Rapidly Progressive Deterioration: Causes & Reasons

Possible Causes for Rapidly Progressive Deterioration

Generalized Herpes Simplex Infection of the Newborn

The patient’s status rapidly deteriorated. [academic.oup.com]

She became progressively lethargic and developed respiratory failure with severe metabolic acidosis requiring intubation and aggressive ventilation strategies including high-frequency [academic.oup.com]

Developmental and Epileptic Encephalopathy Type 3

Rapidly progressive deterioration was noticed after a few days. Acute encephalopathy associated with sleepiness and respiratory failure developed. [ncbi.nlm.nih.gov]

The clinical course of the disease is highly variable; in this case, rapidly progressive internal hydrocephalus accompanied acute deterioration of the patient’s state. [thieme-connect.com]

Aicardi-Goutières Syndrome Type 6

Highlights • Aicardi-Goutières syndrome (AGS) as differential diagnosis of acute encephalopathy in infancy. • First case of AGS6 related subacute encephalopathy in infancy with restitutio ad integrum. • Case of AGS6 exhibiting highly clinical variability and intrafamilial phenotypic diversity. • Timely diagnosis is[…] [ejpn-journal.com]

Early-Onset Progressive Encephalopathy with Brain Edema - Leukoencephalopathy Type 2

Homepage Rare diseases Search Search for a rare disease Disease definition A rare neurometabolic disease characterized by infantile onset of rapidly progressive neurological [orpha.net]

deterioration, typically precipitated by a febrile illness. [orpha.net]

Smoldering Myeloma

The search for new ALS treatments The deterioration of his left arm progressed rapidly, especially in the lower part, and within a month it had lost most of its function. [everyone.org]

Nasal-Type Extranodal NK-T-Cell Lymphoma Stage 2

Furthermore, due to the patient’s progressive clinical deterioration, it was not possible to supplement radiation therapy with chemotherapy sessions, which could have slowed [revistas.unal.edu.co]

[…] the lymphoma’s progression. [revistas.unal.edu.co]

Conclusion ENKL is an aggressive, rapidly progressive infiltrative neoplasm that usually appears in the nasal cavity and perinasal regions but may also appear anywhere in [revistas.unal.edu.co]

Nasal-Type Extranodal NK-T-Cell Lymphoma Stage 1

[…] the lymphoma’s progression. [revistas.unal.edu.co]

Conclusion ENKL is an aggressive, rapidly progressive infiltrative neoplasm that usually appears in the nasal cavity and perinasal regions but may also appear anywhere in [revistas.unal.edu.co]

Pulmonary Lymphangitic Carcinomatosis

In most cases, lymphangitic carcinomatosis progresses rapidly and patients deteriorate (see treatment and prognosis below), however in some cases changes may remain stable [radiopaedia.org]

HHHH Syndrome

One case of rapidly progressive deterioration after formula feeding, leading to neonatal death, has been reported. [emedicine.medscape.com]

Neuronal Ceroid Lipofuscinosis Type 7

Cognitive decline Cognitive decline, progressive Intellectual deterioration Progressive cognitive decline [ more ] 0001268 Neurodegeneration Ongoing loss of nerve cells 0002180 [rarediseases.info.nih.gov]

Optic atrophy 0000648 Pigmentary retinopathy 0000580 Rapidly progressive Worsening quickly 0003678 Retinopathy Noninflammatory retina disease 0000488 Sleep disturbance Difficulty [rarediseases.info.nih.gov]

[…] abnormality 0002353 Generalized myoclonic seizures 0002123 Global developmental delay 0001263 Juvenile onset Signs and symptoms begin before 15 years of age 0003621 Mental deterioration [rarediseases.info.nih.gov]

Late-Infantile Neuronal Ceroid Lipofuscinosis

This form progresses rapidly and ends in death between ages 8 and 12. This is the disease Noah and Laine are fighting. [noahshope.com]

The typical early signs are loss of muscle coordination (ataxia) and seizures along with progressive mental deterioration. [mackenzieshope.com]

This form progresses rapidly and ends in death between ages 8 and 12. •Juvenile NCL (Batten disease) begins between the ages of 5 and 8. [bradysbattle.wordpress.com]

Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome

progressive deterioration (asymptomatic in breastfed infants) Infant-Onset Type: Choreoathetosis episodes, seizures, hypotonia, and developmental and growth retardation [accessanesthesiology.mhmedical.com]

Four clinical types are described: Neonatal-Onset Type: Vomiting and lethargy following feeding of high-protein formula leading to severe hyperammonemia with rapidly progressive [accessanesthesiology.mhmedical.com]

One case of rapidly progressive deterioration after formula feeding, leading to neonatal death, has been reported. [emedicine.medscape.com]

Tumor of Endocrine Glands

Despite an initial temporary improvement of CNS symptoms after the cranial irradiation, the patient suffered rapidly progressive deterioration of the disease in the lung, [endocrine-abstracts.org]

Prerenal Azotemia

Type I Type II Rapidly progressive Slower deterioration Serum creatinine double to >2.5 mg/dL or creatinine clearance Serum creatinine >1.5 mg/dL or creatinine clearance Prognosis [academic.oup.com]

A small subgroup of glomerular diseases can present with rapidly deteriorating renal function, termed rapidly progressive glomerulonephritis (RPGN). [unboundmedicine.com]

progressive Slower deterioration Serum creatinine double to >2.5 mg/dL or creatinine clearance Serum creatinine >1.5 mg/dL or creatinine clearance Prognosis—80% die in 2 [academic.oup.com]

