Recurrent Infection: Causes & Reasons

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Possible Causes for Recurrent Infection

Primary Immune Deficiency Disorder

[…] with age Recurrent serious infections with common pathogens Serious infections with unusual pathogens Table 3. [aafp.org]

Important signs that may indicate a PIDD include: • Recurrent, unusual or difficult to treat infections • Poor growth or loss of weight • Recurrent pneumonia, ear infections [aaaai.org]

Recurrent infections Permanent damage to the bronchi may occur, resulting in bronchiectasis. [emedicine.medscape.com]

Congenital Neutropenia

Herein, we describe two siblings with SCN born from consanguineous parents who were referred for complaints of recurrent cutaneous infections, gingivitis, purulent otitis [ncbi.nlm.nih.gov]

Herein, we describe an 11-month-old male who was referred with recurrent cutaneous infections and chronic diarrhea. [ncbi.nlm.nih.gov]

Recurrent and severe infections should alert physicians to possible immunodeficiency disease. [ncbi.nlm.nih.gov]

Congenital AIDS

infections. [healthdirect.gov.au]

[…] sinopulmonary or GI infections, candidiasis, meningitis X-linked agammaglobulinemia X-linked BTK Recurrent sinopulmonary and skin infections during infancy, transient neutropenia [msdmanuals.com]

causing recurrent chest infections in cystic fibrosis). [racgp.org.au]

Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by antibody deficiency, poor humoral response to antigens, and recurrent infections. [ncbi.nlm.nih.gov]

Patients with CVID are at lifelong risk of recurrent infections, particularly of the respiratory and gastrointestinal tracts. [ncbi.nlm.nih.gov]

English common variable immunodeficiency immune disorder characterized by recurrent infections and low antibody levels, specifically in immunoglobulin CVID acquired agammaglobulinemia [wikidata.org]

Hypogammaglobulinemia

Recurrent infections are clinical hallmarks of CVID as well. [symptoma.com]

Patients with hypogammaglobulinemia are susceptible to recurrent bacterial, viral, fungal, and parasitic infections. [ncbi.nlm.nih.gov]

Patients with IgG subclass deficiency may be asymptomatic or have recurrent infections. [online.epocrates.com]

Lymphoproliferative Syndrome 1

Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma. [uniprot.org]

[…] aphthous stomatitis ; Recurrent infections ; Splenomegaly ; Stomatitis ; Thrombocytopenia Associated Genes ITK (Withdrawn symbols: EMT, LYK, PSCTK2 ) Mouse Orthologs Itk [mousephenotype.org]

infections Cirrhosis Lymphopenia Recurrent upper respiratory tract infections Vasculitis Ascites Recurrent respiratory infections Ptosis Combined immunodeficiency Erythema [mendelian.co]

Ataxia Telangiectasia

infections, and cancer susceptibility. [ncbi.nlm.nih.gov]

Some of the complications of A-T include cancer (typically leukemia or lymphoma), recurrent infections and chronic lung disease. [hopkinsmedicine.org]

BACKGROUND: Ataxia telangiectasia (AT) is a primary immunodeficiency associated with recurrent infections. [ncbi.nlm.nih.gov]

Primary Ciliary Dyskinesia

infections such as bronchitis and pneumonias Excess mucus Difficulty clearing mucus Chronic nasal congestion Recurrent middle ear infections Recurrent cold symptoms Abnormality [chop.edu]

Primary ciliary dyskinesia is a genetic disorder in which impaired development and function of cilia leads to recurrent respiratory infections, hearing deficits and congenital [symptoma.com]

infections and development of bronchiectasis with daily physiotherapy. [ncbi.nlm.nih.gov]

Severe Combined Immunodeficiency

A 15-month-old boy presented with failure to thrive, neutropenia and recurrent infections. He was diagnosed with T-B-NK+ SCID. [ncbi.nlm.nih.gov]

Affected infants are born with profound abnormalities of immune cell function that lead to severe and recurrent infection that are almost always fatal in the first year of [ncbi.nlm.nih.gov]

Most children with SCID presented with failure to thrive and recurrent infections and there was no significant delay between presentation and diagnosis. [ncbi.nlm.nih.gov]

Pediatric Chronic Granulomatous Disease

Chronic granulomatous disease (CGD), a rare immunodeficiency, typically presents with recurrent infections caused by catalase-positive organisms. [scholars.northwestern.edu]

Chronic granulomatous disease is a rare, inherited immunodeficiency disorder that reduces the superoxide generation ability of phagocytes, leading to recurrent infections [ncbi.nlm.nih.gov]

Chronic granulomatous disease is a rare primary immunodeficiency disorder, which leads to increased susceptibility to recurrent infections and severe inflammatory manifestations [ncbi.nlm.nih.gov]

Cyclic Neutropenia

Recurrent infections, inflammation, and ulcers can lead to significant chronic morbidity. [ncbi.nlm.nih.gov]

