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198 Possible Causes for Pyruvic Acid Increased

  • Asthma

    Beta-adrenergic receptors when stimulated have been hypothesised to increase lipolysis, producing free fatty acids, which inhibit the conversion of pyruvate to coenzyme A[ncbi.nlm.nih.gov] This increased pyruvate load is shunted through anaerobic glycolysis, producing increased lactate.[ncbi.nlm.nih.gov]

  • Beriberi

    It may increase the amount of lactic acid and pyruvic acid within the blood. In advanced cases, the disease may cause high output cardiac failure and death.[flipper.diff.org] It may increase the amount of lactic acid and pyruvic acid within the blood. In advanced cases, the disease may cause high-output cardiac failure and death.[ipfs.io]

  • Wernicke Encephalopathy

    Thus, thiamine deficiency causes increased accumulation of pyruvic acid and lactic acid leading to inadequate production of energy currency adenosine 5'-triphosphate (ATP)[jpma.org.pk] Increased lactic acid production ensues in the absence of pyruvate dehydrogenase function, as the reduced conversion of pyruvate to acetyl coenzyme A results in less efficient[emedicine.medscape.com] […] demyelination, and cellular degeneration may occur in the central nervous system (CNS), due to thiamine deficiency, which is the co-factor of enzymes such as transketolase, pyruvate[jpma.org.pk]

  • Infantile Beriberi

    It may increase the amount of lactic acid and pyruvic acid within the blood. In advanced cases, the disease may cause high output cardiac failure and death.[flipper.diff.org] Lactic acid accumulates with a breakdown of the Krebs cycle, producing a metabolic acidosis. Any factor leading to an increased thiamine demand may be etiological.[jdrntruhs.org] In subjects on a relatively high carbohydrate diet, this results in increased plasma concentrations of lactate and pyruvate, which may cause life-threatening lactic acidosis[jdrntruhs.org]

  • Glycogen Storage Disease Type 1

    In addition, the increased pyruvate is oxidized via the pyruvate dehydrogenase complex (PDHc) leading to increased production of acetyl-CoA which is, in turn, used for the[themedicalbiochemistrypage.org] […] synthesis of fatty acids and cholesterol.[themedicalbiochemistrypage.org]

  • Acute Arsenic Poisoning

    .  Interferes with cellular respiration: It combines with sulphydryl groups of mitochondrial membrane especially pyruvate dehydrogenase  It is a capillary poison: increased[slideshare.net] […] permeability, causes tissue oedema and hemorrhage  Hyperaemia and haemorrhage in the intestine.  Interferes with glucose uptake, gluconeogenesis, fatty acid oxidation:[slideshare.net]

  • Aspirin

    Capsular warning syndrome is characterized by recurrent transient ischemic attacks and is caused by microthrombosis or hypoperfusion of small-sized vessels. The pathophysiological basis of this syndrome is not well understood and currently a consensus has not been reached on its optimal treatment. In this study,[…][ncbi.nlm.nih.gov]

  • Diabetes Mellitus

    Neonatal diabetes is a rare form of monogenic diabetes characterised by persistent hyperglycaemia during the first 6-9 months of age. About half of the cases of neonatal diabetes are transient forms resulting from mutations in the genes in the imprinted region of chromosome 6q24 and the other half are[…][ncbi.nlm.nih.gov]

  • Multiple Sclerosis

    Multiple sclerosis (MS) is associated with serious morbidity and labor force absenteeism, but little is known of the long-term impact of the disease on personal income. To assess long-term consequences of MS on personal salary and disposable income. Patients with MS in Sweden were identified in a nationwide,[…][ncbi.nlm.nih.gov]

  • Glucose Intake

    Cancer cells consume high amounts of glucose to produce ATP and molecules entering biosynthesis. Numerous experimental studies have demonstrated that glucose deprivation and/or glycolysis inhibition arrest cancer cell growth and may increase the efficiency of cytotoxic drugs. In contrast, increasing glycolysis in[…][ncbi.nlm.nih.gov]

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