Reactive Gliosis: Causes & Reasons

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Possible Causes for Reactive Gliosis

Developmental and Epileptic Encephalopathy Type 14

The cortex and underlying white matter displayed intense reactive gliosis (Figure 3 H). The white matter contained virtually no mature myelin, as expected for the age. [frontiersin.org]

Autosomal Recessive Spinocerebellar Ataxia

Spinocerebellar ataxias are phenotypically, neuropathologically, and genetically heterogeneous. The locus of autosomal recessive spinocerebellar ataxia type 7 (SCAR7) was previously linked to chromosome band 11p15. We have identified TPP1 as the causative gene for SCAR7 by exome sequencing. A missense and a splice[…] [ncbi.nlm.nih.gov]

Fibrillary Astrocytoma

gliosis. [ncbi.nlm.nih.gov]

gliosis: evenly distributed hypertrophic astrocytes, IDH1 negative Board review style question #1 Which of the following is true about IDH-mutant diffuse astrocytoma?   [pathologyoutlines.com]

In the remaining four cases, two neuropathologists deviated from the majority opinion; in each of these cases, the diagnostic problem involved differentiating tumor from reactive [ncbi.nlm.nih.gov]

Diffuse Astrocytoma

Numerical chromosomal aberrations were found in 80% of low-grade astrocytoma specimens and in none of the reactive gliosis specimens. [neurology.org]

Especially, reactive gliosis must be considered and must not be misdiagnosed as an astrocytoma component of an oligodendroglial tumour. [astrocytomaoptions.com]

This subset of gliomas are distinct from other glioma types that exhibit a more circumscribed appearance, and they are most often surrounded by reactive gliosis along their [emedicine.medscape.com]

Congenital Disorder of Glycosylation Type 1H

Multicystic frontal lesions were detected with reactive gliosis in patient 2. [nature.com]

Siderosis

Microscopically, the end result is neuronal loss, reactive gliosis, and axonal demyelination 9). [ncbi.nlm.nih.gov]

Pontocerebellar Hypoplasia Type 10

The hypoplasia of the pons and cerebellum and spinal anterior horn cell degeneration is also associated with pronounced reactive changes (gliosis). [rarediseases.org]

Leukoencephalopathy

gliosis with enlarged astrocytes 13. [radiopaedia.org]

[…] include infected oligodendrocytes with enlarged amphophilic nuclei located at the periphery of the lesions, macrophages containing phagocytosed cellular debris and myelin, and reactive [radiopaedia.org]

New-Onset Refractory Status Epilepticus

Histopathology showed reactive gliosis and inflammatory markers in the AMT-PET-positive cortex. [ncbi.nlm.nih.gov]

Labrune Syndrome

(B) Dilated capillaries with calcification, hemosiderin deposits and reactive gliosis. [link.springer.com]

The biopsy specimen of his white matter and cyst wall revealed a pronounced reactive gliosis with conspicuous formation of Rosenthal fibers. [link.springer.com]

Figure 2 Biopsy revealed a pronounced reactive gliosis with conspicuous formation of Rosenthal fibers and calcification, with frequent hemosiderin deposits. [link.springer.com]

Cardioneuromyopathy with Hyaline Masses and Nemaline Rods

[…] by reactive gliosis. presentation : loss of pain and temperature sensation in upper extremities. non-aggressive motor deficits from pre- and perinatal neurologic insults. [brainscape.com]

[…] risk factor: prematurity. can have brain injury without reactive gliosis. intraparenchymal hemorrhage, periventricular leukomalacia, multicystic encephalopathy, ulegyria, [brainscape.com]

⇒ cell necrosis or apoptosis. intense cytoplasmic eosinophilia and nuclear pyknosis = red neurons Subacute and Chronic Neuronal Injury degeneration = neuronal death and reactive [brainscape.com]

Retinal Angioma

Massive gliosis in VHL disease is a true reactive retinal gliosis. [ncbi.nlm.nih.gov]

