Pulmonary Hypoplasia: Causes & Reasons

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Possible Causes for Pulmonary Hypoplasia

Mayer-Rokitansky-Küster-Hauser Syndrome

[…] malformations that have been published are practically anecdotal, including a case of pulmonary hypoplasia 4 and a case of total anomalous pulmonary venous drainage. 3 We [archbronconeumol.org]

[…] right thumb Farih 1987 Transphalangeal thumb Atrial septal defect Holt–Oram syndrome Massafa 1988 Ectrodactyly Lopez 2002 Duplicate thumb Kula 2004 Pulmonary stenosis twin A Pulmonary [academic.oup.com]

Hereditary renal adysplasia, pulmonary hypoplasia and Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome: a case report. [archbronconeumol.org]

Joubert Syndrome Type 21

Gaucher Disease

Summary Epidemiology The prevalence is approximately 1/100,000. The annual incidence of GD in the general population is about 1/60,000, but it can reach up to 1/1,000 in Ashkenazi Jewish populations. Clinical description The clinical manifestations of this disease are highly variable. GD type 1 (90% of cases) is the chronic[…] [orpha.net]

Gaucher Disease Type 2

Collodion membrane is most closely associated with forms of autosomal recessive congenital ichthyosis, but the differential diagnosis includes many other less common etiologies. Herein we present a case of Gaucher disease (GD) type 2 in a neonate presenting with collodion membrane in addition to blueberry muffin[…] [ncbi.nlm.nih.gov]

Spontaneous Rupture of Membranes

Gestational Age, wk Birth Weight, g 1 min 5 min Cause of Death 1 17 26 875 8 9 Pulmonary hypoplasia 2 16 24.3 652 3 4 Pulmonary hypoplasia 3 16 27.8 865 3 6 Pulmonary hypoplasia [jaoa.org]

Fetal complications were recorded, including pulmonary hypoplasia and skeletal abnormalities. Pulmonary hypoplasia was diagnosed by postmortem examination. [nature.com]

The most important complications are maternal and foetal infection, prematurity, umbilical cord compression, hypoxia or asphyxia due to cord prolapse, pulmonary hypoplasia [go.gale.com]

Diaphragmatic Hernia

Infants born with diaphragmatic hernia experience respiratory failure due to both pulmonary hypertension and pulmonary hypoplasia. [en.wikipedia.org]

Differential diagnoses Prenatal CDH Postnatal CDH Other causes of pulmonary hypoplasia (e.g., oligohydramnios, renal hypoplasia) Other causes of pulmonary hypertension of [amboss.com]

This is called lethal pulmonary hypoplasia. One of the major complications of congenital diaphragmatic hernia is the risk for lethal pulmonary hypoplasia. [umm.edu]

Congenital Diaphragmatic Hernia

hypoplasia. clinicaltrials.gov Identifier: G170062. [ncbi.nlm.nih.gov]

hypoplasia): virtually no chance of survival O/E LHR 15-25% (severe pulmonary hypoplasia): predicted survival ≈ 15% O/E LHR 26-45% (moderate pulmonary hypoplasia): predicted [radiopaedia.org]

[…] the first fetoscopic therapy for CDH at Mayo Clinic reveals its feasibility and safety, with early signs of benefit documented by fetal lung growth and reversal of severe pulmonary [ncbi.nlm.nih.gov]

Oligohydramnios

Abstract From January 1986 to December 1988, 5 cases of oligohydramnios with pulmonary hypoplasia were experienced. [ncbi.nlm.nih.gov]

BACKGROUND/PURPOSE: Severe neonatal pulmonary hypoplasia incurs mortality rates approaching 71% to 95%. [ncbi.nlm.nih.gov]

Oligohydramnios reduces the intrathoracic cavity size, thus disrupting fetal lung growth and leading to pulmonary hypoplasia. [ncbi.nlm.nih.gov]

Neurogenic Arthrogryposis Multiplex Congenita

hypoplasia Arthrogryposis multiplex congenita-pulmonary hypoplasia Arthrogryposis multiplex congenita-pulmonary hypoplasia Arthrogryposis Multiplex due to muscular dystrophy [acronyms.thefreedictionary.com]

About 30% are stillborn, and the majority of those live-born die of the complications of pulmonary hypoplasia. [orpha.net]

This child had clinically satisfactory pulmonary function, and did not have evidence of pulmonary hypoplasia (10,11,12). [web.archive.org]

Arthrogryposis Multiplex Congenita

About 30% are stillborn, and the majority of those live-born die of the complications of pulmonary hypoplasia. [orpha.net]

This child had clinically satisfactory pulmonary function, and did not have evidence of pulmonary hypoplasia (10,11,12). [web.archive.org]

Arthrogryposis due to Muscular Dystrophy

Some cases of AMC are lethal because of associated CNS and other pathology, especially pulmonary hypoplasia. [neuropathology-web.org]

