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14 Possible Causes for Pruritic Rash, Vacuolation of Granular Layer

  • Epidermodysplasia Verruciformis

    layer.[ncbi.nlm.nih.gov] The vacuolated cells are present in the upper malpighian and granular layer [Figure 3] a. The keratinocytes have abundant basophilic cytoplasm.[ijpd.in] Skin biopsy of a macular lesion revealed epidermal acanthosis with vacuolated keratinocytes presenting blue-gray pallor, arranged in clusters at the granular and upper spinous[ncbi.nlm.nih.gov]

  • Polymorphic Photodermatitis

    Pruritic and often painful rash developing in sun-exposed areas Phototoxic ( 3 ) Erythema With increasing severity: vesicles and bullae Classic example: sunburn Nails may[5minuteconsult.com] Keratinocytes in the granular layer are vacuolated due to being infected with the wart virus. si Common warts.[studfiles.net] Contact dermatitis is a rash caused by direct skin exposure to a substance.[aafp.org]

  • Glucagonoma

    It is a pruritic rash that occurs in the lower abdomen, lower extremities, perineum, perioral area, and feet ( FIGS 1 and 2 ).[basicmedicalkey.com] A skin biopsy performed on a peritibial lesion showed a spongiotic epidermis with vacuolization of the granular layer and presence of necrotic keratinocytes in the horny layer[jmedicalcasereports.biomedcentral.com] One year later, the patient developed a painful and pruritic perirectal rash that spread to her perineum.[heart.bmj.com]

  • Condyloma Acuminatum

    Case 2 Biopsy of an extremely pruritic rash on the right hand of a 20-year-old man with similar rash on the left foot. Previous biopsy was non-diagnostic.[ispub.com] High-magnification view of the granular layer demonstrates coarse hyaline granules with scattered koilocytic changes (hyperchromatic nuceli with vacuolization).[dermatologyadvisor.com]

  • Pityriasis Lichenoides

    A 61-year-old male presented with a three-week history of a widespread, non-pruritic rash.[practicaldermatology.com] layer, basilar necrosis of keratinocytes, vacuolar interface dermatitis with a lymphocyte in nearly every vacuole, erythrocyte extravasation, and dermal oedema PLC lesions[pcds.org.uk] […] are characterised by a superficial dermal infiltrate, focal parakeratosis, preservation of the granular layer, and focal disappearance of the dermal-epidermal interface Management[pcds.org.uk]

  • Pityriasis Rubra Pilaris

    rash commencing on the face and spreading distally to the trunk and limbs.[casereports.bmj.com] Hyperkeratosis, parakeratosis, preserved granular layer and psoriasiform hyperplasia were showed in all biopsies.[ncbi.nlm.nih.gov] […] red, scaly rash, that started on the chest and spread to the neck, face, back, arms, and legs.[jddonline.com]

  • Pityriasis Lichenoides et Varioliformis

    As expected, a range of clinical presentations was reported, including single nodules, plaques, multiple pruritic papules, or a rash-like presentation.[academic.oup.com] layer, basilar necrosis of keratinocytes, vacuolar interface dermatitis with a lymphocyte in nearly every vacuole, erythrocyte extravasation, and dermal oedema PLC lesions[pcds.org.uk] […] are characterised by a superficial dermal infiltrate, focal parakeratosis, preservation of the granular layer, and focal disappearance of the dermal-epidermal interface Management[pcds.org.uk]

  • Erythema Palmaris Hereditarium

    Folliculitis of Pregnancy) Pruritic Urticarial Papules and Plaques of Pregnancy (PUPPP); (Polymorphic Eruption of Pregnancy); (Toxemic Erythema of Pregnancy); (Toxemic Rash[catdir.loc.gov] The granular cells are small cytoplasmic vacuoles.[dermatologyadvisor.com] (Diffuse Systemic Sclerosis) Prurigo of Pregnancy (Pruritis of Pregnancy); (Prurigo Gestationis); (Early-Onset Prurigo of Pregnancy); (Papular Dermatitis of Pregnancy); (Pruritic[catdir.loc.gov]

  • Lamellar Ichthyosis

    . 1) Atopic dermatitis 2) Ichthyosis vulgaris 3) Harlequin baby 4) Pityriasis alba 5) Allergic contact dermatitis 6) Scabies Chronic, pruritic, inflammatory disorder which[quizlet.com] In the prominent granular layer some of the keratinocytes exhibited cytoplasmic edema and coarse inclusions of keratohyalin.[dokumen.tips] […] tunnels and perhaps offending organism. 1) Atopic dermatitis 2) Ichthyosis vulgaris 3) Harlequin baby 4) Pityriasis alba 5) Allergic contact dermatitis 6) Scabies Itch that rashes[quizlet.com]

  • Hereditary Koilonychia

    A Puerto Rican woman is seen in clinic for a pruritic rash on her trunk. A punch biopsy is performed. The biopsy site continues to bleed, with hematoma formation.[quizlet.com] Cellular breakdown in the spinous and granular cell layers occurs rarely and can lead to blister formation.[emedicine.medscape.com] Perinuclear vacuolization and large keratohyalin granules are seen.[emedicine.medscape.com]

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