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48 Possible Causes for Rapid Progression to Disability, Slow Speech

  • Alzheimer Disease

    Our findings may reflect the presence of greater comorbidity leading to earlier death among men than among women with AD, 57 or a more rapid progression of AD in women. 58[] - 61 The inherent survival advantage of women in general may lead women to live longer, tolerating greater disability, than men.[]

  • Primary Progressive Multiple Sclerosis

    Although progression is more rapid, age-related disability milestones are identical to relapsing-onset disease.[] A previous analysis of the British Columbia MS database challenged the view that disability progression is rapid in PPMS, but identified few predictors of disease progression[] , for which prognosis is considered as poor due to the relatively rapid development of advanced disability as compared with RRMS.[]

  • Transient Ischemic Attack

    Rapid recognition and response is essential to reduce the risk of disability and death. 4,8,10 As the American Heart Association/American Stroke Association (AHA/ASA) points[] […] similar episodes, and absence of nonspecific symptoms such as gastrointestinal distress, chest pain, or shortness of breath. 1 No one can predict which TIAs are likely to progress[]

  • Amyotrophic Lateral Sclerosis

    Symptoms of ALS include progressive muscle weakness beginning in the limbs, muscle twitching and cramping, slowed speech becoming progressively harder to understand, difficulty[] One woman with ALS received intracranial injection of adult olfactory ensheathing glia (OEG) transplantation and her disease progressed at a more rapid rate after the procedure[] In a physical exam, your neurologist will also look for the signs of ALS, including: Muscle weakness, often on only one side of the body Slurred or slowed speech and other[]

  • Multiple Sclerosis

    Speech may become slow, slurred, and hesitant. People with multiple sclerosis may become unable to control emotional responses and may laugh or cry inappropriately.[] progression of disability, more frequent relapses, and worse postrelapse recoveries.[] […] or difficult speech purple patches or pinpoint dots (rash) on the skin decreased urination or blood in the urine Interferon beta-1a may cause other side effects.[]

  • Chorea Gravidarum

    […] or abnormal eye movements Irregular gait and abnormal posture and balance Difficulty with speech or swallowing Cognitive impairments are also a component of Huntington’s[] ; • Disability out of proportion to the movement disorder.[] […] involuntary movements and a loss of control in voluntary actions: Involuntary jerking or writhing movements; this is the chorea component Rigid or contracted muscles (dystonia) Slow[]

  • Hallervorden-Spatz Syndrome

    These abnormalities progressed over the years with slowing of voluntary movements, rigidity of limbs and dystonic posturing. Speech was slurred.[] Rapid progression of the disease may lead to severe disability, life-threatening state, the status dystonicus, and several critical events such as hyperpyrexia, dehydration[] Intermediate forms manifest onset in first decade with slow progression or onset in second decade with rapid progression.[]

  • Huntington's Disease

    First, the disease progresses more rapidly in homozygotes than in heterozygotes.[] speech or difficulty swallowing Slowed thinking and reaction time, difficulty planning and organizing, inflexible thinking, poor decision making skills or problems with short-term[] ., slow, slurred speech; difficulty in finding words; disorganized speech and sentence construction) Behavioral/personality changes Change in personal hygiene and habits Unusually[]

  • Guillain-Barré Syndrome

    A number of factors, including preceding diarrhoea, older age, rapid progression, disability at nadir and specific neurophysiological parameters have been associated with[] progression of symptoms Severity of symptoms at their peak Table 4.[] […] require artificial ventilation due to involvement of respiratory and bulbar muscles ( Hughes 2006a ), and approximately 20% of GBS survivors have residual permanent severe disability[]

  • Creutzfeldt Jakob Disease

    A 59-year-old woman presented with a 2-month history of headache, difficulty in finding words, and slow speech.[] The condition is hard to link to a specific symptom, although it is mistaken for CJD because of rapid progression of disability and its common involvement of visual pathways[] Within weeks the person may complain of clumsiness and feeling muddled, become unsteady walking, and have slow or slurred speech.[]

Further symptoms