Psychomotor Deterioration: Causes & Reasons

Possible Causes for Psychomotor Deterioration

deterioration 0002361 Rigidity Muscle rigidity 0002063 Rod-cone dystrophy 0000510 Scanning speech Explosive speech 0002168 Seizures Seizure 0001250 Vacuolated lymphocytes [rarediseases.info.nih.gov]

deterioration Rigidity Rod-cone dystrophy Scanning speech Seizures Vacuolated lymphocytes (Source: Neuronal Ceroid Lipofuscinosis 9; Genetic and Rare Diseases Information [dovemed.com]

In PPT-1-related NCL, early psychomotor development is normal until the age of 6-18 months and then rapid psychomotor deterioration sets in. [neurologyindia.com]

Juvenile Neuronal Ceroid Lipofuscinosis

Psychomotor deterioration becomes evident in the early school years, and seizures start at a mean age of 10 years. [pediatricneurologybriefs.com]

deterioration 0002361 Psychosis 0000709 Rod-cone dystrophy 0000510 Seizures Seizure 0001250 Undetectable electroretinogram 0000550 Vacuolated lymphocytes 0001922 Showing [rarediseases.info.nih.gov]

It is characterized by rapid deterioration with psychomotor retardation, loss of speech, seizures, ataxia, blindness, hypotonia, microcephaly, and occasional convulsions. [icd10data.com]

Neuronal Ceroid Lipofuscinosis Type 1

As children age, the psychomotor abilities (abilities that require coordination of muscular and mental activity) will deteriorate. [rarediseases.org]

Tay-Sachs Disease

Then, as nerve cells become distended with fatty material, a relentless deterioration of mental and physical abilities occurs. [whonamedit.com]

Early symptoms become apparent within the first 3 to 6 months of life, with muscle weakness, blindness, psychomotor retardation, feeding difficulty, and general paralysis. [whonamedit.com]

Fucosidosis

Abstract Fucosidosis is a lysosomal storage disorder characterised by progressive psychomotor deterioration, angiokeratoma and growth retardation. [ncbi.nlm.nih.gov]

Psychomotor deterioration progressed slowly. [ncbi.nlm.nih.gov]

deterioration, growth retardation, hepatosplenomegaly, cardiomegaly, and seizures. fucosidosis (fyo͞o-kō′sĭ-dō′sĭs) n. [medical-dictionary.thefreedictionary.com]

Late-Infantile Neuronal Ceroid Lipofuscinosis

deterioration Tay-Sachs Disease b- Hexosaminidase A AR variable progressive psychomotor deterioration Sandhoff Disease b-Hexosaminidases A and B AR variable progressive psychomotor [ntsad.org]

These children suffer from severe psychomotor deterioration that leads to vegetative states, seizures, profound visual loss secondary to retinal degeneration and, ultimately [reviewofoptometry.com]

Characteristic features at onset include clumsiness; deterioration of vision and psychomotor functions; seizures and behavioral changes. [preventiongenetics.com]

Central Nervous System Calcification-Deafness-Tubular Acidosis-Anemia Syndrome

deterioration, deafness, microcytic hypochromic anemia, and variable distal renal tubular acidosis. [orpha.net]

[…] definition A rare, genetic, syndromic, neurological disorder characterized by early infantile-onset of the progressive brain and spinal cord calcification, growth retardation, psychomotor [orpha.net]

GM1 Gangliosidosis Type 3

It has generalized CNS involvement with psychomotor deterioration (NPMD regression), seizures, and localized skeletal involvement. [scielo.br]

Odontomatosis - Aortae Esophagus Stenosis Syndrome

deterioration Exaggerated startle response Decerebrate rigidity Psychotic episodes Cherry red spot of the macula Abnormal anterior horn cell morphology Therapeutic abortion [mendelian.co]

[…] abnormality Hypercholesterolemia Aspiration Poor head control Apathy Incoordination Spinal muscular atrophy Proximal amyotrophy Urinary incontinence Action tremor Torsion dystonia Psychomotor [mendelian.co]

Fucosidosis Type 1

[…] and neurological deterioration; • Joint contractures; • Abnormal bone development; • Enlargement of the heart, liver and spleen; • Abnormal posture (bent arms, clenched fists [secure.ssa.gov]

Initial symptoms may be associated with mental and motor deterioration such as delayed acquisition of skills required to coordinate mental and muscular activities (psychomotor [rarediseases.org]

[…] individuals with Fucosidosis Type I include: • Distinct facial features such as, flat face, depressed nasal bridge, and bulging forehead; • Spasticity; • Seizures; • Progressive psychomotor [secure.ssa.gov]

