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10 Possible Causes for Psychiatric Manifestation, Relative Macrocephaly in Childhood

  • Autistic Disorder

    CRS may lead to new physical symptoms during adolescence or adulthood, referred to as "late manifestations".[ncbi.nlm.nih.gov] Brain Overgrowth and Macrocephaly The findings of early postnatal brain “overgrowth” in ASD followed by normalization or relative growth arrest in childhood are intriguing[ncbi.nlm.nih.gov] […] linked with the manifestation of catatonia.[ncbi.nlm.nih.gov]

  • Legius Syndrome

    Other studies showed that these duplications can manifest with dysmorphic features without a recognizable pattern, microcephaly, congenital anomalies (including torticollis[healthdocbox.com] The number of café au lait macules increases with age in childhood, similar to what is observed in NF1 [Author, personal observation]. Macrocephaly.[ncbi.nlm.nih.gov] Recurrent 16p11.2 microduplications have been initially associated with phenotypes ranging from normal to ID, autistic spectrum disorders and psychiatric problems [Fernandez[healthdocbox.com]

  • Spastic Paraplegia

    Non-neurological manifestations may include ophthalmological abnormalities (cataracts, retinitis pigmentosa, macular degeneration), and orthopedic abnormalities (scoliosis[orpha.net] Clinical features that may be recognized from birth in the Amish, where the condition occurs at an increased frequency, include low birth weight, relative macrocephaly, triangular[ncbi.nlm.nih.gov] […] dementia), sensory impairment (optic, auditive neuropathy), epilepsy, myopathic features (ptosis, opthalmoparesis), extrapyramidal features (Parkinsonism, chorea, dystonia), psychiatric[orpha.net]

  • Autosomal Recessive Spastic Paraplegia Type 20

    […] psychological assessment as indicated Developmental assessment / cognitive testing as indicated depending on age and severity Annual assessment of orthopedic manifestations[ncbi.nlm.nih.gov] Clinical features that may be recognized from birth in the Amish, where the condition occurs at an increased frequency, include low birth weight, relative macrocephaly, triangular[ncbi.nlm.nih.gov] […] required depending on age and severity) to review symptoms, assess need for multidisciplinary input, and update medications Monitor for dysphagia to reduce risk of aspiration Psychiatric[ncbi.nlm.nih.gov]

  • Fragile X Syndrome

    Fragile X syndrome: psychiatric manifestations, assessment and emerging therapies.[ncbi.nlm.nih.gov] Seizures have been reported in approximately 13% to 18% of affected males and 5% of females with a full mutation, and there may be relative macrocephaly.[pediatrics.aappublications.org] As is the case with ADHD in FXS, many of the other psychiatric manifestations of FXS appear to follow a developmental course; in other words, they are noted to change over[doi.org]

  • X-linked Intellectual Disability Type Raymond

    manifestations.[uniprot.org] The key elements of the clinical phenotype are absolute or relative macrocephaly with a long narrow face; tall forehead; dolicocephalic head shape; an open mouth; small, simple[nature.com] […] deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric[uniprot.org]

  • Kondoh Syndrome

    Psychiatric manifestations including social inhibition or psychosis have been also noticed [ 19 , 20 ]. Dilatation of the cerebral ventricles is common.[ojrd.biomedcentral.com] In group 3, furthermore, the low prevalence of relative macrocephaly at birth appears to be discordant with the high prevalence of prominent forehead during early childhood[journals.plos.org] macrocephaly at birth, i.e., SDS for birth length or birth weight minus SDS for birth occipitofrontal circumference (OFC) –1.5, (iii) prominent forehead during early childhood[journals.plos.org]

  • Opitz-Kaveggia Syndrome

    manifestations Psychopathology and related behavioral abnormalities are typically seen in LFS, and they may be considered in the diagnosis of the disorder. [7] The most common[wikiwand.com] The key elements of the clinical phenotype are absolute or relative macrocephaly with a long narrow face; tall forehead; dolicocephalic head shape; an open mouth; small, simple[nature.com] […] a rate of approximately 73 percent. [12] A correlation between agenesis of the corpus callosum and intellectual disability in LFS, however, has not been suggested. [13] Psychiatric[wikiwand.com]

  • Pseudohypoparathyroidism Type 1B

    […] disorders have been reported that are associated with hypoparathyroidism in general and with PHP in particular, often with overt clinical manifestations such as complaints[pediatricneurosciences.com] Many patients have relatively high birth weight and/or early-onset obesity that persists into childhood and later; relative macrocephaly and tall stature have also been observed[academic.oup.com] […] the presence (PHP Ia and Ic) or absence (PHP Ib) of clinical features of Albright hereditary osteodystrophy More Details. [2] In adulthood, heterogeneous neurological and psychiatric[pediatricneurosciences.com]

  • Macrocephaly - Intellectual Disability - Autism Syndrome

    Variation in associated cognitive, neurological, and psychiatric features is extensive.[medicalhomeportal.org] Seizures have been reported in approximately 13% to 18% of affected males and 5% of females with a full mutation, and there may be relative macrocephaly.[pediatrics.aappublications.org] The manifestations of the core features of autism vary between individuals and within the same individual at different developmental stages.[medicalhomeportal.org]

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