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51 Possible Causes for Pyruvate Kinase Decreased

  • Pyruvate Kinase Deficiency

    […] erythrocyte pyruvate kinase (PK) activity.[ncbi.nlm.nih.gov] Pyruvate kinase activities of his family members were normal or slightly decreased.[ncbi.nlm.nih.gov] Sequencing of the PK-LR genes showed that she was also heterozygous for the L272V mutation in exon 7, which is known to cause pyruvate kinase (PK) deficiency.[ncbi.nlm.nih.gov]

  • Neonatal Jaundice

    ., pyruvate kinase def.) Clotting disorders, inc. DIC Polycythemia and consequent hemolysis Extravasated blood, inc. cephalhematoma & swallowed blood; peaks 3-7d IV.[faculty.washington.edu] Metabolic factors, i.e. decreased hepatic clearance Congenital hypothyroidism Crigler-Najjar sd., awa Gilbert?[faculty.washington.edu]

  • Pouchitis

    […] the PDAI score, and also decreased the fecal pyruvate kinase and calprotectin.[ncbi.nlm.nih.gov] The concentrations of calprotectin and pyruvate kinase isoenzyme M2-PK significantly decreased after the therapy.[ncbi.nlm.nih.gov] Concentrations of calprotectin and pyruvate kinase isoenzyme M2-PK were determined in all cases.[ncbi.nlm.nih.gov]

  • Pulmonary Hypertension

    Many experimental therapies reduce PAH by decreasing the proliferation/apoptosis ratio; these include inhibitors of pyruvate dehydrogenase kinase (PDK), serotonin transporters[doi.org]

  • Zieve's Syndrome

    Some authors showed that hyperlipidemia stopped before the appearance of haemolysis that is caused by an acquired deficiency of pyruvate kinase blood red cells’s.[omicsonline.org] A further cause for underdiagnosing of this illness may be that hyperlipidemic status rapidly decreases after stop alcohol intaken.[omicsonline.org]

  • Glioblastoma Multiforme

    In their two publications, they found that by targeting Notch1/2 and pyruvate kinase M2 (PKM2), miR-326 was able to decrease proliferation and invasiveness in a subset of[doi.org]

  • Splenic Rupture

    Subsequent laboratory investigations showed a pyruvate kinase deficiency.[em-consulte.com] Other findings consistent with hemolysis included reticulocytosis (140 x 10 9 /L), decreased haptoglobin, lactate dehydrogenase levels three times higher than normal, and[em-consulte.com]

  • Splenic Subcapsular Hematoma

    Subsequent laboratory investigations showed a pyruvate kinase deficiency.[em-consulte.com] Other findings consistent with hemolysis included reticulocytosis (140 x 10 9 /L), decreased haptoglobin, lactate dehydrogenase levels three times higher than normal, and[em-consulte.com]

  • Cardiac Hypertrophy

    […] dehydrogenase kinase (PDK)-4 proteins and decreased the expression levels of myocardial PPARγ, glycerol-3-phosphate acyltransferase genes (GPAT), and glucose transporter[ncbi.nlm.nih.gov] It is important to note that apigenin decreased the expression level of myocardial HIF-1α protein.[ncbi.nlm.nih.gov] Moreover, apigenin simultaneously increased the expression levels of myocardial peroxisome proliferator-activated receptor (PPAR) α, carnitine palmitoyltransferase (CPT)-1, and pyruvate[ncbi.nlm.nih.gov]

  • Combined Oxidative Phosphorylation Defect Type 14

    It also inhibits the conversion of pyruvate to acetyl-CoA via the activation of pyruvate dehydrogenase kinase 1 (PDK1), leading to a decrease of mitochondrial OXPHOS.[spandidos-publications.com] Recent studies show that mTOR upregulation of pyruvate kinase M2 (PKM2) is critical for aerobic glycolysis and tumor growth ( 62 ).[spandidos-publications.com]

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