GM1 Gangliosidosis Type 2

deterioration, dullness of senses, lethargy, seizures, decerebrate rigidity, and terminal bronchopneumonia at the age of 3 to 10 years and rarely later. [linkedlifedata.com]

The juvenile form, type II, has a later onset with psychomotor deterioration, seizures and skeletal changes apparent between 7 and 36 months and death in childhood. [disorders.eyes.arizona.edu]

deterioration 0007272 Sea-blue histiocytosis 0001982 Spastic tetraplegia 0002510 Ventriculomegaly 0002119 Showing of 15 | Last updated: 5/1/2019 If you need medical advice [rarediseases.info.nih.gov]

Mucolipidosis Type 2

Physical findings: • Psychomotor deterioration; • Short stature; • Characteristic coarse facial features with bulging eyes, low nasal bridge, and overgrown gums (gingival [secure.ssa.gov]

GM1 Gangliosidosis

The juvenile form, type II, has a later onset with psychomotor deterioration, seizures and skeletal changes apparent between 7 and 36 months and death in childhood. [disorders.eyes.arizona.edu]

Early psychomotor deterioration: decreased activity and lethargy in the first weeks; never sit; feeding problems - failure to thrive; visual failure (nystagmus noted) by 6 [en.wikipedia.org]

It has generalized CNS involvement with psychomotor deterioration (NPMD regression), seizures, and localized skeletal involvement. [scielo.br]

Neuronal Ceroid Lipofuscinosis

We report on a 4-year-old boy who presented with an acute onset of seizures followed by rapid psychomotor deterioration, ataxia, and visual failure. [ncbi.nlm.nih.gov]

We experienced a case of late infantile neuronal ceroid lipofuscinosis in a 6-year-old boy who had progressive myoclonic seizures, ataxia, rapid psychomotor deterioration [ncbi.nlm.nih.gov]

The clinical phenotype is that of a variant late-infantile neuronal ceroid lipofuscinosis and consisted of early-onset visual loss, psychomotor deterioration, and seizures [ncbi.nlm.nih.gov]

Neuronal Ceroid Lipofuscinosis Type 7

[…] delay, and vision deterioration at age of 5 years, which could be the consequence of macular dystrophy, was referred to us for genetic testing. [ncbi.nlm.nih.gov]

Clinical features consist of various combinations of seizures, psychomotor deterioration and blindness, the ages and order of onset differing for each NCL 4. [scielo.br]

[…] neurodegenerative disorder with speech problems, lack of concentration, walking disability at age of 4 years leading to quadriplegia, spontaneous laughing, hidden seizure, clumsiness, psychomotor [ncbi.nlm.nih.gov]

Gangliosidosis

deterioration. [uniprot.org]

The juvenile form, type II, has a later onset with psychomotor deterioration, seizures and skeletal changes apparent between 7 and 36 months and death in childhood. [disorders.eyes.arizona.edu]

Early psychomotor deterioration: decreased activity and lethargy in the first weeks; never sit; feeding problems - failure to thrive; visual failure (nystagmus noted) by 6 [en.wikipedia.org]

Glycogen Storage Disease Type 1C

deterioration GM2 Gangliodisosis, AB variant GM2 Activator Protein AR infancy progressive psychomotor deterioration Fabry Disease 8-Galactosidase A adolesence - adulthood [ntsad.org]

deterioration www.mpssociety.org Sanfillippo B (MPS IIIB) N-Acetylglucosaminidase AR infancy - childhood progressive psychomotor deterioration www.mpssociety.org Sanfillippo [ntsad.org]

Neuronal Ceroid Lipofuscinosis Type 3

Psychomotor deterioration becomes evident in the early school years, and seizures start at a mean age of 10 years. [pediatricneurologybriefs.com]

The number of NCL forms can still grow, since syndromes with seizures and a variable degree of psychomotor deterioration will probably get in this group of disorders 2. [scielo.br]

Initial signs of this disorder include delayed psychomotor development with progressive deterioration, other motor disorders, or seizures. [brainfoundation.org.au]

Dimethoate Poisoning

At day 13th onset of psychomotor agitation, cognitive deterioration, reduction of ventilatory performance up to respiratory arrest with need for re-intubation were present [jeccm.amegroups.com]

Leptomeningeal TTR Amyloidosis

Clinical features Seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humour. [medical-dictionary.thefreedictionary.com]

Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. [malacards.org]

