Psychiatric Manifestation & Vertical Gaze Palsy: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Psychiatric Manifestation & Vertical Gaze Palsy

Neurologic Manifestation of Whipple Disease

In our case after the confirmation of possible CNS WD (fever of unknown origin, chronic migratory arthralgias, unexplained lymphadenopathy, supranuclear vertical gaze palsy [benthamopen.com]

myelopathy, ataxia and psychiatric manifestations. [ncbi.nlm.nih.gov]

gaze palsy, and occasionally, rhythmic movements of the limbs (see video in Media below). [eyewiki.aao.org]

Huntington Disease

Huntington's disease (HD) is an autosomal dominant and progressive neurodegenerative syndrome characterized by motor, cognitive and psychiatric manifestations. [ncbi.nlm.nih.gov]

Although noncompliance to oral antipsychotic drugs can be a practical problem, especially when significant psychiatric manifestations of HD are present, the effect of depot [ncbi.nlm.nih.gov]

To our knowledge, this is the first case report on combat related PTSD as psychiatric disorder manifested prior to HD. [ncbi.nlm.nih.gov]

Primary Progressive Multiple Sclerosis

We present three patients with a clinical course and cerebrospinal fluid findings consistent with a diagnosis of primary progressive multiple sclerosis (PPMS). Extensive and repeated magnetic resonance imaging (MRI) examinations showed only diffuse abnormality in brain and spinal cord, but no focal lesions. We propose[…] [ncbi.nlm.nih.gov]

Multiple Sclerosis

Fatigue and psychiatric symptoms, such as depression or euphoria, can also be manifestations of MS. Symptoms (attacks) of MS need disseminated in “time and space.” [clinicaladvisor.com]

Psychiatric manifestations of multiple sclerosis: A review. Can J Psychiatry 1996 ; 41: 441 – 445. Google Scholar | SAGE Journals | ISI 5. [dx.doi.org]

Whipple Disease

We describe a patient with cerebral Whipple disease who presented with changes in mental status, confusion, inverse sleep-wake cycle, bilateral ptosis and vertical gaze palsy [ncbi.nlm.nih.gov]

Patients with central nervous system (CNS) involvement may present in a variety of ways, including cognitive impairment, psychiatric manifestations, gaze palsies, upper motor [link.springer.com]

gaze palsy, and occasionally, rhythmic movements of the limbs (see video in Media below). [eyewiki.aao.org]

Neurotic Disorder

Vertical gaze palsy (the inability to move the eyes up and down), enlarged liver, enlarged spleen, or jaundice in young children are strong indications that NPC should be [nnpdf.org]

psychiatric disorder (V71.01-V71.02) personality disorder with predominantly sociopathic or asocial manifestations (301.7) sexual deviations (302.0-302.9) The following fifth-digit [icd9.chrisendres.com]

Vertical supranuclear gaze palsy may be present. [patient.info]

Niemann-Pick Disease Type C1

[…] supranuclear gaze palsy (VSPG), dysarthria, dysphagia, dystonia, seizures, gelastic cataplexy, and psychiatric disorders. [orpha.net]

Individuals have been described in the medical literature with other psychiatric manifestations such as obsessive-compulsive disorder, bipolar disorders, and hallucinations [rarediseases.org]

Supranuclear Gaze Palsy) Unsteadiness of gait, clumsiness, problems in walking (ataxia) Difficulty in posturing of limbs (dystonia) Slurred, irregular speech (dysarthria) [npuk.org]

Niemann-Pick Disease Type C

The second developed progressive ataxia, accompanied by a vertical gaze palsy, when she was 13. [ncbi.nlm.nih.gov]

NP-C is characterised by visceral, neurological and psychiatric manifestations that are not specific to the disease and that can be found in other conditions. [ncbi.nlm.nih.gov]

Neurological examination revealed a broad-based ataxic gait, limb dysmetria, downward vertical gaze palsy, brisk lower limb reflexes and ankle clonus, while neuropsychological [ncbi.nlm.nih.gov]

Tourette Syndrome

The neurological examination revealed vertical gaze palsy with preserved vertical oculocephalic movements. [ncbi.nlm.nih.gov]

Trial Registration clinicaltrials.gov Identifier: NCT00139308 Tourette syndrome (TS) is characterized by motor and vocal tics associated with various psychiatric manifestations [dx.doi.org]

Ackermans L, Temel Y, et al: Vertical gaze palsy after thalamic stimulation for Tourette syndrome: case report. Neurosurgery 2007;61:E1100. [dx.doi.org]

Niemann-Pick Disease Type C2

Neimann-Pick disease type C2 may be characterized by ataxia (difficulty coordinating movements), vertical supranuclear gaze palsy (inability to move the eyes vertically), [monarchinitiative.org]

