Recurrent Fractures: Causes & Reasons

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Possible Causes for Recurrent Fractures

Hereditary Hypophosphatemic Rickets with Hypercalciuria

[…] phosphorus level in patients with suspected but unexplained osteoporosis and/or recurrent renal stones. [ncbi.nlm.nih.gov]

The severe presentation of this proband in adulthood with marked nephrolithiasis, multiple fractures and low bone density emphasizes the importance of measuring the serum [ncbi.nlm.nih.gov]

Osteogenesis Imperfecta Type 15

OI15 is characterized by early-onset recurrent fractures, bone deformity, significant reduction of bone density, short stature, and, in some patients, blue sclerae. [malacards.org]

Keupp et al. (2013) and Pyott et al. (2013) described osteogenesis imperfecta type XV, an autosomal recessive form of the disorder characterized by early-onset recurrent fractures [malacards.org]

Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. [malacards.org]

Calvarial Doughnut Lesions - Bone Fragility Syndrome

New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. [books.google.com]

fractures, several of which may havecraniofacial abnormalities. [docslide.net]

This chapter outlines an approach to the evaluation and treatment of children with recurrent fractures and describes three common scenarios involving infants, children with [karger.com]

Osteogenesis Imperfecta Type 5

New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. [books.google.com]

Introduction: Osteogenesis imperfecta is a rare disease leading to immobility by recurrent fractures, immobilization, short stature and muscular weakness. [bone-abstracts.org]

Type IV This may be apparent at birth with fractures or bowing of leg bones or recurrent fractures on walking. [patient.info]

Cole-Carpenter Syndrome

fractures; Scoliosis; Shallow orbits; Short stature; Vertebral compression fractures Associated Genes P4HB (Withdrawn symbols: DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PO4DB [mousephenotype.org]

Differential diagnosis OI is not the only cause of recurrent fractures among children. [orthopaedicsone.com]

fractures Increased fracture rate Increased fractures Multiple fractures Multiple spontaneous fractures Varying degree of multiple fractures [ more ] 0002757 Scoliosis 0002650 [rarediseases.info.nih.gov]

Osteogenesis Imperfecta Type 13

OI13 is characterized by normal teeth, faint blue sclerae, severe growth deficiency, borderline osteoporosis, severe bone deformity, and recurrent fractures affecting both [malacards.org]

Hyper-IgE Syndrome

Common findings among patients were recurrent fractures (in 57 percent of patients), hyperextensible joints (in 68 percent), and scoliosis (in 76 percent of patients 16 years [scienceopen.com]

Patients have coarse facial features, delayed shedding of baby teeth, osteopenia, and recurrent fractures. [msdmanuals.com]

Hypophosphatasia

There is also an orthopedic procedure called, “rodding,” which has proven to be helpful for adults with recurrent fractures. [blogs.longwood.edu]

A few patients have been reported with recurrent fractures or osteoporosis but these are not considered features of the disease. [ncbi.nlm.nih.gov]

fractures, pain, respiratory problems, impaired growth and mobility, premature tooth loss, developmental delay, and seizures. [ncbi.nlm.nih.gov]

Osteogenesis Imperfecta Type 16

Heterozygous family members may exhibit recurrent fractures with minimal trauma, osteopenia, and blue sclerae (Keller et al., 2018; Lindahl et al., 2018). (616229) [malacards.org]

New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. [books.google.com]

Recurrent fractures in childhood are possible. Type II (neonatal lethal type or osteogenesis imperfecta congenita) is the most severe and is lethal. [merckmanuals.com]

Osteogenesis Imperfecta

Osteogenesis imperfecta (OI) is a group of hereditary disorders characterized by low bone mass and recurrent fractures. [ncbi.nlm.nih.gov]

The clinical phenotypes of the patient included recurrent fractures, muscle weakness, bone deformity, macrocephaly and elbow contractures, but no blue sclera or dentinogenesis [ncbi.nlm.nih.gov]

In family 1, the proband was a 23-year-old male; he had recurrent fractures and dentinogenesis imperfecta. [ncbi.nlm.nih.gov]

