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2 Possible Causes for Recurrent Infections due to Ciliary Dysfunction

  • Primary Ciliary Dyskinesia 18

    OMIM : 58 Primary ciliary dyskinesia-18 is an autosomal recessive disorder characterized by early infantile onset of recurrent sinopulmonary infections due to ciliary dysfunction[malacards.org]

  • Dextrocardia

    Impaired mucociliary clearance leads to recurrent lung infections, bronchiectasis, chronic sinusitis, and otitis media.[ajronline.org] The primary abnormality is termed “immotile cilia syndrome” or “primary ciliary dyskinesia” and stems from defective ciliary motility due to genetically determined structural[ajronline.org] Ciliary dysfunction also causes reduced fertility in women and sterility in men from reduced motility of spermatozoa [ 18 ].[ajronline.org]

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