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169 Possible Causes for Proximal Muscle Weakness of the Lower Extremity, Thigh Weakness

  • Polymyositis

    […] in the quadriceps (main thigh muscles), weakness in the forearm muscles that flex the fingers, and weakness in the muscles below the knee, which can cause foot drop , making[] Three months later he experienced severe proximal muscle weakness, more pronounced in the lower extremities.[] […] of both thighs.[]

  • Diabetic Amyotrophy

    […] pain, weakness, and atrophy; one type of diabetic polyradiculopathy.[] Diabetic amyotrophy is a syndrome consisting of bilateral, but often asymmetrical, proximal muscle weakness and atrophy primarily affecting the lower extremities accompanied[] , hip, and anterior thigh heralds onset Within days to weeks, weakness of proximal and, to a lesser extent, distal lower-extremity muscles (iliopsoas, gluteus, thigh adductor[]

  • Lambert Eaton Myasthenic Syndrome

    After diltiazem was prescribed, she began to feel systemic malaise and weakness in both thighs. She stopped taking diltiazem and the symptoms improved.[] In fact, almost all LEMS patients with oculobulbar or proximal upper extremity weakness also have proximal lower extremity weakness.[] […] the pelvic girdle (the pelvis and hips) and the thighs, with relative sparing of eye and respiratory muscles.[]

  • Cushing's Disease

    […] buffalo hump) Skin changes with easy bruising, purplish stretch marks (stria) and red cheeks (plethora) Excess hair growth (hirsutism) on face, neck, chest, abdomen, and thighs[] Generalized weakness and fatigue; wasting of muscles, most noticeably in the upper thighs.[] Generalized weakness and fatigue Loss of muscle Menstrual disorders in women (amenorrhea) Decreased fertility and/or sex drive (libido) Hypertension Diabetes mellitus Depression[]

  • Polymyalgia Rheumatica

    The symptoms of PMR include: Aching pain and stiffness in the neck, shoulders, hips, and thighs. Fatigue. General muscle weakness. Unintended weight loss.[] Sometimes, pain and stiffness can lead to lack of use of some body parts, which could result in weakness.[] Most people with PMR have pain and stiffness in at least two of the following areas: Buttocks Hips Neck Thighs Upper arms and shoulders Other symptoms of PMR include: Fatigue[]

  • Adrenal Cortex Hormone

    , buttocks, arms, and breasts Bone and muscle weakness Severe fatigue High blood sugar Irritability and anxiety Excessive hair growth in females Irregular or stopped menstrual[] Round or moon-shaped face Increased fat around neck Thinning arms and legs Fragile and thin skin Darkened pigmentation of the skin Acne Bruising Stretch marks on abdomen, thighs[]

  • Iatrogenic Cushing's Disease

    […] in your upper arms and thighs a low libido and fertility problems depression and mood swings Cushing's syndrome can also cause high blood pressure, which can be serious if[] Female balding Generalized weakness and fatigue Blurry vision Vertigo Muscle weakness Menstrual disorders in women ( amenorrhea ) Decreased fertility and/or sex drive (libido[] […] or cataracts Increased susceptibility to infections Thin, fragile skin that bruises easily and heals slowly Pinkish streaks that look like stretch marks on the abdomen, thighs[]

  • Graves Disease

    Graves' disease Synonyms Toxic diffuse goiter, Flajani–Basedow–Graves disease The classic finding of exophthalmos and lid retraction in Graves' disease Specialty Endocrinology Symptoms Enlarged thyroid , irritability, muscle weakness, sleeping problems, fast heartbeat , poor tolerance of heat Graves' disease at Curlie[…][]

  • Secondary Hyperparathyroidism

    A 48-year-old male was admitted to our hospital because of increasing knee pain and thigh muscle weakness. He had been undergoing hemodialysis for 15 years.[] Physical examination on admission revealed a blood pressure of 155/89 mmHg, pulse rate of 81/min, and severe flaccid weakness of the proximal muscles of all four limbs, with[] […] relative sparing of the distal groups and tenderness in the lower extremities.[]

  • Inclusion Body Myositis

    […] and visible wasting of the quadriceps muscles (the large muscles on the front part of the thighs) Weakness of the lower leg muscles, below the knees Weakness of the esophageal[] Inclusion body myositis features a slowly progressive inflammatory myopathy characterized by progressive proximal muscle weakness in the lower extremities, followed by proximal[] […] and noticeable shrinking of the quadriceps (main muscle of the thighs) Weakness in the forearm muscles Pain or discomfort as muscles weaken Difficulty swallowing[]

Further symptoms