Psychomotor Retardation: Causes & Reasons

Possible Causes for Psychomotor Retardation

A 4 1/2-month-old girl suffered from psychomotor retardation, generalized hypotonia, poor feeding, hyperreflexia, nystagmus, optical atrophy and choreoathetosis from the age [ncbi.nlm.nih.gov]

A two-and-a-half-year-old male child presented with recurrent attacks of intractable vomiting, psychomotor retardation since 14 months of age. [ncbi.nlm.nih.gov]

Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision [uniprot.org]

Lissencephaly

Symptoms of the disorder may include unusual facial appearance, difficulty swallowing, failure to thrive, muscle spasms, seizures, and severe psychomotor retardation. [ninds.nih.gov]

During follow-up period, 8/9 children had catastrophic epilepsy and severe psychomotor retardation. [scielo.conicyt.cl]

MR imaging of a patient with epilepsy and psychomotor retardation at 5 months revealed parieto-occipital pachygyria with almost normal cortical appearance and thickness in [ncbi.nlm.nih.gov]

Endogenous Depression

It is generally accepted that endogenous depression includes marked vegetative changes, such as loss of appetite, loss of weight, loss of sleep, psychomotor retardation or [link.springer.com]

[…] score, presumably measuring mainly depressive mood and psychomotor retardation. [ncbi.nlm.nih.gov]

[…] depression major depressive disorder characterized by signs and symptoms of psychomotor retardation, such as burdened movements and slowed, toneless speech. en·dog·e·nous [medical-dictionary.thefreedictionary.com]

Pyruvate Carboxylase Deficiency

The most severe form (form B) is characterized by neonatal lethal lactic acidosis, whereas patients with form A suffer chronic lactic acidosis with psychomotor retardation [ncbi.nlm.nih.gov]

Psychomotor retardation with seizures and spasticity are the major clinical manifestations. [merckmanuals.com]

retardation. [merckmanuals.com]

Fucosidosis

In type 2, patients have angiokeratoma, milder psychomotor retardation and neurologic signs, longer survival, and normal salinity in the sweat. [ncbi.nlm.nih.gov]

Three sisters with adult fucosidosis showed prominent psychomotor retardation, gargoyle features, and angiokeratoma corporis diffusum, meeting the criteria for type II fucosidosis [ncbi.nlm.nih.gov]

Because of the slowly progressing psychomotor retardation and recurrent upper respiratory tract infections that the prognosis for patients with this disease is poor. [ncbi.nlm.nih.gov]

Disease description A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation [uniprot.org]

Patients with a TMEM70 defect have a variable phenotype which may include, hypertrophic cardiomyopathy, myopathy, dysmorphism, cataracts, psychomotor retardation, lactic acidosis [invitae.com]

retardation, and, in most cases, 3-methyl-glutaconic aciduria. [basicmedicalkey.com]

Late-Onset Depression

Measures of depression severity, psychomotor retardation, verbal and visual memory and vascular and specific genetic risk factors were collected. [ncbi.nlm.nih.gov]

CONCLUSION: We concluded that early onset depression patients have more severe psychomotor retardation and general somatic symptoms than late onset depression patients in [koreamed.org]

retardation Physical pains without any discernable reason Gastrointestinal symptoms Headaches Multiple diffuse symptoms Insomnia or hypersomnia Fatigue or reduction in energy [valleybehavioral.com]

Marshall-Smith Syndrome

Accompanied by severe respiratory problems that are often fatal during the first year of life, mental retardation, hypotonia, muscle weakness, and psychomotor retardation. [accessanesthesiology.mhmedical.com]

Slow development of voluntary movements (psychomotor retardation) may also occur. [rarediseases.org]

Other symptoms include diminished muscle tone (hypotonia), muscle weakness, hernias in the abdomen (umbilical hernias), and/or mental retardation. [rarediseases.org]

Dihydropyrimidine Dehydrogenase Deficiency

We report a case of an 8-year-old girl with psychomotor retardation and mild course of the disease. [ncbi.nlm.nih.gov]

In a patient presenting with convulsions, psychomotor retardation and Reye like syndrome, strongly elevated levels of uracil and thymine were detected in urine. [ncbi.nlm.nih.gov]

Haploinsufficiency of NTNG1, LPPR4, GPSM2, COL11A1 and VAV3 might have contributed to the severe psychomotor retardation and unusual craniofacial features in this patient. [ncbi.nlm.nih.gov]

Aromatic L-Amino Acid Decarboxylase Deficiency

These patients were born to healthy and non-consanguineous parents, and presented oculogyric crises, paroxysmal dystonic attacks, and severe psychomotor retardation since [ncbi.nlm.nih.gov]

psychomotor development, Retarded mental development, Delayed cognitive development, Retarded development, Delayed developmental milestones, Delayed development, Psychomotor [rarediseases.oscar.ncsu.edu]