Autosomal Dominant Osteopetrosis Type 2

[…] infection, massive hemorrhage, terminal leukemia) Benign adult autosomal dominant type 50% asymptomatic Recurrent fractures Mild anemia Cranial nerve palsy (rarely) Prognosis [learningradiology.com]

On the other hand, as with osteopetrosis, the bones are brittle and prone to recurrent fractures. 20. [slideshare.net]

[…] may occur (due to thrombocytopenia) May be associated with: Renal tubular acidosis Cerebral calcification Prognosis: survival beyond middle age is uncommon (death due to recurrent [learningradiology.com]

Osteopetrosis

recurrent fractures; - type I: sclerosis of the cranial vault; - type II: - rugger jersey spine and pelvic endobones; - defects in the chloride channel (CLCN7 gene) - spine [wheelessonline.com]

Patients with adult osteopetrosis are often diagnosed incidentally by Xray or on the presence of recurrent fractures. [pure.au.dk]

On the other hand, as with osteopetrosis, the bones are brittle and prone to recurrent fractures. 20. [slideshare.net]

Osteogenesis Imperfecta Type 2

fractures no cure for disease Prevention screening for mutation in family members prenatal screening with chorionic villus sampling Complications recurrent fractures leads [medbullets.com]

Type IV This may be apparent at birth with fractures or bowing of leg bones or recurrent fractures on walking. [patient.info]

fractures Increased fracture rate Increased fractures Multiple fractures Multiple spontaneous fractures Varying degree of multiple fractures [ more ] 0002757 Reduced bone [rarediseases.info.nih.gov]

Spondylo-Ocular Syndrome

New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. [books.google.com]

A Practical Approach to Children with Recurrent Fractures. Endocrine Development, 28, 210-225. [sydney.edu.au]

Diagnosis of Recurrent Fracture in a Pediatric Cohort. Calcified Tissue International, 103(5), 529-539. [sydney.edu.au]

Autosomal Recessive Osteopetrosis Type 6

Affiliated tissues include bone and bone marrow, and related phenotypes are back pain and recurrent fractures Disease Ontology : 12 An osteopetrosis characterized by autosomal [malacards.org]

They present with severe anemia, recurrent fractures, growth retardation, deafness, blindness and massive hepatosplenomegaly. 1 Marble Bone Disease Marble bone disease, the [aafp.org]

The susceptibility is variable and in some children recurrent fractures are the most debilitating part of the disease.4 7-9 13 They tend to occur only after moderate trauma [adc.bmj.com]

Blue Sclera

Her daughter aged 8 years had a similar appearance of the eye with recurrent fractures since childhood without any other congenital deformity. [ijo.in]

Case summary A 5-year-old boy was presented with a recurrent history of fractures since the age of 3 years. [ncbi.nlm.nih.gov]

recurrent fracture,contussions,have effective treatment in homeopathy 0 Reply [dailyrounds.org]

Platyspondyly

Recurrent fractures in childhood possible II Autosomal recessive (Neonatal lethal type or osteogenesis imperfecta congenita). Most severe and lethal. [learningradiology.com]

Keupp et al. (2013) and Pyott et al. (2013) described osteogenesis imperfecta type XV, an autosomal recessive form of the disorder characterized by early-onset recurrent fractures [mendelian.co]

fractures Arthralgia Flared femoral metaphysis Exostoses Spondylolisthesis Skin erosion Generalized joint laxity Otosclerosis Lower limb asymmetry Biconcave flattened vertebrae [mendelian.co]

Presenile Dementia with Bone Cysts

[…] bone fractures due to polycystic osseous lesions of the lower and upper extremities that has_material_basis_in homozygous mutation in the TYROBP gene on chromosome 19q13 [informatics.jax.org]

Patients then start suffering from recurrent bone fractures due to polycystic osseous and osteoporotic lesions in the limb bones (osseous stage). [orpha.net]

[…] bone fractures due to polycystic osseous lesions of the lower and upper extremities. [mendelian.co]

Pathological Fracture

KEYWORDS: Adjuvant; Curettage; GCT; Giant cell tumour; Local recurrence; Pathologic fracture; Wide resection [ncbi.nlm.nih.gov]