Schindler Disease Type 1

deterioration GM2 Gangliodisosis, AB variant GM2 Activator Protein AR infancy progressive psychomotor deterioration Fabry Disease 8-Galactosidase A adolesence - adulthood [ntsad.org]

deterioration www.mpssociety.org Sanfillippo B (MPS IIIB) N-Acetylglucosaminidase AR infancy - childhood progressive psychomotor deterioration www.mpssociety.org Sanfillippo [ntsad.org]

GM2-Gangliosidosis Types B - B1 - Ab

deterioration, general dystrophy, feeding problems Juvenilea By 4 years or later: dysarthria, extrapyramidal signs including dystonia Slight intellectual impairment, mild [jneurosci.org]

Cherry-red macular spotc, nystagmus, seizures, splenomegaly, joint contractures, hematologic signs, vacuolated blood lymphocytesd Rapid or 1–2 year downhill course with psychomotor [jneurosci.org]

Infantile Neuronal Ceroid Lipofuscinosis

In PPT-1-related NCL, early psychomotor development is normal until the age of 6-18 months and then rapid psychomotor deterioration sets in. [neurologyindia.com]

Clinical features consist of various combinations of seizures, psychomotor deterioration and blindness, the ages and order of onset differing for each NCL4. [scielo.br]

Clinical features consist of various combinations of seizures, psychomotor deterioration and blindness, the ages and order of onset differing for each NCL 4. [scielo.br]

Adult Neuronal Ceroid Lipofuscinosis

deterioration, ataxia, hypotonia, and seizures.2 Retinal pigment aggregation does not usually occur. [n.neurology.org]

Clinical features often include progressive visual impairment, seizures, psychomotor deterioration, dementia, and a premature death. [humgen.nl]

Initial signs of this disorder include delayed psychomotor development with progressive deterioration, other motor disorders, or seizures. [brainfoundation.org.au]

Developmental and Epileptic Encephalopathy Type 12

MPSI is an early onset epileptic encephalopathy characterized by randomly migrating focal seizures and psychomotor deterioration. [pediatricneurologybriefs.com]

[…] of psychomotor development, and usually early mortality. [orpha.net]

[…] of psychomotor development combined with frequent evolution of acquired microcephaly, and lack of a significant familial and etiological context. [books.google.de]

GM1 Gangliosidosis Type 1

The juvenile form, type II, has a later onset with psychomotor deterioration, seizures and skeletal changes apparent between 7 and 36 months and death in childhood. [disorders.eyes.arizona.edu]

Early psychomotor deterioration: decreased activity and lethargy in the first weeks; never sit; feeding problems - failure to thrive; visual failure (nystagmus noted) by 6 [en.wikipedia.org]

[…] progressive intellectual deterioration, involuntary movements, ataxia, and spasticity. [icd10data.com]

Neuronal Ceroid Lipofuscinosis Type 10

Clinical features consist of various combinations of seizures, psychomotor deterioration and blindness, the ages and order of onset differing for each NCL4. [scielo.br]

Clinical features consist of various combinations of seizures, psychomotor deterioration and blindness, the ages and order of onset differing for each NCL 4. [scielo.br]

Neurodegenerative Syndrome due to Cerebral Folate Transport Deficiency

Developmental regression Psychomotor regression, Psychomotor regression in infants, Psychomotor regression beginning in infancy, Loss of developmental milestones, Mental deterioration [rarediseases.oscar.ncsu.edu]

[…] in childhood, Psychomotor regression, progressive, Neurodevelopmental regression [more] Loss of developmental skills, as manifested by loss of developmental milestones. [rarediseases.oscar.ncsu.edu]

GM2 Gangliosidosis

deterioration. [uniprot.org]

[…] of life, central nervous system degeneration, coarse facial features, hepatosplenomegaly, skeletal dysmorphology reminiscent of Hurler syndrome, and rapidly progressive psychomotor [uniprot.org]

deterioration 0007272 Sea-blue histiocytosis 0001982 Spastic tetraplegia 0002510 Ventriculomegaly 0002119 Showing of 15 | Last updated: 12/1/2018 If you need medical advice [rarediseases.info.nih.gov]

Deoxyribose-5-Phosphate Aldolase Deficiency

ORPHA:2070 Infantile Neuroaxonal Dystrophy Ataxia, Hyperactivity, Mental deterioration, Gait disturbance, Psychomotor deterioration, Unstead... [mousephenotype.org]

deterioration, Cognitive im... [mousephenotype.org]

Syndrome, Finnish Type T2 hypointense thalamus ORPHA:1947 Severe Neurodegenerative Syndrome With Lipodystrophy Generalized hirsutism, Ataxia, Hyperactivity, Progressive psychomotor [mousephenotype.org]