Recurrent Fractures: Causes & Reasons

Possible Causes for Recurrent Fractures

Patients have coarse facial features, delayed shedding of baby teeth, osteopenia, and recurrent fractures. [merckmanuals.com]

Hereditary Hypophosphatemic Rickets with Hypercalciuria

[…] phosphorus level in patients with suspected but unexplained osteoporosis and/or recurrent renal stones. [ncbi.nlm.nih.gov]

Page K, Bergwitz C, Jaureguiberry G, Harinarayan CV, Insogna K (2008) A patient with hypophosphatemia, a femoral fracture, and recurrent kidney stones: report of a novel mutation [link.springer.com]

The severe presentation of this proband in adulthood with marked nephrolithiasis, multiple fractures and low bone density emphasizes the importance of measuring the serum [ncbi.nlm.nih.gov]

Spinal Muscular Atrophy Type 2

Klinische Langzeitbeobachtung von Patienten mit spinaler Muskelatrophie und Atemnot Typ 1 (SMARD1) Haupttitel: Klinische Langzeitbeobachtung von Patienten mit spinaler Muskelatrophie und Atemnot Typ 1 (SMARD1) Titel Übersetzt: The natural course of infantile spinal muscular atrophy with respiratory distress type 1[…] [refubium.fu-berlin.de]

Osteogenesis Imperfecta Type 15

Keupp et al. (2013) and Pyott et al. (2013) described osteogenesis imperfecta type XV, an autosomal recessive form of the disorder characterized by early-onset recurrent fractures [ncbi.nlm.nih.gov]

OI15 is characterized by early-onset recurrent fractures, bone deformity, significant reduction of bone density, short stature, and, in some patients, blue sclerae. [malacards.org]

fractures Blue sclerae And another 7 symptoms. [mendelian.co]

Osteogenesis Imperfecta Type 5

New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. [books.google.com]

Introduction: Osteogenesis imperfecta is a rare disease leading to immobility by recurrent fractures, immobilization, short stature and muscular weakness. [bone-abstracts.org]

Case characteristics: A 16-year-old boy who presented with history of recurrent fractures, had hard persistent swellings at fracture sites, and had radiographic features of [indianpediatrics.net]

Osteogenesis Imperfecta Type 13

OI13 is characterized by normal teeth, faint blue sclerae, severe growth deficiency, borderline osteoporosis, severe bone deformity, and recurrent fractures affecting both [malacards.org]

Osteogenesis Imperfecta Type 16

Heterozygous family members may exhibit recurrent fractures with minimal trauma, osteopenia, and blue sclerae (Keller et al., 2018; Lindahl et al., 2018). [ncbi.nlm.nih.gov]

New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. [books.google.com]

Recurrent fractures in childhood are possible. Type II (neonatal lethal type or osteogenesis imperfecta congenita) is the most severe and is lethal. [merckmanuals.com]

Hypophosphatasia

A few patients have been reported with recurrent fractures or osteoporosis but these are not considered features of the disease. [ncbi.nlm.nih.gov]

fractures, pain, respiratory problems, impaired growth and mobility, premature tooth loss, developmental delay, and seizures. [ncbi.nlm.nih.gov]

There is also an orthopedic procedure called, “rodding,” which has proven to be helpful for adults with recurrent fractures. [blogs.longwood.edu]

Osteogenesis Imperfecta

Here we report a teenage girl with OI type IV, who was started on cyclical intravenous pamidronate therapy at age 6 years because of recurrent fractures. [ncbi.nlm.nih.gov]

fractures no cure for disease Prevention screening for mutation in family members prenatal screening with chorionic villus sampling Complications recurrent fractures leads [medbullets.com]

Osteogenesis imperfecta (OI) is a group of hereditary disorders characterized by low bone mass and recurrent fractures. [ncbi.nlm.nih.gov]

Autosomal Dominant Osteopetrosis Type 2

On the other hand, as with osteopetrosis, the bones are brittle and prone to recurrent fractures. 20. [de.slideshare.net]

[…] infection, massive hemorrhage, terminal leukemia) Benign adult autosomal dominant type 50% asymptomatic Recurrent fractures Mild anemia Cranial nerve palsy (rarely) Prognosis [learningradiology.com]

