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143 Possible Causes for Rapid Progression to Disability

  • Polyneuropathy

    For example, patients with GBS present with a definite date of onset followed by rapid progression of impairment and disability.[neurology.org] Symptom onset and tempo often correlate because they both represent the pace of disease progression.[neurology.org]

  • Alzheimer Disease

    Our findings may reflect the presence of greater comorbidity leading to earlier death among men than among women with AD, 57 or a more rapid progression of AD in women. 58[doi.org] - 61 The inherent survival advantage of women in general may lead women to live longer, tolerating greater disability, than men.[doi.org]

  • Primary Progressive Multiple Sclerosis

    Although progression is more rapid, age-related disability milestones are identical to relapsing-onset disease.[ncbi.nlm.nih.gov] A previous analysis of the British Columbia MS database challenged the view that disability progression is rapid in PPMS, but identified few predictors of disease progression[ncbi.nlm.nih.gov] , for which prognosis is considered as poor due to the relatively rapid development of advanced disability as compared with RRMS.[globenewswire.com]

  • Transient Ischemic Attack

    Rapid recognition and response is essential to reduce the risk of disability and death. 4,8,10 As the American Heart Association/American Stroke Association (AHA/ASA) points[journals.lww.com] […] similar episodes, and absence of nonspecific symptoms such as gastrointestinal distress, chest pain, or shortness of breath. 1 No one can predict which TIAs are likely to progress[journals.lww.com]

  • Spinal Demyelination

    progression to disability within several days to weeks, culminating in the need for hospital admission and aggressive therapy for an acute attack. 5 Among fulminant demyelinating[nature.com] However, the higher incidence of spinal cord lesions often found in primary progressive multiple sclerosis (PPMS) does contribute to a more rapid development of disability[healthcentral.com] Serial MRI revealed rapid enlargement and post-contrast enhancement ( Figures 1d–f and Figures 2a–c ).[nature.com]

  • Muscular Dystrophy

    It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling.[webmd.com] Disease progression is typically very slow, with intermittent spurts of rapid muscle deterioration.[web.archive.org] Most individuals have a normal life span, but some individuals become severely disabled.[web.archive.org]

  • Campylobacter Jejuni Infection

    C. jejuni-associated GBS patients were younger than others (p 0.010), and they had a rapid progression to reach peak disability (p 0.018).[ncbi.nlm.nih.gov] progression, slow recovery, and substantial residual disability.[nejm.org] […] spectrum of Guillain–Barré syndrome, there is a subgroup of patients presenting with a “hyperacute” onset, commonly after having gastroenteritis, that is characterized by rapid[nejm.org]

  • Paraneoplastic Syndrome

    progression to severe disability and the absence of regeneration in a sural nerve biopsy.[doi.org] The rapid progression early on followed by stabilisation suggests that by the time a PND is diagnosed, irreversible neurological damage has already occurred.[doi.org] Often the patient is so severely disabled by the time the diagnosis is made that no specific treatment is effective.[doi.org]

  • Duchenne Muscular Dystrophy

    Disease progression is typically very slow, with intermittent spurts of rapid muscle deterioration.[web.archive.org] Most individuals have a normal life span, but some individuals become severely disabled.[web.archive.org]

  • Chronic Daily Headaches

    Its progression is rapid and leads to significant disability and loss of function [ 18 ]. Treatment focuses primarily on reducing symptoms [ 19 ].[ods.od.nih.gov]

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