Nasal-Type Extranodal NK-T-Cell Lymphoma Stage 4

[…] the lymphoma’s progression. [revistas.unal.edu.co]

Conclusion ENKL is an aggressive, rapidly progressive infiltrative neoplasm that usually appears in the nasal cavity and perinasal regions but may also appear anywhere in [revistas.unal.edu.co]

Nasal-Type Extranodal NK-T-Cell Lymphoma Stage 3

[…] the lymphoma’s progression. [revistas.unal.edu.co]

Conclusion ENKL is an aggressive, rapidly progressive infiltrative neoplasm that usually appears in the nasal cavity and perinasal regions but may also appear anywhere in [revistas.unal.edu.co]

Bilateral Massive Adrenal Hemorrhage

progressive deterioration. [mitchmedical.us]

Amador remains unchanged today.23 The sudden onset of steady pain in the upper abdomen, flanks, and lower back, accompanied by mild tenderness, heralds the development of rapidly [mitchmedical.us]

Fucosidosis

Fucosidosis type I rapidly evolves toward a progressive neurologic deterioration and death. [ncbi.nlm.nih.gov]

A minority of patients have rapidly progressive neurologic deterioration leading to death before age 5 years, while the majority have slower neurologic deterioration and survive [genedx.com]

Fucosidosis type I is characterized by early mental and motor regression with rapidly progressive neurologic deterioration to a decerebrate state and death in the first decade [ajnr.org]

Waterhouse-Friderichsen Syndrome

We describe three children who died at our institution after rapidly progressive clinical deterioration from this infection, with necrotizing pneumonia and multiple-organ-system [ncbi.nlm.nih.gov]

All three had rapidly progressive clinical deterioration with leukopenia, neutropenia, severe metabolic acidosis, profound tachycardia, and secondary hypotension during their [doi.org]

He was lethargic but rousable, although he rapidly became obtunded and intubation was performed. Cardiac and respiratory function continued to deteriorate. [doi.org]

GM1 Gangliosidosis Type 2

progressive psychomotor deterioration, dullness of senses, lethargy, seizures, decerebrate rigidity, and terminal bronchopneumonia at the age of 3 to 10 years and rarely [linkedlifedata.com]

The disorder often progresses rapidly, resulting in significant mental and physical deterioration. Infants may appear completely unaffected at birth. [rarediseases.org]

[…] initial symptoms with onset at about one year of life, is followed by strabismus, inability to control hand movements, slurred speech, muscle weakness of the extremities, rapidly [linkedlifedata.com]

Atypical Glycine Encephalopathy

Pediatrics 95:142–146 PubMed Google Scholar [64] Tekgul H, Serdaroğlu G, Karapinar B et al. (2006) Vigabatrin caused rapidly progressive deterioration in two cases with early [link.springer.com]

Inferior Vena Cava Syndrome

However, rapidly progressive deterioration and chemotherapy resistance in our patient led us to surgical intervention. [apspjcaserep.com]

Boztug et al, reported successful treatment of a progressive stage 4S neuroblastoma in a neonate with hepatic artery embolization in addition to multimodality treatment [2 [apspjcaserep.com]

Non-Oliguric Renal Failure

A small subgroup of glomerular diseases can present with rapidly deteriorating renal function, termed rapidly progressive glomerulonephritis. [unboundmedicine.com]

progressive Slower deterioration Serum creatinine double to >2.5 mg/dL or creatinine clearance Serum creatinine >1.5 mg/dL or creatinine clearance Prognosis—80% die in 2 [ndt.oxfordjournals.org]

Mitochondrial Trifunctional Protein Deficiency

Nine (43%) patients presented with rapidly progressive clinical deterioration; six (67%) of them had hypoketotic hypoglycemia. [ncbi.nlm.nih.gov]

Disorder of Lipid Metabolism

Patients with Schindler disease type 1 have infantile onset of neuroaxonal dystrophy, developmental delay, and rapidly progressive psychomotor deterioration without organomegaly [emedicine.medscape.com]

Infantile Neuronal Ceroid Lipofuscinosis

The infantile subtype of NCL (INCL), linked to chromosome 1p32, is characterized by early visual loss and rapidly progressing mental deterioration, resulting in a flat electroencephalogram [nature.com]

The typical early signs are loss of muscle coordination (ataxia) and seizures along with progressive mental deterioration.. [katwasabi.com]

The typical early signs are loss of muscle coordination (ataxia) and seizures along with progressive mental deterioration. [hope4bridget.com]

Lethal Infantile Mitochondrial Myopathy

Over the next 21 days the condition rapidly deteriorated with a progressive hypertrophic cardiomyopathy, hepatic dysfunction, and generalized seizure activity. [pediatricneurologybriefs.com]

Muscular Dystrophy-Dystroglycanopathy Type C7

Rapidly progressive scoliosis and respiratory deterioration in Ullrich congenital muscular dystrophy. J Neurol Neurosurg Psychiatry. 2013;84:982–8. [doi.org]

Congenital Neutropenia - Myelofibrosis - Nephromegaly Syndrome

The disease may remain indolent for years or may progress rapidly by further deterioration in hematopoiesis, by massive splenic enlargement and its sequelae, or by transformation [accessmedicine.mhmedical.com]

Pulmonary Tumor Embolism

Pulmonary tumor embolism (PTE) and intravascular lymphoma cause rapidly progressive deterioration and an antemortem diagnosis is difficult. [ncbi.nlm.nih.gov]