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50 Possible Causes for Red Blood Cell Distribution Width Increased

  • Iron Deficiency

    Average size of RBCs (MCV) — may be decreased Average amount of Hb in RBCs (MCH) — may be decreased Increased variation in the size of RBCs (red cell distribution width (RDW[labtestsonline.org.au] This is reflected in the red blood cell distribution width (RDW); thus, the earliest evidence of the development of an iron-deficient erythropoiesis is seen in the peripheral[emedicine.com] Alternatively, other laboratory tests (e.g., mean cell volume, red blood cell distribution width, and serum ferritin concentration) can be used to differentiate iron-deficiency[cdc.gov]

  • Vitamin B12 Deficiency

    Folate deficiency in the periconceptional period contributes to neural tube defects; deficits in vitamin B12 (cobalamin) have negative consequences on the developing brain during infancy; and deficits of both vitamins are associated with a greater risk of depression during adulthood. This review examines two[…][ncbi.nlm.nih.gov]

  • Iron Deficiency Anemia

    […] high red blood cell distribution width, reflecting an increased variability in the size of red blood cells.A low mean corpuscular volume also appears during the course of[en.wikipedia.org] This is reflected in the red blood cell distribution width (RDW); thus, the earliest evidence of the development of an iron-deficient erythropoiesis is seen in the peripheral[emedicine.com] If the anemia is due to iron deficiency, one of the first abnormal values to be noted on a complete blood count, as the body's iron stores begin to be depleted, will be a[en.wikipedia.org]

  • Thalassemia

    blood cell distribution width High Normal; occasionally high Normal Ferritin Low Normal Normal Mentzer index for children (MCV/red blood cell count) 13 13 13 Hb electrophoresis[aafp.org] Though some overlap with α-thalassemia carrier states exists, individuals with iron deficiency anemia show a marked increase in red blood cell distribution width (RDW), a[ncbi.nlm.nih.gov] Normal (may have reduced HbA2) Increased HbA2, reduced HbA, and probably increased HbF Adults: normal Newborns: may have HbH or Hb Bart's Table 3.[aafp.org]

  • Myelodysplasia

    Myelodysplasia, or myelodysplastic syndrome (MDS), is a group of hematopoietic disorders characterized by dysmyelopoiesis and cytopenias. Abnormal hematopoiesis may include erythrocytes, granulocytes and megakaryocytes. Initial stages of MDS may be characterized by macrocytic anemia with mild thrombocytopenia or[…][symptoma.com]

  • Vitamin B12 Deficiency Anemia

    Abstract Paraoxonase-1 is an esterase enzyme and it has 3 types of activity, namely paraoxonase, arylesterase, and diazoxonase. It has been reported that paraoxonase-1 deficiency is related to increased susceptibility to development of atherosclerosis and cardiovascular disease. The aim of this study was to[…][ncbi.nlm.nih.gov]

  • Chronic Liver Disease

    A 64-year-old Japanese woman with a history of bronchiectasis presented with multiple hypervascular nodules in both lobes of the liver without hepatitis B or C virus infection. Imaging studies, including ultrasound, contrast-enhanced computed tomography and magnetic resonance imaging, showed hypervascularity in the[…][ncbi.nlm.nih.gov]

  • Immune Hemolytic Anemia

    The treatment of immune-mediated hemolytic anemia (IHA) complicating hematopoietic stem cell transplantation (HSCT) is often unsatisfactory. We report a case of IHA which occurred after T- and B-cell depleted unrelated donor HSCT carried out for mucopolysaccharidosis type I-H (Hurler syndrome) which was[…][ncbi.nlm.nih.gov]

  • Megaloblastic Anemia

    Megaloblastic anemia is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis during red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M) stage. This leads to continuing cell growth without division, which[…][en.wikipedia.org]

  • Sickle Cell Disease

    Sickle cell disease (SCD) usually manifests early in childhood. For the first 6 months of life, infants are protected largely by elevated levels of Hb F; soon thereafter, the condition becomes evident. The most common clinical manifestation of SCD is vaso-occlusive crisis. A vaso-occlusive crisis occurs when the[…][emedicine.medscape.com]

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