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772 Possible Causes for Recurrent Pneumonia, Splenomegaly

  • Felty's Syndrome

    Computed tomography of the pelvis led to an incorrect diagnosis of malignancy, while radionuclide imaging using Tc-99m sulfur colloid confirmed the diagnosis of ectopic splenomegaly[ncbi.nlm.nih.gov] We report on a 67-year-old man with Felty's syndrome (FS) complicated by recurrent pneumonia and an infected wound, which was not healing in spite of maximal antibiotic and[ncbi.nlm.nih.gov] Abstract The syndrome of atrophic polyarthritis occurring in an adult, associated with fever, secondary anemia, leukopenia and splenomegaly, was described by Felty 1 in 1924[annals.org]

  • Mucopolysaccharidosis 6

    Macrocephaly Enlarged tongue Prominent forehead Possible coarse texture of hair Hepatomegaly and splenomegaly are often present in patients with MPS VI.[emedicine.medscape.com] Patients are typically susceptible to developing obstructive and restrictive lung disease which are accompanied by complications such as recurrent pneumonia and obstructive[symptoma.com] Less often, the spleen may also be enlarged (splenomegaly).[rarediseases.org]

  • Pulmonary Histoplasmosis

    Patients present with recurrent pneumonia, haemoptysis or respiratory failure.[life-worldwide.org] […] young, very old, HIV ) to liver, spleen, bone marrow, nodes, lung, rarely to skin Disseminated disease: strongly associated with AIDS; patients have fever, weight loss, splenomegaly[pathologyoutlines.com] In patients with underlying lung disease, particularly COPD, a subacute pneumonia can evolve into chronic pulmonary histoplasmosis and is characterized by persistent or recurrent[swjpcc.com]

  • Non-Hodgkin Lymphoma

    During RTX/CHOP treatment, human-IgG-immunoglobulin (IVIg) therapy was introduced in six patients after recurrent infections, including community-acquired pneumonia (85.7%[ncbi.nlm.nih.gov] Splenomegaly is observed in approximately 40% of patients; the spleen is rarely the only involved site at presentation.[emedicine.medscape.com] Slow growing or indolent lymphomas usually present with lymphadenopathy, hepatomegaly, splenomegaly or different types of cytopenias.[symptoma.com]

  • Chronic Lymphocytic Leukemia

    In the physical examination, generalized lymphadenopathy and hepato- and/or splenomegaly may be noted.[symptoma.com] After 3 years, he presented a CLL progression with worsening lymphocytosis, anemia, thrombocytopenia, increased splenomegaly, and lymphadenopathies.[ncbi.nlm.nih.gov] ; anterior nasal bleeding; pustulous non-itching lesions at the cervical region and posterior thorax; enlarged bilateral axillary lymph nodes; hepatomegaly; and moderate splenomegaly[ncbi.nlm.nih.gov]

  • Histoplasmosis

    […] constitutional symptoms, namely weight loss and Karnofsky classification 30, gastrointestinal manifestations with alteration of liver enzymes and hepatosplenomegaly and/or splenomegaly[ncbi.nlm.nih.gov] Patients present with recurrent pneumonia, haemoptysis or respiratory failure.[life-worldwide.org] These include recurrent pneumonia , respiratory failure , fibrosing mediastinitis , superior vena cava syndrome , pulmonary vessel obstruction, progressive fibrosis of lymph[en.wikipedia.org]

  • Hairy Cell Leukemia

    Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] It typically affects middle-aged to elderly male who present with pancytopenia and massive splenomegaly. Lymphadenopathy is usually not seen.[ncbi.nlm.nih.gov] All patients were adults with splenomegaly.[ncbi.nlm.nih.gov]

  • Rheumatoid Arthritis

    It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] […] anti-citruillated plasma antibody (ACPA): it is more than 80% sensitive and more than 95% specific elevated ESR or C-reactive protein Associations Felty syndrome : rheumatoid arthritis, splenomegaly[radiopaedia.org] This is characterized by splenomegaly, and leukopenia – predominantly granulocytopenia.[hopkinsarthritis.org]

  • Visceral Larva Migrans

    Follow-up showed increased physical activity, improved respiratory status, and resolution of splenomegaly.[ncbi.nlm.nih.gov] Clinical findings were pain, fever, anorexia, dizziness, dyspnea, weight loss, cough, hepatomegaly, splenomegaly and lymphadenopathy.[ijph.tums.ac.ir] […] larva migrans and hypereosinophilia syndrome with persistently elevated white blood cell count despite adequate medical therapy in a 4-year-old boy with leukocytosis and splenomegaly[ncbi.nlm.nih.gov]

  • Sickle Cell Disease

    Clinical findings are wide and include 1,6 : bone pain bone infarction subperiosteal haemorrhage osteomyelitis pulmonary acute chest syndrome recurrent pneumonia (impaired[radiopaedia.org] Sickle trait does not cause anemia, microcytosis, splenomegaly, or pain. Further, people with sickle trait can donate blood.[clinicaladvisor.com] , Streptococcus pneumoniae ).[emedicine.medscape.com]

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