Here we report on an exceptional CVID patient with recurrent episodes of cyclic neutropenia, skin vasculitis and recurrent infections associated with a transient, but reproducible [ncbi.nlm.nih.gov]

infections. [askdrshah.com]

Netherton Syndrome

infections. [krystalbio.com]

Other problems associated with Netherton syndrome are delayed growth and development, immune abnormalities, recurrent infections, and intermittent aminoaciduria. [ncbi.nlm.nih.gov]

Affected infants typically have delayed growth and development, immune abnormalities with recurrent infections, and intermittent aminoaciduria. [ncbi.nlm.nih.gov]

Hyper-IgE Syndrome

Synonyms: Hyper IgE Syndrome, Hyper IgE Syndrome, Autosomal Dominant, Hyperimmunoglobulin E, Recurrent Infection Syndrome, Jobs Syndrome, Hyper-Immunoglobulin E Syndrome, [ebi.ac.uk]

Hyper-IgE recurrent infection syndrome is a primary immunodeficiency disorder characterized by chronic eczema, recurrent staphylococcal infections, increased serum IgE, and [humpath.com]

[…] and recurrent sinopulmonary infections. [ijdvl.com]

Wiskott-Aldrich Syndrome

We investigated two Malay boys who presented with congenital thrombocytopenia, eczema and recurrent infections. [ncbi.nlm.nih.gov]

Affiliated tissues include t cells, bone and bone marrow, and related phenotypes are thrombocytopenia and recurrent infections [malacards.org]

Infections - Recurrent bacterial, viral or opportunistic infections, like eczema, are invariably reported by patients, examples being bacterial pneumonia, pneumocystis jiroveci [symptoma.com]

Chédiak-Higashi Syndrome

Most patients undergo a variable period of recurrent infections before going into the accelerated phase. [ncbi.nlm.nih.gov]

Because the beige mouse demonstrates many characteristics similar to those of human CHS patients, including dilution of coat color, recurrent infections, and the presence [ncbi.nlm.nih.gov]

Chediak-Higashi Syndrome is a rare autosomal recessive disease characterized by recurrent infections, giant cytoplasmic granules and oculocutaneous albinism. [ncbi.nlm.nih.gov]

Cartilage Hair Hypoplasia

infections. [symptoma.com]

infections usually due to cellular and/or humoral immunodeficiency. [ncbi.nlm.nih.gov]

Despite mutation homogeneity, eight (32%) patients had severe or recurrent infections, two (8%) of these children underwent bone-marrow transplantation for combined immunodeficiency [ncbi.nlm.nih.gov]

DiGeorge Syndrome

A 2-year-old boy with chromosome 22q11.2 deletion syndrome was referred for recurrent sinopulmonary infections. [ncbi.nlm.nih.gov]

Its symptoms vary greatly between individuals but commonly include a history of recurrent infection, heart defects, and characteristic facial features. [ncbi.nlm.nih.gov]

infections and other comorbidities. [ncbi.nlm.nih.gov]

Alpha-Mannosidosis

The disease characterized by mental retardation, skeletal changes, hearing impairment, and recurrent infections. [ncbi.nlm.nih.gov]

In humans, alpha-mannosidosis results in progressive facial- and skeletal abnormalities, motor impairment, hearing impairment, intellectual disability, recurrent infections [ncbi.nlm.nih.gov]

Major symptoms include mental retardation, skeletal changes and recurrent infections. [ncbi.nlm.nih.gov]

Autoimmune Lymphoproliferative Syndrome Type 3

Some patients have recurrent infections, and there may be an increased risk of hematologic malignancy (summary by {2:Oliveira, 2013} and {1:Niemela et al., 2010}). [diseaseinfosearch.org]

Infection Syndrome, Autosomal Dominant Hies, Autosomal Dominant Hyper-IgE Syndrome, Autosomal Dominant Job Syndrome 147060 Genetic Test Registry Hyper-IgE Recurrent Infection [ukgtn.nhs.uk]

Autosomal recessive/ loss of function mutation in PRKCD gene (3p21.1) Hypogammaglobinemia, recurrent infections, lymphadenopathy, hepatosplenomegaly, autoimmunity and NK [emedicine.medscape.com]

Idiopathic Neutropenia

A 48-year-old woman who presented with chronic idiopathic neutropenia causing life-long recurrent infections, and postoperative suppurative wound infections, presented for [ncbi.nlm.nih.gov]

None had recurrent infections, leukemia, lupus erythematosus, or rheumatoid arthritis. [nejm.org]

In addition to a laboratory assessment, neutropenia patients may have a history of frequent/recurrent infections, lung infections, chronic ear infections, skin infections, [luriechildrens.org]

Hairy Cell Leukemia

Patients require treatment when they have significant cytopenia or recurrent infections. [ncbi.nlm.nih.gov]