It is a highly heterogeneous disease, characterized by visceral, neurological and psychiatric manifestations. [content.iospress.com]

Common symptoms include hepatomegaly, splenomegaly, jaundice and vertical supranuclear gaze palsy (VSGP). 95% of NPC patients will have mutations in the NPC1 gene. [mangen.co.uk]

Neurocysticercosis

A sign of worsening hydrocephalus is vertical gaze palsy, the inability to gaze upward or downward when asked. The head of Mr. [americannursetoday.com]

In this communication we describe an interesting case of multiple neurocysticercosis in a young presenting with psychiatric manifestations. [ncbi.nlm.nih.gov]

H. de Camargo, et al., “Psychiatric Manifestations of Neurocysticercosis: A Study of 38 Patients from a Neurology Clinic in Brazil,” Journal of Neurology, Neurosurgery & Psychiatry [scirp.org]

Psychosis

Most notably, vertical supranuclear gaze palsy (VSGP) – particularly paresis of downgaze – is a highly specific and highly prevalent sign that may be present at an early stage [doi.org]

According to the literature, this psychiatric manifestation resolves within 2 weeks of discontinuing the offending agent. [ncbi.nlm.nih.gov]

There is growing evidence that a proportion of psychosis/ psychiatric manifestations in children may be immunemediated, and physicians should consider this etiology in each [ncbi.nlm.nih.gov]

Mental Disorder

Alongside psychiatric disorders, patients develop early motor signs: ataxia, abnormal movements and, an almost consistent finding, vertical supranuclear gaze palsy. [ncbi.nlm.nih.gov]

Psychiatric manifestations may remain isolated for several years. [dx.doi.org]

Most notably, vertical supranuclear gaze palsy (VSGP) – particularly paresis of downgaze – is a highly specific and highly prevalent sign that may be present at an early stage [dx.doi.org]

Anxiety Disorder

Alongside psychiatric disorders, patients develop early motor signs: ataxia, abnormal movements and, an almost consistent finding, vertical supranuclear gaze palsy. [ncbi.nlm.nih.gov]

Psychiatric manifestations may remain isolated for several years. [dx.doi.org]

Psychiatric manifestations in cerebrotendinous xanthomatosis. Transl. [ncbi.nlm.nih.gov]

Spastic Ataxia with Congenital Miosis

Upgaze palsy with gaze-evoked nystagmus can be a transient side effect of barbiturate toxicity (42). See Case 42. Supranuclear vertical gaze palsy. [neuroophthalmology.ca]

Find the answers you need on the hottest topics in neurology, including involuntary movement disorders; single gene mutations with neuropsychiatric manifestations; psychiatric [books.google.ro]

manifestations]; Psychosis; Mood instability; Schizophrenic symptoms (reported in 1 patient) MISCELLANEOUS: Slowly progressive; Highly variable phenotype with respect to [findzebra.com]

Spinocerebellar Ataxia with Rigidity and Peripheral Neuropathy

Ocular Motility: Supranuclear vertical gaze palsy (saccades and pursuit) Slow to initiate horizontal eye movements on command Slow horizontal hypometric saccades To look rapidly [collections.lib.utah.edu]

It can lead to neurological involvement, acute renal failure, hepatitis, hypoglycaemia, psychiatric manifestations etc. [casereports.in]

In addition, almost half of the patients present with psychiatric manifestations (psychosis), slowly progressive SMA with muscle weakness (often limb-girdle in distribution [neuroweb.us]

Suprasellar Tumor

This phenomenon is caused by involvement of midbrain structures adjacent to the pineal GCT and is characterised by vertical gaze palsy, nystagmus on convergence and pupillary [tandfonline.com]

Psychiatric manifestations as initial presentation for pediatric CNS germ cell tumors, a case series. Childs Nerv Syst 32 (8): 1359-62, 2016. [cancer.gov]

Niemann-Pick Disease

Examination showed ataxia, moderate cognitive impairment, and vertical gaze palsy. EEG revealed diffuse slowing and disorganization of background rhythms. [ncbi.nlm.nih.gov]

Other features presenting later in life may include dystonia and vertical supranuclear gaze palsy, dementia and psychiatric manifestations. [genedx.com]

Classically, children with NPC demonstrate neurological dysfunction with cerebellar ataxia, dysarthria, seizures, vertical gaze palsy, motor impairment, dysphagia, psychotic [clinicaltrials.gov]

Pineal Gland Dysfunction

[…] eye movements Problems with the visual pathways in pineal tumors: Accommodation deficiency Oculomotor nerve palsy Failure of downward gaze Visual field disturbance (mass [pedsoncologyeducation.com]

It is very likely that the pineal plays a significant role in the manifestation of several mental illnesses. [thebridgelifeinthemix.info]

[…] pretectum - eye symptoms are common The pretectum: Includes the ocular motor centre and pupillary control centre Between the thalamus and the midbrain Responsible for mediating vertical [pedsoncologyeducation.com]