• 50% patients are asymptomatic • Recurrent fractures • Mild anemia • Rarely cranial nerve palsy X-ray findings • Diffuse osteosclerosis • Cortical thickening with medullary [de.slideshare.net]

Cole-Carpenter Syndrome

fractures; Scoliosis; Shallow orbits; Short stature; Vertebral compression fractures Associated Genes P4HB (Withdrawn symbols: DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PO4DB [mousephenotype.org]

Differential diagnosis OI is not the only cause of recurrent fractures among children. [orthopaedicsone.com]

fractures Increased fracture rate Increased fractures Multiple fractures Multiple spontaneous fractures Varying degree of multiple fractures [ more ] 0002757 Scoliosis 0002650 [rarediseases.info.nih.gov]

Osteopetrosis

recurrent fractures; - type I: sclerosis of the cranial vault; - type II: - rugger jersey spine and pelvic endobones; - defects in the chloride channel (CLCN7 gene) - spine [wheelessonline.com]

Patients with adult osteopetrosis are often diagnosed incidentally by Xray or on the presence of recurrent fractures. [pure.au.dk]

They present with severe anemia, recurrent fractures, growth retardation, deafness, blindness and massive hepatosplenomegaly. 1 Marble Bone Disease Marble bone disease, the [aafp.org]

Osteogenesis Imperfecta Type 2

fractures no cure for disease Prevention screening for mutation in family members prenatal screening with chorionic villus sampling Complications recurrent fractures leads [medbullets.com]

Type IV This may be apparent at birth with fractures or bowing of leg bones or recurrent fractures on walking. [patient.info]

fractures Increased fracture rate Increased fractures Multiple fractures Multiple spontaneous fractures Varying degree of multiple fractures [ more ] 0002757 Reduced bone [rarediseases.info.nih.gov]

Spondylo-Ocular Syndrome

New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. [books.google.com]

A Practical Approach to Children with Recurrent Fractures. Endocrine Development, 28, 210-225. [sydney.edu.au]

Diagnosis of Recurrent Fracture in a Pediatric Cohort. Calcified Tissue International, 103(5), 529-539. [sydney.edu.au]

Osteogenesis Imperfecta Type 3

Recurrent fractures in childhood are possible. Type II (neonatal lethal type or osteogenesis imperfecta congenita) is the most severe and is lethal. [msdmanuals.com]

Type IV This may be apparent at birth with fractures or bowing of leg bones or recurrent fractures on walking. [patient.info]

The clinical signs and radiological features, such as recurrent fractures, blue sclera and low bone mineral density (BMD) level, all led to the diagnosis of a mild form of [spandidos-publications.com]

Autosomal Recessive Osteopetrosis Type 6

Affiliated tissues include bone and bone marrow, and related phenotypes are back pain and recurrent fractures Disease Ontology : 12 An osteopetrosis characterized by autosomal [malacards.org]

They present with severe anemia, recurrent fractures, growth retardation, deafness, blindness and massive hepatosplenomegaly. 1 Marble Bone Disease Marble bone disease, the [aafp.org]

The susceptibility is variable and in some children recurrent fractures are the most debilitating part of the disease.4 7-9 13 They tend to occur only after moderate trauma [adc.bmj.com]

Blue Sclera

Case summary A 5-year-old boy was presented with a recurrent history of fractures since the age of 3 years. [ncbi.nlm.nih.gov]

Her daughter aged 8 years had a similar appearance of the eye with recurrent fractures since childhood without any other congenital deformity. [ijo.in]

recurrent fracture,contussions,have effective treatment in homeopathy 0 Reply [dailyrounds.org]

Schimmelpenning-Feuerstein-Mims Syndrome

[Article in French] Affiliations PMID: 33058640 [Schimmelpenning-Feuerstein-Mims syndrome] [Article in French] Sabah Bazouti et al. Rev Prat. 2020 May. No abstract available Keywords: Jadassohn's Sebaceous Nevus. Conflict of interest statement Les auteurs déclarent n’avoir aucun lien d’intérêts. Similar articles[…] [pubmed.ncbi.nlm.nih.gov]