Arthrogryposis multiplex congenita pulmonary hypoplasia, also with a large number of synonyms. [monsterologist.blogspot.com]

Arthrogryposis Complications AMC may lead to the following complications: Scoliosis Abdominal hernias Growth retardation Respiratory problems Pulmonary hypoplasia Midfacial [primehealthchannel.com]

Urinary Tract Obstruction

Survival of neonates with intrauterine renal insufficiency and oligo- or anhydramnios correlates with the severity of secondary pulmonary hypoplasia. [ncbi.nlm.nih.gov]

All 3 twins with complete urinary tract obstruction and anhydramnios died within 2 days after birth, with confirmed severe pulmonary hypoplasia. [ncbi.nlm.nih.gov]

None of the remaining six had pulmonary hypoplasia. Three remain alive. [ncbi.nlm.nih.gov]

Swyer-James Syndrome

Unilateral pulmonary hypoplasia in an adult. [mjdrdypu.org]

Pulmonary hypoplasia. Available from : 2627.htm. [lungindia.com]

pulmonary embolism, congenital pulmonary hypoplasia, pulmonary artery hypoplasia, bronchial atresia, and Williams Campbell syndrome. 4,6 However, the closest resemblance [ispub.com]

Spondylocostal Dysostosis

This case shows the worst spectum of the Jarcho-Levin syndrome: pulmonary hypoplasia not compatible with extrauterine life. [ncbi.nlm.nih.gov]

This case shows the worst spectrum of the Jarcho-Levin syndrome: pulmonary hypoplasia not compatible with extrauterine life. [prhsj.rcm.upr.edu]

Jarcho-Levin syndrome with association of unilateral pulmonary hypoplasia and diastometamyelia: A case illustration. [lungindia.com]

Cystic Kidney Disease

Further MKS can be associated with polydactyly, situs inversus, biliary duct proliferation and pulmonary hypoplasia. [neocyst.de]

Pulmonary hypoplasia is the leading cause of death. Improvements in ultrasonography have enabled prenatal diagnosis as early as 10 weeks' gestation [ 8 ]. 2. [article.sciencepublishinggroup.com]

[…] disorder, characterized by renal cystic dysplasia, central nervous system malformations (occipital encephalocele), polydactyly (post axial), hepatic developmental defects, and pulmonary [ipfs.io]

Congenital Chylothorax

However, early occurrence of congenital chylothorax or accumulation of a large amount of chylous fluid sometimes leads to pulmonary hypoplasia or persistent pulmonary hypertension [ncbi.nlm.nih.gov]

Fetal pleural effusion causes pulmonary hypoplasia of the lungs. [gorm.com.tr]

Pulmonary hypoplasia was successfully prevented by OK-432. [ncbi.nlm.nih.gov]

Posterior Urethral Valve

At autopsy, the anterior part of the corpus callosum was absent on the left side of the brain; no information is available concerning possible pulmonary hypoplasia. [mcgill.ca]

Postnatal complications include: -pulmonary hypoplasia (a result of oligohydramnios) -renal insufficiency, either due to obstructive uropathy or renal dysplasia -urinary ascites [renalfellow.blogspot.com]

Fetal surgery is a high risk procedure reserved for cases with severe oligohydramnios, to try to limit the associated lung underdevelopment, or pulmonary hypoplasia, that [en.wikipedia.org]

Megacystis - Megaureter Syndrome

Characterized at birth by pulmonary hypoplasia, limb deformations, and flattened facies. [dailyrounds.org]

Serial thoracic versus abdominal circumference ratios for the prediction of pulmonary hypoplasia in premature rupture of the membranes remote from term. [books.google.com]

Death is usually from pulmonary insufficiency from pulmonary hypoplasia rather than renal failure. 2 Reply Potter syndrome (Bilateral renal agenesis). [dailyrounds.org]

Atresia of Urethra

The most severe is pulmonary hypoplasia associated with oligohydramnios and Potter's facies. [nature.com]

hypoplasia. [mhnpjournal.biomedcentral.com]

Discussion: associate conditions  Kidneyfailure  Pulmonary hypoplasia  compression deformities (Potter’s syndrome)  spontaneous bladder rupture 9/11/2013 36. [slideshare.net]

Congenital Malformation of the Lung

Babies with pulmonary hypoplasia will often need respiratory support immediately after birth. [rbhh-specialistcare.co.uk]

If large, they may cause pulmonary hypoplasia, with resultant poor prognosis. [radiopaedia.org]

Pulmonary agenesis and hypoplasia Both pulmonary agenesis and hypoplasia may be accompanied by renal anomalies, which are usually apparent soon after birth and associated [emedicine.medscape.com]

Urethral Valve Formation

In contrast to the other cases, Case 6 had a posterior urethral valve and pulmonary hypoplasia. [turkjpath.org]