Deafness - Opticoacoustic Nerve Atrophy - Dementia Syndrome

[…] preference, and downbeating nystagmus Parinaud syndrome (a type of conjugate vertical gaze palsy) Pineal tumor Dorsal midbrain infarct Bilateral paresis of downward eye movements [merckmanuals.com]

The earliest manifestations are usually psychiatric, but progressive abnormal involuntary movements and cognitive deficits are also major features. [aao.org]

CNS manifestations are a neurodegenerative basal ganglia disease including movement disorder, cognitive impairment, and psychiatric symptoms. [ncbi.nlm.nih.gov]

Sellar Tumor with Suprasellar Extension

Psychiatric [ edit ] Various psychiatric manifestations have been associated with pituitary disorders including pituitary adenomas. [en.wikipedia.org]

Psychiatric manifestations may include depression, anxiety, easy irritability and emotional instability. It may also result in various cognitive difficulties. [en.wikipedia.org]

Psychiatric symptoms such as depression, anxiety [10] apathy, emotional instability, easy irritability and hostility have been noted. [11] Complications [ edit ] Acromegaly [en.wikipedia.org]

Perry Syndrome

Perry syndrome due to the DCTN1 G71R mutation: a distinctive levodopa responsive disorder with behavioral syndrome, vertical gaze palsy, and respiratory failure. [orca.cf.ac.uk]

manifesting as depression, lethargy, withdrawal, apathy, and changes in character, as well as sleep difficulties. [orpha.net]

gaze palsy, and respiratory failure. [genome.jp]

Lead Encephalopathy

Neurologic and psychiatric manifestations of lead poisoning in adults (case report and review of the literature) [in German]. [ajnr.org]

HIV encephalopathy ( HIV-related encephalopathy ) a progressive primary encephalopathy caused by infection with human immunodeficiency virus type I, manifested by a variety [medical-dictionary.thefreedictionary.com]

Fortschr Neurol Psychiatr 1991 ; 59 : 413 –24 ↵ Tuzun M, Tuzun D, Salan A, et al. Lead encephalopathy: CT and MR findings. [ajnr.org]

Boxer's Dementia

Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. [actaneurocomms.biomedcentral.com]

[…] involving the brain stem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. [actaneurocomms.biomedcentral.com]

PSP presents classically with postural instability and falls, slurred speech, a vertical supranuclear gaze palsy and a dysexecutive syndrome[ 12 ], but there are a number [actaneurocomms.biomedcentral.com]

Spastic Paraplegia - Ataxia - Mental Retardation

manifestations is not clear. [ruralneuropractice.com]

gaze palsy (saccades and pursuit) Slow horizontal hypometric saccades with catch-up saccades Convergence absent Smooth pursuit to a slow target normal Saccadic pursuit to [repository.countway.harvard.edu]

Olfactory Groove Meningioma

Most common symptoms are anosmia, headaches, and visual disturbances, but a range of manifestations, both neurologic and psychiatric, has been described in a significant number [symptoma.com]

Niemann-Pick Disease Type B

[…] supranuclear gaze palsy (VSPG), dysarthria, dysphagia, dystonia, seizures, gelastic cataplexy, and psychiatric disorders. [orpha.net]

Individuals have been described in the medical literature with other psychiatric manifestations such as obsessive-compulsive disorder, bipolar disorders, and hallucinations [rarediseases.org]

Vertical gaze palsy (the inability to move the eyes up and down), enlarged liver, enlarged spleen, or jaundice in young children are strong indications that NPC should be [nnpdf.org]

Pseudobulbar Palsy

vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. ( 24963673 ) Steele J.C....Olszewski J. 2014 8 Pseudobulbar paralysis in the Renaissance: Cosimo I de' [malacards.org]

Find the answers you need on the hottest topics in neurology, including involuntary movement disorders; single gene mutations with neuropsychiatric manifestations; psychiatric [books.google.com]

Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia [dovemed.com]

Niemann-Pick Disease Type D

Visceral, neurologic, ophthalmologic, and psychiatric manifestations should be explored in depth. 1 Details of the signs, symptoms, and disease stages of NP-C are covered [cp.neurology.org]

J.S. had a vertical supranuclear gaze palsy, which was most pronounced on downward gaze. [primarypsychiatry.com]

Parkinson Disease Type 19A

A heterogeneous degeneration involving the brain stem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. ‎ [books.google.ro]

Disease definition A complex form of young-onset Parkinson disease that manifests with pyramidal signs, eye movement abnormalities, psychiatric manifestations (depression, [orpha.net]

Exclusion criteria  Early dementia (will exclude some patients with corticobasal degeneration)  Early vertical gaze palsy  Rest tremor  Severe autonomic disturbances  [slideshare.net]