Keywords Genetic Analysis Positive Signal Gene Locus Reactive Process Gene Deletion These keywords were added by machine and not by the authors. [link.springer.com]

Genetic analysis of the pleomorphic glial proliferation showed no allelic VHL gene deletion, which is consistent with the assessment that the glial component represents a reactive [ncbi.nlm.nih.gov]

Pilocytic Astrocytoma

Reactive gliosis may resemble PA in histological findings and MAPK activation. [ncbi.nlm.nih.gov]

The lesion was associated with advanced reactive gliosis and foci of dysplastic changes in the adjacent cortex. [ncbi.nlm.nih.gov]

Sometimes, the neoplastic piloid tissue can resemble reactive gliosis, related to long-standing non neoplastic lesions. [ncbi.nlm.nih.gov]

Calvarial Doughnut Lesions - Bone Fragility Syndrome

Outer layer = reactive gliosis. Focal process with localized suppurative destruction of brain tissue. [quizlet.com]

Does NOT contain: Neuron cell bodies, lymphocytes, activated macrophage, reactive astrocytes (gliosis) Histology of biopsy of MS lesion Well-demarcated lesion of white matter [quizlet.com]

Contains axons, oligodendrocytes, non-reactive astrocytes, unactivated microglia. [quizlet.com]

Pituicytoma

Surrounding brain parenchyma showed marked reactive piloid gliosis. [mayoclinic.pure.elsevier.com]

Frontal Lobe Neoplasm

gliosis at the edges. [path.upmc.edu]

[…] common but atypical mitoses were rarely seen; There were occasionally bizarre and multi-nucleated tumor cells; The tumor invaded the brain with an ill-defined border, and reactive [path.upmc.edu]

Ring Chromosome 13

Microscopic examination showed a detached retina with reactive gliosis and neovascularisation. [ncbi.nlm.nih.gov]

Gemistocytic Astrocytoma

gliosis in inflammation, infection, or demyelinating disease Toxic/metabolic leukoencephalopathy Gross Pathology On gross pathology, gemistocytic astrocytoma is characterized [wikidoc.org]

[…] conditions that have gemistocytes or gemistocyte-like cells include: [2] Oligodendroglioma with "minigemistocytes" Ependymoma Subependymal giant cell astrocytoma Astroblastoma Reactive [wikidoc.org]

Peripheral Vasoproliferative Retinopathy

Over time in a long-standing mass, or following treatment, reactive gliosis predominates over the vascular component, and in the end-stage, the color of the mass changes to [ijo.in]

gliosis”. 1 There appears to be an association between VPTR and other ocular diseases, in particular, uveitis. 8 The vasoproliferative tumours could possibly be a reactive [bjo.bmj.com]

gliosis”.1 There appears to be an association between VPTR and other ocular diseases, in particular, uveitis.8 The vasoproliferative tumours could possibly be a reactive [bjo.bmj.com]

Classic Paraneoplastic Limbic Encephalitis

Figure 5 (A-D): 200× H and E and immunohistochemistry slide shows multiple neoplastic astrocytes with high mitotic index (A-D). 200× H and E slide shows reactive gliosis with [ijri.org]

gliosis with interstitial and perivascular infiltrates of lymphocytes, a feature of paraneoplastic encephalitis [Figure 5] D. [ijri.org]

[…] perivascular infiltrates of lymphocytes, a feature of paraneoplastic encephalitis (D) Click here to view Biopsy of cortical area showing non-neoplastic signal abnormality revealed reactive [ijri.org]

Spinocerebellar Ataxia Type 1

Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited progressive neurological disorder characterized by neuronal degeneration and reactive gliosis in the cerebellum [ncbi.nlm.nih.gov]

First, one must consider that processes such as reactive gliosis may attenuate changes in the ADC, leaving FA comparisons more significant. [ajnr.org]

However, little is known about reactive Bergmann glia (Bergmann gliosis) and its beneficial or detrimental role. [ncbi.nlm.nih.gov]