Ehlers-Danlos Syndrome Spondylodysplastic Type 1

[…] delay 0001270 Proptosis Bulging eye Eyeballs bulging out Prominent eyes Prominent globes Protruding eyes [ more ] 0000520 Radioulnar synostosis Fused forearm bones 0002974 Recurrent [rarediseases.info.nih.gov]

Familial Otosclerosis

Osteogenesis imperfecta (OI) is a genetic disorder characterized by recurrent fractures, blue sclera, and varying degrees of hearing impairment; and is a known risk factor [pubmed.ncbi.nlm.nih.gov]

NEMO Mutation with Immunodeficiency

Patients with the NEMO syndrome should also be monitored for bone health, as patients with NEMO syndrome may be less able to make strong bones, though recurrent fractures [primaryimmune.org]

Congenital Disorder of Glycosylation Type 2B

Sandrine Dubois4, Vassili Valayannopoulos4, Eliane Depondt5, Chris Ottolenghi6 & […] Daniel Rabier6 Chapter 848 Accesses Résumé Les anomalies congénitales de glycosylation ou CDG (Congenital Disorders of Glycosylation) forment une classe d’erreurs innées du métabolisme, affectant la synthèse des glycannes des[…] [link.springer.com]

Exudative Vitreoretinopathy Type 1

We report a new locus for familial exudative vitreoretinopathy (FEVR), on chromosome 11p12-13 in a large autosomal dominant pedigree. Statistically significant linkage was achieved across a 14-cM interval flanked by markers GATA34E08 and D11S4102, with a maximum multipoint LOD score of 6.6 at D11S2010. FEVR is a disease[…] [ncbi.nlm.nih.gov]

Dent Disease Type 1

Note : les liens hypertextes menant vers d'autres sites ne sont pas mis à jour de façon continue. Il est possible qu'un lien devienne introuvable. Veuillez alors utiliser les outils de recherche pour retrouver l'information désirée. Bibliographie Mayo Foundation for Medical Education and Research (Ed). Diseases &[…] [passeportsante.net]

X-Linked Recessive Hypophosphatemic Rickets

Id: lil-709213 LILACS-Express Autor: Velásquez-Jones, Luis; Medeiros-Domingo, Mara. Título: Raquitismos hipofosfatémicos hereditarios / Hereditary hypophosphatemic rickets Fonte: Bol. méd. Hosp. Infant. Méx;70(6):421-431, nov.-dic. 2013. tab. Idioma: es. Resumo: Los raquitismos hipofosfatémicos hereditarios (RHH) son un[…] [bases.bireme.br]

Vitamin D-Dependent Rickets Type 1B

Leading clinicians review in depth the clinical and molecular aspects of the hormone resistance syndromes caused by receptor mutations. These mutations are involved in a large number of disorders, including dwarfism, Laron syndrome, pseudohypoparathyroidism, insulin resistance, resistance to thyroid hormone,[…] [books.google.com]

Vitamin D-Dependent Rickets Type 2A

CLCN-Related Osteopetrosis

Fractures and arthritis require specialized treatment and follow-up since there is usually a delay in consolidation, osteomyelitis, and recurrent fractures. [scielo.org.mx]

Grange Syndrome

Recurrent fractures Abnormality of the nervous system Intellectual disability Growth abnormality Decreased body weight IMPORTANT NOTE: NIH does not independently verify information [ncbi.nlm.nih.gov]

Recurrent fractures MedGen UID: 42094 •Concept ID: C0016655 • Injury or Poisoning The repeated occurrence of bone fractures (implying an abnormally increased tendency for [ncbi.nlm.nih.gov]

[…] artery stenosis Renal artery stenosis Abnormality of the genitourinary system Renovascular hypertension Abnormality of the musculoskeletal system Increased susceptibility to fractures [ncbi.nlm.nih.gov]

Suárez-Stickler Syndrome

[…] in the skull, dentinogenesis imperfecta, recurrent bone fractures, hypertelorism, and eye puffiness.[1][2] This disorder is unique from osteogenesis imperfecta because of [wikiwand.com]

Wormian bone-multiple fractures-dentinogenesis imperfecta-skeletal dysplasia syndrome is a rare genetic bone disorder which is characterized by the presence of wormian bones [wikiwand.com]