Posterior urethral valves are the most common cause of urinary obstruction in newborn boys and can be associated with hydronephrosis, renal failure, and pulmonary hypoplasia [amboss.com]

Severe cases with obstructive cystic renal dysplasia, oligohydramnios and pulmonary hypoplasia are often incompatible with life 2. [radiopaedia.org]

Bochdalek Hernia

[…] renal hypertrophy Pulmonary hypoplasia Pulmonary hypoplasia, which may be unilateral or bilateral, is a serious complication of congenital diaphragmatic hernia. [emedicine.com]

hypoplasia Persistent Fetal Circulation Syndrome Treatment Surgical repair Many demonstrate ipsilateral pulmonary hypoplasia for years after repair Obstructive emphysema [learningradiology.com]

Currently, exclusively tracheal occlusion is performed in selected cases to prevent pulmonary hypoplasia. [springerplus.springeropen.com]

Renal Agenesis

Additionally, a chest x-ray is used to assess pulmonary hypoplasia. [symptoma.com]

The infant had no significant pulmonary hypoplasia and none of the compression effects usually associated with the oligohydramnios sequence. [journals.lww.com]

Bilateral agenesis is lethal with pulmonary hypoplasia being the most common cause of death. [radiopaedia.org]

Lung Hernia

This is termed pulmonary hypoplasia. CDH allows the intestines to move up into the chest cavity. [med.brown.edu]

The prevailing opinion is that this variation is related directly to the degree of pulmonary hypoplasia. [pediatrics.aappublications.org]

This underdevelopment of the lungs is called pulmonary hypoplasia. A diaphragmatic hernia is a life-threatening illness. [stanfordchildrens.org]

Scimitar Syndrome

Some cases are asymptomatic with others diagnosed in early-childhood period with pulmonary hypoplasia and other associated malformations. [ncbi.nlm.nih.gov]

hypoplasia) - association to a moderate hypoplasia of the right lung without sequestration: left-to-right shunt - absence of pulmonary hypoplasia with sequestration: real [sites.uclouvain.be]

We report a case of a young woman (age 18 years) with suspected right pulmonary hypoplasia in whom a scimitar syndrome was diagnosed. [ncbi.nlm.nih.gov]

Bilateral Multicystic Dysplastic Kidney

We describe a preterm neonate of Prune Bellysyndrome who had abdominal muscle deficiency, multicystic dysplastic kidney,urethral hypoplasia and pulmonary hypoplasia. [pediatricurologycasereports.com]

hypoplasia If blastema present, patient is at a slightly higher risk for Wilms tumor Segmental dysplasia is seen in children with duplex (duplicated) kidney (incomplete fusion [pathologyoutlines.com]

If the disease is bilateral then there will be no liquor (anhydramnios) and pulmonary hypoplasia leading to death in early neonatal life will result. [perinatal.nhs.uk]

Congenital Pulmonary Hypoplasia

All this information confirmed the diagnosis of primary congenital pulmonary hypoplasia. [ncbi.nlm.nih.gov]

pulmonary hypoplasia is rare and familial occurrence exceptional.[2] Pulmonary hypoplasia occurs commonly in association with congenital diaphragmatic hernia, oligohydramnios [patient.info]

hypoplasia. [books.google.com]

Pulmonary Agenesis, Hypoplasia and Dysplasia

pulmonary hypoplasia is rare and familial occurrence exceptional. [ 2 ] Pulmonary hypoplasia occurs commonly in association with congenital diaphragmatic hernia, oligohydramnios [patient.info]

Incidence of pulmonary hypoplasia ranges from 9–11 per 10,000 live births and 14 per 10,000 births. [1] Pulmonary hypoplasia is a relatively common cause of neonatal death [en.wikipedia.org]

hypoplasia. [books.google.com]

Autosomal-Recessive Non-Lethal Multiple Pterygium Syndrome

The features are pterygia, cardiac defects, pulmonary hypoplasia, rocker bottom feet deformity, hydrops, and hydronephrosis. [1] The lethal form of MPS (OMIM 253290) has a [jfmpc.com]

hypoplasia As the name implies, the condition is fatal with fetal death occurring usually by mid-gestation 3. [radiopaedia.org]

Classification by Hall [18, 19] and Entezami et al [20, 21] is as follows: Type I (Gillin-Pryse-Davis syndrome): Multiple pterygia, pulmonary hypoplasia, genital anomalies [emedicine.medscape.com]

Mediastinal Hernia

[…] renal hypertrophy Pulmonary hypoplasia Pulmonary hypoplasia, which may be unilateral or bilateral, is a serious complication of congenital diaphragmatic hernia. [emedicine.medscape.com]

The primary pulmonary hypoplasia and pulmonary hypertension would lead to hypoxemia. [mjdrdypu.org]

Mortality in babies with congenital diaphragmatic hernia is largely confined to those with bilateral pulmonary hypoplasia; however, hypoplasia is always more severe in the [emedicine.medscape.com]