Progressive Multifocal Leukoencephalopathy

gliosis with enlarged astrocytes 13. [radiopaedia.org]

gliosis Unusual astrocytes may cause confusion with glioma on biopsy Minimal inflammation Immunohistochemistry – JCV staining in oligodendroglial cells and astrocytes Imaging [arupconsult.com]

Rasmussen Syndrome

Immunization with the glutamate receptor derived peptide GluR3B induces neuronal death and reactive gliosis, but confers partial protection from pentylenetetrazole-induced [doi.org]

Biopsy for the diagnosis of RE shows multifocal changes of the T cell dominated encephalitis with activated microglia and reactive gliosis [ 11 ], but some believe that CSF [omicsonline.org]

Bien et al. demonstrated that this signal change is correlated with the number of T cells in brain parenchyma and reactive gliosis, indicating ongoing damage 4,24. [scielo.br]

Protoplasmic Astrocytoma

Central nervous system injury initiates reactive gliosis and angiogenesis. Fibroblast growth factor-2 is overexpressed in the injured brain. [cnjournal.biomedcentral.com]

This hypothesis let us speculate that the collision tumor might have been caused by malignant transformation of the reactive gliosis surrounding the meningioma. [cnjournal.biomedcentral.com]

Muscular Dystrophy-Dystroglycanopathy Type A14

gliosis in the cerebral cortex of the mouse model of muscle-eye-brain disease. ( 17924568 ) Yang Y....Hu H. 2007 24 Prenatal diagnosis of muscle-eye-brain disease. ( 17154333 [malacards.org]

22 Novel POMGnT1 mutations define broader phenotypic spectrum of muscle-eye-brain disease. ( 17906881 ) Hehr U....Winkler J. 2007 23 Ectopia of meningeal fibroblasts and reactive [malacards.org]

Neonatal Adrenoleukodystrophy

gliosis highlighted by GFAP Electron microscopy images Images hosted on other servers : Peroxisomal: X linked adreno-leukodystrophy: trilamellar lipid products Lysosomal: [pathologyoutlines.com]

XALD: gliosis and inflammation XALD. Lipid macrophages, lymphocytes, and reactive astrocytes in the white matter. [neuropathology-web.org]

[…] astrocytic gliosis Metachromatic leukodystrophy: accumulation of PAS and Luxol fast blue / LFB+ macrophages that show brown metachromasia with acidified cresyl violet, toluidine [pathologyoutlines.com]

Temporal Lobe Tumor

Hemosiderin-laden macrophages and reactive gliosis are seen throughout the tissue. GFAP highlights the reactive gliosis and outlines the tumor nodules. [sekelsky.bio.unc.edu]

The GFAP and CD34 immunostain demonstrated cortex with reactive gliosis and intraparenchymal thin-walled as well as thickened blood vessels with intervening brain tissue. [frontiersin.org]

Gliomatosis Cerebri

gliosis Br J Neurosurg 10 103 107 PubMed CrossRef Google Scholar 33. [dx.doi.org]

Difficulties in the antemortem diagnosis of gliomatosis cerebri: report of a case with diffuse increase of gemistocytic-like cells, mimicking reactive gliosis. [link.springer.com]

Difficulties in the antemortem diagnosis of gliomatosis cerebri: report of a case with diffuse increase of gemistocyte-like cells, mimicking reactive gliosis. [ajnr.org]

ABri Amyloidosis

gliosis. [nature.com]

[…] progressive deposition of amyloid β (Aβ) protein in plaques and cerebral blood vessels, by the appearance of intraneuronal neurofibrillary tangles (NFT), cell death, and reactive [nature.com]

Familial Cerebral Cavernous Malformation

Due to repeated haemorrhages and reactive gliosis, CCM are surrounded by hemosiderin, gliosis and calcifications. [sisav.eu]

The sinusoids are lined by a thin layer of endothelium devoid of mature vessel elements and embedded in a dense, multilayered basal lamina often surrounded by reactive gliosis [flipper.diff.org]