In 1990, Hyland et al., diagnosed the first case of AADC deficiency by screening CSF samples in patients with psychomotor retardation. [6] Main clinical features are muscular [annalsofian.org]

Farber Disease

retardation. [medical-dictionary.thefreedictionary.com]

retardation, and varying degrees of ocular, pulmonary or hepatic involvement. [ncbi.nlm.nih.gov]

The main features were a shrill voice, joint swelling, subcutaneous nodules and retarded psychomotor development. [ncbi.nlm.nih.gov]

Pelizaeus-Merzbacher Disease

Pelizaeus-Merzbacher disease (PMD) is a rare X-linked recessive disorder with severe psychomotor retardation and neurological symptoms due to an inborn abnormality of proteolipid [ncbi.nlm.nih.gov]

The typical clinical manifestations of PMD include psychomotor retardation, nystagmus, abnormal muscle tone, seizures, and cognitive impairment. [ncbi.nlm.nih.gov]

Diffuse hypotonia, nystagmus, psychomotor retardation, visual and hearing impairment have been observed in the patient since the age of 6 weeks. [ncbi.nlm.nih.gov]

Dysequilibrium Syndrome

retardation 0025356 Simplified gyral pattern 0009879 Truncal ataxia Instability or lack of coordination of central trunk muscles 0002078 Showing of 35 | Last updated: 3/1 [rarediseases.info.nih.gov]

Intention tremor 0002080 Nonprogressive 0003680 Pachygyria Fewer and broader ridges in brain 0001302 Pes planus Flat feet Flat foot [ more ] 0001763 Poor speech 0002465 Psychomotor [rarediseases.info.nih.gov]

Infantile Neuronal Ceroid Lipofuscinosis

[symptoma.com] psychiatrical Psychomotor Retardation It is characterized by rapid deterioration with psychomotor retardation, loss of speech, seizures, ataxia, blindness, [symptoma.com]

It is characterized by rapid deterioration with psychomotor retardation, loss of speech, seizures, ataxia, blindness, hypotonia, microcephaly, and occasional convulsions. [icd10data.com]

Seizures (6 patients) and psychomotor retardation (1 patient) were the initial symptoms in the INCL group. All the patients in the group of LINCL had the usual findings. [scielo.br]

Smith-Magenis Syndrome

A 3-year-old girl was referred for evaluation of moderate psychomotor retardation and several behavioral problems including self-injuring behavior, hyperactivity, and sleep [ncbi.nlm.nih.gov]

The central nervous system is affected and this may be shown by psychomotor retardation, intellective deficit, electroencephalographic alterations (reduced/missing REM phase [ncbi.nlm.nih.gov]

[…] and growth retardation, and, to a lesser extent, genitourinary and cardiac anomalies. [taylorfrancis.com]

Reactive Depression

[…] depression major depressive disorder characterized by signs and symptoms of psychomotor retardation, such as burdened movements and slowed, toneless speech. re·ac·tive de [medical-dictionary.thefreedictionary.com]

“A patient who has psychomotor retardation, hypersomnia, and gaining weight is scored as having identical symptoms as another who is agitated, sleeping badly, and has weight [theatlantic.com]

It is often identified with a specific symptom complex—psychomotor retardation, early morning awakening, weight loss, excessive guilt, and lack of reactivity to the environment—that [medical-dictionary.thefreedictionary.com]

Propionic Acidemia

The clinical picture varies from patients presenting with mild psychomotor retardation to those with severe metabolic decompensation with vomiting, dehydration, encephalopathy [webmedcentral.com]

retardation 0025356 Seizures Seizure 0001250 Short stature Decreased body height Small stature [ more ] 0004322 Tachypnea Increased respiratory rate or depth of breathing [rarediseases.info.nih.gov]

[…] count [ more ] 0001875 Osteoporosis 0000939 Pancreatitis Pancreatic inflammation 0001733 Pancytopenia Low blood cell count 0001876 Poor appetite Decreased appetite 0004396 Psychomotor [rarediseases.info.nih.gov]

Baraitser-Winter Syndrome

The overall risk of psychomotor retardation is high, but 34 of our 113 patients had an IQ greater than 70. [jamanetwork.com]

Global developmental delay Psychomotor developmental delay, Psychomotor retardation, Developmental delay, Lack of psychomotor development, Cognitive delay, Delayed intellectual [rarediseases.oscar.ncsu.edu]

Infantile Neuroaxonal Dystrophy

Axonic and synaptic changes in a case of psychomotor retardation: An electron microscopic study. J. Neuropath. exp. [link.springer.com]

Axonic and synaptic changes in case of psychomotor retardation; an electron microscopic study. J. Neuropath. exp. [springerlink.com]

The broad spectrum is completed by a very heterogeneous group of patients with various degrees of epilepsy/behavioural difficulties/psychomotor retardation (four patients) [nature.com]

Depression

Changes in Activity or Energy Level Physical Changes Caused by Depression Unexplained aches and pains Weight loss or gain Decreased or increased appetite Psychomotor agitation [verywell.com]

