavicular fat pads, buffalo hump, truncal obesity, and purple striae, as shown in the image[emedicine.medscape.com] Weight gain in face ( moon face ) Weight gain above the collar bone (supraclavicular fat pad) Weight gain on the back of neck ( buffalo hump ) Skin changes with easy bruising[aans.org]

  • Cushing's Disease

    Weight gain in face ( moon face ) Weight gain above the collar bone (supraclavicular fat pad) Weight gain on the back of neck ( buffalo hump ) Skin changes with easy bruising[aans.org] Individuals with Cushing syndrome can develop moon facies, facial plethora, supraclavicular fat pads, buffalo hump, truncal obesity, and purple striae, as shown in the image[emedicine.medscape.com]

  • Adrenocortical Carcinoma

    pads.[symptoma.com] The majority of patients with functional tumors shows symptoms of Cushing syndrome including truncal obesity, striae, malar flushing, supraclavicular and dorsocervical fat[symptoma.com]

  • ACTH-Independent Cushing Syndrome

    fat pad, sometimes known as a 'buffalo hump' purple skin striae easy skin bruising acanthosis nigricans proximal myopathy depression and other mood disorders osteoporosis[radiopaedia.org] : muscle weakness is more often proximal and is usually most prominent in the lower extremities (myopathy) BONE : significant osteopenia and osteoporosis fractures, typically[slideplayer.com] Presentation Truncal obesity, supraclavicular fat pads, buffalo hump, weight gain. Facial fullness, moon facies, facial plethora. Proximal muscle wasting and weakness.[patient.info]

  • Corticotroph Pituitary Adenoma

    fat pad, sometimes known as a 'buffalo hump' purple skin striae easy skin bruising acanthosis nigricans proximal myopathy depression and other mood disorders osteoporosis[radiopaedia.org] Weight gain (with centripetal distribution, buffalo-hump, supraclavicular fat pad), arterial hypertension, ecchymoses and purple striae on flanks and lower abdomen are all[primarycare.imedpub.com] Typically, patients have the following clinical features 6 : rounded face, sometimes described as 'moon-shaped' progressive centripetal obesity and weight gain prominent supraclavicular[radiopaedia.org]

  • Bronchogenic Carcinoma

    – between scapula and neck Supraclavicular fat pads I mmunosuppression (Opportunistic infection) – decreases lymphocyte and monocyte function and production; decreased complement[epomedicine.com] ): omental fat are able to convert inactive cortisone to cortisol via enzyme (11B-HSD1) Moon facies (bitemporal fat deposition) Buffalo hump (cervicodorsal fat deposition)[epomedicine.com] […] in muscle (negative nitrogen balance) and hypokalemia O besity – Insulin resistance and hyperphagia Central obesity (intra-abdominal visceral fat rather than subcutaneous fat[epomedicine.com]

  • Adrenal Cortex Hormone

    Cortisol and its synthetic analogs have been in widespread clinical use for the treatment of a variety of disorders for more than 50 years. Since their first clinical application, intensive research has expanded our understanding of the physiology, biochemistry, and pharmacology of steroids and has led to a large[…][ncbi.nlm.nih.gov]

  • Carcinoma of the Prostate

    The patient had oral candidiasis, thin skin, multiple petechiae on the chest, a small supraclavicular fat pad and proximal muscle weakness.[ec.bioscientifica.com] Weakness usually affects the proximal muscles of the lower extremities and may or may not involve sensory loss.[aafp.org] Muscle weakness evolves over a few days to weeks after the initial pain.[aafp.org]

  • Nelson Syndrome

    fat pad, sometimes known as a 'buffalo hump' purple skin striae easy skin bruising acanthosis nigricans proximal myopathy depression and other mood disorders osteoporosis[radiopaedia.org] Clinical Features Weakness o Onset is gradual and progresses over weeks o Lower extremities (unable/refusal to walk)  trunks  upper limbs  bulbar muscles  flaccid tetraplegia[slideshare.net] Individuals with Cushing syndrome can develop moon facies, facial plethora, supraclavicular fat pads, buffalo hump, truncal obesity, and purple striae, as shown in the image[emedicine.medscape.com]

  • Secondary Aldosteronism

    Weight gain, glucose intolerance, striae, skin thinning, increase in cervical, supraclavicular fat pad, facial plethora, muscle weakness, or osteoporosis in an obese patient[thecurbsiders.com] Physical examination on admission revealed a blood pressure of 155/89 mmHg, pulse rate of 81/min, and severe flaccid weakness of the proximal muscles of all four limbs, with[edmcasereports.com] […] relative sparing of the distal groups and tenderness in the lower extremities.[edmcasereports.com]

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