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147 Possible Causes for Pyruvic Acid Increased

  • Wernicke Encephalopathy

    The cerebrospinal fluid lactate levels were detected in 4/36 cases (all increased), serum lactic acid levels in 7/36 cases (6/7 cases increased), serum pyruvate in 4/36 cases[ncbi.nlm.nih.gov] Thus, thiamine deficiency causes increased accumulation of pyruvic acid and lactic acid leading to inadequate production of energy currency adenosine 5'-triphosphate (ATP)[jpma.org.pk] Increased lactic acid production ensues in the absence of pyruvate dehydrogenase function, as the reduced conversion of pyruvate to acetyl coenzyme A results in less efficient[emedicine.com]

  • Beriberi

    Increased lactic acid production ensues in the absence of pyruvate dehydrogenase function, as the reduced conversion of pyruvate to acetyl coenzyme A results in less efficient[web.archive.org] It may increase the amount of lactic acid and pyruvic acid within the blood. In advanced cases, the disease may cause high output cardiac failure and death.[flipper.diff.org] Lactic acid accumulates with a breakdown of the Krebs cycle, producing a metabolic acidosis. Any factor leading to an increased thiamine demand may be etiological.[jdrntruhs.org]

  • Infantile Beriberi

    It may increase the amount of lactic acid and pyruvic acid within the blood. In advanced cases, the disease may cause high output cardiac failure and death.[flipper.diff.org] Lactic acid accumulates with a breakdown of the Krebs cycle, producing a metabolic acidosis. Any factor leading to an increased thiamine demand may be etiological.[jdrntruhs.org] pyruvic acid & lactic acid) Neurological manifestation (due to decreased transketolase activity is a major feature) : a. anxiety b. mental confusion c. motor and sensory[slideshare.net]

  • Thiamine Deficiency

    Increased lactic acid production ensues in the absence of pyruvate dehydrogenase function, as the reduced conversion of pyruvate to acetyl coenzyme A results in less efficient[web.archive.org] Lactic acid accumulates with a breakdown of the Krebs cycle, producing a metabolic acidosis. Any factor leading to an increased thiamine demand may be etiological.[jdrntruhs.org] Increased cell death then feeds the localized vasogenic response. [11] Additionally, the reduced production of succinate, which plays a role in gamma-aminobutyric acid (GABA[emedicine.medscape.com]

  • Asthma

    Beta-adrenergic receptors when stimulated have been hypothesised to increase lipolysis, producing free fatty acids, which inhibit the conversion of pyruvate to coenzyme A[ncbi.nlm.nih.gov] This increased pyruvate load is shunted through anaerobic glycolysis, producing increased lactate.[ncbi.nlm.nih.gov]

  • Glycogen Storage Disease Type 1

    In addition, the increased pyruvate is oxidized via the pyruvate dehydrogenase complex (PDHc) leading to increased production of acetyl-CoA which is, in turn, used for the[themedicalbiochemistrypage.org] […] synthesis of fatty acids and cholesterol.[themedicalbiochemistrypage.org]

  • Aerobic Exercise

    An interesting alternative mechanism is that pyruvate-derived acetyl-CoA effectively competes with fatty acid-derived acetyl-CoA for entry into the TCA-cycle (1).[zowerkthetlichaam.nl] The decrease in muscle pH could increase the sensitivity of CPT-1 for malonyl-CoA (12).[zowerkthetlichaam.nl]

  • Acute Arsenic Poisoning

    WHAT IS KNOWN AND OBJECTIVE: Massive acute arsenic poisoning is rare yet potentially life-threatening. 2,3-dimercaptopropane-1-sulphonate (DMPS) appears to have the appropriate chelating property. However, clinical experience on the use of DMPS in massive arsenic poisoning is limited. CASE DESCRIPTION: A 37-year-old[…][ncbi.nlm.nih.gov]

  • Glucose Intake

    Abstract The effect of simple carbohydrate intake on the state of urine saturation was studied in 44 patients with calcium kidney stones and in 28 healthy subjects. Renal excretion of calcium, magnesium and oxalate significantly increased and pH of urine decreased after an intake of 100 g glucose in stone formers[…][ncbi.nlm.nih.gov]

  • Diabetes Mellitus

    Aims: Several studies suggested that diabetes mellitus (DM) was associated with the risk of glioma. However, other studies did not confirm the result. Therefore, I conducted this meta-analysis. Materials and Methods: I retrieved the PubMed, Embase, and Web of Science database, by adopting keywords "glioma," and[…][ncbi.nlm.nih.gov]

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