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19 Possible Causes for Recurrent Pneumonia due to Aspiration, Tongue Weakness, Vacuolization

  • Oculo-Pharyngo-Distal Myopathy

    Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[ncbi.nlm.nih.gov] […] muscles Bulbar Dysphagia: Oropharyngeal Dysarthria: Hoarse & Nasal voice Tongue weakness Limbs Legs Arms Distal: Anterior tibial; Finger extensors Onset: 5 years after disease[neuromuscular.wustl.edu] Myopathological findings showed rimmed vacuoles with varying degrees of muscular dystrophic changes.[ncbi.nlm.nih.gov]

  • Distal Myopathy Type 3

    […] suck Pharyngela: Difficulty swallowing, recurrent aspiration pneumonia, cough during meals, weight loss Weakness of jaw when chewing.[sites.google.com] Tubulofilamentous inclusion, myeloid bodies, and autophagic vacuoles in the area corresponding to rimmed vacuoles ( d ; bar 1 μm).[karger.com] Yonsei Medical Journal. 2013; 54(3): 578-582 [Pubmed] 7 Distal myopathy with rimmed vacuoles and inflammation: A genetically proven case Kannan, M.A. and Challa, S. and Urtizberea[neurologyindia.com]

  • Secondary Myopathy

    […] suck Pharyngela: Difficulty swallowing, recurrent aspiration pneumonia, cough during meals, weight loss Weakness of jaw when chewing.[sites.google.com] Sensorimotor neuropathy Hypothyroid (amiodarone) Elevated serum CK EMG: fibs, PSWs, myotonia (choroquine), myopathic MUAPs NCS: axonal sensorimotor neuropathy Autophagic vacuoles[neurology.mhmedical.com] Vacuoles rimmed with basophilic granules. Inclusion body myositis IBM. Vacuole filled with granules. Modified Gomori trichrome stain. Inclusion body myositis IBM.[neuropathology-web.org]

  • GM2-Gangliosidosis

    Causes of death include pneumonia due to recurrent aspiration and cardiopulmonary failure.[orpha.net] Cytoplasmic vacuoles were found in the liver, kidneys and chondrocytes and foamy macrophages within the lungs.[ncbi.nlm.nih.gov] The remainder of the examination revealed supranuclear gaze palsy in all directions, tongue fasciculations, diffuse weakness, brisk reflexes, and flexor plantar responses.[jamanetwork.com]

  • Polyglucosan Body Myopathy Type 2

    ; DMRV; Nonaka myopathy; Rimmed vacuole myopathy; Quadriceps Sparing Myopathy; GNE myopathy "OMIM Entry # 605820 - Nonaka Myopathy" .[en.wikipedia.org] […] suck Pharyngela: Difficulty swallowing, recurrent aspiration pneumonia, cough during meals, weight loss Weakness of jaw when chewing.[sites.google.com] […] connective tissue Storage material PAS Glycogen ; Carbohydrate Alcian blue Mucopolysaccharide Sudan black B Lipid Oil red O Lipid Other Congo red Amyloid ; Inflammation; Vacuoles[grants.hhp.uh.edu]

  • Distal Spinal Muscular Atrophy Type 3

    Bulbar involvement predisposes the person with spinal muscular atrophy to recurrent aspiration pneumonia, due to weakening of the muscles necessary for efficient swallowing[encyclopedia.com] - Facioscapulohumeral dystrophy : Read PDF pp. 127-128 Case 44 - Miyoshi distal myopathy, dysferlin myopathy : Read PDF pp. 128-132 Case 45 - Distal myopathy with rimmed vacuoles[cco.cup.cam.ac.uk] […] cry Weak cough Swallowing, feeding, and handling of oral secretion are affected before 1 year of age Atrophy and fasciculation of the tongue Weakness and hypotonia in the[togetherinsma-hcp.com]

  • Intestinal Hypomotility

    […] tongue, jaw, esophagus, and throat muscles Aspiration due to pharyngeal weakness, potentially causing pneumonia Recurrent post-prandial abdominal pain and bloating due to[myotonic.org] Reduced actin level, degeneration of vacuoles and reduction in cytoskeleton protein have also been described.[radiopaedia.org] […] skeletal anomalies, or weakness, incoordination and myotonia of face, tongue, jaw, esophagus, and throat muscles Aspiration due to pharyngeal weakness, potentially causing[myotonic.org]

  • Autosomal Dominant Myoglobinuria

    […] suck Pharyngela: Difficulty swallowing, recurrent aspiration pneumonia, cough during meals, weight loss Weakness of jaw when chewing.[sites.google.com] The vacuoles also stain intensely to acid phosphates, confirming that the vacuoles filled with glycogen are secondary lysosomes.[annalsofneurosciences.org] Involvement of the heart, respiratory muscles or tongue. (Facial weakness is not usual.)[patient.info]

  • Congenital Myopathy with Excess of Thin Filaments

    […] suck Pharyngela: Difficulty swallowing, recurrent aspiration pneumonia, cough during meals, weight loss Weakness of jaw when chewing.[sites.google.com] Autophagic vacuoles, tubulofilamentous aggregates and paired helical filaments have occasionally been seen in DRM. [14], [24], [25] Similar morphological features and a variety[bioline.org.br] […] ability to ubiquinate may result in accumulation of proteins that are not tagged for degradation by the proteosomal system. [65] EM reveals numerous small, membrane-bound vacuoles[misc.medscape.com]

  • Myoadenylate Deaminase Deficiency

    […] suck Pharyngela: Difficulty swallowing, recurrent aspiration pneumonia, cough during meals, weight loss Weakness of jaw when chewing.[sites.google.com] The vacuoles also stain intensely to acid phosphates, confirming that the vacuoles filled with glycogen are secondary lysosomes.[annalsofneurosciences.org] Weakness in the tongue, hands or feet which slowly spreads to other parts of the body.[mda.org.au]

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