The clinical features are often related to cytopenias and include recurrent infections (due to neutropenia) and weakness and fatigue (due to anemia). [webpathology.com]

These include weight loss, fatigue, easy bruising, anemia and recurrent infections. [medindia.net]

Dubowitz Syndrome

Eczema and recurrent infections require conservative treatment. [orpha.net]

She/he may be prone to recurrent infections, hypogammaglobulinemia, IgA deficiency, aplastic anemia, acute lymphatic leukemia, lymphoma, and/or neuroblastoma. contributor: [dubowitzsyndrome.net]

Mucopolysaccharidosis Type 2

Most patients with MPS 2 have progressive hearing loss and recurrent infections of the middle ear. [symptoma.com]

[…] ear infections Frequent ear infections 0410018 Recurrent upper respiratory tract infections Recurrent colds 0002788 Retinal degeneration Retina degeneration 0000546 Retinopathy [rarediseases.info.nih.gov]

Mucopolysaccharidosis type II is a multisystem disorder and symptoms include coarse face, short stature, skeletal abnormalities, recurrent infections, cardiomyopathy, hepatomegaly [symptoma.com]

Rubinstein-Taybi Syndrome

It is estimated that approximately 75% of patients with RTS experience recurrent respiratory infections. [ncbi.nlm.nih.gov]

Respiratory system - Recurrent infections, sleep apnea, and lung lobulation, while increased susceptibility to the collapse of the larynx and breathing difficulties are also [symptoma.com]

In the present study, the humoral immune response in 16 RTS patients with recurrent respiratory infections of possible bacterial etiology was evaluated. [ncbi.nlm.nih.gov]

Aspartylglucosaminuria

infections and diarrhea; mental retardation, seizures, coarse facial features, and skeletal abnormalities become evident by adolescence. [medical-dictionary.thefreedictionary.com]

Clincal signs and symptoms include hepatomegaly, splenomegaly, hearing loss, mental retardation, skeletal abnormalities, and recurrent respiratory infections. [icd10data.com]

infections and diarrhea; mental retardation, seizures, coarse facial features, and skeletal abnormalities that become evident by adolescence. [medical-dictionary.thefreedictionary.com]

Congenital Generalized Lipodystrophy Type 4

infections Frequent infections Frequent, severe infections Increased frequency of infection infections, recurrent Predisposition to infections Susceptibility to infection [rarediseases.info.nih.gov]

[…] umbilicus Prominent belly button Prominent navel [ more ] 0001544 Proximal muscle weakness Weakness in muscles of upper arms and upper legs 0003701 Pyloric stenosis 0002021 Recurrent [rarediseases.info.nih.gov]

Mohr Syndrome

In those with a contiguous gene deletion syndrome (CGS), recurrent infections may be present. [rarediseases.info.nih.gov]

If the CGS includes the Bruton agammaglobulinemia tyrosine kinase (BTK) gene, recurrent infections secondary to this X-linked agammaglobulinemia (XLA) are present. [findzebra.com]

At age 2 years, bilateral hearing loss appeared and recurrent infections led to a diagnosis of Bruton agammaglobulinemia. [n.neurology.org]

Donohue Syndrome

Other abnormalities that have been observed in infants with leprechaunism include recurrent infections, abnormalities of the intellect and unusually large hands and feet. [symptoma.com]

Although some patients survived for several years, most die of severe failure to thrive with recurrent infections in the first year of life. [accessanesthesiology.mhmedical.com]

Mucopolysaccharidosis Type 1

[…] respiratory infections Frequent respiratory infections Multiple respiratory infections respiratory infections, recurrent Susceptibility to respiratory infections [ more ] [rarediseases.info.nih.gov]

Sleep apnea Hydrocephalus Hepatosplenomegaly (enlarged liver and spleen) Umbilical hernia Inguinal hernia Hearing loss Recurrent ear infections Corneal clouding Carpal tunnel [rarediseases.info.nih.gov]

[…] more ] 0000256 Malabsorption Intestinal malabsorption 0002024 Microdontia Decreased width of tooth 0000691 Paresthesia Pins and needles feeling Tingling [ more ] 0003401 Recurrent [rarediseases.info.nih.gov]

Myelodysplasia

For thymoma patients with recurrent infections, comprehensive immunologic studies to exclude the possibility of Good's syndrome and prophylactic intravenous immunoglobulin [ncbi.nlm.nih.gov]

A Japanese patient presented with lymphedema, severe Varicella zoster, and Salmonella infection, recurrent respiratory infections, panniculitis, monocytopenia, B- and NK-cell [ncbi.nlm.nih.gov]

Clinical features vary depending on the type of MDS and the affected cell lines, and may include signs of anemia (e.g., fatigue, weakness, pallor), recurrent infections, and [amboss.com]