This is called psychomotor retardation. [health.com]

Psychomotor agitation or retardation nearly every day. Fatigue or loss of energy nearly every day. [depression.org]

Menkes Disease

Kinky-hair syndrome, a progressive neurodegenerative disorder which affects infant males and is characterized by unusual hair, seizures, psychomotor retardation, growth failure [jamanetwork.com]

Patients are normal in the first 2 or 3 months of life but then they develop failure to thrive, hypothermia, hypotonia, seizures, severe psychomotor retardation, and usually [neuropathology-web.org]

These patients can present with failure to thrive, severe psychomotor retardation, seizures and hypopigmented hair, which is characteristic of this condition. [pediatricneurosciences.com]

Congenital Disorder of Glycosylation Type 1C

In CDG type IIc, patients present with moderate-to-severe psychomotor retardation, seizures, hypotonia, strabismus, and feeding difficulties. [accessanesthesiology.mhmedical.com]

CDG-Ic patients have moderate to severe psychomotor retardation, seizures, hypotonia, strabismus, and feeding difficulties. [onlinelibrary.wiley.com]

Jaeken J, Vanderschueren-Lodewyckx M, Caeser P, Snoeck L, Corbeel L, Eggermont E, et al: Familial psychomotor retardation with markedly fluctuating serum prolactin, FSH and [karger.com]

Congenital Disorder of Glycosylation Type 1A

CDG-IId was described in a patient with moderate psychomotor retardation and macrocephaly as well as myopathy. [nature.com]

Article CAS PubMed Google Scholar Jaeken J, Vanderschueren-Lodeweyckx M, Casaer P, Snoeck L, Corbeel L, Eggermont E, Eeckels R: Familial psychomotor retardation with markedly [ojrd.biomedcentral.com]

Intellectual retardation is often overestimated because of dysarthria and motor difficulties. Psychomotor reeducation might improve quality of life. [pubmed.ncbi.nlm.nih.gov]

Revesz Syndrome

[…] calcifications, extensor hypertonia, and progressive psychomotor retardation. [cags.org.ae]

Medical Term Other Names Description Global developmental delay Psychomotor developmental delay, Psychomotor retardation, Developmental delay, Lack of psychomotor development [rarediseases.oscar.ncsu.edu]

[…] cerebral calcifications, extensor hypertonia, and progressive psychomotor retardation. [cags.org.ae]

Congenital Disorder of Glycosylation Type 1D

CDG type 1 diseases result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia [reactome.org]

They share similar clinical features with previously reported patients including facial dysmorphism, severe psychomotor retardation, microcephaly, seizures, and gastrointestinal [ncbi.nlm.nih.gov]

Depressive Disorder

retardation (a slowing of a person’s physical movements) for two months or more. [psychcentral.com]

They may be despondent and despairing, feel excessive or inappropriate guilt, or have early morning awakenings, marked psychomotor retardation or agitation, and significant [merckmanuals.com]

retardation by professionals) Fatigue, tiredness, or loss of energy nearly every day — even the smallest tasks, like dressing or washing, seem difficult to do and take longer [psychcentral.com]

LIG4 Syndrome

[…] syndrome,241410 TBCE151.60.990.98Kenny-Caffey syndrome, type 1244460 TBCK97.60.950.89Hypotonia, infantile, with psychomotor retardation and characteristic facies 3,6169244460 [qgenomics.com]

Anophthalmia or Microphthalmia - Esophageal Atresia Syndrome

retardation / learning disability - Micropenis / small penis / agenesis - Patent ductus arteriosus - Rib number anomalies - Sclerocornea - Ventricular septal defect / interventricular [csbg.cnb.csic.es]

retardation has never been described before. [gooa.las.ac.cn]

Mental retardation may appear, but psychomotor development may also be normal. ***See our SMOC1 mutation database! [bredagenetics.com]

Arima Syndrome

The common clinical findings of three unrelated patients (two boys and one girl) included severe visual impairment from early infancy, profound psychomotor retardation, hypotonia [ncbi.nlm.nih.gov]

retardation, dysmorphic face, nystagmus, retinopathy, cystic kidney disease, and brain malformation. [genome.jp]

Arima syndrome Supergrp Joubert syndrome and related disorders [DS:H00530] Description Arima syndrome (AS) is a rare autosomal recessive disease characterized by severe psychomotor [genome.jp]

Ribose-5-Phosphate Isomerase Deficiency

Symptoms include optic atrophy, nystagmus, cerebellar ataxia, seizures, spasticity, psychomotor retardation, leukoencephalopathy and global developmental delay. [en.wikipedia.org]

The boy had psychomotor retardation from early in life and developed epilepsy at age 4 years. [ncbi.nlm.nih.gov]

He had psychomotor retardation from early in life and developed epilepsy at age 4 years. [ncbi.nlm.nih.gov]