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1,070 Possible Causes for Recurrent Fractures

  • Vitamin D Deficiency

    Hyperparathyroidism can become apparent early in its course when a patient presents with symptoms of abdominal pain, recurrent renal calculi, repeated fractures, or behavior[] Manias K, McCabe D, Bishop N (2006) Fractures and recurrent fractures in children; varying effects of environmental factors as well as bone size and mass.[] Fracture prevention with vitamin D supplementation: A meta-analysis of randomized controlled trials. JAMA, 293 (18), 2257–2264. Review.[]

  • Osteoporosis

    We hypothesize that overexpression of bone morphogenetic protein 2 may be the underlying mechanism of osteoporosis and recurrent fractures.[] Osteogenesis imperfecta (OI) is an inherited disorder with osteoporosis and recurrent fractures.[] The HORIZON Recurrent Fracture Trial: design of a clinical trial in the prevention of subsequent fractures after low trauma hip fracture repair.[]

  • Primary Hyperoxaluria

    Summary Epidemiology The prevalence of PH1 reported in Europe ranges from 1/333,000 - 1/1,000,000. Higher values are reported in specific populations with a high rate of consanguinity. Clinical description There exists an important heterogeneity in the clinical presentation and onset of PH1. The severe infantile form is[…][]

  • Calvarial Doughnut Lesions - Bone Fragility Syndrome

    New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included.[] This chapter outlines an approach to the evaluation and treatment of children with recurrent fractures and describes three common scenarios involving infants, children with[] fractures, several of which may havecraniofacial abnormalities.[]

  • Cole-Carpenter Syndrome

    fractures Increased fracture rate Increased fractures Multiple fractures Multiple spontaneous fractures Varying degree of multiple fractures [ more ] 0002757 Scoliosis Abnormal[] Prenatal growth deficiency Prenatal growth retardation [ more ] 0001511 Kyphosis Hunched back Round back [ more ] 0002808 Muscular hypotonia Low or weak muscle tone 0001252 Recurrent[]

  • Autosomal Dominant Hyper-IgE Syndrome

    Common findings among patients were recurrent fractures (in 57 percent of patients), hyperextensible joints (in 68 percent), and scoliosis (in 76 percent of patients 16 years[] Patients have coarse facial features, delayed shedding of baby teeth, osteopenia, and recurrent fractures.[] […] sinopulmonary infections joint hyperextensibility decreased bone mineral density recurrent fractures eczema, severe recurrent skin abscesses recurrent Staphylococcus aureus[]

  • Common Cold

    Patients with HIES typically also have eczema, distinct facial features, and a tendency to experience bone fractures.[] People with autosomal dominant hyper-immunoglobulin E syndrome (HIES) have recurrent bacterial infections of the skin and lungs.[]

  • Osteogenesis Imperfecta

    Here we report a teenage girl with OI type IV, who was started on cyclical intravenous pamidronate therapy at age 6 years because of recurrent fractures.[] Osteogenesis imperfecta (OI) is a group of hereditary disorders characterized by low bone mass and recurrent fractures.[] The clinical phenotypes of the patient included recurrent fractures, muscle weakness, bone deformity, macrocephaly and elbow contractures, but no blue sclera or dentinogenesis[]

  • Osteogenesis Imperfecta Type 5

    New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included.[] Introduction: Osteogenesis imperfecta is a rare disease leading to immobility by recurrent fractures, immobilization, short stature and muscular weakness.[] Type IV This may be apparent at birth with fractures or bowing of leg bones or recurrent fractures on walking.[]

  • Osteogenesis Imperfecta Type 15

    OI15 is characterized by early-onset recurrent fractures, bone deformity, significant reduction of bone density, short stature, and, in some patients, blue sclerae.[] Keupp et al. (2013) and Pyott et al. (2013) described osteogenesis imperfecta type XV, an autosomal recessive form of the disorder characterized by early-onset recurrent fractures[] Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality.[]

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