KEYWORDS: Amputation; Event-free survival; Limb salvage; Local recurrence; Osteosarcoma; Pathological fracture [ncbi.nlm.nih.gov]

At the 1-year follow-up visit, the patient did not have any complaints, and the radiographs indicated the consolidation of the fracture without recurrence of cyst. [ncbi.nlm.nih.gov]

Bruck Syndrome

In infancy and early childhood recurrent fractures of ribs and long bones and persistent Wormian bones in the calvarium are reminiscent of osteogenesis imperfecta (OI) even [ncbi.nlm.nih.gov]

[…] fragility fractures mutations in FKBP10 and PLOD2 were identified as the underlying genetic defects of Bruck syndrome (1) Bruck syndrome was first reported by Dr. [gpnotebook.com]

fractures Increased fracture rate Increased fractures Multiple fractures Multiple spontaneous fractures Varying degree of multiple fractures [ more ] 0002757 Short stature [rarediseases.info.nih.gov]

Schimmelpenning-Feuerstein-Mims Syndrome

Ehlers-Danlos Syndrome Spondylodysplastic Type 1

[…] delay 0001270 Proptosis Bulging eye Eyeballs bulging out Prominent eyes Prominent globes Protruding eyes [ more ] 0000520 Radioulnar synostosis Fused forearm bones 0002974 Recurrent [rarediseases.info.nih.gov]

Congenital Disorder of Glycosylation Type 2B

Pascale De Lonlay Sandrine Dubois Vassili Valayannopoulos Eliane Depondt Chris Ottolenghi Daniel Rabier Résumé Les anomalies congénitales de glycosylation ou CDG (Congenital Disorders of Glycosylation) forment une classe d’erreurs innées du métabolisme, affectant la synthèse des glycannes des glycoprotéines [1, 2]. La[…] [link.springer.com]

Exudative Vitreoretinopathy Type 1

BACKGROUND: Familial exudative vitreoretinopathy (FEVR) is a hereditary disorder characterized by impaired vascularization of parts of the peripheral retina. Autosomal dominant FEVR (adFEVR), a major form of FEVR and assigned to chromosome 11q13-23 (EVR1) locus, is caused by deletion mutations in the C- terminal[…] [ncbi.nlm.nih.gov]

Dent Disease Type 1

X-Linked Recessive Hypophosphatemic Rickets

Id: lil-709213 LILACS-Express Autor: Velásquez-Jones, Luis; Medeiros-Domingo, Mara. Título: Raquitismos hipofosfatémicos hereditarios / Hereditary hypophosphatemic rickets Fonte: Bol. méd. Hosp. Infant. Méx;70(6):421-431, nov.-dic. 2013. tab. Idioma: es. Resumo: Los raquitismos hipofosfatémicos hereditarios (RHH) son un[…] [bases.bireme.br]

Vitamin D-Dependent Rickets Type 1B

Overcome the toughest clinical challenges in nephrology with the new 9th edition of Brenner/Rector’s The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M. Chertow, Philip A. Marsden, Karl Skorecki, Alan S. L. Yu, and Barry M. Brenner,, together with a diverse list of international contributors bring[…] [books.google.com]

Vitamin D-Dependent Rickets Type 2A

Bilateral Genu Valgum

There was no history of recurrent fractures, polyuria, abdominal pains, recurrent vomiting or constipation. [academic.oup.com]

Medial ligamentous strain may be associated with recurrent knee pain. [emedicine.medscape.com]

There was no family history of frequent fractures, renal calculi, hypertension or multiple endocrine neoplasia (MEN)-related disorders. [academic.oup.com]

Autosomal Recessive Osteopetrosis Type 8

The susceptibility is variable and in some children recurrent fractures are the most debilitating part of the disease.4 7-9 13 They tend to occur only after moderate trauma [adc.bmj.com]

Other presentations include failure to thrive and recurrent infection, both secondary to the underlying anaemia and bone marrow involvement. [adc.bmj.com]

Hypocalcaemic seizures, excessive bruising, fractures, nasal congestion, and an abnormal craniofacial appearance are less common presenting complaints.4 7-9 These symptoms [adc.bmj.com]