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13 Possible Causes for Pruritus Secondary to Liver Disease

  • Cholestasis

    Cholestasis can give rise to secondary liver disease like hepatic fibrosis, metabolic bone disease like osteopenia and osteoporosis, and life threatening bleeding tendencies[symptoma.com] Pruritus is treated with phototherapy, ursodeoxycholic acid, colestyramine, rifampicin and external biliary drainage.[symptoma.com]

  • Biliary Tract Infection

    Liver transplantation is now the treatment of choice for patients with advanced liver disease secondary to PSC.[emedicine.medscape.com] An important potential clinical benefit is the relief of jaundice and pruritus, although a benefit on disease progression has not been clearly established.[emedicine.medscape.com]

  • Hardikar Syndrome

    Hardikar syndrome is a multiple congenital anomaly syndrome first characterized in 1992 by Hardikar et al. to describe two individuals with cholestasis, cleft lip/palate, retinal pigmentation, intestinal abnormalities, and genitourinary anomalies. Between 1992 and 2002, four individuals with Hardikar syndrome were reported[…][ncbi.nlm.nih.gov]

  • Psychogenic Pruritus

    Metabolic disorders include chronic renal failure (dialysis) and liver disease (with or without cholestasis).[dermnetnz.org] Organomegly (liver, spleen), which increases the likelihood of an underlying systemic disease, should be assessed.[racgp.org.au] Uraemic pruritus arises in patients undergoing dialysis is due to a combination of xerosis (dry skin), secondary hyperparathyroidism, peripheral neuropathy (nerve changes)[dermnetnz.org]

  • Progressive Familial Intrahepatic Cholestasis

    Pruritus secondary to increased bile salts in the serum may not respond to medical treatment.[ncbi.nlm.nih.gov] Abstract Progressive familial intrahepatic cholestasis (PFIC) is a cholestatic liver disease of childhood.[ncbi.nlm.nih.gov]

  • Protein Losing Enteropathy

    We describe a patient with PFIC 1 who presented with cholestasis in infancy, who developed intractable pruritus and liver fibrosis.[ncbi.nlm.nih.gov] […] fatty liver disease trough graft steatohepatitis.[ncbi.nlm.nih.gov] The child underwent living donor LT at 3.6 yr of age, and he early developed severe refractory diarrhea, secondary malabsorption with protein-losing enteropathy, and an early[ncbi.nlm.nih.gov]

  • Pruritic Rash

    Metabolic disorders include chronic renal failure (dialysis) and liver disease (with or without cholestasis).[dermnetnz.org] Uraemic pruritus arises in patients undergoing dialysis is due to a combination of xerosis (dry skin), secondary hyperparathyroidism, peripheral neuropathy (nerve changes)[dermnetnz.org]

  • Hepatobiliary Disorder

    Ascites Accumulation of fluid in the peritoneal cavity chronic liver disease,cirrhosis, most common cause also can result from malignancy, right sided heart failure, pancreatitis[unf.edu] Liver transplantation is now the treatment of choice for patients with advanced liver disease secondary to PSC.[emedicine.medscape.com] secondary to deposition of bile salts Body Image Disturbance r/t to skin discolor Interventions Discuss these with me![unf.edu]

  • Phosphorus Poisoning

    Examination revealed clinical jaundice with excoriation marks all over the body secondary to severe pruritus.[jpharmacol.com] His liver was palpable 4 cm below the costal margin and was firm in consistency.[jpharmacol.com] Detailed examination failed to show any stigma of underlying chronic liver disease, splenomegaly, or ascites.[jpharmacol.com]

  • Nalmefene

    secondary to cholestatic liver disease and to assess the safety of long-term administration of this drug to these patients.[ncbi.nlm.nih.gov] Fourteen patients with unrelieved chronic pruritus of cholestasis were studied.[ncbi.nlm.nih.gov] […] aims of this study were to determine whether long-term oral administration of the opiate antagonist nalmefene is associated with any beneficial effects in patients with pruritus[ncbi.nlm.nih.gov]

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